9999 Results for "

Isotopes

" in MedChemExpress (MCE) Product Catalog:
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9999 Results for "Isotopes" in MCE Product Catalog:

2
γ-Aminobutyric acid-d6
γ-Aminobutyric acid-d6
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2 Cited Publications
Cat. No.: HY-N0067S
CAS No.: 70607-85-1
Synonyms: 4-Aminobutyric acid-d6
γ-Aminobutyric acid-d6 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain , binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors) .
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Hypoxanthine-15N4
Hypoxanthine-15N4
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2 Cited Publications
Cat. No.: HY-N0091S7
CAS No.: 77910-30-6
Synonyms: Purin-6-ol-15N4; Sarcine-15N4
Hypoxanthine- 15N4 is the 15N labeled Hypoxanthine . Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia .
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Inosine-13C5
Inosine-13C5
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2 Cited Publications
Cat. No.: HY-N0092S2
CAS No.: 503173-79-3
Inosine- 13C5 is the 13C5 labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors .
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L-Phenylalanine-13C9
L-Phenylalanine-13C9
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2 Cited Publications
Cat. No.: HY-N0215S10
CAS No.: 439685-11-7
Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C9
L-Phenylalanine- 13C9 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
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Progesterone-13C3
Progesterone-13C3
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2 Cited Publications
Cat. No.: HY-N0437S2
CAS No.: 327048-87-3
Synonyms: Pregn-4-ene-3,20-dione-13C3
Progesterone- 13C3 is the 13C-labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
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L-Tryptophan-13C
L-Tryptophan-13C
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2 Cited Publications
Cat. No.: HY-N0623S1
CAS No.: 115709-68-7
Synonyms: Tryptophan-13C; Tryptophane-13C
L-Tryptophan- 13C is the 13C-labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .
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L-Serine-d3
L-Serine-d3
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2 Cited Publications
Cat. No.: HY-N0650S8
CAS No.: 105591-10-4
Synonyms: (-)-Serine-d3; (S)-Serine-d3
L-Serine-d3 is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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Terephthalic acid-13C2
Terephthalic acid-13C2
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2 Cited Publications
Cat. No.: HY-W010098S1
CAS No.: 121191-53-5
Terephthalic acid- 13C2 is the 13C-labeled Terephthalic acid. Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. Terephthalic acid can be used to build skin tumor models .
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Creatine-d3
Creatine-d3
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2 Cited Publications
Cat. No.: HY-W010388S1
CAS No.: 143827-19-4
Creatine-d3 is the deuterium labeled Creatine (HY-W010388) . Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain .
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Pyruvic acid-13C3 sodium
Pyruvic acid-13C3 sodium
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2 Cited Publications
Cat. No.: HY-W015913S
CAS No.: 142014-11-7
Synonyms: Sodium 2-oxopropanoate-13C3; Acetylformic acid-13C3 sodium
Sodium 2-oxopropanoate- 13C3 is the 13C-labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS .
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Phenylacetylglutamine-d5
Phenylacetylglutamine-d5
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2 Cited Publications
Cat. No.: HY-W050026S
CAS No.: 1331909-01-3
Synonyms: NSC 203800-d5; Phenylacetyl-L-glutamine-d5
Phenylacetylglutamine-d5 (NSC 203800-d5) is the deuterium labeled Phenylacetylglutamine (HY-W050026). Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation .
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L-Lactate-13C sodium (20% in water)
L-Lactate-13C sodium (20% in water)
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1 Cited Publications
Cat. No.: HY-Y0479AS2
CAS No.: 201595-69-9
Synonyms: (S)-2-Hydroxypropanoic acid-13C sodium
L-Lactate- 13C ((S)-2-Hydroxypropanoic acid- 13C) sodium is the 13C-labeled L-Lactic acid sodium (HY-W040233). L-lactate Sodium is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid Sodium has antiproliferative activity .
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3-Methyl-L-histidine-d3 hydrochloride
3-Methyl-L-histidine-d3 hydrochloride
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1 Cited Publications
Cat. No.: HY-W017007SA
3-Methyl-L-histidine-d3 hydrochloride is the deuterium labeled 3-Methyl-L-histidine hydrochloride. 3-Methyl-L-histidine hydrochloride is an endogenous amino acid that can be found in actin and myosin .
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Benzoic acid-d5
Benzoic acid-d5
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1 Cited Publications
Cat. No.: HY-N0216S
CAS No.: 1079-02-3
Benzoic acid-d5 is a deuterium substitute for Benzoic acid. Benzoic acid is an aromatic alcohol that occurs naturally in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid can act as a preservative by inhibiting bacteria and fungi .
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Bz-DTPA
Bz-DTPA
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1 Cited Publications
Cat. No.: HY-156035
CAS No.: 102650-30-6
Purity:  96.05%
Target:  

Drug Intermediate

Research Areas:  

Others

Bz‑DTPA is a bifunctional chelator that can conjugate indium radionuclides to targeting proteins for tumor-targeted tracing. Bz‑DTPA is mainly used in studies related to radioactive targeting molecules .
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Ticagrelor-d7
Ticagrelor-d7
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1 Cited Publications
Cat. No.: HY-10064S
CAS No.: 1265911-55-4
Ticagrelor-d7 is the deuterium labeled Ticagrelor. Ticagrelor (AZD6140) is a reversible oral P2Y12 receptor antagonist for the treatment of platelet aggregation .
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Navitoclax-d8
Navitoclax-d8
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1 Cited Publications
Cat. No.: HY-10087S
CAS No.: 1217620-38-6
Purity:  99.71%
Navitoclax-d8 is the d8-labeled Navitoclax (HY-10087). Navitoclax (ABT-263 ) is an orally active BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w, with a Ki value of <1 nM for each target. Navitoclax triggers endogenous Apoptosis and downregulates the expression of Survivin and TGFβ2. Navitoclax alleviates fibrosis and induces thrombocytopenia. Navitoclax exhibits anticancer activity against a variety of tumors and enhances the efficacy of chemotherapy and radiotherapy. Navitoclax can be used in the research of acute lymphoblastic leukemia, ovarian cancer, and fibrotic diseases .
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D-erythro-Sphingosine-d7
D-erythro-Sphingosine-d7
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1 Cited Publications
Cat. No.: HY-101047S
CAS No.: 1246304-34-6
Purity:  99.00%
Synonyms: Erythrosphingosine-d7; erythro-C18-Sphingosine-d7; trans-4-Sphingenine-d7
D-erythro-Sphingosine-d7 is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator .
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Dasatinib-d8
Dasatinib-d8
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1 Cited Publications
Cat. No.: HY-10181S
CAS No.: 1132093-70-9
Purity:  98.17%
Synonyms: BMS-354825-d8
Dasatinib-d8 (BMS-354825-d8) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.
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Sorafenib-d3
Sorafenib-d3
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1 Cited Publications
Cat. No.: HY-10201S
CAS No.: 1130115-44-4
Purity:  98.17%
Synonyms: Donafenib; Bay 43-9006-d3
Sorafenib-d3 (Donafenib) is the deuterated-labeled Sorafenib (HY-10201). Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma .
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