PI3Kγ inhibitor 7
PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity. PI3Kγ inhibitor 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- CAS No.: 2575863-25-9
- Formula: C31H25N9O2
- Molecular Weight:555.59
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PI3Kα 4768 nM (IC50) |
PI3Kβ 878.1 nM (IC50) |
PI3Kγ 3.42 nM (IC50) |
PI3Kδ 355.2 nM (IC50) |
PI3Kγ inhibitor 7 (60 mg/kg; p.o.; daily for 21 days) shows antitumor activity in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female BALB/c mice (CT26 cells)[1]
-
Dosage:60 mg/kg
-
Administration:P.o.; daily for 21 days
-
Result:Decreased the tumor weight and with TGI of 51.2%, IR of 52.1%.
Chemical Information
-
CAS No. 2575863-25-9
-
Molecular Weight 555.59
-
Formula C31H25N9O2
-
SMILES
O=C1C2=C(C#CC3=CN(C4CC4)N=C3)C=CC=C2N=C(N1C5=CC=CC=C5)[C@H](C)NC(C6=C7N(C=CC=N7)N=C6N)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz