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Cat. No.: HY-149980

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DCN-83

DCN-83, an anti-leishmania agent, is most potent against the amastigote form with an IC₅₀ of 0.71 μM. DCN-83 has the potential to cross the blood-brain barrier and central nervous system.

For research use only. We do not sell to patients.

Formula: C₂₀H₁₈BrN₃S
Molecular Weight:412.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

DCN-83 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DCN-83, an anti-leishmania agent, is most potent against the amastigote form with an IC₅₀ of 0.71 μM. DCN-83 has the potential to cross the blood-brain barrier and central nervous system^[1].

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	CC₅₀	>100 μM Compound: 8CN-83	Cytotoxicity against mouse J774.A1 cells incubated for 72 hrs by MTT colorimetric assay Cytotoxicity against mouse J774.A1 cells incubated for 72 hrs by MTT colorimetric assay	[PMID: 36848847]

In Vitro

DCN-83 has no AMES toxicity and hepatotoxicity^[1].
DCN-83 has a slight inhibitory effect on Macrophage J774.A1, with a CC₅₀ value of 84.73 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 412.35
Formula C₂₀H₁₈BrN₃S
SMILES

N#CC1=C(SC2=C1CCCCCC2)/N=C/C3=CNC4=C3C=C(C=C4)Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Luna IS, et al. Computer-Aided drug design of new 2-amino-thiophene derivatives as anti-leishmanial agents. Eur J Med Chem. 2023 Mar 15;250:115223. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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