Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
101 Results for "
PC12
" in MedChemExpress (MCE) Product Catalog:
Products (101)
101 Results for "PC12" in MCE Product Catalog:
Cat. No.: HY-137325A
CAS No.: 301334-89-4
Target:
Research Areas:
2-Chloro-ATP sodium (2-Chloro ATP) is an adenine nucleotide and an analog of ATP. It is an antagonist of the purinergic P2Y1 receptor and inhibits intracellular calcium mobilization induced by ADP (HY-W010918) in Jurkat cells expressing the human receptor (Ki=2.3 μM). 2-Chloro-ATP sodium is an agonist of the purinergic P2X receptor and induces inward currents in HEK293 cells expressing human bladder smooth muscle or rat PC12 forms of the receptor (EC50=0.5 and 2.5 μM). 2-Chloro-ATP sodium induces relaxation of precontracted guinea pig cecal strips in a concentration-dependent manner. 2-Chloro-ATP sodium has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases such as protein kinase A (PKA) and PKG.
Cat. No.: HY-117517
CAS No.: 141731-76-2
Target:
Cat. No.: HY-P5156
CAS No.: 207621-38-3
Target:
Research Areas:
Cat. No.: HY-125172
CAS No.: 300670-16-0
Synonyms: Polyglutamine Aggregation inhibitor III
Target:
Research Areas:
C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
Target:
Cat. No.: HY-N3562
CAS No.: 75513-81-4
Category:
Cedrus deodara (Roxburgh) G. Don Flavonoids Neurological Disease Flavonones Plants Pinaceae Extract Disease Research Fields
Target:
Cat. No.: HY-N3489
CAS No.: 62499-71-2
Target:
Cat. No.: HY-P11082
CAS No.: 126675-52-3
Target:
Research Areas:
Cat. No.: HY-P5754B
Target:
Research Areas:
Cat. No.: HY-165616
CAS No.: 309711-72-6
Target:
Research Areas:
NS 1231 is a neurotrophic-like compound with neuroprotective effect. NS 1231 can rescue nerve growth factor (NGF)-differentiated PC12 cells from death induced by withdrawal of trophic factors. NS 1231 can stimulate NGF-induced neurite outgrowth of undifferentiated PC12 cells. NS 1231 can be used for the research of neurological disease, such as stroke .
Cat. No.: HY-N9085
CAS No.: 180964-26-5
Category:
Target:
Cat. No.: HY-N3550
CAS No.: 34168-56-4
Category:
Other Terpenoids Catalpa ovata G. Don Terpenoids Plants Bignoniaceae Extract Disease Research Fields Cancer
Target:
Cat. No.: HY-N3938
CAS No.: 110414-77-2
Target:
Cat. No.: HY-N15711
CAS No.: 2230922-02-6
Category:
Target:
Cat. No.: HY-179533
Target:
Research Areas:
SOD1-aggregation-IN-1 (compound 20) is a potent SOD aggregation inhibitor. SOD1-aggregation-IN-1 inhibits MG132 (HY-13259)-induced mutant SOD1 intracellular aggregation in PC12-SOD1 G85R YFP cells with an EC50 of 2.63 μM. SOD1-aggregation-IN-1 can be used for amyotrophic lateral sclerosis (ALS) research .
Category:
Cardiovascular Disease Flavones Plants Other Families Extract Flavonoids Monophenols Phenols Disease Research Fields Docyniopsis tschonoski Cancer
Target:
Cat. No.: HY-11055
CAS No.: 393856-87-6
Target:
Research Areas:
KP 544 is a potent neurotrophic protein enhancer that amplifies nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells and SH-SY5Y neuroblastoma cells. KP544 also enhances choline acetyltransferase activity. KP 544 selectively interact in the differentiation pathway downstream of MAPK in a manner that amplifies nerve growth factor and cyclic AMP effects and is also neuroprotective .
Cat. No.: HY-P5754
Target:
Research Areas:
Cat. No.: HY-151431
CAS No.: 2883506-31-6
Target:
Research Areas:
Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent Nrf2/HO-1 activator. Nrf2/HO-1 activator 2 has neuroprotective and antioxidant effects through the Nrf2/HO-1 pathway mediated by phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. Nrf2/HO-1 activator 2 can be used in the research of Parkinson's disease (PD) .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
