NLRP3-IN-24
NLRP3-IN-24 (Compounds 15a) is an inhibitor against NLRP3. NLRP3-IN-24 has an inhibitory effect on the activation of NLRP3 inflammasome.
For research use only. We do not sell to patients.
- Formula: C19H26O3Si
- Molecular Weight:330.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 |
IL-1β |
NLRP3-IN-24 (0.1-10 μM, 1 h) inhibits the activity against heme-induced NLRP3 mediated inflammation in THP-1 cells and J774A.1 cells [1].
NLRP3-IN-24 (10 μM, 24 h) is nontoxic in J774A.1 cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774A.1 cells
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Concentration:10.0 μM
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Incubation Time:24 h
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Result:Showed nontoxic in J774A.1 cells at 10 μM
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Peritoneal inflammation model[1]
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Dosage:10 mg/kg, 30 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Significant decreased the levels of IL-1β.
Chemical Information
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Molecular Weight 330.49
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Formula C19H26O3Si
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SMILES
O=C(C=C1[Si](C)(C)C)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NLRP3-IN-24 Related Classifications
HY-157147 Related Classifications
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