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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
278 Results for "
splice
" in MedChemExpress (MCE) Product Catalog:
Products (278)
278 Results for "splice" in MCE Product Catalog:
Cat. No.: HY-W683756
CAS No.: 16625-69-7
Target:
Telomerase Gap Junction Protein P2X Receptor Calcium Channel Reactive Oxygen Species (ROS) NF-κB SGK TNF Receptor
Research Areas:
Boldine hydrochloride is an aporphine alkaloid telomerase (telomerase) inhibitor (IC50 of 0.17 μM for TERT) and a pannexin/connexin hemichannel blocker, with oral activity and blood-brain barrier permeability. Boldine hydrochloride inhibits telomerase activity through direct interaction with the telomerase ribonucleoprotein and non-competitive binding near the TERT active site, and downregulates hTERT mRNA while shifting alternative splicing toward non-functional transcripts. Boldine hydrochloride blocks Panx1, Cx43, Cx26, and Cx30 hemichannels as well as P2X7 receptor-mediated calcium influx. Boldine hydrochloride exhibits antioxidant, anti-inflammatory, antiproliferative, and cytotoxic activities by scavenging ROS, inhibiting NFκB, dephosphorylating SGK1, and reducing TNF-alpha levels. Boldine hydrochloride can be used in research on breast cancer, Alzheimer's disease, glioblastoma, diabetes, and spinal cord injury .
Cat. No.: HY-P86957
Synonyms: CXXC 3 antibody; CXXC-type zinc finger protein 3 antibody; CXXC3 antibody; MBD 1 antibody; Mbd1 antibody; MBD1_HUMAN antibody; MECP1 COMPLEX antibody; Methyl CpG binding domain protein 1 antibody; Methyl CpG binding domain protein 1 isoform PCM1 antibody; Methyl CpG binding protein MBD1 antibody; CXXC 3 antibody; CXXC-type zinc finger protein 3 antibody; CXXC3 antibody; MBD 1 antibody; Mbd1 antibody; MBD1_HUMAN antibody; MECP1 COMPLEX antibody; Methyl CpG binding domain protein 1 antibody; Methyl CpG binding domain protein 1 isoform PCM1 antibody; Methyl CpG binding protein MBD1 antibody; Methyl CpG binding protein splice variant 1 antibody; Methyl CpG binding protein splice variant 2 antibody; Methyl CpG binding protein splice variant 3 antibody; Methyl CpG binding protein splice variant 4 antibody; Methyl-CpG-binding domain protein 1 antibody; Methyl-CpG-binding protein MBD1 antibody; PCM 1 antibody; PCM1 antibody; Protein containing methyl-CpG-binding domain 1 antibody; Regulator of fibroblast growth factor 2 (FGF 2) transcription antibody; RFT antibody; The regulator of fibroblast growth factor 2(FGF 2) transcription antibody;
Cat. No.: HY-P72088
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AR; Spinal And Bulbar Muscular Atrophy; Prev. DHTR; Androgen Receptor splice Variant 6; Prev. SBMA; Androgen Receptor Variant 5,6,7es; Dihydrotestosterone Receptor; Testicular Feminization; NR3C4; Kennedy Disease; Nuclear Receptor Subfamily 3 Group C Memb
Species:
Human
Source:
E. coli
Cat. No.: HY-P77120A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ADCYAP1R1; PAC1 Receptor; ADCYAP Receptor Type I; PACAP-R1; PAC1R; Pituitary Adenylate Cyclase Activating Polypeptide 1 Receptor Type I Hiphop splice Variant; Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor; Pituitary Adenylate Cyclase
Species:
Human
Source:
HEK293
Cat. No.: HY-13650R
CAS No.: 165668-41-7
Synonyms: E 7070 (Standard)
Research Areas:
Indisulam (Standard) (E 7070 (Standard)) is the analytical standard of Indisulam (HY-13650). This product is intended for research and analytical applications. Indisulam (E 7070) is a carbonic anhydrase inhibitor and RBM39 molecular glue degrader, with Ki values of 31, 15, and 24 nM against human carbonic anhydrase I, II, and IX, respectively, and a Ki value of 65 nM against bovine carbonic anhydrase IV. Indisulam promotes the recruitment of RBM39 to the CUL4-DCAF15 E3 ubiquitin ligase complex, triggering polyubiquitination and proteasomal degradation of RBM39. Indisulam induces aberrant pre-mRNA splicing, G1 cell cycle arrest, and cell death in cancer cells. As an anticancer agent, Indisulam drives tumor regression and growth inhibition in xenograft models. Indisulam can be used in research related to solid tumors, hematologic and lymphoid malignancies, colorectal cancer, and non-small cell lung cancer .
Cat. No.: HY-145425
CAS No.: 2771006-54-1
Research Areas:
PAIR2 is a highly selective inhibitor targeting the kinase domain of human IRE1α, with a Ki value of 8.8 nM against human IRE1α. PAIR2 fully occupies the ATP-binding site of the IRE1α kinase domain, partially antagonizes the ribonuclease activity of IRE1α, specifically inhibits regulated IRE1α-dependent decay (RIDD) and its mediated substrate cleavage, while preserving the splicing function of Xbp1 mRNA. PAIR2 also promotes the differentiation of B cells into plasma cells, blocks IRE1α-induced cell apoptosis, and restores the expression of Fgfr2 mRNA in AT2 cells. PAIR2 effectively reaches a steady-state concentration in the lung tissues of Mus musculus, and serves as an important tool for investigating the function of the IRE1α signaling pathway in diseases such as pulmonary fibrosis .
Cat. No.: HY-P11698
CAS No.: 476667-31-9
Research Areas:
Cat. No.: HY-P71297
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPING1; Serine (Or Cysteine) Proteinase Inhibitor, Clade G (C1 Inhibitor), Member 1, (Angioedema, Hereditary); Prev. C1NH; Serine/Cysteine Proteinase Inhibitor Clade G Member 1 splice Variant 2; Plasma Protease C1 Inhibitor; Serine/Cysteine Proteinase I
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P72086
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AQP1; Aquaporin 1 (Channel-Forming Integral Protein, 28kDa); Prev. CO; Aquaporin 1, Colton Blood Group Antigen; CHIP28; Aquaporin 1 splice Variant 2; Aquaporin-CHIP; Colton Blood Group Antigen; Aquaporin-1; Bloodgroup CO Protein; Aquaporin 1 (Channel-Form
Species:
Human
Source:
E. coli
Cat. No.: HY-P73654
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPING1; Serine (Or Cysteine) Proteinase Inhibitor, Clade G (C1 Inhibitor), Member 1, (Angioedema, Hereditary); Prev. C1NH; Serine/Cysteine Proteinase Inhibitor Clade G Member 1 splice Variant 2; Plasma Protease C1 Inhibitor; Serine/Cysteine Proteinase I
Species:
Rat
Source:
HEK293
Cat. No.: HY-P77120
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ADCYAP1R1; PAC1 Receptor; ADCYAP Receptor Type I; PACAP-R1; PAC1R; Pituitary Adenylate Cyclase Activating Polypeptide 1 Receptor Type I Hiphop splice Variant; Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor; Pituitary Adenylate Cyclase
Species:
Human
Source:
HEK293
Cat. No.: HY-P701076
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGR2; Epididymis Secretory Protein Li 116; Anterior Gradient 2, Protein Disulphide Isomerase Family Member; HEL-S-116; HAG-2; AG-2; AG2; HPC8; PDIA17; Anterior Gradient 2 splice Variant C; XAG-2; Secreted Cement Gland Homolog; Protein Disulfide Isomerase
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P702958
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CDKN3; Cyclin-Dependent Kinase Inhibitor; Cyclin Dependent Kinase Inhibitor 3; CIP2; CDI1; Cyclin-Dependent Kinase Inhibitor 3 splice Variant; KAP; Cyclin-Dependent Kinase Interacting Protein 2; Cyclin-Dependent Kinase Inhibitor 3; Cyclin-Dependent Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703829
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGR2; Epididymis Secretory Protein Li 116; Anterior Gradient 2, Protein Disulphide Isomerase Family Member; HEL-S-116; HAG-2; AG-2; AG2; HPC8; PDIA17; Anterior Gradient 2 splice Variant C; XAG-2; Secreted Cement Gland Homolog; Protein Disulfide Isomerase
Species:
Human
Source:
E. coli
Cat. No.: HY-P7465
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGR2; Epididymis Secretory Protein Li 116; Anterior Gradient 2, Protein Disulphide Isomerase Family Member; HEL-S-116; HAG-2; AG-2; AG2; HPC8; PDIA17; Anterior Gradient 2 splice Variant C; XAG-2; Secreted Cement Gland Homolog; Protein Disulfide Isomerase
Species:
Human
Source:
HEK293
Cat. No.: HY-P72085
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AQP1; Aquaporin 1 (Channel-Forming Integral Protein, 28kDa); Prev. CO; Aquaporin 1, Colton Blood Group Antigen; CHIP28; Aquaporin 1 splice Variant 2; Aquaporin-CHIP; Colton Blood Group Antigen; Aquaporin-1; Bloodgroup CO Protein; Aquaporin 1 (Channel-Form
Species:
Human
Source:
E. coli
Cat. No.: HY-P78771
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AGR2; Epididymis Secretory Protein Li 116; Anterior Gradient 2, Protein Disulphide Isomerase Family Member; HEL-S-116; HAG-2; AG-2; AG2; HPC8; PDIA17; Anterior Gradient 2 splice Variant C; XAG-2; Secreted Cement Gland Homolog; Protein Disulfide Isomerase
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P7465A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AGR2; Epididymis Secretory Protein Li 116; Anterior Gradient 2, Protein Disulphide Isomerase Family Member; HEL-S-116; HAG-2; AG-2; AG2; HPC8; PDIA17; Anterior Gradient 2 splice Variant C; XAG-2; Secreted Cement Gland Homolog; Protein Disulfide Isomerase
Species:
Human
Source:
HEK293
Cat. No.: HY-P77297
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ART4; Dombrock Blood Group Carrier Molecule splice Variant III; Prev. DO; NAD(P)(+)--Arginine ADP-Ribosyltransferase; ARTC4; Mono(ADP-Ribosyl)Transferase 4; DOK1; Mono-ADP-Ribosyltransferase 4; ADP-Ribosyltransferase 4 (Dombrock Blood Group); Mono(ADP-Rib
Species:
Cynomolgus
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
