2954 Results for "

D3

" in MedChemExpress (MCE) Product Catalog:
Products (2954)

2954 Results for "D3" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-115463
CAS No.: 1839150-63-8
Purity:  99.57%
Target:  

AMPK Apoptosis

Research Areas:  

Cancer

EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity [3].
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2
2 Cited Publications
Cat. No.: HY-12407
CAS No.: 186371-96-0
Purity:  ≥98.0%
Target:  

VD/VDR

Research Areas:  

Metabolic Disease

ZK168281 is a 25-carboxylic ester 1α,25(OH)2D3 analog and a pure VDR antagonist with a Kd value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor .
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2
2 Cited Publications
Cat. No.: HY-N0113
CAS No.: 539-15-1
Synonyms: Ordenina; Peyocactine
Hordenine (Ordenina; Peyocactine) is a multifunctional alkaloid with oral activity and blood-brain barrier penetration. Hordenine inhibits LPS-induced phosphorylation of p38, JNK, ERK1/2, p65, IκB, and AKT, prevents p65 nuclear translocation, and suppresses inflammatory cytokines and mediators. Hordenine promotes M2 macrophage polarization, restores blood-milk barrier integrity, alleviates oxidative stress by reducing ROS and MDA, and attenuates LPS-induced lung injury and pulmonary edema. Hordenine inhibits cAMP production, CREB phosphorylation, and MITF expression, thereby suppressing melanin synthesis in melanocytes and reconstructed epidermis. Hordenine activates the Wnt/β-catenin signaling pathway, promotes dermal papilla cell proliferation and hair shaft elongation, and accelerates hair regeneration. Hordenine activates DRD2, acts as a D3R partial agonist, α2A-AR full agonist, and 5-HT2A-R antagonist, and inhibits SERT and DAT. Hordenine inhibits α-synuclein accumulation and ameliorates motor deficits in Parkinson's disease models. Hordenine limits alcohol intake, reduces relapse drinking behavior, and modulates alcohol-induced conditioned place preference. Hordenine can be used for research on mastitis, skin pigmentation, acute lung injury, foodborne diseases, hair loss, Parkinson's disease, bacterial infections, and alcohol use disorder [3] .
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2
2 Cited Publications
Cat. No.: HY-N0113B
CAS No.: 6027-23-2
Synonyms: Ordenina hydrochloride; Peyocactine hydrochloride
Hordenine hydrochloride (Ordenina hydrochloride; Peyocactine hydrochloride) is a multifunctional alkaloid with oral activity and blood-brain barrier penetration. Hordenine hydrochloride inhibits LPS-induced phosphorylation of p38, JNK, ERK1/2, p65, IκB, and AKT, prevents p65 nuclear translocation, and suppresses inflammatory cytokines and mediators. Hordenine hydrochloride promotes M2 macrophage polarization, restores blood-milk barrier integrity, alleviates oxidative stress by reducing ROS and MDA, and attenuates LPS-induced lung injury and pulmonary edema. Hordenine hydrochloride inhibits cAMP production, CREB phosphorylation, and MITF expression, thereby suppressing melanin synthesis in melanocytes and reconstructed epidermis. Hordenine hydrochloride activates the Wnt/β-catenin signaling pathway, promotes dermal papilla cell proliferation and hair shaft elongation, and accelerates hair regeneration. Hordenine hydrochloride activates DRD2, acts as a D3R partial agonist, α2A-AR full agonist, and 5-HT2A-R antagonist, and inhibits SERT and DAT. Hordenine hydrochloride inhibits α-synuclein accumulation and ameliorates motor deficits in Parkinson's disease models. Hordenine hydrochloride limits alcohol intake, reduces relapse drinking behavior, and modulates alcohol-induced conditioned place preference. Hordenine hydrochloride can be used for research on mastitis, skin pigmentation, acute lung injury, foodborne diseases, hair loss, Parkinson's disease, bacterial infections, and alcohol use disorder [3] .
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1
1 Cited Publications
Cat. No.: HY-N3519
CAS No.: 67884-03-1
Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC50 value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases [3] .
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1
1 Cited Publications
Cat. No.: HY-141412
CAS No.: 80731-10-8
Purity:  ≥98.0%
Synonyms: 3-Phospho-D-glyceric acid disodium
D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalyzed glycolysis process. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase (enolase). D-(-)-3-Phosphoglyceric acid disodium can regulate the activity of phosphoglycerate dehydrogenase (PHGDH) to modulate p53 protein and apoptosis [3].
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1
1 Cited Publications
Cat. No.: HY-30219
CAS No.: 7326-19-4
Synonyms: D-3-Phenyllactic acid
D-​(+)​-​Phenyllactic acid is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits a range of Gram-positive from humans and foodstuffs and Gram-negative bacteria found in humans .
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1
1 Cited Publications
Cat. No.: HY-N3520
CAS No.: 67884-05-3
Deapi-platycodin D3 is a triterpenoid saponin from the roots of Platycodon grandiflorum .
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1
1 Cited Publications
Cat. No.: HY-15254
CAS No.: 163018-26-6
Purity:  98.46%
Synonyms: 25-Hydroxy Vitamin D3 3,3’-Aminopropyl Ether
Target:  

VD/VDR

Research Areas:  

Metabolic Disease

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 is a Vitamin D3 derivative.
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1
1 Cited Publications
Cat. No.: HY-N8357
CAS No.: 927822-16-0
Vitamin D3 octanoate is an octanoate ester of vitamin D3 . Vitamin D3 (Cholecalciferol; HY-15398) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells .
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1
1 Cited Publications
Cat. No.: HY-P81203
Synonyms: Vitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 1 antibody 1,25-@dihydroxyvitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 25-dihydroxyvitamin D3 receptor; NR1I1; Nuclear receptor subfamily 1 group I member 1; VDR; VDR_HUMAN; Vitamin D (1,25- dihydroxyvitamin D3) receptor; Vitamin D hormone receptor; Vitamin D receptor; Vitamin D3 receptor,

Host:  

Rabbit

Application:  

IHC-P, IHC-F, ICC/IF

Reactivity:  

Human, Rat

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1
1 Cited Publications
Cat. No.: HY-B1453S
CAS No.: 350818-62-1
Synonyms: (R)-Carnitine-D3 hydrochloride; Levocarnitine-D3 hydrochloride
L-Carnitine-d3 (hydrochloride) is the deuterium labeled L-Carnitine hydrochloride .
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1
1 Cited Publications
Cat. No.: HY-10394S
CAS No.: 1127120-38-0
Purity:  99.80%
Synonyms: PNU-100766-d3
Linezolid-d3 (PNU-100766-d3) is a deuterium labeled Linezolid (PNU-100766). Linezolid is a synthetic antibiotic that acts by inhibiting the initiation of bacterial protein synthesis .
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1
1 Cited Publications
Cat. No.: HY-132949S
CAS No.: 2483831-87-2
Purity:  99.94%
Decanoyl-L-carnitine-d3 (chloride) is the deuterium labeled Decanoyl-L-carnitine chloride .
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1
1 Cited Publications
Cat. No.: HY-B0125S
CAS No.: 1173147-91-5
Synonyms: Hoe-280-d3
Ofloxacin-d3 is the deuterium labeled Ofloxacin .
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1
1 Cited Publications
Cat. No.: HY-78131CS
CAS No.: 1219805-09-0
Synonyms: (±)-Ibuprofen-D3 sodium
Ibuprofen-d3 ((±)-Ibuprofen-d3) sodium is the deuterium labeled Ibuprofen sodium (HY-78131C). Ibuprofen sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers [3] .
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1
1 Cited Publications
Cat. No.: HY-10219S
CAS No.: 392711-19-2
Purity:  ≥93.0%
Synonyms: Sirolimus-d3; AY-22989-d3; NSC 226080-d3
Rapamycin-d3 (Sirolimus-d3; AY-22989-d3; NSC 226080-d3) is the deuterated-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant [3] .
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1
1 Cited Publications
Cat. No.: HY-P73543
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VDR; Vitamin D Receptor; NR1I1; Nuclear Receptor Subfamily 1 Group I Member 1; 1,25-Dihydroxyvitamin D3 Receptor; Vitamin D3 Receptor; PPP1R163; Vitamin D (1,25-Dihydroxyvitamin D3) Receptor; Protein Phosphatase 1, Regulatory Subunit 163; 1,25-Dihydroxyvi
Species:  
Human
Source:  
Sf9 insect cells
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1
1 Cited Publications
Cat. No.: HY-112624I
CAS No.: 9004-54-0
Synonyms: Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
Dextran T3 (Dextran 3; Dextran T3(MW 2400-3600)) is a neural tracer and intestinal permeability probe that can move anterogradely and retrogradely in neuronal axons by passive diffusion. Dextran T3 (MW 3,000) is able to permeate across the intestinal epithelial cell membrane in the presence of cholera toxin-induced cytoskeletal disturbance. Dextran T3 (MW 3,000) is used as a fluorescent marker to rapidly label developing neurons (such as Xenopus retinal ganglion cells) and to assess intestinal barrier function. It can be used to study axonal transport in neuroanatomy and permeability changes in intestinal pathophysiology. The Dextran series of compounds are also natural polysaccharide drug carriers that can be connected to drugs through covalent bonding methods such as ester bonds, amide bonds or click chemistry, or self-assembled to form carriers such as nanoparticles and hydrogels. Dextran is biodegradable and biocompatible, and can achieve targeted delivery and controlled release of drugs. Dextran derivatives can prolong the half-life of drugs, increase local concentrations, and reduce the activity of immune clearance [3].
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1
1 Cited Publications
Cat. No.: HY-158285
Purity:  ≥95.0%
25-OH Vitamin D3/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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