country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-153096

Copy Link Print Information

OICR12694

(Synonyms: JNJ-65234637)

OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6).

For research use only. We do not sell to patients.

CAS No.: 2360625-97-2
Formula: C₂₉H₂₈ClF₃N₈O₄
Molecular Weight:645.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

OICR12694 Chemical Structure

CAS No.: 2360625-97-2

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

OICR12694 (JNJ-65234637) is an orally active inhibitor of B cell lymphoma 6 (BCL6)^[1].

IC₅₀ & Target

B cell lymphoma 6 (BCL6)^[1]

All Bcl-2 Family Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-422	IC₅₀	0.092 μM Compound: 58	Antiproliferative activity against human KARPAS-422 cell assessed as cell growth inhibition incubated for 6 days by ATPlite reagent based luminescence assay Antiproliferative activity against human KARPAS-422 cell assessed as cell growth inhibition incubated for 6 days by ATPlite reagent based luminescence assay	[PMID: 36793435]

Chemical Information

CAS No. 2360625-97-2
Molecular Weight 645.03
Formula C₂₉H₂₈ClF₃N₈O₄
SMILES

O=C1C2=C(N=C3N1CCC3)N(CC(NC4=C(Cl)C(F)=NC(N5[C@H](CN(CC5)C)C)=C4)=O)C=C2C6=CC(C(N)=O)=C(C(F)=C6F)O
Synonyms

JNJ-65234637
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mamai A, et al. Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor. ACS Med Chem Lett. 2023 Jan 12;14(2):199-210. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

OICR12694

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

OICR12694 Related Classifications

HY-153096 Related Classifications