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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1815 Results for "
Tnf
" in MedChemExpress (MCE) Product Catalog:
Products (1815)
1815 Results for "Tnf" in MCE Product Catalog:
10
10 Cited Publications
Cat. No.: HY-P70697
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Tnf; Tumor Necrosis Factor (Tnf Superfamily, Member 2); Prev. TnfA; Tumor Necrosis Factor-Alpha; Tnf-Alpha; Tumor Necrotic Factor Alpha; TnfSF2; Tnf Superfamily, Member 2; Tumor Necrosis Factor Ligand Superfamily Member 2; Tnf, Macrophage-Derived; Tnf-A; Tnf, Monocyte-Derived; DIF; APC1 Protein; Cachectin; IMD127; TNLG1F; Tumor Necrosis Factor; Tumor Necrosis Factor Ligand 1F
Species:
Rat
Source:
E. coli
10
10
Research Areas:
Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM .
10
10 Cited Publications
Cat. No.: HY-19975
CAS No.: 946387-07-1
Target:
Research Areas:
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM) . RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells .
10
9
9 Cited Publications
Cat. No.: HY-N0509
CAS No.: 29838-67-3
Category:
Flavanonols Flavonoids Microorganisms Phenols Polyphenols Plants Other Families Extract Disease Research Fields Cancer
Target:
9
9 Cited Publications
Target:
Research Areas:
GSK583 is a highly potent, orally active and selective inhibitor of RIP2 Kinase, with IC50 of 5 nM. GSK583 inhibits both TNF-α and IL-6 production with an IC50 value of 200 nM.
9
9 Cited Publications
Cat. No.: HY-N0029
CAS No.: 81525-13-5
Category:
Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Oleaceae Extract Disease Research Fields Inflammation/Immunology
Target:
8
8 Cited Publications
Cat. No.: HY-P70426A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Tnf; Tumor Necrosis Factor (Tnf Superfamily, Member 2); Prev. TnfA; Tumor Necrosis Factor-Alpha; Tnf-Alpha; Tumor Necrotic Factor Alpha; TnfSF2; Tnf Superfamily, Member 2; Tumor Necrosis Factor Ligand Superfamily Member 2; Tnf, Macrophage-Derived; Tnf-A; Tnf, Monocyte-Derived; DIF; APC1 Protein; Cachectin; IMD127; TNLG1F; Tumor Necrosis Factor; Tumor Necrosis Factor Ligand 1F
Species:
Human
Source:
E. coli
8
8
8 Cited Publications
Target:
Research Areas:
SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .
8
8 Cited Publications
Target:
Research Areas:
SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α .
8
8 Cited Publications
Target:
Research Areas:
CAY10602 is a SIRT1 activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells .
8
8 Cited Publications
Cat. No.: HY-N1949
CAS No.: 17680-84-1
Category:
Flavonoids Flavones Cassia Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Labiatae Extract
Target:
8
8 Cited Publications
Cat. No.: HY-N6607
CAS No.: 13220-57-0
7
7 Cited Publications
Cat. No.: HY-N0405
CAS No.: 28608-75-5
Target:
7
7 Cited Publications
XRK3F2 is a p62 (sequestosome-1) ZZ domain inhibitor that has specificity for the p62-ZZ domain over other p62 signaling domains. XRK3F2 blocks TNFα effects and upregulation in bone marrow stromal cells, and induces multiple myeloma cell apoptosis. XRK3F2 can be used for the research of multiple myeloma bone disease, acute myeloid leukemia, and multiple myeloma .
7
7 Cited Publications
Cat. No.: HY-N0631
CAS No.: 131189-57-6
7
7 Cited Publications
Cat. No.: HY-W013636C
CAS No.: 997-43-3
Synonyms: Alpha-Ketoglutaric acid potassium
6
6 Cited Publications
Synonyms: Tnf Protease Inhibitor 2
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
