229 Results for "

affinity labeling

" in MedChemExpress (MCE) Product Catalog:
Products (229)

229 Results for "affinity labeling" in MCE Product Catalog:

Cat. No.: HY-156842
CAS No.: 1625629-51-7
Purity:  96.12%
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

MCAAD-3 is a near-infrared Aβ imaging probe with blood-brain barrier penetrability. MCAAD-3 has a strong affinity for Aβ polymers (Ki >106 nM) and can label Aβ plaques in the brains of transgenic mice .
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Cat. No.: HY-149869
CAS No.: 2941187-68-2
Target:  

PSMA

Research Areas:  

Cancer

PSMA-IN-3 (compound 17) is a novel high-affinity PSMA inhibitor with an IC50 value of 13 nM. PSMA-IN-3 is suitable for developing an 18F-labeled radioligand for PET imaging of PSMA in prostate cancer .
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Cat. No.: HY-172366
CAS No.: 3055338-52-5
Target:  

PSMA

Research Areas:  

Cancer

BQ0413 exhibits good affinity to PSMA with a KD of 89 pM. BQ0413 exhibits good uptake and internalization property with an internalization rate of 44% in PC3-pip cell. BQ0413 can be used as tumor imaging agent when labeled with 99mTc .
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Cat. No.: HY-B0251S
Synonyms: Epoxymexrenone-d3
Eplerenone-d3 is the deuterium labeled Eplerenone. Eplerenone (Epoxymexrenone) is a selective, competitive and oreally active aldosterone antagonist with an IC50 of 138 nM. Eplerenone has low affinity for progesterone, androgen, estrogen and glucocorticoid receptors. Eplerenone can be used for hypertension and heart failure after myocardial infarction reserch .
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Cat. No.: HY-174977
Target:  

P2Y Receptor

Research Areas:  

Neurological Disease

P2Y12R ligand-1 (Compound 41) is a high-affinity P2Y12R ligand with a Ki value of 17.1 nM. P2Y12R ligand-1 labeled with [ 18F] can be used in studies of brain PET imaging .
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Cat. No.: HY-B0652S1
Synonyms: 3-Oxodesogestrel-d6; 3-keto-Desogestrel-d6
Etonogestrel-d6 is deuterium labeled Etonogestrel. Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs . Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs) .
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Cat. No.: HY-15296S1
CAS No.: 2738376-76-4
Synonyms: FCE-21336-d6
Cabergoline-d6 is deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).
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Cat. No.: HY-12987S
CAS No.: 1803193-57-8
Purity:  ≥98.0%
Synonyms: R6238-d4
Pimozide-d4 is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5 .
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Cat. No.: HY-18037
CAS No.: 947192-73-6
Research Areas:  

Others

AMG-7980 exhibits high affinity to phosphodiesterase 10A (PDE10A), with a KD of 0.94 nM. AMG-7980 can be used as a tracer of PDE10A, when labeled with radioactive isotope .
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Cat. No.: HY-W716520
CAS No.: 1308278-69-4
Synonyms: RGH-188-d8
Cariprazine-d8-1 (RGH-188-d8-1) is the deuterium labeled Cariprazine (HY-14763). Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).
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Cat. No.: HY-120842
CAS No.: 157097-10-4
Target:  

mAChR

Research Areas:  

Neurological Disease

RLH-033 is a potent and selective ligand for the sigma 1 recognition site. RLH-033 has high affinity for sigma 1 sites labeled by [ 3H](+)-pentazocine with a Ki of 50 pM .
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Cat. No.: HY-13604S
CAS No.: 2376035-90-2
Cyproterone acetate-d3 is deuterium labeled Cyproterone acetate. Cyproterone acetate is an anti-androgen (IC50=7.1 nM) and progestogen synthetic steroid. Cyproterone acetate has affinity with progesteron and with glucocorticoidal receptors .
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Cat. No.: HY-14171S2
Synonyms: LGD1069-13C6
Bexarotene- 13C6 (LGD1069- 13C6) is 13C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
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Cat. No.: HY-W705168
CAS No.: 106324-70-3
Yangonin-d3 is the deuterium labeled Yangonin (HY-N0919). Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.
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Cat. No.: HY-138199S1
CAS No.: 2748468-58-6
Omeprazole sulfone N-Oxide-d3 is the d3-labeled Omeprazole sulfone N-Oxide (HY-138199). Omeprazole sulfone N-Oxide is an Omeprazole (HY-B0113) analog with binding affinity to Nilaparvata lugens choline acetyltransferase (ChAT) .
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Cat. No.: HY-124356AS
Alcaftadine carboxylic acid-d3 (sodium) is deuterium labeled Alcaftadine carboxylic acid. Alcaftadine carboxylic acid is a broad-spectrum antihistamine compound with high affinity for histamine H1 and H2 receptors and low affinity for H4 receptors. Alcaftadine carboxylic acid has also demonstrated effects on modulating immune cell recruitment and stabilizing mast cells. Alcaftadine carboxylic acid is more effective than placebo in preventing ocular itching associated with allergic conjunctivitis and is at least as effective as olopatadine 0.01% .
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Cat. No.: HY-W777169
CAS No.: 1185030-01-6
Synonyms: LGD1069-13C4
Bexarotene- 13C4 (LGD1069- 13C4) is the 13C-labeled Bexarotene (HY-14171). Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
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Cat. No.: HY-15851S1
Synonyms: TD-4208-d9; GSK1160724-d9
Revefenacin-d9 (TD-4208-d9) is deuterium labeled Revefenacin. Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.
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Cat. No.: HY-15851S2
Synonyms: TD-4208-d3; GSK1160724-d3
Revefenacin-d3 (TD-4208-d3) is deuterium labeled Revefenacin. Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.
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Cat. No.: HY-15851S3
Synonyms: TD-4208-d4; GSK1160724-d4
Revefenacin-d4 (TD-4208-d4) is deuterium labeled Revefenacin. Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.
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