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PI3Kα-IN-24

PI3Kα-IN-24 (WR23) is a PI3Kα inhibitor with an IC₅₀ of 0.025 μM and exhibits a significant pAkt^Ser473 suppression effect. PI3Kα-IN-24 can be utilized in cancer research.

For research use only. We do not sell to patients.

CAS No.: 1350960-66-5
Formula: C₁₉H₁₈BrN₃O₃S
Molecular Weight:448.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PI3Kα-IN-24 Chemical Structure

CAS No.: 1350960-66-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

PI3Kα-IN-24 (WR23) is a PI3Kα inhibitor with an IC₅₀ of 0.025 μM and exhibits a significant pAkt^Ser473 suppression effect. PI3Kα-IN-24 can be utilized in cancer research^[1].

IC₅₀ & Target

PI3Kα

0.025 μM (IC₅₀)

All PI3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.95 μM Compound: 10d, WR23	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 22480851]
HCT-116	IC₅₀	1.65 μM Compound: 10d, WR23	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 22480851]
HL-60	IC₅₀	0.34 μM Compound: 10d, WR23	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 22480851]
KB	IC₅₀	2.32 μM Compound: 10d, WR23	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 22480851]
PC-3	IC₅₀	2.02 μM Compound: 10d, WR23	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 22480851]

Chemical Information

CAS No. 1350960-66-5
Molecular Weight 448.33
Formula C₁₉H₁₈BrN₃O₃S
SMILES

O=S(C1=CC=C(C=C1)Br)(C2=NC3=C(N=C2N4CCC(CC4)O)C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu P, et al. Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors. Bioorg Med Chem. 2012 May 1;20(9):2837-44. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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