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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
60 Results for "
β-secretase 2
" in MedChemExpress (MCE) Product Catalog:
Products (60)
60 Results for "β-secretase 2" in MCE Product Catalog:
14
14 Publications Verification
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LY2811376 is the first orally available non-peptidic β-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease Aβ secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
9
9 Cited Publications
Synonyms: CERM 1978; Org 5730 hydrochloride
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Calcium Channel Sodium Channel Potassium Channel SARS-CoV Beta-secretase Amyloid-β Proteasome γ-secretase Calmodulin
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Bepridil hydrochloride (CERM 1978; Org 5730 hydrochloride) is an orally active non-selective calcium channel antagonist with multi-ion channel blocking activity. Bepridil hydrochloride modulates Calmodulin, the 20S proteasome, T-type/L-type calcium channels, cardiac sodium channels, multiple potassium channels, γ-secretase, β-secretase, and mitoKATP/sarcKATP channels. Bepridil hydrochloride acts as a hydroxyl radical scavenger, regulates mitochondrial and intracellular calcium handling, and exerts antiarrhythmic, antianginal, and cardioprotective effects. Bepridil hydrochloride alters amyloid precursor protein processing, reduces β-amyloid and thalamic calcium levels, restores seladin-1/DHCR24 expression, and improves sensorimotor recovery after cerebral ischemia. Bepridil hydrochloride also exhibits potent inhibitory effects on SARS-CoV-2 replication. Bepridil hydrochloride is used in studies related to stable angina, arrhythmias, cerebral ischemia, Alzheimer's disease, and SARS-CoV-2 infection [2] .
9
Target:
Calcium Channel Sodium Channel Potassium Channel SARS-CoV Beta-secretase Amyloid-β Proteasome γ-secretase Calmodulin
Research Areas:
Bepridil (CERM 1978 (free base); Org 5730) is an orally active non-selective calcium channel antagonist with multi-ion channel blocking activity. Bepridil modulates Calmodulin, the 20S proteasome, T-type/L-type calcium channels, cardiac sodium channels, multiple potassium channels, γ-secretase, β-secretase, and mitoKATP/sarcKATP channels. Bepridil acts as a hydroxyl radical scavenger, regulates mitochondrial and intracellular calcium handling, and exerts antiarrhythmic, antianginal, and cardioprotective effects. Bepridil alters amyloid precursor protein processing, reduces β-amyloid and thalamic calcium levels, restores seladin-1/DHCR24 expression, and improves sensorimotor recovery after cerebral ischemia. Bepridil also exhibits potent inhibitory effects on SARS-CoV-2 replication. Bepridil is used in studies related to stable angina, arrhythmias, cerebral ischemia, Alzheimer's disease, and SARS-CoV-2 infection [2] .
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9 Cited Publications
Cat. No.: HY-16952A
CAS No.: 74764-40-2
Synonyms: CERM 1978 hydrate; Org 5730 hydrochloride hydrate
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Calcium Channel Sodium Channel Potassium Channel SARS-CoV Beta-secretase Amyloid-β Proteasome γ-secretase Calmodulin
Research Areas:
Bepridil hydrochloride hydrate (CERM 1978 hydrate; Org 5730 hydrochloride hydrate) is an orally active non-selective calcium channel antagonist with multi-ion channel blocking activity. Bepridil hydrochloride hydrate modulates Calmodulin, the 20S proteasome, T-type/L-type calcium channels, cardiac sodium channels, multiple potassium channels, γ-secretase, β-secretase, and mitoKATP/sarcKATP channels. Bepridil hydrochloride hydrate acts as a hydroxyl radical scavenger, regulates mitochondrial and intracellular calcium handling, and exerts antiarrhythmic, antianginal, and cardioprotective effects. Bepridil hydrochloride hydrate alters amyloid precursor protein processing, reduces β-amyloid and thalamic calcium levels, restores seladin-1/DHCR24 expression, and improves sensorimotor recovery after cerebral ischemia. Bepridil hydrochloride hydrate also exhibits potent inhibitory effects on SARS-CoV-2 replication. Bepridil hydrochloride hydrate is used in studies related to stable angina, arrhythmias, cerebral ischemia, Alzheimer's disease, and SARS-CoV-2 infection [2] .
Cat. No.: HY-N0702
CAS No.: 20183-47-5
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Flavonoids Flavones Aconitum apetalum (Huth) B. Fedtsch. Plants Disease Research Fields Inflammation/Immunology Rhamnaceae Extract
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Cat. No.: HY-B0703
CAS No.: 236395-14-5
Synonyms: BIA 2-093
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Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
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β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
Cat. No.: HY-P1962
CAS No.: 350228-37-4
Synonyms: [Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)
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NB-360 is a potent, brain penetrable and orally active β‐secretase 1/2 (BACE1/BACE2) dual inhibitor with IC50 values of 5 and 6 nM. NB-360 can inhibit amyloid-β protein accumulation. NB-360 can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease [2].
Cat. No.: HY-N2215
CAS No.: 105317-67-7
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Monophenols Simple Phenylpropanols Aloe vera (L.) Burm. f. Phenols Phenylpropanoids Plants Liliaceae Extract
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Cat. No.: HY-N1280
CAS No.: 129280-33-7
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Flavonoids Phenols Polyphenols Leguminosae Extract Plants Glycyrrhiza uralensis Fisch. Isoflavones
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Aftin-5 is an inducer for Amyloid-β 42 (Aβ42). Aftin-5 upregulates Aβ42 and downregulates Aβ38 levels in a β-secretase- and γ-secretase-dependent manner by altering the ultrastructure of mitochondria. Aftin-5 exhibits slightly cytotoxicity in cell SH-SY5Y, HT22, N2a and N2a-AβPP695, with IC50s of 180, 194, 178 and 150 μM, respectively .
Cat. No.: HY-N11709
CAS No.: 220114-28-3
Cat. No.: HY-P10191
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β-Secretase Substrate-1, Fluorogenic is a fluorogenic substrate of β-Secretase that can be used to test β-Secretase activity .
Cat. No.: HY-126548
CAS No.: 1818239-19-8
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β-Secretase Inhibitor I is an extremely potent β-secretase inhibitor with reduced cardiovascular and liver toxicity.
Cat. No.: HY-136736
CAS No.: 263563-09-3
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β-Secretase Inhibitor II is a β-Secretase inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC50=700 nM for inhibition of total Aβ and IC50=2.5 μM for Aβ1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease .
Cat. No.: HY-139720
CAS No.: 2760674-85-7
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β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (Ki = 0.13 nM).
Cat. No.: HY-P4428
CAS No.: 141223-71-4
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Cat. No.: HY-P4899
CAS No.: 310427-94-2
Synonyms: RE(EDANS)EVNLDAEFK(DABCYL)R
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
