397 Results for "

Complement

" in MedChemExpress (MCE) Product Catalog:
Products (397)

397 Results for "Complement" in MCE Product Catalog:

Cat. No.: HY-P991585

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

MORAb-028 is a humanized IgG1 monoclonal antibody inhibitor targeting GD2. MORAb-028 has a potent antitumor activity and kills GD2-expressing target cells via complement-mediated cytotoxicity (CDC). MORAb-028 significantly inhibits tumor growth in EL-4-luc xenograft mice model. MORAb-028 can be used for melanoma cancer research .
loading...
    loading...
Cat. No.: HY-P992512
Target:  

Complement System

Research Areas:  

Neurological Disease

ANX-M1 Mouse IgG1 is a brain-penetrant C1q inhibitor. ANX-M1 Mouse IgG1 blocks classical complement pathway activation, reduces C1q concentrations in brain and plasma, and inhibits microglia-mediated synapse engulfment. ANX-M1 Mouse IgG1 can be used for the research of Huntington's disease, Alzheimer's disease, retinopathy and neuropathic pain .
loading...
    loading...
Cat. No.: HY-P99674
CAS No.: 2364496-42-2
Synonyms: GEN3009
Research Areas:  

Cancer

Ivicentamab (GEN3009) is a bispecific antibody targeting CD37 with dual epitopes. Ivicentamab carries an E430G mutation in the Fc region, which efficiently promotes IgG hexamer formation on the surface of target cells. Ivicentamab provides the parental variable regions for an H429F-engineered anti-CD37 bispecific antibody, enabling it to exert complement-dependent cytotoxicity in Daudi lymphoma cells. Ivicentamab is mainly used in lymphoma-related research .
loading...
    loading...
Cat. No.: HY-P87304
Synonyms: CD93; C1QR1; MXRA4; Complement component C1q receptor; C1q/MBL/SPA receptor; CDw93; Complement component 1 q subcomponent receptor 1; Matrix-remodeling-associated protein 4; C1qR; C1qR(p); C1qRp

Host:  

Mouse

Application:  

WB, ICC/IF, IHC-P, FC

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P80795A
Synonyms: CD18; Integrin beta-2; Complement receptor C3 subunit beta; Itgb2

Host:  

Rabbit

Application:  

WB, IP

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-112307A
CAS No.: 124011-52-5
Purity:  99.97%
Target:  

Liposome

(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q) .
loading...
    loading...
Cat. No.: HY-P991458

Research Areas:  

Cancer

hu3S193 is a human IgG monoclonal antibody (mAb) targeting Lewis Y. hu3S193 has excellent immune effector function (complement-dependent cytotoxicity) (IC50: 1.0 μg/ml) and antibody-dependent cellular cytotoxicity (IC50: 5.0 μg/ml). hu3S193 can be used in small cell lung cancer (SCLC) research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
loading...
    loading...
Cat. No.: HY-P991791

Target:  

Integrin

Research Areas:  

Inflammation/Immunology

Anti-Rat CD11b/c Antibody (OX42) reacts with rat CD11b and CD11c. Anti-Rat CD11b/c Antibody (OX42) inhibits complement-mediated rosettes formation and leukocyte migration in vitro, and blocks the binding of iC3b to CR3 in vitro and in vivo. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .
loading...
    loading...
Cat. No.: HY-P991869
Synonyms: AQmabAM; rAb-53

Target:  

Aquaporin

Research Areas:  

Neurological Disease

Aquaporumab (AQmabAM) is an engineered human monoclonal IgG antibody. Aquaporumab is a selective inhibitor of aquaporin 4 (AQP4), binding tightly to AQP4 and competitively displacing AQP4-IgG from serum [1][2]. Aquaporumab significantly reduces neuromyelitis optica lesions in spinal cord slice cultures and in mice receiving intracerebral injection of AQP4-IgG and complement [1][2]. Aquaporumab can be used for research on neuromyelitis optica spectrum disorders [1][2]."}
loading...
    loading...
Cat. No.: HY-P992349

Target:  

CD20 Apoptosis

Research Areas:  

Cancer

DXL625 is an autophilic CD20-targeting agent. DXL625 triggers downstream apoptosis signaling pathways dependent on intact lipid rafts and extracellular Ca 2+. DXL625 induces caspase-mediated apoptosis in cancer cells and selectively targets cells in the actively proliferative S phase. DXL625 mediates complement-dependent cytotoxicity in cancer cells and primary B lymphocytes. DXL625 can be used in research related to Burkitt's lymphoma and B-cell lymphoma .
loading...
    loading...
Cat. No.: HY-P81583
Synonyms: CD35; C3BR; CR1; Complement receptor type 1; C3b/C4b receptor

Host:  

Rabbit

Application:  

IHC-P

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P85894
Synonyms: CD35; C3BR; CR1; Complement receptor type 1; C3b/C4b receptor

Host:  

Mouse

Application:  

IHC-P, WB, ICC/IF, ELISA

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P86007
Synonyms: CD35; C3BR; CR1; Complement receptor type 1; C3b/C4b receptor

Host:  

Mouse

Application:  

IHC-P, ELISA

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-N17326
CAS No.: 242794-72-5
Ilekudinol B is an inhibitor of ACAT and PTP1B, with an IC50 of 5.3 μM and a Ki of 11.6 μM against human PTP1B. Ilekudinol B inhibits the classical pathway of the complement system, with an IC50 of 51 μM. Ilekudinol B inhibits TNF-α-induced cellular IL-8 secretion, promotes glucose uptake in skeletal muscle myotubes, and acts as an insulin mimetic and insulin sensitizer. Ilekudinol B can be used in research related to type 2 diabetes, obesity, and inflammatory diseases .
loading...
    loading...
Cat. No.: HY-P991229
Synonyms: AGS-1C4D4; AGS-PSCA

Target:  

Complement System

Research Areas:  

Cancer

AGS-1C4D4 is a fully human IgG1κ monoclonal antibody targeting PSCA, with a Kd value of 0.2 nM. AGS-1C4D4 mediates antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) against PSCA-expressing cells. AGS-1C4D4 can be used for the research of pancreatic cancer .
loading...
    loading...
Cat. No.: HY-P80577
Synonyms: CPAMD1; C3; Complement C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P87675
Synonyms: CPAMD1; C3; Complement C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, ELISA

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-P81583A
Synonyms: CD35; C3BR; CR1; Complement receptor type 1; C3b/C4b receptor

Host:  

Rabbit

Application:  

IHC-P

Reactivity:  

Human

loading...
    loading...
Cat. No.: HY-P78098
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD93; DJ737E23.1; Prev. C1QR1; ECSM3; Prev. MXRA4; Matrix-Remodeling-Associated Protein 4; C1qR(P); Matrix-Remodelling Associated 4; CDw93; C1qR; Complement Component 1 Q Subcomponent Receptor 1; Complement Component 1, Q Subcomponent, Receptor 1; Complement Component C1q Receptor; C1q Receptor 1; C1q/MBL/SPA Receptor; C1qRp; CD93 Antigen; CD93 Molecule; C1qRP
Species:  
Human
Source:  
HEK293
loading...
    loading...
Cat. No.: HY-P83897
Synonyms: CPAMD1; C3; Complement C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC, ELISA

Reactivity:  

Human

loading...
    loading...