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Cat. No.: HY-179273

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Proteasome-IN-8

Proteasome-IN-1 (Compound 130) is a proteasome inhibitor. Proteasome-IN-1 exhibits antiparasitic activity against P. faciparum 3D7.

For research use only. We do not sell to patients.

CAS No.: 3097658-48-2
Formula: C₂₇H₂₉F₃N₄O₃S
Molecular Weight:546.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Proteasome-IN-8 Chemical Structure

CAS No.: 3097658-48-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Proteasome-IN-1 (Compound 130) is a proteasome inhibitor. Proteasome-IN-1 exhibits antiparasitic activity against P. faciparum 3D7^[1].

All Parasite Isoforms :

Chemical Information

CAS No. 3097658-48-2
Molecular Weight 546.60
Formula C₂₇H₂₉F₃N₄O₃S
SMILES

O=C([C@@H]1CN(C(COC[C@H](N)C2=CC=CC=C2)=O)CCC1)NCC3=NC(C4=CC=C(C(F)(F)F)C=C4)=CS3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gahalawat S, et al. Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria. J Med Chem. 2025 Nov 13;68(21):23485-23520. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Chemical Information
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Proteasome-IN-8

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Proteasome-IN-8 Related Classifications

HY-179273 Related Classifications