PI3Kα-IN-6
PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2272894-14-9
- Formula: C16H15IN2OS
- Molecular Weight:410.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kα |
PI3Kα-IN-6 (Compound 5b) shows cell growth inhibition with IC50 values of 3.5, 8.7, 8.9, 26.5, 89.9, 61.1 and 112.02 against HCT-116, A-549, MiaPaca-2, MCF-7, MDA-MB-231, PC-3 and HEK-293 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2272894-14-9
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Molecular Weight 410.27
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Formula C16H15IN2OS
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SMILES
COC1=CC=C(C=C1)SCC2=C(N=C3C=CC(C)=CN32)I
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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