Monascin
Based on 2 publication(s) in Google Scholar
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist.
For research use only. We do not sell to patients.
- Purity : 99.72%
- CAS No.: 21516-68-7
- Formula: C21H26O5
- Molecular Weight:358.43
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-12041
SP600125JNK Inhibitor -
HY-N6642
AnkaflavinPPARγ Agonist -
HY-N7766
RubropunctatinApoptosis Inducer -
HY-N6641R
Monascin (Standard)Azaphilonoid Pigment -
HY-W040129
Chromomycin A3Chemical Sensitizer -
HY-N4170
Chebulic acidAntioxidant Agent -
HY-W040129R
Chromomycin A3 (Standard) -
HY-N4170R
Chebulic acid (Standard)Antioxidant Agent
Publications Citing Use of MedChemExpress (MCE) Monascin
More
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
17.77 μM
Compound: 7
|
Antiproliferative activity against human A431 cells after 72 hrs
Antiproliferative activity against human A431 cells after 72 hrs
|
[PMID: 20655237] |
| IGROV-1 | IC50 |
>30 μM
Compound: 7
|
Antiproliferative activity against human IGROV1 cells after 72 hrs
Antiproliferative activity against human IGROV1 cells after 72 hrs
|
[PMID: 20655237] |
| NCI-H460 | IC50 |
>50 μM
Compound: 7
|
Antiproliferative activity against human NCI-H460 cells after 72 hrs
Antiproliferative activity against human NCI-H460 cells after 72 hrs
|
[PMID: 20655237] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:SENCAR mouse using a UVB irradiation as an initiator and TPA as a promoter[1].
-
Dosage:0.0025% in drinking water.
-
Administration:Orally daily for 2 weeks in drinking water.
-
Result:Reduced the number of the papillomas.
Chemical Information
-
CAS No. 21516-68-7
-
Appearance Solid
-
Molecular Weight 358.43
-
Formula C21H26O5
-
Color Light yellow to yellow
-
SMILES
O=C([C@@H]1C(CCCCC)=O)O[C@]2(C)[C@]1([H])CC(C=C(/C=C/C)OC3)=C3C2=O
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
ACS Appl Bio Mater
PLGA-Loaded Monascin Intranasal Delivery System: Sustained-Release and Immunomodulatory Effect for Treatment of Allergic Rhinitis by Improving Regulatory T Cell Function. [Abstract]2025 Jul 21;8(7):5718-5731. PMID: 40518762 -
Spectrochim Acta A Mol Biomol Spectrosc
Active pharmaceutical ingredient-correlated wavelength selection of UV-vis spectroscopy for the rapid quality assessment of red yeast Rice. [Abstract]2026 Jul 5:355:127669. PMID: 41785610
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (139.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Akihisa T, et al. Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice). Chem Biodivers. 2005 Oct;2(10):1305-9. [Content Brief]
[2]. Lee CL, et al. Monascus fermentation of dioscorea for increasing the production of cholesterol-lowering agent--monacolin K and antiinflammation agent--monascin. Appl Microbiol Biotechnol. 2006 Oct;72(6):1254-62. [Content Brief]
[3]. Shi YX, Chen WS. Monascin ameliorate inflammation in the lipopolysaccharide-induced BV-2 microglial cells via suppressing the NF-κB/p65 pathway. Iran J Basic Med Sci. 2020;23(4):461-468. [Content Brief]
[4]. Hsu WH, et al. A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia. Toxicol Appl Pharmacol. 2013 Nov 1;272(3):842-51. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7899 mL | 13.9497 mL | 27.8995 mL | 69.7486 mL |
| 5 mM | 0.5580 mL | 2.7899 mL | 5.5799 mL | 13.9497 mL | |
| 10 mM | 0.2790 mL | 1.3950 mL | 2.7899 mL | 6.9749 mL | |
| 15 mM | 0.1860 mL | 0.9300 mL | 1.8600 mL | 4.6499 mL | |
| 20 mM | 0.1395 mL | 0.6975 mL | 1.3950 mL | 3.4874 mL | |
| 25 mM | 0.1116 mL | 0.5580 mL | 1.1160 mL | 2.7899 mL | |
| 30 mM | 0.0930 mL | 0.4650 mL | 0.9300 mL | 2.3250 mL | |
| 40 mM | 0.0697 mL | 0.3487 mL | 0.6975 mL | 1.7437 mL | |
| 50 mM | 0.0558 mL | 0.2790 mL | 0.5580 mL | 1.3950 mL | |
| 60 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL | 1.1625 mL | |
| 80 mM | 0.0349 mL | 0.1744 mL | 0.3487 mL | 0.8719 mL | |
| 100 mM | 0.0279 mL | 0.1395 mL | 0.2790 mL | 0.6975 mL |
Monascin Related Classifications
HY-N6641 Related Classifications
Powered by Bioz