321 Results for "

B7

" in MedChemExpress (MCE) Product Catalog:
Products (321)

321 Results for "B7" in MCE Product Catalog:

28
28 Publications Verification
Cat. No.: HY-B0511
CAS No.: 58-85-5
Synonyms: Vitamin B7; Vitamin H; D-Biotin
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids .
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19
19 Cited Publications
Cat. No.: HY-P99145

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) is an anti-mouse PD-L1/B7-H1 IgG2b antibody inhibitor derived from host rat. Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) blocks PD-1 signaling. Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) can be used for the research of cancer, such as colon cancer .
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19
19 Cited Publications
Cat. No.: HY-N0372
CAS No.: 58749-22-7
Licochalcone A (LCA), a chalconoid, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) .
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9
9 Cited Publications
Cat. No.: HY-P73361
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Programmed cell death 1 ligand 1; PD-L1; B7-H1; CD274; PDL1
Species:  
Source:  
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6
6 Cited Publications
Cat. No.: HY-N0762
CAS No.: 31524-62-6
Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease [7] .
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4
4 Cited Publications
Cat. No.: HY-P80609
Synonyms: CD86; CD28LG2; T-lymphocyte activation antigen CD86; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1; CD antigen CD86

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, FC

Reactivity:  

Human, Rat

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3
3 Cited Publications
Cat. No.: HY-P99132

Target:  

CTLA-4

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse CTLA-4 Antibody (9D9) is an anti-mouse CTLA-4 IgG2b monoclonal antibody. Anti-Mouse CTLA-4 Antibody (9D9) can bind to CTLA-4 and block its binding to B7. Anti-Mouse CTLA-4 Antibody (9D9) enhances T cell function by increasing the ratio of CD8 + T cells to regulatory T cells (Tregs). Anti-Mouse CTLA-4 Antibody (9D9) can be used for research on cancer such as colon cancer and melanoma .
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2
2 Cited Publications
Cat. No.: HY-P74394
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4
Species:  
Source:  
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2
2 Cited Publications
Cat. No.: HY-155747
CAS No.: 2768426-49-7
Purity:  99.41%
Target:  

Autophagy Akt mTOR

Research Areas:  

Cancer

FDW028 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research .
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2
2 Cited Publications
Cat. No.: HY-P70632
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1; PD-L1; PDCD1 ligand 1; programmed death ligand 1; B7 homolog 1; B7-H1; CD274
Species:  
Source:  
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2
2 Cited Publications
Cat. No.: HY-108829
CAS No.: 332348-12-6
Purity:  ≥99.0%
Synonyms: CTLA4lg; BMS-188667

Target:  

CTLA-4

Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains) . Abatacept is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .
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2
2 Cited Publications
Cat. No.: HY-108829A
CAS No.: 332348-12-6
Purity:  95.00%
Synonyms: CTLA4lg (powder); BMS-188667 (powder); Orencia
Abatacept (CTLA4lg; BMS-188667) powder is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). Abatacept powder is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .
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2
2 Cited Publications
Cat. No.: HY-N0235
CAS No.: 10309-37-2
Synonyms: (S)-(+)-Bakuchiol
Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC50s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.
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2
2 Cited Publications
Cat. No.: HY-P79222
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Osteopontin; Spp1; Bone sialoprotein 1; Secreted phosphoprotein 1; SPP-1; 2B7; Secreted Phosphoprotein 1 [BNSP]
Species:  
Rat
Source:  
CHO
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2
2 Cited Publications
Cat. No.: HY-107836
CAS No.: 74611-28-2
Purity:  99.60%
Synonyms: Metitepine mesylate; Ro 8-6837 mesylate
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

Methiothepin (Metitepine) mesylate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).
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2
2 Cited Publications
Cat. No.: HY-12307
CAS No.: 90365-57-4
Purity:  98.42%
Synonyms: Indolactam V
Target:  

PKC

Research Areas:  

Cancer

(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.
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1
1 Cited Publications
Cat. No.: HY-P9966
CAS No.: 1353485-38-7
Synonyms: MGA271

Target:  

CD276/B7-H3

Research Areas:  

Cancer

Enoblituzumab (MGA271) is a humanized IgG1κ monoclonal antibody recognizing human B7-H3 protein, a member of the B7 family of immune regulators .
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1
1 Cited Publications
Cat. No.: HY-P99762
CAS No.: 2069959-72-2
Synonyms: MGD009

Target:  

CD3

Research Areas:  

Cancer

Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer .
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1
1 Cited Publications
Cat. No.: HY-P84266
Synonyms: B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1

Host:  

Mouse

Application:  

IHC-P, FC, ELISA

Reactivity:  

Human, Mouse, Rat, Rabbit

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1
1 Cited Publications
Cat. No.: HY-P74395
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4
Species:  
Source:  
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