NLRP3-IN-24

Cat. No.: HY-157147: FAQs
Data Sheet Handling Instructions

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NLRP3-IN-24 (Compounds 15a) is an inhibitor against NLRP3. NLRP3-IN-24 has an inhibitory effect on the activation of NLRP3 inflammasome.

For research use only. We do not sell to patients.

NLRP3-IN-24 Chemical Structure

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Description

NLRP3-IN-24 (Compounds 15a) is an inhibitor against NLRP3. NLRP3-IN-24 has an inhibitory effect on the activation of NLRP3 inflammasome^[1].

IC₅₀ & Target

IL-6

IL-1β

In Vitro

NLRP3-IN-24 (0.1-10 μM, 1 h) inhibits the activity against heme-induced NLRP3 mediated inflammation in THP-1 cells and J774A.1 cells ^[1].
NLRP3-IN-24 (10 μM, 24 h) is nontoxic in J774A.1 cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	J774A.1 cells
Concentration:	10.0 μM
Incubation Time:	24 h
Result:	Showed nontoxic in J774A.1 cells at 10 μM

In Vivo

NLRP3-IN-24 (10-30 mg/kg, Intraperitoneal injection, 30 min before the administration of LPS, single dose) inhibits the activation of NLRP3 inflammasome in peritoneal inflammation model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Peritoneal inflammation model^[1]
Dosage:	10 mg/kg, 30 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Significant decreased the levels of IL-1β.

Molecular Weight

330.49

Formula

C₁₉H₂₆O₃Si

SMILES

O=C(C=C1[Si](C)(C)C)C([C@@H]2C=C(C)CC[C@H]2C(C)=C)=C(O)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shete S S, et al. Sila-CBD Derivatives as Inhibitors of Heme-Induced NLRP3 Inflammasome: Application in Hemolytic Diseases[J]. ACS Medicinal Chemistry Letters, 2023.

NLRP3-IN-24 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-24TNF ReceptorInterleukin RelatedTumor Necrosis Factor ReceptorTNFRILanti-inflammatoryJ774A.1 cellsTHP-1 cellsPeritoneal inflammation modelInhibitorinhibitorinhibit

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