2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kγ inhibitor 7

PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity. PI3Kγ inhibitor 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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PI3Kγ inhibitor 7 Chemical Structure

PI3Kγ inhibitor 7 Chemical Structure

CAS No. : 2575863-25-9

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PI3Kγ inhibitor 7 Related Antibodies

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Description

PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity[1]. PI3Kγ inhibitor 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

PI3Kα

4768 nM (IC50)

PI3Kβ

878.1 nM (IC50)

PI3Kγ

3.42 nM (IC50)

PI3Kδ

355.2 nM (IC50)

In Vivo

PI3Kγ inhibitor 7 (compound 2) (5 mg/kg; p.o.) shows good pharmacokinetic absorption with t1/2 of 3.4 h, F of 60 % in ICR mice[1].
PI3Kγ inhibitor 7 (60 mg/kg; p.o.; daily for 21 days) shows antitumor activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (CT26 cells)[1]
Dosage: 60 mg/kg
Administration: P.o.; daily for 21 days
Result: Decreased the tumor weight and with TGI of 51.2%, IR of 52.1%.
Molecular Weight

555.59

Formula

C31H25N9O2
CAS No.
SMILES

O=C1C2=C(C#CC3=CN(C4CC4)N=C3)C=CC=C2N=C(N1C5=CC=CC=C5)[C@H](C)NC(C6=C7N(C=CC=N7)N=C6N)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3Kγ inhibitor 7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kγ inhibitor 72575863-25-9PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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