PRMT5-IN-35

Cat. No.: HY-160865 Purity: 99.63%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PRMT5-IN-35 (Compound 87) is a potent, selective and orally active PRMT5 inhibitor with an IC₅₀ value of 1 nM. PRMT5-IN-35 can be used in cancer research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

PRMT5-IN-35 화학구조

CAS No. : 1989620-03-2

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms

EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Biological Activity
순도&문서
References
고객리뷰

제품 설명

PRMT5-IN-35 (Compound 87) is a potent, selective and orally active PRMT5 inhibitor with an IC₅₀ value of 1 nM. PRMT5-IN-35 can be used in cancer research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	10.8 nM Compound: 46	Antiproliferation activity against human A-375 cells assessed as cell growth inhibition Antiproliferation activity against human A-375 cells assessed as cell growth inhibition	[PMID: 36274274]
A-375	IC₅₀	11 nM Compound: 2	Antiproliferative activity against human A375 cells measured after 7 days by cell titer glo-based luminescence assay Antiproliferative activity against human A375 cells measured after 7 days by cell titer glo-based luminescence assay	[PMID: 30956011]
A549	IC₅₀	5 nM Compound: 2	Antiproliferative activity against human A549 cells incubated for 7 days with compound replacement on day 4 by cell titer glo-based luminescence assay Antiproliferative activity against human A549 cells incubated for 7 days with compound replacement on day 4 by cell titer glo-based luminescence assay	[PMID: 30956011]
Sf21	IC₅₀	1 nM Compound: 2	Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells using H4(1-21) peptide SGRGKGGKGLGKGGAKRHRKV as substrate measured after 25 minutes in the presence of [3H]SAM by liquid scintillation counting Inhibition of full length N-terminal FLAG-tagged PRMT5 (unknown origin)/MEP50 (unknown origin) expressed in baculovirus infected Sf21 insect cells using H4(1-21) peptide SGRGKGGKGLGKGGAKRHRKV as substrate measured after 25 minutes in the presence of [3H]SAM by liquid scintillation counting	[PMID: 30956011]
Sf9	IC₅₀	4.3 nM Compound: 2	Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovirus infected Sf9 insect cells assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H-SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin measured after 2 hrs by liquid scintillation counting Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (1 to 637 residue) /full length human N-terminal His tagged MEP50 expressed in baculovirus infected Sf9 insect cells assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H-SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin measured after 2 hrs by liquid scintillation counting	[PMID: 30956011]

Clinical Trial

분자량

376.79

화학식

C₁₇H₁₇ClN₄O₄

CAS No.

1989620-03-2

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3C=C2)O[C@@H]1[C@H](O)C4=CC=C(Cl)C=C4

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 125 mg/mL (331.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6540 mL	13.2700 mL	26.5400 mL
5 mM	0.5308 mL	2.6540 mL	5.3080 mL
10 mM	0.2654 mL	1.3270 mL	2.6540 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.63%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (252 KB) HNMR (258 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Ferrarotto R, et al. PRT543, a protein arginine methyltransferase 5 inhibitor, in patients with advanced adenoid cystic carcinoma: An open-label, phase I dose-expansion study. Oral Oncol. 2024 Feb;149:106634. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6540 mL	13.2700 mL	26.5400 mL	66.3500 mL
	5 mM	0.5308 mL	2.6540 mL	5.3080 mL	13.2700 mL
	10 mM	0.2654 mL	1.3270 mL	2.6540 mL	6.6350 mL
	15 mM	0.1769 mL	0.8847 mL	1.7693 mL	4.4233 mL
	20 mM	0.1327 mL	0.6635 mL	1.3270 mL	3.3175 mL
	25 mM	0.1062 mL	0.5308 mL	1.0616 mL	2.6540 mL
	30 mM	0.0885 mL	0.4423 mL	0.8847 mL	2.2117 mL
	40 mM	0.0663 mL	0.3317 mL	0.6635 mL	1.6587 mL
	50 mM	0.0531 mL	0.2654 mL	0.5308 mL	1.3270 mL
	60 mM	0.0442 mL	0.2212 mL	0.4423 mL	1.1058 mL
	80 mM	0.0332 mL	0.1659 mL	0.3317 mL	0.8294 mL
	100 mM	0.0265 mL	0.1327 mL	0.2654 mL	0.6635 mL

PRMT5-IN-35 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-IN-351989620-03-2Histone MethyltransferaseAnticancer AgentInhibitorinhibitorinhibit

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PRMT5-IN-35

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PRMT5-IN-35 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Histone Methyltransferase Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

PRMT5-IN-35 Related Classifications

Keywords:

최근 본 상품:

고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report