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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
clathrin
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "clathrin" in MCE Product Catalog:
Cat. No.: HY-P4092
CAS No.: 386223-83-2
HN-1 is a tumor-specific internalizing peptide . HN-1 internalizes through receptor-mediated, energy-dependent, Clathrin-mediated endocytosis. HN-1 preferentially binds to invasive head and neck squamous cell carcinoma and is selectively internalized. HN-1 enhances the transfer of liposome-DNA complexes to head and neck squamous cell carcinoma. HN-1 can be used for research on head and neck squamous cell carcinoma .
Cat. No.: HY-P991105
Cat. No.: HY-B0407AR
CAS No.: 69-09-0
Research Areas:
Chlorpromazine (hydrochloride) (Standard) is the analytical standard of Chlorpromazine (hydrochloride). This product is intended for research and analytical applications. Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .
Cat. No.: HY-158097
Target:
Research Areas:
IAV-IN-2 (Compound MC-22) inhibits for Influenza A Virus (IAV) through blocking the entry of IAV into host cell via clathrin-mediated endocytosis (CME) .
Cat. No.: HY-164290
CAS No.: 1367579-04-1
Target:
Research Areas:
Rhodady C10 (Compound C10) is a dynamin I GTPase inhibitor. Rhodady C10 blocks receptor-mediated endocytosis (IC50: 7 μM). Dynamin is involved in clathrin-independent endocytosis, phagocytosis, and caveolae internalization .
Cat. No.: HY-122564
CAS No.: 1440126-94-2
Pyrimidyn 7 is an inhibitor of dynamin I/II with IC50 values of 1.1 μM and 1.8 μM, respectively. Pyrimidyn 7 competitively inhibits the interactions between GTP and phospholipids with dynamin I. Additionally, Pyrimidyn 7 reversibly inhibits clathrin-mediated endocytosis (CME) of transferrin and epidermal growth factor (EGF) in various non-neuronal cell linecell [1.
Cat. No.: HY-145082
CAS No.: 1419320-93-6
Target:
Research Areas:
4-Sulfo-N-(4-aminobenzyl)-1,8-naphthalimide potassium is an inactive 1,8-Naphthalimide derivative. 4-Sulfo-N-(4-aminobenzyl)-1,8-naphthalimide potassium can be used as a negative control for the clathrin inhibitor 3-Sulfo-N-benzyl-1,8-naphthalimide, potassium salt .
Cat. No.: HY-181933
CAS No.: 339025-18-2
Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC50 of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC50 of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC50 of 29.7 μM .
Cat. No.: HY-W041470R
CAS No.: 5349-62-2
Cat. No.: HY-115604R
CAS No.: 1419320-73-2
Target:
Research Areas:
Pitstop 2 (Standard) is the analytical standard of Pitstop 2 (HY-115604). This product is intended for research and analytical applications. Pitstop 2 is a clathrin inhibitor which inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. Pitstop 2 has the potential for anti-cancer research .
Cat. No.: HY-P701135
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PICALM; CLTH; Phosphatidylinositol Binding clathrin Assembly Protein; clathrin Assembly Lymphoid Myeloid Leukemia Protein; CALM; Alternative Protein PICALM; Phosphatidylinositol-Binding clathrin Assembly Protein; LAP
Species:
Human
Source:
HEK293
Cat. No.: HY-P71807
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CLINT1; EPN4; clathrin Interactor 1; clathrin Interacting Protein Localized In The Trans-Golgi Region; ENTH; clathrin-Interacting Protein Localized In The Trans-Golgi Region; EPNR; clathrin Interactor 1 Isoform 2; KIAA0171; clathrin Interactor 1 Isoform 1
Species:
Staphylococcus aureus
Source:
P. pastoris
Cat. No.: HY-186017
Pitstop 2c is a clathrin terminal domain inhibitor with an IC50 of 1.8 μM. Pitstop 2c blocks the binding of epsin 1 to the clathrin terminal domain and impairs epsin 1-mediated membrane curvature formation at the early stage of clathrin-mediated endocytosis (CME). Pitstop 2c enhances the clathrin-independent endocytosis of galectin-3 and alters its intracellular distribution. Pitstop 2c causes mild defects in lysosomal acidification, as well as a slight increase in mitochondrial number but a reduction in average mitochondrial size. Pitstop 2c can be used in studies related to vesicular stomatitis virus infection .
Cat. No.: HY-P87010
Synonyms: CALM antibody; clathrin assembly lymphoid myeloid leukemia antibody; clathrin assembly lymphoid myeloid leukemia protein antibody; CLTH antibody; LAP antibody; Phosphatidylinositol-binding clathrin assembly protein antibody; PICAL_HUMAN antibody; PICALM antibody;
Cat. No.: HY-P82368A
Synonyms: AP-2 complex subunit mu; AP-2 mu chain; Adapter-related protein complex 2 subunit mu; Adaptin-mu2; clathrin assembly protein complex 2 mu medium chain; clathrin coat assembly protein AP50
Cat. No.: HY-125188
CAS No.: 2306305-57-5
Target:
Research Areas:
NEU-4438 is an antimalarial agent. NEU-4438 inhibits DNA synthesis, reduces AMPK-γ, and increases Clathrin heavy chain. NEU-4438 exhibits antiparasitic activity against Trypanosoma brucei. NEU-4438 reduces trypanosome tissue burden in a chronic HAT mouse model .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
