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Cat. No.: HY-133029

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PI3K-IN-9

PI3K-IN-9 (compound 1-14) is a potent and selective PI3Kδ inhibitor with an IC₅₀ of 8.9 nM.

For research use only. We do not sell to patients.

CAS No.: 2360875-63-2
Formula: C₁₉H₂₃N₇O
Molecular Weight:365.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PI3K-IN-9 Chemical Structure

CAS No.: 2360875-63-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PI3K-IN-9 (compound 1-14) is a potent and selective PI3Kδ inhibitor with an IC₅₀ of 8.9 nM^[1].

IC₅₀ & Target

^[1]

PI3Kδ

All PI3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	IC₅₀	9 nM Compound: 29	Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr	[PMID: 31757666]

Chemical Information

CAS No. 2360875-63-2
Molecular Weight 365.43
Formula C₁₉H₂₃N₇O
SMILES

O=C([C@@H]1C[C@H]1C)N(CC2)[C@H](C)CN2C3=CN=C(C#N)C(C4=CN(C)N=C4)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Meredeth A. MCGOWAN, et al. Inhibiteurs puriques de la phosphatidylinositol 3-kinase delta humaine. WO2019125839.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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