Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
AMP-activated protein kinase
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "AMP-activated protein kinase" in MCE Product Catalog:
48
48 Publications Verification
Cat. No.: HY-50662
CAS No.: 844499-71-4
Target:
Research Areas:
A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes .
38
38 Cited Publications
Cat. No.: HY-19805
CAS No.: 52029-86-4
Research Areas:
STO-609 is a selective and cell-permeable inhibitor of the Ca 2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.
8
8 Cited Publications
Target:
Research Areas:
EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively.
3
Research Areas:
Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets .
3
3 Cited Publications
Target:
Research Areas:
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
3
3 Cited Publications
Target:
Research Areas:
Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
3
3 Cited Publications
Cat. No.: HY-P0136
CAS No.: 125911-68-4
Target:
Research Areas:
2
2 Cited Publications
Cat. No.: HY-P76141
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-activated protein kinase, Gamma-1 Subunit; protein kinase AMP-activated Non-Catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-activated protein kinase Subunit Gamma-1; AMPK Gamma-1 Chain; protein kinase, AMP-activated, Gamma 1 Non-Cat
Species:
Human
Source:
Sf9 insect cells
2
2 Cited Publications
Cat. No.: HY-P76143
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-activated protein kinase, Gamma-1 Subunit; protein kinase AMP-activated Non-Catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-activated protein kinase Subunit Gamma-1; AMPK Gamma-1 Chain; protein kinase, AMP-activated, Gamma 1 Non-Cat
Species:
Human
Source:
Sf9 insect cells
2
2 Cited Publications
Cat. No.: HY-P80541
Synonyms: PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase
1
1
1 Cited Publications
Cat. No.: HY-P80452
Synonyms: AMPK, AMPK2, PRKAA2, 5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, Acetyl-CoA carboxylase kinase, Hydroxymethylglutaryl-CoA reductase kinase, ACACA kinase, HMGCR kinase
1
1 Cited Publications
Cat. No.: HY-P80791
Synonyms: PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase
Cat. No.: HY-N2055
CAS No.: 19895-95-5
Cat. No.: HY-160004
CAS No.: 1523493-53-9
Target:
PXL770 is an orally active, direct allosteric AMP-activated protein kinase (AMPK) activator. PXL770 decreases C26:0 levels, improves mitochondrial respiration, reduces expression of proinflammatory genes and induces expression of compensatory transporters (ABCD2/3) in ALD fibroblasts/lymphocytes. PXL770 normalizes plasma VLCFA levels, significantly reduces elevated VLCFA levels in brain and spinal cord in Abcd1 KO mice. PXL770 improves glycemia, dyslipidemia, and insulin resistance in ob/ob and high-fat diet (HFD)-fed mice. PXL770 can be used for the study of X-linked adrenoleukodystrophy (ALD), autosomal dominant polycystic kidney disease and nonalcoholic steatohepatitis (NASH) .
Synonyms: WS070117
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
IMM-H007 (WS070117) is an orally active and potent AMPK (AMP-activated protein kinase) activator and TGFβ1 (transforming growth factor β1) antagonist. IMM-H007 has protective effects in cardiovascular diseases via activation of AMPK. IMM-H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. IMM-H007 inhibits ABCA1 degradation. IMM-H007 resolves hepatic steatosis in HFD-fed hamsters by the regulation of lipid metabolism. IMM-H007 can be used for the research of nonalcoholic fatty liver disease (NAFLD) and inflammatory atherosclerosis .
Cat. No.: HY-P0136AF
Target:
Research Areas:
Cat. No.: HY-P5435
CAS No.: 835653-81-1
Target:
Research Areas:
Cat. No.: HY-P11358
CAS No.: 159718-10-2
Research Areas:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
