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Cat. No.: HY-187736

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R34803

R34803 is an orally effective Microtubule inhibitor and antiparasitic agent. R34803 impedes directional migration by interfering with the cytoplasmic microtubule complex, and causes metaphase arrest to inhibit the growth of cancer cell aggregates while preventing their invasion into other tissues. R34803 exhibits activity against a variety of parasites. R34803 can be used for research on fibrosarcoma and helminthiasis.

For research use only. We do not sell to patients.

CAS No.: 64420-40-2
Formula: C₁₈H₁₆FN₃O₄
Molecular Weight:357.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

R34803 Chemical Structure

CAS No.: 64420-40-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All Parasite Isoforms :

In Vitro

R34803 (1 μg/mL; 2-7 days) prevents invasion of MO₄ mouse fibrosarcoma cells into embryonic chick heart tissue and inhibits growth of the confronting tissues without causing central necrosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Invasion Assay^[1]

Cell Line:

MO₄ mouse fibrosarcoma cell line
Concentration:

1 μg/mL
Incubation Time:

2, 4, 7 days
Result:

Prevented invasion of MO₄ cells into embryonic chick heart tissue.
Inhibited growth of confronting tissues.
Did not cause central necrosis.

Related Protocols :

Chemical Information

CAS No. 64420-40-2
Molecular Weight 357.34
Formula C₁₈H₁₆FN₃O₄
SMILES

O=C(OC)NC1=NC=2C=CC(=CC2N1)C3(OCCO3)C4=CC=C(F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Storme G, et al. Effect of anticancer agents on invasion of mouse fibrosarcoma cells in vitro. Oncology. 1981;38(3):182-6.

[2]. Restrepo M, et al. Evaluación del R-34803 en el tratamiento de helmintiasis. Acta Med Colomb. 1983;8(4):224-27.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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