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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
156 Results for "
hypoglycemic
" in MedChemExpress (MCE) Product Catalog:
Products (156)
156 Results for "hypoglycemic" in MCE Product Catalog:
Research Areas:
Phenformin (Phenethylbiguanide) (Standard) is the analytical standard of Phenformin (HY-16397). This product is intended for research and analytical applications. Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential.
Cat. No.: HY-182280
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BDM71230 is an orally active inducer of insulin-degrading enzyme (IDE), with an EC50 of 1.9 μM against human IDE. BDM71230 binds to the interface of IDE dimers and enhances the catalytic activity of IDE via steric effects. BDM71230 can potentiate the hydrolytic effect of IDE on insulin and slightly attenuate the hypoglycemic effect of insulin. BDM71230 serves as a pharmacological tool for investigating IDE function and is applicable to studies related to glucose intolerance .
Cat. No.: HY-183489
CAS No.: 1357266-44-4
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TAAR1-agonist-4 is a TAAR1 agonist and oral hypoglycemic agent with an EC50 of 0.0046 μM for TAAR1. TAAR1-agonist-4 alleviates antipsychotic-related metabolic side effects, improves negative and cognitive symptoms, and reduces drug abuse behaviors. TAAR1-agonist-4 is applicable to research on schizophrenia, acute manic episodes associated with bipolar disorder, and glucose intolerance .
Cat. No.: HY-N0821R
CAS No.: 63492-69-3
Synonyms: Griffonin (Standard)
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Cat. No.: HY-N21974
CAS No.: 152041-26-4
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Cat. No.: HY-111294
CAS No.: 851389-35-0
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ASP4000 hydrochloride is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 hydrochloride reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 hydrochloride can be used in studies related to type 2 diabetes .
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GLP-1R agonist 3 is a potent agonist of GLP-1R. GLP-1R agonist 3 is a thickened imidazole derivative compound. Glucagon-like peptide-1 (GLP-1) is an intestinal hypoglycemic hormone secreted by L-cells in the lower gastrointestinal tract. GLP-1R agonist 3 has the potential for the research of diabetes (extracted from patent WO2021197464A1, compound 1) .
Cat. No.: HY-182346
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FBPase-IN-7 is a fructose-1,6-bisphosphatase (FBPase) inhibitor with an IC50 of 0.75 μM. FBPase-IN-7 binds to a cryptic allosteric pocket of FBPase, induces conformational rearrangement of key residues, forms a hydrogen-bond network, and disrupts substrate catalysis. FBPase-IN-7 confirms cellular stabilizes HuFBPase in hepatic cells. FBPase-IN-7 has hypoglycemic activity. FBPase-IN-7 can be used for the research of type 2 diabetes .
Cat. No.: HY-I0786
CAS No.: 1404559-15-4
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(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). (2S,4R)-Teneligliptin increases the plasma concentration of active glucagon-like peptide-1 (GLP-1), which promotes insulin secretion in response to elevated blood glucose levels, exerting hypoglycemic activity. (2S,4R)-Teneligliptin is promising for research of type 2 diabetes .
Cat. No.: HY-W540188
CAS No.: 21085-60-9
Synonyms: Ketomalonic acid calcium; Mesoxalic acid calcium; Oxomalonic acid calcium
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Calcium mesoxalate (Ketomalonic acid calcium) is an orally active antidiabetic agent. Calcium mesoxalate increases pancreatic insulin content. Calcium mesoxalate reduces dietary hyperglycemia. Calcium mesoxalate inhibits Epinephrine-induced hyperglycemia in rabbits and exacerbates Alloxan (HY-116823)-induced hypoglycemic convulsions. Calcium mesoxalate exerts no antidiabetic effect in pancreatectomized dogs and fails to reduce the susceptibility of rabbits to Alloxan-induced diabetes. Calcium mesoxalate can be used in diabetes-related research .
Cat. No.: HY-167075
CAS No.: 851510-67-3
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ASP4000 free base is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC50 value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 free base reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 free base can be used in studies related to type 2 diabetes .
Cat. No.: HY-181335
CAS No.: 3093938-66-7
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SKL1223 is an orally effective thioredoxin-interacting protein (TXNIP) inhibitor with an IC50 of 0.64 µM. SKL1223 interacts with the E-box region of the TXNIP promoter to inhibit TXNIP transcription and related signaling pathways. SKL1223 reduces hepatic glucose output. SKL1223 exerts hypoglycemic effects by regulating the action of glucagon, and modulates blood glucose levels in Streptozotocin (HY-13753)-induced and obesity-induced diabetic mice. SKL1223 can be used in the research of type 1 diabetes and type 2 diabetes .
Cat. No.: HY-19904A
CAS No.: 872260-47-4
Synonyms: (+/-)-LY2409021
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(+/-)-Adomeglivant ((+/-)-LY2409021) is a potent and selective glucagon receptor antagonist with hypoglycemic activity. (+/-)-Adomeglivant is effective in lowering blood sugar levels in both healthy people and people with type 2 diabetes. (+/-)-Adomeglivant is well tolerated by glucagon signaling blockade in patients with type 2 diabetes and significantly reduces fasting and postprandial blood glucose with a concomitant reversible elevation of aminotransferases. Glucagon signaling inhibition by (+/-)-Adomeglivant is a promising potential inhibitory approach for patients with type 2 diabetes and warrants further evaluation of its benefits and risks in longer clinical trials .
Cat. No.: HY-N5083R
CAS No.: 20310-89-8
Synonyms: GPi 819
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Cardiovascular Disease Neurological Disease Metabolic Disease
CP-316819 (GPi 819) is a blood-brain barrier permeable glycogen phosphorylase inhibitor. CP-316819 inhibits hepatic glycogenolysis, safely reduces blood glucose in type 2 diabetes, and rarely induces hypoglycemia. CP-316819 increases brain glycogen reserves, protects neurons, alleviates hypoglycemic brain injury, and inhibits excessive platelet activation, exerting both neuroprotective and vasculoprotective effects. CP-316819 can be used in research related to hypoglycemia, thrombosis, autoimmune inflammatory diseases, and type 2 diabetes .
Cat. No.: HY-189219
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GLP-1R modulator-3 is an orally active positive allosteric modulator of GLP-1R, with a Kd of 11.4 μM. GLP-1R modulator-3 exhibits no intrinsic GLP-1R agonistic activity. GLP-1R modulator-3 exerts a hypoglycemic effect in hGLP-1R knock-in mice. GLP-1R modulator-3 is applicable for the research of type 2 diabetes .
Cat. No.: HY-W008321
CAS No.: 66361-67-9
Cat. No.: HY-165175
CAS No.: 25518-51-8
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(+)-Decanoylcarnitine is an (S)-acylcarnitine derivative and a potent inhibitor of carnitine-acylcarnitine translocase, with an IC50 of 5 μM. (+)-Decanoylcarnitine acts as a competitive inhibitor of long-chain acylcarnitine transferase and (-)-carnitine palmityltransferase. (+)-Decanoylcarnitine blocks hepatic fatty acid oxidation, ketogenesis, oleate-induced activation of gluconeogenesis, as well as associated changes in acetyl-CoA, citrate, redox pair ratios, flavins and pyridine nucleotides. (+)-Decanoylcarnitine reverses ketosis in vivo, enhances insulin-mediated hypoglycemic effects in anesthetized animals, and reduces plasma ketone body levels when used in combination with insulin. (+)-Decanoylcarnitine can be used in studies related to diabetic ketoacidosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
