(Rac)-Acuminatin
(Rac)-Acuminatin is a c-Myc transcription inhibitor. (Rac)-Acuminatin reduces c-Myc mRNA and protein levels. (Rac)-Acuminatin induces cell cycle arrest. (Rac)-Acuminatin exhibits anticancer activity against colorectal cancer. (Rac)-Acuminatin possesses antiplatelet aggregation and antioxidant/hepatoprotective activities.
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- 화학식: C21H24O4
- 분자량:340.41
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
제품 설명
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SW480 | IC50 |
10.76 μM
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Antiproliferative activity against human SW480 colorectal cancer cells assessed as viability reduction by CCK-8 assay.
Antiproliferative activity against human SW480 colorectal cancer cells assessed as viability reduction by CCK-8 assay.
|
42805086 |
| HCT-116 | IC50 |
14.29 μM
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Antiproliferative activity against human HCT116 colorectal cancer cells assessed as viability reduction by CCK-8 assay.
Antiproliferative activity against human HCT116 colorectal cancer cells assessed as viability reduction by CCK-8 assay.
|
42805086 |
| SW-620 | IC50 |
17.60 μM
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Antiproliferative activity against human SW620 colorectal cancer cells assessed as viability reduction by CCK-8 assay.
Antiproliferative activity against human SW620 colorectal cancer cells assessed as viability reduction by CCK-8 assay.
|
42805086 |
| RKO | IC50 |
5.521 μM
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Antiproliferative activity against human RKO colorectal cancer cells assessed as viability reduction by CCK-8 assay.
Antiproliferative activity against human RKO colorectal cancer cells assessed as viability reduction by CCK-8 assay.
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42805086 |
In Vitro
(Rac)-Acuminatin inhibits colorectal cancer cell viability, with IC50 values of 10.76 μM, 14.29 μM, 17.60 μM, and 5.521 μM in SW480, HCT116, SW620, and RKO cells, respectively[1].
(Rac)-Acuminatin inhibits colony formation in SW480, HCT116, RKO, and SW620 colorectal cancer cells, with a weaker effect on NCM460 cells[1].
(Rac)-Acuminatin exerts antiproliferative activity in HCT116 colorectal cancer cells, and this activity depends at least in part on c-MYC[1].
(Rac)-Acuminatin downregulates the c-MYC target gene program in colorectal cancer cells[1].
(Rac)-Acuminatin reduces the expression of stemness-related genes CD166, CD133, CD44, and LGR5 in colorectal cancer cells[1].
(Rac)-Acuminatin (10-20 μM; 24 h) reduces c-myc mRNA levels in SW480 and HCT116 colorectal cancer cells[1].
(Rac)-Acuminatin (10 μM) inhibits c-MYC promoter activity in SW480 colorectal cancer cells[1].
(Rac)-Acuminatin induces G1 phase cell cycle arrest in colorectal cancer cells[1].
(Rac)-Acuminatin (6 h), despite inducing early changes in cell cycle-related proteins, does not immediately inhibit the transcription of CCND1, CCNE1, or PCNA in colorectal cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SW480 and HCT116 colorectal cancer cells
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Concentration:20 μM (24 h screening); 0, 2, 5, 10, 15, 20 μM (dose-response)
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Incubation Time:24 h (screening)
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Result:Met the screening criterion of reducing c-MYC below 50% in both SW480 and HCT116 cells.
Dose-response experiments showed reduced c-MYC protein levels at 15 μM in both cell lines.
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Cell Line:SW480 and HCT116 colorectal cancer cells
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Concentration:10 and 20 μM
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Incubation Time:24 h
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Result:Significantly reduced c-myc mRNA levels in both SW480 and HCT116 cells.
Chemical Information
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분자량 340.41
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화학식 C21H24O4
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SMILES
C/C=C/C1=CC(OC)=C(OC(C2=CC=C(OC)C(OC)=C2)C3C)C3=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-Acuminatin Related Classifications
HY-N2817A Related Classifications
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