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Cat. No.: HY-182474

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INDOPY-1

Name: INDOPY-1
Brand: MedChemExpress
SKU: HY-182474
Availability: PreOrder

(Synonyms: Indolopyridone-1)

INDOPY-1 (Indolopyridone-1) is a selective, reversible, and competitive HIV-1 reverse transcriptase inhibitor. INDOPY-1 reversibly binds to the active site of reverse transcriptase. INDOPY-1 inhibits DNA synthesis. INDOPY-1 exhibits antiviral activity against various retroviruses, including HIV-1 IIIB, HIV-1 HXB2 K103N Y181C, HIV-2 ROD, and SIV Mac251. INDOPY-1 can be used in the research of immunodeficiency virus infection.

For research use only. We do not sell to patients.

CAS No.: 352548-47-1
Formula: C₁₉H₁₂N₄O₃
Molecular Weight:344.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

INDOPY-1 Chemical Structure

CAS No.: 352548-47-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

HIV-1

HIV-2

All DNA/RNA Synthesis Isoforms :

All HIV Isoforms :

In Vitro

INDOPY-1 inhibits DNA synthesis, with an IC₅₀ of 0.29 μM measured using Poly (rA) · poly (dT) and an IC₅₀ of 1.1 μM measured using Poly (rI) · poly (dC)^[1].
INDOPY-1 exhibits antiviral activity against diverse retroviruses, including HIV-1 IIIB, HIV-1 HXB2 K103N Y181C, HIV-2 ROD, and SIV Mac251^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 352548-47-1
Molecular Weight 344.32
Formula C₁₉H₁₂N₄O₃
SMILES

N#CC(C(N1C2=CC=C([N+]([O-])=O)C=C2)=O)=CC(N3C)=C1C4=C3C=CC=C4
Synonyms

Indolopyridone-1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jochmans D, et al. Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action. J Virol. 2006;80(24):12283-12292. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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INDOPY-1

All DNA/RNA Synthesis Isoforms

All HIV Isoforms