Scr-IN-2
Scr-IN-2 is an effective c-Scr inhibitor with an IC50 of 302 nM. Scr-IN-2 exhibits nanomolar-level anti-breast cancer activity. Scr-IN-2 increases the level of ROS in cells, induces mitochondrial damage, G1 phase arrest, and apoptosis. Scr-IN-2 can be used in the research of breast cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2787582-78-7
- 分子式: C21H33N7
- 分子量:383.53
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Scr-IN-2 (Compound 3g) inhibits MDAMB-231, T47D, and MCF-7 cell proliferation with IC50s of 0.812, 1.03 and 0.568 μM, and shows no significant toxicity to normal breast cells (MCF-10A)[1].
Scr-IN-20 (500 nM, 48 h) increases the ROS production, causes damage to mitochondria, induces apoptosis and halts the cell cycle at the G1 phase in the MCF-7 cells [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7 cells
-
Concentration:500 nM
-
Incubation Time:48 h
-
Result:Reached the proportion of apoptotic cells by 62.5%.
-
Cell Line:MCF-7 cells
-
Concentration:500 nM
-
Incubation Time:48 h
-
Result:Blocked MCF-7 cells in the G1 phase to inhibit DNA replication and cell proliferation.
化学情報
-
CAS 番号 2787582-78-7
-
分子量 383.53
-
分子式 C21H33N7
-
SMILES
CCCCN1C(NC(C)(C)C)=NC2=CC=CC=C2C1C3=NN=NN3C(C)(C)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Powered by Bioz