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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
pi-pi stacking
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "pi-pi stacking" in MCE Product Catalog:
Cat. No.: HY-W004078R
CAS No.: 696-60-6
Cat. No.: HY-189228
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HPPD-IN-15 is a potent HPPD inhibitor with an IC50 of 52 nM (Arabidopsis thaliana). HPPD-IN-15 inhibits HPPD through chelation of Fe 2+ by the pyrazole group, π-π stacking, and insertion of the benzyl group into a hydrophobic pocket. HPPD-IN-15 can be used for herbicide development research .
Cat. No.: HY-182783
CAS No.: 862248-40-6
Synonyms: NTM-006
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NTM-006 is a selective and brain-penetrant adenosine A3 receptor (A3AR) agonist. NTM-006 selectively interacts with adenosine A3AR via π-π stacking with Phe168 and π-alkyl interactions receptor residues. NTM-006 inhibits Acetic acid (HY-Y0319)-induced writhing responses in mice. NTM-006 can be used for the research of chronic neuropathic pain, cancer-related pain, osteoarthritis-associated pain .
Cat. No.: HY-181171
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HIT-2 is an estrogen receptor alpha (ERα) inhibitor that can bind to the ERα ligand binding domain. HIT-2 forms stable interactions including hydrogen bonds, π-π stacking, and hydrophobic contacts to disrupt ERα-driven signaling. HIT-2 exhibits antineoplastic activity against breast cancer. HIT-2 can be used for the research of breast cancer .
Cat. No.: HY-189010
HPPD-IN-13 is a potent herbicide targeting HPPD, with an IC50 value of 0.132 μM against EcHPPD. HPPD-IN-13 primarily forms bidentate coordination with the ferrous ion in the active site of HPPD, and competitively blocks HPPA metabolism via π-π stacking and multiple hydrogen bonds, ultimately leading to plant albinism and death. HPPD-IN-13 can be used in the research and development of novel bleaching herbicides .
Cat. No.: HY-187377
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α-Glucosidase-IN-121 is a yeast α-glucosidase inhibitor with an IC50 of 3.8 μM and a Ki of 12.9 μM. α-Glucosidase-IN-121 binds to the active site of the enzyme, competes with substrate binding, and forms stable interactions with Phe137, Ser308, Pro309, Arg312 and Glu350 via hydrogen bonding, π-π stacking and hydrophobic interactions. α-Glucosidase-IN-121 can be used in the research of diabetes .
Cat. No.: HY-187383
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Carbonic anhydrase-IN-40 is a human carbonic anhydrase I/II inhibitor, with an IC50 of 16.900 nM against hCA I and an IC50 of 4.682 nM against hCA II. Carbonic anhydrase-IN-40 binds to the active site of the enzyme, coordinates with the catalytic zinc ion, forms π-π stacking interactions with active site residues, and makes hydrophobic contacts with the hydrophobic pocket. Carbonic anhydrase-IN-40 can serve as a lead compound for studies related to carbonic anhydrase inhibitors .
Cat. No.: HY-181445
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NSC 620023 TFA is a highly selective butyrylcholinesterase (BChE) inhibitor with an IC50 of 32 nM. NSC 620023 TFA acts via π-stacking interactions with dual benzimidazole moieties and hydrophobic interactions within the BChE binding site. NSC 620023 TFA can be used for the research of alzheimer’s disease .
Cat. No.: HY-D3136
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MC-PSE is a fluorescent probe that can be used for glutathione (GSH) detection, NIR-II fluorescence imaging and ratiometric photoacoustic imaging. MC-PSE spontaneously forms J-aggregates in aqueous solution through π-π stacking, and its phenylselenyl group acts as a fluorescence quencher and GSH recognition receptor, thereby eliminating intrinsic fluorescence and generating a maximum absorption peak at 1000 nm. The excitation/emission wavelengths of MC-PSE are Ex = 808 nm and Em = 940 nm. MC-PSE can be applied in tumor-related research .
Cat. No.: HY-I0135
CAS No.: 24886-52-0
Synonyms: Azafen free base; pipofezin; pipofezine
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Azaphen free base (Azafen free base) is an orally active tricyclic antidepressant that inhibits the reuptake of serotonin and monoamines, regulates the 5-HT2c receptor, and exerts sedative, antidepressant and anxiolytic effects. Azaphen free base increases the bioavailability of serotonin in the synaptic cleft, does not block muscarinic receptors or affect monoamine oxidase activity, and binds to the human serotonin transporter via salt bridges, π-stacking, π-cation and hydrophobic interactions. Azaphen free base can be used in studies related to depression .
Cat. No.: HY-103084
CAS No.: 2109805-65-2
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PDE5-IN-1 is an orally active, selective PDE5 inhibitor with an IC50 of 5.6 nM. PDE5-IN-1 forms hydrogen bond interactions with the Q817 residue in the catalytic domain of PDE5, and aromatic π-π stacking interactions with the F820 residue. PDE5-IN-1 exerts anti-cardiac hypertrophy and vasodilatory effects, reduces mean pulmonary arterial pressure and right ventricular hypertrophy index. PDE5-IN-1 can be used in the research of pulmonary arterial hypertension .
Cat. No.: HY-N19818
CAS No.: 2088505-67-1
Cat. No.: HY-183427
CAS No.: 2660138-04-3
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KBJK557 is a Plk1 PBD inhibitor with a human-derived IC50 value of 3.05 μM. KBJK577 binds to Plk1 PBD through electrostatic interactions, π-π stacking, hydrogen bonds, salt bridges and hydrophobic interactions, thereby disrupting the subcellular localization and function of Plk1. KBJK557 induces mitotic arrest, S-phase delay, G2/M-phase arrest and apoptosis, and inhibits cancer cell proliferation. KBJK557 can be used in research related to cancer and non-small cell lung cancer .
Cat. No.: HY-184287
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Antibacterial agent 352 is an orally active Antibacterial agent. Antibacterial agent 352 binds to the active cavity of Staphylococcus aureus DNA gyrase via hydrogen bonding, π-π stacking and hydrophobic interactions, thereby blocking bacterial DNA synthesis. Antibacterial agent 352 exhibits antibacterial activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus pumilus, Staphylococcus epidermidis and Enterococcus faecalis. Antibacterial agent 352 can disrupt established Staphylococcus aureus biofilms and inhibit the formation of Staphylococcus aureus biofilms. Antibacterial agent 352 can be used in the research of Staphylococcus aureus wound infections .
Cat. No.: HY-187539S
CAS No.: 3085716-86-2
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IPR agonist-1 is a prostaglandin-based IP receptor agonist. IPR agonist-1 binds to the IP receptor, forms hydrogen bonds with Tyr75-Ser168-Arg279, and undergoes π-π stacking with Tyr281, thereby triggering downstream signaling pathways. IPR agonist-1 inhibits ADP (Adenosine 5'-diphosphate) (HY-W010918)-induced platelet aggregation in rabbit platelet-rich plasma. IPR agonist-1 can be used in the research of pulmonary arterial hypertension .
Cat. No.: HY-187996
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P-gp-IN-37 is a ligand of P-glycoprotein (P-gp), with an EC50 value of 1.8 μM. P-gp-IN-37 stabilizes the inward-facing conformation of P-gp through hydrogen bonding and π-stacking interactions, and can be used as a PET radiotracer for imaging the function and expression of P-gp. P-gp-IN-37 is applied in the research of heart failure .
Cat. No.: HY-182030
RSV fusion protein IN-1 is an orally active RSV pre-fusion F protein inhibitor with an IC50 of 0.10 nM against RSV. RSV fusion protein IN-1 forms stable hydrogen bonds and π-π stacking interactions with pre-fusion F protein to block viral fusion and entry. RSV fusion protein IN-1 suppresses RSV F protein expression in epithelial cells. RSV fusion protein IN-1 reduces viral burden in the lungs of RSV-infected murine models.RSV fusion protein IN-1 can be used for the research of respiratory syncytial virus (RSV) infection .
Cat. No.: HY-183105
CAS No.: 2133291-32-2
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DC551040 is an orally active and selective lysine demethylase 1 (LSD1) inhibitor with a human IC50 of 2.14 nM. DC551040 binds to LSD1 via π-π stacking with Trp552, polar interactions with Phe538, and covalent adduct formation with FAD, and disrupts the LSD1-GFI1B-CoREST complex. DC551040 induces H3K4me2 accumulation, apoptosis, and cell differentiation, activates STAT5, NF-κB, AKT, and IL6-STAT3 pathways, and upregulates IL6 expression. DC551040 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-W016174
CAS No.: 139-66-2
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Diphenyl sulfide is an additive for organic photovoltaic devices. Diphenyl sulfide modulates vertical composition distribution of PTB7-Th:PC71BM photoactive layers, promoting enrichment of PTB7-Th at the upper surface and PC71BM at the bottom. Diphenyl sulfide promotes ordered molecular packing and crystallinity of PTB7-Th:PC71BM photoactive layers, including more compact π−π stacking of PTB7-Th. Diphenyl sulfide improves exciton dissociation, charge transport, and charge collection in PTB7-Th:PC71BM-based inverted polymer solar cells. Diphenyl sulfide acts as a solvent additive to improve the photovoltaic performance of inverted organic photovoltaic devices .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
