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β-1 adrenoceptors

" in MedChemExpress (MCE) Product Catalog:

標的別:	5-HT Receptor (4) Adrenergic Receptor (71) Apoptosis (10) Drug Isomer (2) Isotope-Labeled Compounds (15) mAChR (1) Ornithine decarboxylase (ODC) (1) Potassium Channel (2) Reference Standards (11) Renin (3) Sodium Channel (1)
研究分野別:	Cancer (23) Cardiovascular Disease (53) Endocrinology (36) Infection (7) Inflammation/Immunology (11) Metabolic Disease (10) Neurological Disease (17)

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天然物

同位体標識化合物

製品番号	製品名	Target	研究分野	構造式

HY-17498

Atenolol 20+ Cited Publications (RS)-Atenolol	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17503

Metoprolol 10+ Cited Publications	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-116771A

CL 316243 Maximum Cited Publications 24 Publications Verification	Adrenergic Receptor	Metabolic Disease
CL316243 is a highly potent selective *β3-adrenoceptor* agonist with a EC₅₀ of 3 nM, but is an extremely poor to β1/2- receptors .CL316243 is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate . CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence .

HY-15746

Dobutamine hydrochloride 5 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-17503B

Metoprolol tartrate 10+ Cited Publications	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol tartrate is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-14302

Salmeterol 5+ Cited Publications GR33343X	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-A0295

(R)-Propranolol hydrochloride 1 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology
(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β₁AR and β₂AR with K_i values of 1.8 nM and 0.8 nM, respectively .

HY-17503A

Metoprolol succinate 10+ Cited Publications	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol succinate is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-12463

Carmoterol hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Carmoterol hydrochloride is a highly potent, selective and long-acting *β2-adrenoceptor* agonist with the pEC₅₀ of 10.19. Carmoterol has 53 times higher affinity for the β2-adrenoceptors than for the β1-adrenoceptors. Carmoterol hydrochloride can be used for the research of asthma and chronic obstructive pulmonary disease (COPD) .

HY-15746A

Dobutamine 5 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion .

HY-101355B

CGP 20712 A CGP 20712 mesylate	Adrenergic Receptor	Cardiovascular Disease
CGP 20712 A (CGP 20712 mesylate) is a highly selective *β1-adrenoceptor* antagonist with an IC₅₀ of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors .

HY-107327

Carazolol 1 Publications Verification (±)-Carazolol; DL-Carazolol; Suacron	Adrenergic Receptor	Cardiovascular Disease
Carazolol is a **β₁/β₂ adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β₃-adrenoceptor** agonist .

HY-103211

L748337 1 Publications Verification	Adrenergic Receptor	Cardiovascular Disease Metabolic Disease Cancer
L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The K_i values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively . L748337 couples predominantly to G_i to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC₅₀ value of 11.6 . L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases .

HY-17453

Salmeterol xinafoate 5+ Cited Publications GR 33343X xinafoate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-101327A

Xamoterol hemifumarate Corwin hemifumarate; ICI 118587 hemifumarate	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Xamoterol (Corwin; ICI 118587) hemifumarate is an orally active and selective *β₁-adrenoceptor* partial agonist. Xamoterol hemifumarate acts as agonist at low sympathetic tone, antagonist at high sympathetic tone, with context-dependent cardiovascular effects including modulated heart rate, blood pressure, and cardiac output. Xamoterol hemifumarate can be used for the research of heart failure, postural hypotension, and ischemic heart disease .

HY-101325

(S,S)-BRL-37344 sodium	Drug Isomer Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
(S,S)-BRL-37344 sodium is an isomer of BRL-37344 (HY-101325B). BRL-37344 is a *β-adrenoceptor* agonist with EC₅₀ values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes .

HY-17498S

Atenolol-d7 (RS)-Atenolol-d₇	Adrenergic Receptor	Neurological Disease Endocrinology
Atenolol-d₇ is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17503AS

Metoprolol-d7 hydrochloride	Isotope-Labeled Compounds Adrenergic Receptor	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol-d₇ (hydrochloride) is the deuterium labeled Metoprolol. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17498R

Atenolol (Standard) 20+ Cited Publications (RS)-Atenolol (Standard)	Reference Standards Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Atenolol (Standard) is the analytical standard of Atenolol. This product is intended for research and analytical applications. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17503R

Metoprolol (Standard)	Reference Standards Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol (Standard) is the analytical standard of Metoprolol. This product is intended for research and analytical applications. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503AR

Metoprolol succinate (Standard)	Reference Standards Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol (succinate) (Standard) is the analytical standard of Metoprolol (succinate). This product is intended for research and analytical applications. Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-116771

CL 316243 free acid Maximum Cited Publications 24 Publications Verification	Adrenergic Receptor	Metabolic Disease
CL316243 free acid is a highly potent selective *β3-adrenoceptor* agonist with a EC₅₀ of 3 nM, but is an extremely poor to β1/2- receptors. CL316243 free acid is a effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 free acid has the potential for the treatment obesity, diabetes and urge urinary incontinence .

HY-B1562B

Bopindolol malonate (±)-Bopindolol malonate	Adrenergic Receptor Renin 5-HT Receptor	Cardiovascular Disease Neurological Disease
Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.

HY-101355A

CGP 20712 dihydrochloride	Adrenergic Receptor	Neurological Disease Endocrinology
CGP 20712 dihydrochloride is a highly selective *β1-adrenoceptor* antagonist with an IC₅₀ of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors .

HY-A0249

Bevantolol	Adrenergic Receptor	Cardiovascular Disease
Bevantolol is a selective β-1 adrenoceptor antagonist. Bevantolol can be used for the research of angina pectoris and hypertension .

HY-W517264

Carazolol hydrochloride BM 51052 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Carazolol (BM 51052) hydrochloride is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor** agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-135119

Salmeterol-d3	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol-d₃ is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-148527

LAS190792 AZD8999	Adrenergic Receptor mAChR	Others
LAS190792 (AZD8999) is a potent muscarinic antagonist and *β2-adrenoceptor* agonist with pIC₅₀ 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilator .

HY-101325A

(S,S)-BRL-37344	Drug Isomer Adrenergic Receptor	Cardiovascular Disease Metabolic Disease
(S,S)-BRL-37344 is an isomer of BRL-37344 (HY-101325B). BRL-37344 is a *β-adrenoceptor* agonist with EC₅₀ values of 5.3, 18 and 570 nM for β3, β2 and β1. BRL-37344 induces concentration-dependent increases in atria1 rate, relaxation of guinea pig trachea and lipolysis of brown adipocytes .

HY-123268A

Ro 363 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective *β1-adrenoceptor* agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility .

HY-17503S3

Metoprolol-d5	Apoptosis Adrenergic Receptor	Cancer
Metoprolol-d₅ is the deuterium labeled Metoprolol . Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-123268

Ro 363	Adrenergic Receptor	Cardiovascular Disease
Ro 363, an effective inotropic stimulant, is a potent and highly selective *β1-adrenoceptor* agonist. RO 363 is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility .

HY-16056

Arbutamine	Adrenergic Receptor	Cardiovascular Disease
Arbutamine is a short-acting, potent and nonselective *β-adrenoceptor* agonist. Arbutamine stimulates cardiac β₁-, tracheal β₂-, and adiopocyte β₃- adrenergic receptors. Arbutamine provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine can be used for cardiac stress agent .

HY-16056A

Arbutamine hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Arbutamine hydrochloride is a short-acting, potent and nonselective *β-adrenoceptor* agonist. Arbutamine hydrochloride stimulates cardiac β₁-, tracheal β₂-, and adiopocyte β₃- adrenergic receptors. Arbutamine hydrochloride provides cardiac stress increases heart rate, cardiac contractility, and systolic blood pressure. Arbutamine hydrochloride can be used for cardiac stress agent .

HY-17503BR

Metoprolol tartrate (Standard)	Reference Standards Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol (tartrate) (Standard) is the analytical standard of Metoprolol (tartrate). This product is intended for research and analytical applications. Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-101327

Xamoterol Corwin; ICI 118587	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease
Xamoterol (Corwin; ICI 118587) is an orally active and selective *β₁-adrenoceptor* partial agonist. Xamoterol acts as agonist at low sympathetic tone, antagonist at high sympathetic tone, with context-dependent cardiovascular effects including modulated heart rate, blood pressure, and cardiac output. Xamoterol can be used for the research of heart failure, postural hypotension, and ischemic heart disease .

HY-14302R

Salmeterol (Standard) GR33343X (Standard)	Adrenergic Receptor Reference Standards	Inflammation/Immunology Endocrinology
Salmeterol (Standard) is the analytical standard of Salmeterol. This product is intended for research and analytical applications. Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively .

HY-17453R

Salmeterol xinafoate (Standard) GR 33343X xinafoate (Standard)	Reference Standards Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol (xinafoate) (Standard) is the analytical standard of Salmeterol (xinafoate). This product is intended for research and analytical applications. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively .

HY-17498B

Atenolol hydrochloride (RS)-Atenolol hydrochloride; Tenormin hydrochloride; ICI 66082 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Atenolol hydrochloride is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol hydrochloride can be used for the research of hypertension and angina pectoris .

HY-17503D

Metoprolol Hydrochloride	Adrenergic Receptor Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Metoprolol Hydrochloride is an orally active and selective *β1-adrenoceptor* antagonist. Metoprolol Hydrochloride exhibits anti-inflammatory, antitumor, and anti-angiogenic properties .

HY-129660

LK 204-545	Adrenergic Receptor	Cardiovascular Disease
LK 204-545 is a potent and highly selective *β₁-adrenoceptor* antagonist. LK 204-545 is promising for research of cardiovascular diseases .

HY-101355

CGP 20712	Adrenergic Receptor	Cardiovascular Disease
CGP 20712 is a highly selective *β1-adrenoceptor* antagonist (K_i=0.3 nmol/L). CGP 20712’s primary mechanism of action is through competitively binding to β1-receptors, thereby blocking the positive chronotropic effects of adrenaline and noradrenaline .

HY-U00183

Epanolol Visacor; ICI141292	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Epanolol (Visacor; ICI141292) is a potent *β-adrenoceptor* partial agonist with a greater affinity for β1- than β2-adrenoceptors.

HY-17503C

Metoprolol fumarate CGP 2175C; Lopressor OROS	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol fumarate (CGP 2175C) is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17498S1

Atenolol-d6 (RS)-Atenolol-d₆	Isotope-Labeled Compounds	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Atenolol-d₆ ((RS)-Atenolol-d₆) is deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17498S3

Atenolol-13C6 (RS)-Atenolol-¹³C₆	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Atenolol- ¹³C₆ ((RS)-Atenolol- ¹³C₆) is ¹³C labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-101355AR

CGP 20712 dihydrochloride (Standard)	Adrenergic Receptor Reference Standards	Neurological Disease Endocrinology
CGP 20712 (dihydrochloride) (Standard) is the analytical standard of CGP 20712 (dihydrochloride). This product is intended for research and analytical applications. CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors .

HY-107327R

Carazolol (Standard) (±)-Carazolol (Standard); DL-Carazolol (Standard); Suacron (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Carazolol (Standard) is the analytical standard of Carazolol. This product is intended for research and analytical applications. Carazolol is a **β₁/β₂ adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β₃-adrenoceptor** agonist .

HY-17503BS

Metoprolol-d6 tartrate	Isotope-Labeled Compounds Adrenergic Receptor	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol-d₆ (tartrate) is the deuterium labeled Metoprolol tartrate. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-107327S

Carazolol-d7 (±)-Carazolol-d₇; DL-Carazolol-d₇; Suacron-d₇	Isotope-Labeled Compounds Adrenergic Receptor	Cardiovascular Disease
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor** agonist. Carazolol can be used in the research of hypertension .

製品番号	製品名	Category	Target	構造式

HY-17503

Metoprolol 10+ Cited Publications	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor Apoptosis
Metoprolol is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

製品番号	製品名	構造式

HY-17498S

Atenolol-d7
Atenolol-d₇ is the deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17503AS

Metoprolol-d7 hydrochloride
Metoprolol-d₇ (hydrochloride) is the deuterium labeled Metoprolol. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-135119

Salmeterol-d3
Salmeterol-d₃ is a deuterium labeled Salmeterol. Salmeterol is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-17503S3

Metoprolol-d5
Metoprolol-d₅ is the deuterium labeled Metoprolol . Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17498S1

Atenolol-d6
Atenolol-d₆ ((RS)-Atenolol-d₆) is deuterium labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17498S3

Atenolol-13C6
Atenolol- ¹³C₆ ((RS)-Atenolol- ¹³C₆) is ¹³C labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-17503BS

Metoprolol-d6 tartrate
Metoprolol-d₆ (tartrate) is the deuterium labeled Metoprolol tartrate. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-107327S

Carazolol-d7
Carazolol-d₇ is the deuterium labeled Carazolol (HY-107327). Carazolol is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol is also a potent, selective β₃-adrenoceptor** agonist. Carazolol can be used in the research of hypertension .

HY-17503AS1

Metoprolol-d6 succinate
Metoprolol-d₆ (succinate) is deuterium labeled Metoprolol (succinate). Metoprolol succinate is an orally active, selective *β1-adrenoceptor* antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-107327S1

Carazolol-d7 hydrochloride
Carazolol-d₇ (hydrochloride) is the deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor** agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-W777156

Carazolol-d6 hydrochloride
Carazolol-d₆ (hydrochloride) is deuterium labeled Carazolol hydrochloride (HY-W517264). Carazolol hydrochloride is a highly potent antagonist of **β₁/β₂ adrenoceptor. Carazolol hydrochloride is also a potent, selective β₃-adrenoceptor** agonist. Carazolol hydrochloride can be used in the research of hypertension .

HY-15746S

(rac)-Dobutamine-d4 hydrochloride

(rac)-Dobutamine-d₄ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-15746S1

(rac)-Dobutamine-d6 hydrochloride

(rac)-Dobutamine-d₆ (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .

HY-14302S1

Salmeterol-d5
Salmeterol-d5 is a deuterated labeled Salmeterol . Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-17453S

Salmeterol-d3 xinafoate
Salmeterol-d₃ (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-17453S1

Salmeterol-13C6 xinafoate
Salmeterol- ¹³C₆ (xinafoate) is the ¹³C₆ labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

HY-14300S2

Vilanterol-d12
Vilanterol-d₁₂ (GW642444-d₁₂) is deuterium labeled Vilanterol. Vilanterol (GW642444) is a long-acting *β₂-adrenoceptor* (β₂-AR) agonist with 24 h activity. The pEC₅₀s for β₂-AR,β₁-AR and β₃-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.

HY-W742404

Bopindolol-d9

Bopindolol-d₉ ((±)-Bopindolol-d₉) is the deuterium labeled Bopindolol (HY-B1562). Bopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.

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日本の代理先をお選びくださいナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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