NLRP3-IN-24
NLRP3-IN-24 (Compounds 15a) is an inhibitor against NLRP3. NLRP3-IN-24 has an inhibitory effect on the activation of NLRP3 inflammasome.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C19H26O3Si
- 分子量:330.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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IL-6 |
IL-1β |
体外実験
NLRP3-IN-24 (0.1-10 μM, 1 h) inhibits the activity against heme-induced NLRP3 mediated inflammation in THP-1 cells and J774A.1 cells [1].
NLRP3-IN-24 (10 μM, 24 h) is nontoxic in J774A.1 cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774A.1 cells
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Concentration:10.0 μM
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Incubation Time:24 h
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Result:Showed nontoxic in J774A.1 cells at 10 μM
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Peritoneal inflammation model[1]
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Dosage:10 mg/kg, 30 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Significant decreased the levels of IL-1β.
化学情報
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分子量 330.49
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分子式 C19H26O3Si
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SMILES
O=C(C=C1[Si](C)(C)C)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NLRP3-IN-24 関連分類
HY-157147 関連分類
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