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Isoforms Recommended:	Bcl-2

Results for "

BCL-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (427) 5-HT Receptor (1) ACSL Family (1) ADAMTS (1) ADC Linker (1) Adrenergic Receptor (6) Akt (50) AMPK (7) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (2) Androgen Receptor (3) Antibiotic (4) AP-1 (1) Apoptosis (370) ASK1 (2) Atg8/LC3 (1) Aurora Kinase (1) Autophagy (48) Bacterial (24) Bcr-Abl (3) Beclin1 (3) Beta-secretase (2) Biochemical Assay Reagents (5) Bombesin Receptor (1) Btk (2) c-Met/HGFR (1) c-Myc (10) Cadherin (6) Calcium Channel (3) CaMK (1) Cannabinoid Receptor (1) Carbonic Anhydrase (4) Casein Kinase (2) Caspase (169) CaSR (1) CDK (26) Checkpoint Kinase (Chk) (2) Cholinesterase (ChE) (5) COX (13) Cyclin G-associated Kinase (GAK) (3) Cytochrome P450 (7) Dimethylargininase (DDAH) (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (17) Dopamine Receptor (1) Dopamine β-hydroxylase (2) Drug Derivative (8) Drug Metabolite (2) Dynamin (1) E1/E2/E3 Enzyme (3) EAAT (2) Early 2 Factor (E2F) (1) EGFR (25) Elastase (1) Endogenous Metabolite (17) Endothelin Receptor (2) Environmental Pollutants (6) Epigenetic Reader Domain (6) ERK (21) Estrogen Receptor/ERR (1) Eukaryotic Initiation Factor (eIF) (2) FAK (4) Fat Mass and Obesity-associated Protein (FTO) (1) Fatty Acid Synthase (FASN) (2) Ferroptosis (8) FGFR (1) FLT3 (3) Fluorescent Dye (1) FOXO (2) Fungal (13) FXR (10) G protein-coupled Bile Acid Receptor 1 (8) G-quadruplex (3) GABA Receptor (2) Glucocorticoid Receptor (4) GLUT (1) Glutathione Peroxidase (7) Glutathione S-transferase (1) Glycosidase (2) GSK-3 (6) HBV (1) HCV (5) HDAC (10) Heme Oxygenase (HO) (4) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (4) HIV (2) HSP (7) Hsp-targeting Chimeras (1) HSV (4) IAP (4) iGluR (3) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (4) Insecticide (2) Insulin Receptor (1) Interleukin Related (16) Isotope-Labeled Compounds (8) JAK (4) JNK (21) Keap1-Nrf2 (7) Lactate Dehydrogenase (3) Ligands for E3 Ligase (1) Lipoxygenase (1) LPL Receptor (8) MAP3K (1) MAP4K (1) MDM-2/p53 (49) MEK (3) MetAP (1) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) METTL3 (2) mGluR (1) MicroRNA (1) Microtubule/Tubulin (18) Mitochondrial Metabolism (12) Mitophagy (7) MMP (15) Molecular Glues (3) Monoamine Oxidase (1) mRNA (3) mTOR (15) MyD88 (2) Na+/K+ ATPase (1) Necroptosis (3) NF-κB (41) NO Synthase (3) Notch (2) Nuclear Hormone Receptor 4A/NR4A (2) Orthopoxvirus (1) P-glycoprotein (15) p38 MAPK (37) PAK (3) Parasite (15) PARP (38) PD-1/PD-L1 (3) PERK (4) Phosphodiesterase (PDE) (3) Phospholipase (1) PI3K (31) PIKfyve (1) Pim (1) PKA (1) PKC (1) Polo-like Kinase (PLK) (2) Potassium Channel (2) PPAR (7) Prostaglandin Receptor (1) PROTACs (14) Protease Activated Receptor (PAR) (1) Pyroptosis (1) Raf (6) RAR/RXR (2) Ras (5) Reactive Oxygen Species (ROS) (72) Reference Standards (50) Ribosomal S6 Kinase (RSK) (1) ROS Kinase (2) Serpin (1) SHMT (1) SHP1 (1) Sirtuin (1) Small Interfering RNA (siRNA) (24) Smo (1) SOD (12) Src (2) STAT (15) STING (1) Succinate Dehydrogenase (1) Survivin (7) Syk (1) Tau Protein (1) Telomerase (2) TGF-beta/Smad (10) TGF-β Receptor (2) Thymidylate Synthase (2) TNF Receptor (9) Toll-like Receptor (TLR) (6) Topoisomerase (15) Transferrin Receptor (1) TRP Channel (3) Tyrosinase (2) ULK (5) VD/VDR (1) VDAC (1) VEGFR (24) Virus Protease (1) WDR5 (2) Wnt (3) α-synuclein (1) β-catenin (3)
By Research Areas:	Cancer (480) Cardiovascular Disease (46) Endocrinology (9) Infection (56) Inflammation/Immunology (92) Metabolic Disease (34) Neurological Disease (67)
Oligonucleotides:	Aptamers (2) Rat Pre-designed siRNA Sets (7) mRNA (3) Mouse Pre-designed siRNA Sets (7) Human Pre-designed siRNA Sets (10) Polymers (1) Antisense Oligonucleotides (7) Cholesterol (2) Interleukin & Receptors (1) siRNAs (24)

602

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

137

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Bcl-2 Family BCL6

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10087

Navitoclax 145+ Cited Publications ABT-263	Bcl-2 Family	Cancer
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x_L, Bcl-2 and Bcl-w, with a K_i of less than 1 nM .

HY-117288

S55746 1 Publications Verification BCL201	Bcl-2 Family	Cancer
S55746 (BCL201) is a potent, orally active and selective *BCL-2* inhibitor, with a K_i of 1.3 nM and a K_d of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity .

HY-129179

Lisaftoclax 1 Publications Verification APG-2575; BCL-2/BCL-xl inhibitor 1	Bcl-2 Family	Cancer
Lisaftoclax (compound 6) is a dual *Bcl-2* and *Bcl-xl* inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC₅₀ values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively .

HY-125876

*PROTAC Bcl2* degrader-1** 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of *Bcl-2* (IC₅₀, 4.94 μM; DC₅₀, 3.0 μM) and Mcl-1 (IC₅₀, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).

HY-12020

TW-37 4 Publications Verification	Bcl-2 Family	Cancer
TW-37 is a potent *Bcl-2* inhibitor with K_i values of 260, 290 and 1110 nM for Mcl-1, *Bcl-2* and *Bcl-xL*, respectively.

HY-129700

*MCL-1/BCL-2-IN-2*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor .

HY-142209

ABBV-167	Bcl-2 Family	Cancer
ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax .

HY-138697

S65487 VOB560	Bcl-2 Family Apoptosis	Cancer
S65487 (VOB560), a potent and selective *BCL-2* inhibitor, is a proagent of S55746. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities ^[2].

HY-161410

WH244	PROTACs Apoptosis Bcl-2 Family	Cancer
WH244 is a second generation *BCL-2* and *BCL-xL* dual depressant (PROTAC). The primary activity of WH244 is the specific degradation of *BCL-2* and *BCL-xL* proteins (BCL-xL: DC₅₀=0.6 nM, BCL-2: DC₅₀=7.4 nM). WH244 promotes their ubiquitination and subsequent proteasome degradation by targeting these proteins, thereby restoring the cell's apoptosis pathway. WH244 has good antitumor activity. (Pink: BCL-2/BCL-xL ligand (HY-161415); Blue: E3 ligase ligand (HY-112078); Black: linker) .

HY-120882

BM-1197 UBX1967	Bcl-2 Family	Cancer
BM-1197 (UBX1967) is a potent and selective inhibitor of dual *Bcl-2/Bcl-xL, with IC₅₀s of 3.5 nM and 5.2 nM for Bcl-2* and Bcl-xL, respectively. BM-1197 exhibits antitumor effects both in vitro and in vivo ^[2].

HY-129702

*MCL-1/BCL-2-IN-4*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor .

HY-129681

*MCL-1/BCL-2-IN-1*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor with IC₅₀s of 4.45 and 3.18 μM, respectively .

HY-10087R

Navitoclax (Standard) ABT-263 (Standard)	Reference Standards Bcl-2 Family	Cancer
Navitoclax (Standard) is the analytical standard of Navitoclax. This product is intended for research and analytical applications. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-118874A

Oblimersen sodium	Apoptosis Bcl-2 Family	Cancer
Oblimersen sodium is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen sodium specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen sodium can be used for cancer research ^[2] .

HY-138697A

S65487 sulfate VOB560 sulfate	Bcl-2 Family Apoptosis	Cancer
S65487 (VOB560) sulfate, a potent and selective *Bcl-2* inhibitor, is a proagent of S55746. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities ^[2].

HY-169266

BRD-K56819078	Bcl-2 Family Apoptosis	Metabolic Disease
BRD-K56819078 is a *Bcl-2* inhibitor that significantly reduces senescent cell load and senescence-related genes in the kidney mRNA expression. BRD-K56819078 exerts anti-aging effects by inhibiting apoptosis .

HY-19551

Apogossypolone ApoG2	Bcl-2 Family Apoptosis Autophagy Fungal ROS Kinase	Infection Cancer
Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with K_i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X_L, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy ^[2]. Apogossypolone also has antifungal activity .

HY-135273

A-1211212 BCL2-IN-1	Bcl-2 Family	Cancer
A-1211212 (BCL2-IN-1), a chemical probe, is a potent *Bcl-2* inhibitor. BCL2-IN-1 binds Bcl-2 with a K_i of <0.01 nM .

HY-117288A

S55746 hydrochloride 1 Publications Verification BCL201 hydrochloride	Bcl-2 Family	Cancer
S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective *BCL-2* inhibitor, with a K_i of 1.3 nM and a K_d of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity .

HY-118874

Oblimersen	Bcl-2 Family Apoptosis	Cancer
Oblimersen is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen can be used for cancer research ^[2] .

HY-129701

*MCL-1/BCL-2-IN-3*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor with IC₅₀s of 5.95 and 4.78 μM, respectively .

HY-N1218

Stellasterol	Glycosidase Bcl-2 Family	Others
Stellasterol is a natural product. Stellasterol has high affinity towards *Bcl-2* protein (K_i: 118.05 nM). Stellasterol is a weak α-glucosidase inhibitor ^[2].

HY-P5325A

Bid BH3 (80-99) acetate	Bcl-2 Family	Others
Bid BH3 (80-99) acetate is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-10087S

Navitoclax-d8 1 Publications Verification	Bcl-2 Family	Cancer
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-149009

Bcl-2-IN-9	Bcl-2 Family Apoptosis	Cancer
Bcl-2-IN-9 is a novel proapoptotic *Bcl-2* inhibitor with IC₅₀ value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells .

HY-143872

Bcl-2-IN-4	Bcl-2 Family	Cancer
Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC₅₀ of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC₅₀ of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC₅₀ of 2.7 nM (WO2021180040A1; compound 2) .

HY-174403

*c-MYC/BCL2* ligand 1 iodide**	Bcl-2 Family c-Myc Apoptosis Caspase	Cancer
c-MYC/BCL2 ligand 1 iodide is a dual-targeting *c-MYC/Bcl-2* G4 ligand with K_d values of 0.90 μM (c-MYC G4) and 0.56 μM (Bcl-2** G4). c-MYC/BCL2 ligand 1 iodide inhibits c-MYC and *Bcl-2* gene transcription by binding to G4-forming sequences and downregulates their protein expression. c-MYC/BCL2 ligand 1 iodide inhibits suppresses migration, induces caspase-dependent apoptosis, and triggers cell cycle G1 arrest in MCF-7 cells. c-MYC/BCL2 ligand 1 iodide significantly suppresses tumor growth in a 4T1 syngeneic model with no observable toxicity. c-MYC/BCL2 ligand 1 iodide can be used for the research of breast cancer.

HY-RS01417

BCL2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2 Rat Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2 Rat Pre-designed siRNA Set A BCL2 Rat Pre-designed siRNA Set A

HY-RS01415

BCL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2 Human Pre-designed siRNA Set A BCL2 Human Pre-designed siRNA Set A

HY-149681

*Beclin1-Bcl-2* interaction inhibitor 1**	Bcl-2 Family Beclin1	Neurological Disease Cancer
Beclin1-Bcl-2 interaction inhibitor 1 is a Beclin1 and *Bcl-2* interaction inhibitor with an IC₅₀ value of 4.4 nM. Beclin1-Bcl-2 interaction inhibitor 1 disrupts the binding of the Bcl-2-Beclin 1 BH3 domain. Beclin1-Bcl-2 interaction inhibitor 1 can be used in the research of cancer and neurodegenerative diseases .

HY-131247

Bcl-2-IN-2	Bcl-2 Family	Inflammation/Immunology Cancer
Bcl-2-IN-2 is a potent and selective *Bcl-2* inhibitor with an IC₅₀ of 0.034 nM and also inhibits Bcl-xL with an IC₅₀ of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL .

HY-RS01416

Bcl2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2 Mouse Pre-designed siRNA Set A Bcl2 Mouse Pre-designed siRNA Set A

HY-160108

Bcl-2-IN-17	Bcl-2 Family	Others
Bcl-2-IN-17 is a *Bcl2* inhibitor and can be used for the research of diseases associated with Bcl anti-apoptotic protein .

HY-153953

Bcl-2-IN-11	Bcl-2 Family	Cancer
Bcl-2-IN-11 (compound 6) is a potent and selective *Bcl-2* activity inhibitor, with an IC₅₀ of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC₅₀ > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia .

HY-161415

BCL-xL/BCL-2 ligand 1	Ligands for E3 Ligase	Cancer
BCL-xL/BCL-2 ligand 1 (compound 72-1) is a *BCL-xL* and *BCL-2* protein ligand. BCL-xL/BCL-2 ligand 1 can be connected to the E3 ligase by a linker to form PROTACs (HY-161410) ^[2].

HY-159668

DL002	ADC Linker	Cancer
DL002 is a ADC linker that can be used to synthesize antibody-drug conjugates containing BCL-2 family protein degraders, and it's used in tumor research .

HY-138697B

S65487 hydrochloride VOB560 hydrochloride	Bcl-2 Family Apoptosis	Cancer
S65487 (VOB560) hydrochloride, a potent and selective *Bcl-2* inhibitor, is a proagent of S55746. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 hydrochloride induces apoptosis and has anticaner activities ^[2].

HY-161577

BFC1103	Bcl-2 Family	Cancer
BFC1103 is a small-molecule compound whose primary mechanism of action involves interaction with a specific domain of Bcl-2, particularly its loop domain. This interaction induces a conformational change in Bcl-2, exposing its BH3 (Bcl-2 homology 3) domain, thereby switching Bcl-2's function from anti-apoptotic to pro-apoptotic. The cell death induced by BFC1103 is dependent on the presence of Bax or Bak, both of which are key proteins involved in the intrinsic apoptotic pathway mediated by mitochondria. BFC1103 has successfully inhibited lung metastasis of triple-negative breast cancer in mouse models. It can be utilized in studying the roles of Bcl-2 family proteins in cancer development and how they impact the survival and proliferation of cancer cells .

HY-N3828

epi-Eriocalyxin A	Apoptosis ERK JNK	Cancer
epi-Eriocalyxin A (Epieriocalyxin A), a diterpenoid isolated from Isodon eriocalyx, induces colon cancer apoptosis. epi-Eriocalyxin A also inhibits *ERK1/2* and JNK activation, which suppresses Bcl-2 expression .

HY-10087A1

Navitoclax dihydrochloride ABT-263 dihydrochloride	Bcl-2 Family	Cancer
Navitoclax (ABT-263) dihydrochloride is an orally active *Bcl-2* inhibitor that binds to various *Bcl-2* family proteins, including *Bcl-xL, Bcl-2, and Bcl-w, with a K_i* value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research .

HY-161276

BFC1108 1 Publications Verification	Apoptosis Bcl-2 Family	Cancer
BFC1108 is a small molecule Bcl-2 functional converter. BFC1108 induces a conformational change in Bcl-2, resulting in the exposure of its BH3 domain both in vitro and in vivo. BFC1108 effectively induces apoptosis in Bcl-2 expressing cancers. .

HY-123244

YC137	Bcl-2 Family Apoptosis	Cancer
YC137 is a potent *Bcl-2* antagonist with K_is of 1.3 μM and >100 μM for Bcl-2 and Bcl-xL when assayed in Bis-Tris buffer, respectively. YC137 inhibits the binding of the Bid BH3 peptide to Bcl-2, thus disrupting an interaction essential for the antiapoptotic activity of Bcl-2. YC137 selectively induces apoptosis of Bcl-2-dependent cells. YC137 has the potential for breast cancer research ^[2].

HY-168983

Lonitoclax	Bcl-2 Family	Cancer
Lonitoclax is a B-cell lymphoma 2 (Bcl-2) inhibitor. Lonitoclax has comparable anti-tumor efficacy to Venetoclax (HY-15531) in both B cell and myeloid malignancy models. Lonitoclax is promising for research of relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma, and certain low-grade lymphomas .

HY-174419

TFSeB	Monoamine Oxidase Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
TFSeB is an orally active neuroprotective agent. TFSeB can reduce Streptozotocin (STZ) (HY-13753) induced MAO-B and AChE activity. TFSeB exerts neuroprotective effects by increasing the expression of *BCL-2, BDNF, NRF2, and decreasing the expression of BAX. TFSeB can reduce lipid peroxidation (TBARS) and reactive oxygen species (ROS)* levels. TFSeB can reduce neuroinflammation. TFSeB can be used for research on Alzheimer’s disease .

HY-143873

Bcl-2-IN-5	Bcl-2 Family	Cancer
Bcl-2-IN-5 is a *BCL-2* inhibitor with IC₅₀s of 0.12 nM, 0.14 nM and 0.22 nM for *Bcl-2* wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC₅₀ values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155) .

HY-149623

Bcl-2-IN-13	Bcl-2 Family	Cancer
Bcl-2-IN-13 is a *Bcl-2* inhibitor with an IC₅₀ value of 17 nM. Bcl-2-IN-13 can be used in cancer research .

HY-149624

Bcl-2-IN-14	Bcl-2 Family	Cancer
Bcl-2-IN-14 (Compound 13c) is a *BCL-2* inhibitor with an IC₅₀ value of 0.471 μM. Bcl-2-IN-14 can be used in cancer research .

HY-149622

Bcl-2-IN-12	Bcl-2 Family	Cancer
Bcl-2-IN-12 (Compound 1) is a *Bcl-2* inhibitor (IC₅₀: 6 nM). Bcl-2-IN-12 can be used for cancer research .

HY-149625

Bcl-2-IN-15	Bcl-2 Family	Cancer
Bcl-2-IN-15 (Compound 13d)) is a *Bcl-2* inhibitor (IC₅₀: 363 nM). Bcl-2-IN-15 inhibits the proliferation ofNCI leukemia cancer cell line .

HY-163308

Bcl-2-IN-18	Bcl-2 Family	Cancer
Bcl-2-IN-18 (Compound 23) is a breast cancer *Bcl-2* inhibitor with a IC₅₀ value of 4.7 μM for MCF-7. Bcl-2-IN-18 has antitumor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1423

Glycocholic acid 3 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	P-glycoprotein Bcl-2 Family G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite Bacterial Apoptosis FXR Caspase MDM-2/p53 LPL Receptor
Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, *Bcl-2, MRP1, MRP2* and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and *S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis*, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) ^[2] .

HY-N0292

Oleuropein 5+ Cited Publications	Cardiovascular Disease Classification of Application Fields Anti-aging Plants Burseraceae Iridoids Canarium album (Lour.) Rauesch. Terpenoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification Cancer	Cytochrome P450 PPAR Apoptosis
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

HY-N2342

Procyanidin C1 5+ Cited Publications PCC1	Classification of Application Fields Rosaceae Crataegus pinnatifida Bge. Plants Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Source Classification Cancer	Apoptosis
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-N0168

Hesperetin 20+ Cited Publications	Structural Classification Flavonoids other families Neurological Disease Classification of Application Fields Sunscreen Flavonones Cosmetic Research Plants Disease Research Fields Source Classification Cancer	p38 MAPK Autophagy Apoptosis Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family
Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce *Bcl-2* and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor ^[2] .

HY-13407

Gossypol 5+ Cited Publications BL 193	Malvaceae Classification of Application Fields Phenols Polyphenols Gossypium herbaceum Linn. Plants Disease Research Fields Source Classification Cancer	Bcl-2 Family
Gossypol binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-126477

NNK 2 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates *Bcl2* phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both *ERK1/2* and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure ^[2].

HY-107738

Guggulsterone 20+ Cited Publications Z/E-Guggulsterone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (*IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt* ^[2]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-N0087

Gambogic Acid 5+ Cited Publications Beta-Guttiferrin	Natural Products Classification of Application Fields Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Bcl-2 Family Autophagy
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits *Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, Bfl-1* and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N0674

Dehydrocorydaline 40+ Cited Publications 13-Methylpalmatine	Infection Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-126741

Azadirachtin 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Other Diseases Azadirachta indica A. Juss. Plants Meliaceae Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Environmental Pollutants Parasite Caspase NF-κB Apoptosis Bcl-2 Family
Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting *Bcl-2/Bax* ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells ^[2] .

HY-17510

Gossypol (acetic acid) 5+ Cited Publications (±)-Gossypol-acetic acid; BL-193 (acetic acid)	other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Bcl-2 Family
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N0068

Solasodine 5 Publications Verification Purapuridine; Solancarpidine; Solasodin	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Solanum nigrum Linn. Solanaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	MDM-2/p53 Fungal E1/E2/E3 Enzyme Apoptosis
Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities ^[2] .

HY-N2897

Dihydrokaempferol 5+ Cited Publications	Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Bcl-2 Family
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-N3584

Paris saponin VII 4 Publications Verification Chonglou Saponin VII	Liliaceae Classification of Application Fields Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Source Classification Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N0361

Dihydrocapsaicin 4 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Phenols Metabolic Disease Solanaceae Plants Disease Research Fields Source Classification	Environmental Pollutants Caspase Akt Apoptosis Reactive Oxygen Species (ROS) TRP Channel Bcl-2 Family PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-N0763

Angelicin 10+ Cited Publications Isopsoralen	Classification of Application Fields Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like *Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9* and caspase-3.

HY-P2970

Stem bromelain	Ananas comosus(L.) Merr. Structural Classification Natural Products Classification of Application Fields Bromeliaceae Plants Inflammation/Immunology Disease Research Fields Cancer	Apoptosis PARP Caspase Bcl-2 Family Bacterial Interleukin Related
Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases *Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo* antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning ^[2] .

HY-N0559

Kirenol 1 Publications Verification	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target *CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53* and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the *CK2/AKT* and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis ^[2] .

HY-N0657

Pinoresinol Diglucoside 1 Publications Verification	Structural Classification Eucommia ulmoides Oliver Classification of Application Fields Lignans Other Diseases Eucommiaceae Phenylpropanoids Plants Disease Research Fields Source Classification	NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TGF-beta/Smad Akt mTOR PI3K
Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, *BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads*. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis ^[2] .

HY-N1423A

Glycocholic acid sodium 3 Publications Verification	Triterpenes Structural Classification Terpenoids Endogenous metabolite Source Classification	P-glycoprotein Bcl-2 Family G protein-coupled Bile Acid Receptor 1 Bacterial Apoptosis FXR Caspase MDM-2/p53 LPL Receptor Endogenous Metabolite
Glycocholic acid sodium is a bile acid derivative. Glycocholic acid downregulates MDR1, *Bcl-2, MRP1, MRP2* and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and *S1PR2. Glycocholic acid sodium inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis*, and enhances chemosensitivity. Glycocholic acid sodium modulates related bile acid receptor signaling. Glycocholic acid sodium suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid sodium can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) ^[2] .

HY-N12060

Ginkgo biloba extract	Structural Classification Natural Products Ginkgoaceae Plants Ginkgo biloba Source Classification	Bcl-2 Family Caspase Apoptosis Autophagy Reactive Oxygen Species (ROS) Akt JNK ERK
Ginkgo biloba extract is a natural product that can be isolated from Ginkgo biloba leaves . Ginkgo biloba extract alleviates oxidative stress-induced neuronal apoptosis (Apoptosis) by stabilizing mitochondrial function, regulating *Bcl-2* family proteins and inhibiting caspase activation. Ginkgo biloba extract alleviates testicular injury by upregulating *SKP2* and inhibiting Beclin1-independent autophagy (Autophagy) . Ginkgo biloba extract alleviates various types of neuronal damage in animal models. Ginkgo biloba extract reduces behavioral sensitization in rats. Ginkgo biloba extract counteracts Aβ-induced neurotoxicity by blocking a series of Aβ-triggered events, including glucose uptake, ROS accumulation, AKT activation, mitochondrial dysfunction, JNK and ERK 1/2 pathways, and apoptosis, and also interferes with the formation of Aβ oligomers. Ginkgo biloba extract is applicable to research related to cerebral hypoperfusion, testicular injury, Alzheimer's disease, Parkinson's disease, multi-infarct dementia, stroke, traumatic brain injury and amyotrophic lateral sclerosis ^[2].

HY-N7675

Flavanomarein	Cardiovascular Disease Structural Classification Classification of Application Fields Cercis chinensis Bunge Metabolic Disease Plants Compositae Flavonoids other families Flavonones Phenols Polyphenols Disease Research Fields Source Classification	NF-κB TGF-beta/Smad Syk
Flavanomarein is a substance with cytoprotective, anti-inflammatory and antioxidant activities, with a K_a of 3.064e-5 M against human Syk. Flavanomarein enhances the phosphorylation level of AKT, regulates the expression of PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2 and ICAD, and inhibits the nuclear translocation of NF-κB p65. Flavanomarein regulates EMT marker proteins, promotes the proliferation of HK-2 cells, and protects neuronal cells from 6-OHDA-induced neurotoxic damage. Flavanomarein can be used in studies related to Parkinson's disease and diabetic nephropathy. ^[2]

HY-N2067

Vanillyl alcohol 1 Publications Verification p-(Hydroxymethyl)guaiacol	Structural Classification Monophenols Gastrodia elata Bl. Classification of Application Fields Orchidaceae Other Diseases Phenols Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Bcl-2 Family
Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses Bax, increases *Bcl-2*. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages ^[2] .

HY-N0757

8-O-Acetylharpagide 1 Publications Verification	Infection Structural Classification other families Iridoids Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Akt Bcl-2 Family Apoptosis Adrenergic Receptor
8-O-Acetylharpagide is an orally active iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and *Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor* ^[2] .

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Alkaloids Structural Classification other families Classification of Application Fields Phenols Polyphenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Bcl-2 Family Apoptosis mTOR GABA Receptor PI3K Adrenergic Receptor Beta-secretase Akt
Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine mainly targets the PI3K/Akt/mTOR signaling axis and α1D-adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine is applicable to research related to leukemia, ovarian cancer, and colorectal cancer ^[2] .

HY-N3031

Grosvenorine	Infection Flavonols Structural Classification Flavonoids Classification of Application Fields Cucurbitaceae Phenols Polyphenols Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Source Classification	Bacterial Apoptosis Bcl-2 Family MDM-2/p53 Glutathione Peroxidase SOD TNF Receptor Interleukin Related
Grosvenorine is an orally active flavonoid glycoside found in S. grosvenorii. Grosvenorine exhibits antibacterial, antioxidant and antiinflammation activities. Grosvenorine can induce apoptosis and increases anti-apoptotic *Bcl-2* protein expression and reduces pro-apoptotic P53 protein expression in gastric tissues. Grosvenorine enhances mucin/glycoprotein secretion, regulates gastric pH, and reduces gastric lesion incidence.Grosvenorine increases glutathione peroxidase, catalase, and SOD levels, reduces lipid peroxidation (MDA), and lowers TNF-α and IL-6 levels. Grosvenorine can be used for the researches of bacterial infection and Gastric ulcer ^[2].

HY-N2416

Taccalonolide A	Classification of Application Fields Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer Source Classification	Microtubule/Tubulin Apoptosis
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities ^[2]. Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

HY-N2132

Flavokawain B 2 Publications Verification Flavokavain B	Structural Classification Chalcones Monophenols Flavonoids other families Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Cancer	Apoptosis Caspase PARP Bcl-2 Family NF-κB PI3K Akt p38 MAPK MMP Reactive Oxygen Species (ROS)
Flavokawain B (Flavokavain B) is an orally active chalcone. Flavokawain B results in activation of caspase-9, -3 and -8, cleavage of PARP. Flavokawain B down-regulates *Bcl-2* with concomitant increase in Bax level. Flavokawain B inhibits NF-κB, PI3K/Akt and MAPK signaling pathway. Flavokawain B exhibits Apoptotic effects. Flavokawain B inhibits MMP-9 and promotes ROS generation. Flavokawain B inhibits multiple tumors and inflammation ^[2] .

HY-N1983

Caudatin 1 Publications Verification	Structural Classification Classification of Application Fields Asclepiadaceae Cynanchum otophyllum Schneid． Cynanchum auriculatum Royle ex Wight Plants Disease Research Fields Steroids Source Classification Cancer	Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism PARP Caspase Bcl-2 Family VEGFR FAK WDR5 p38 MAPK JNK PPAR
Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, caspase-3, -7, -9, upregulates pro-apoptotic Bad and Bax and downregulates anti-apoptotic *Bcl-2* and *Bcl-XL. Caudatin suppresses VEGF, FAK* phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARα/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimer's disease ^[2] .

HY-N6082

Rhein 8-O-β-D-Glucopyranoside 1 Publications Verification	Quinones Structural Classification Monophenols Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Phenols Metabolic Disease Plants Disease Research Fields Source Classification	Apoptosis Bcl-2 Family Caspase TGF-beta/Smad Bacterial
Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered *Bcl-2* and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection ^[2] .

HY-N0392

Polygalasaponin F	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polygalaceae Polygala japonica Houtt. Plants Inflammation/Immunology Disease Research Fields Source Classification	Toll-like Receptor (TLR) PI3K Akt NF-κB MDM-2/p53 Caspase MEK Bcl-2 Family p38 MAPK Mitophagy Reactive Oxygen Species (ROS) Apoptosis Calcium Channel
Polygalasaponin F is an orally active triterpenoid saponin monomer. Polygalasaponin F downregulates the expression of Bax, p53, caspase-3, NF-κB p65 and MEK1; restores and upregulates the expression of *Bcl-2; activates the PI3K/Akt* signaling pathway; inhibits the phosphorylation of p38 MAPK, nuclear translocation of NF-κB, TLR4-mediated signaling pathway, mitophagy (Mitophagy) and ROS production; enhances cell viability and suppresses apoptosis (Apoptosis). Polygalasaponin F maintains mitochondrial function, alleviates Ca ²⁺ overload, upregulates pCREB and BDNF, preserves cell viability and inhibits the release of inflammatory cytokines. Polygalasaponin F alleviates lung injury induced by influenza A H1N1 and cerebral ischemia-reperfusion injury. Polygalasaponin F is applicable to researches related to Parkinson's disease, cerebral ischemia, pneumonia induced by influenza A H1N1, stroke and Alzheimer's disease ^[2] .

HY-N0307

Ciwujianoside B	Triterpenes Structural Classification Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Source Classification	Bcl-2 Family NF-κB DNA/RNA Synthesis Apoptosis
Ciwujianoside B is an orally active, blood-brain barrier penetrable radioprotective agent and memory enhancer. Ciwujianoside B reduces radiation-induced DNA damage, cell cycle arrest and apoptosis, downregulates NF-κB and the *Bax/Bcl-2* ratio, and enhances the proliferative capacity of bone marrow cells. Ciwujianoside B enhances object recognition memory in normal mice and induces dendritic extension in primary cultured cortical neurons. Ciwujianoside B can be used in studies related to hematopoietic system radiation injury and memory enhancement ^[2].

HY-119979

Cardanol monoene Cardanol C15:1	Monophenols Classification of Application Fields Phenols Plants Anacardium occidentaleL. Disease Research Fields Anacardiaceae Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism MMP CDK Caspase Bcl-2 Family PARP MDM-2/p53 Cholinesterase (ChE)
Cardanol monoene (Cardanol C15:1) is a phenolic compound which can be found in cashew nut shell liquid. Cardanol monoene can inhibit cancer cells proliferation, migration, cause S phase arrest, induce apoptosis, ROS production and mitochondrial depolarization. Cardanol monoene downregulates *MMP-2, MMP-9, cyclinA1* expression, regulates *CDK2, p53, Bax, cytochrome c, cleaved caspase-3, cleaved PARP, Apaf-1* expression and *Bax/Bcl-2* ratio. Cardanol monoene shows weak DPPH radical scavenging activity and AChE inhibition activity. Cardanol monoene is lethal to Artemia salina nauplii. Cardanol monoene. Cardanol monoene can be used for the research of cancer, infection and inflamation ^[2].

HY-119931

2-Hydroxychalcone	Chalcones Monophenols Flavonoids Classification of Application Fields Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Bcl-2 Family Apoptosis NF-κB Parasite
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB ^[2] .

HY-15464

(R)-(-)-Gossypol 3 Publications Verification AT-101; R-(-)-gossypol acetic acid	Malvaceae Classification of Application Fields Gossypium Phenols Plants Disease Research Fields Cancer Source Classification	Bcl-2 Family Autophagy
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and *Bcl-xL* proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-N13250

Hawthorn Extract	Cardiovascular Disease Classification of Application Fields Rosaceae Plants Disease Research Fields Source Classification	Apoptosis AMPK Elastase Bcl-2 Family Interleukin Related Caspase PI3K Akt SOD
Hawthorn Extract is an orally active hawthorn extract. Hawthorn Extract decreases Bax expression and increases *Bcl-2* expression in the aorta. Hawthorn Extract regulates the AMPK signaling pathway, induces apoptosis, enhances the hepatic antioxidant system, and ameliorates symptoms of liver injury, inflammation and cancer. Hawthorn Extract reduces plasma levels of pro-inflammatory factors, increases plasma levels of anti-inflammatory adiponectin, and alleviates atherosclerotic plaque lesions in the aorta. Hawthorn Extract improves symptoms associated with chronic heart failure . Hawthorn Extract inhibits FMLP-induced superoxide anion production, Elastase release, ILB₄ generation and calcium signaling in neutrophils, and also reduces LPS-induced cytokine production in neutrophils. Hawthorn Extract induces autophagy and inhibits the proliferation of intestinal stem cells. Hawthorn Extract can be used in research related to atherosclerosis, hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, hepatocellular carcinoma, chronic heart failure and hypotension ^[2] .

HY-N0674A

Dehydrocorydaline chloride 40+ Cited Publications 13-Methylpalmatine chloride	Infection Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .

HY-N3405

Lariciresinol 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Lignans Arabidopsis thaliana Phenylpropanoids Plants Brassicaceae Endogenous metabolite Source Classification	Glycosidase Bcl-2 Family Apoptosis TGF-β Receptor NF-κB Fungal
Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC₅₀ of 6.97 μM; K_i of 0.046 μM). Lariciresinol dereases *Bcl-2, upregulates Bax* and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity ^[2] .

HY-N0566

23-Hydroxybetulinic acid Anemosapogenin	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis Autophagy Bcl-2 Family Caspase Survivin p38 MAPK MMP
23-Hydroxybetulinic acid (Anemosapogenin) is an orally active triterpenoid with broad-spectrum anticancer activity. 23-Hydroxybetulinic acid reduces the levels of *Bcl-2* and survivin, elevates the level of Bax, promotes the cleavage/activation of caspase-3 and caspase-9, and induces apoptosis via the endogenous mitochondrial pathway involving cytochrome C release and mitochondrial membrane potential disruption. 23-Hydroxybetulinic acid arrests the cell cycle at S and G1 phases, inhibits cancer cell proliferation, blocks the MAPK signaling pathway, regulates *MMP2, and induces autophagic apoptosis by upregulating beclin-1. 23-Hydroxybetulinic acid inhibits the activity and efflux function of P-gp*, increases the intracellular accumulation of chemotherapeutic drugs, and synergistically enhances cytotoxicity with Doxorubicin (HY-15142). 23-Hydroxybetulinic acid inhibits the phosphorylation and nuclear translocation of STAT6, blocks M2 macrophage polarization, and reduces M2 macrophage-mediated apoptosis resistance of colon cancer cells. 23-Hydroxybetulinic acid can be used in related studies on chronic myeloid leukemia, hepatocellular carcinoma, sarcoma 180, multidrug-resistant breast cancer, leukemia, Doxorubicin-induced cardiotoxicity, and colorectal cancer ^[2] .

HY-N6005

Methyl caffeate	Infection Structural Classification Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Solanum torvum Swartz Phenylpropanoids Solanaceae Plants Disease Research Fields Source Classification	Bacterial Fungal Apoptosis Bcl-2 Family
Methyl caffeate is a phenylpropanoid, antibacterial agent, and Apoptosis-inducing agent. Methyl caffeate can be isolated from the flowers of peach Prunus persica (L.). Methyl caffeate upregulates the expression of pro-apoptotic proteins Bid, Bax and p53, and downregulates the expression of anti-apoptotic protein *BCL-2. Methyl caffeate downregulates SASP* factors. Methyl caffeate enhances glucose-stimulated insulin secretion. Methyl caffeate inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, fungi, and Mycobacterium tuberculosis strains. Methyl caffeate can be used in studies related to breast cancer, type 2 diabetes, and tuberculosis ^[2] .

HY-N2135

Puerarin 6''-O-Xyloside	Structural Classification Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Source Classification	Apoptosis Caspase Bcl-2 Family Tyrosinase
Puerarin 6''-O-Xyloside is one of the major iso-flavones found in P. lobata. Puerarin 6''-O-Xyloside inhibits cancer cells proliferation, induces apoptosis by upregulating cleaved caspase-3, 7, 9, Bax and downregulating *Bcl-2* levles and inhibits tumor growth in mice. Puerarin 6''-O-Xyloside has anti-osteoporotic activity in ovariectomized mice. Puerarin 6''-O-Xyloside inhibits mushroom tyrosinase with an IC₅₀ of 513.8 μM. Puerarin 6''-O-Xyloside can be used for the research of human lung carcinoma, osteoporosis, melanosis and melanomar ^[2] .

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species (ROS) PPAR
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and *Bcl-2* related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses ^[2] .

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Bcl-2 Family Caspase
Thevetiaflavone could upregulate the expression of *Bcl-2* and downregulate that of Bax and caspase-3.

HY-N1423B

Glycocholic acid hydrate 3 Publications Verification	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Caspase G protein-coupled Bile Acid Receptor 1 LPL Receptor MDM-2/p53 Bcl-2 Family P-glycoprotein FXR Bacterial Apoptosis
Glycocholic acid hydrate is a bile acid derivative. Glycocholic acid hydrate downregulates MDR1, *Bcl-2, MRP1, MRP2* and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and *S1PR2. Glycocholic acid hydrate inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis*, and enhances chemosensitivity. Glycocholic acid hydrate modulates related bile acid receptor signaling. Glycocholic acid hydrate suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid hydrate can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) ^[2] .

HY-N3009

Secoxyloganin 1 Publications Verification	Cardiovascular Disease Structural Classification Caprifoliaceae Iridoids Classification of Application Fields Lonicera japonica Thunb. Terpenoids Plants Disease Research Fields Source Classification	Drug Derivative Apoptosis Bcl-2 Family
Secoxyloganin is an orally effective iridoid derivative. Secoxyloganin can be isolated from the flower buds of L. japonica. Secoxyloganin induces Apoptosis by inhibiting the expression of *Bcl-2*. Secoxyloganin potently inhibits the proliferation of breast cancer cells, while exerting weak activity against normal mammary epithelial cells. Secoxyloganin inhibits the decrease in tail vein blood flow associated with allergic reactions ^[2].

HY-N1930

(-)-Hinesol Hinesol	Structural Classification Terpenoids Sesquiterpenes Plants Compositae Erythrina sigmoidea Hua	Apoptosis
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer .

HY-N0867

13-Oxyingenol-13-dodecanoate	Structural Classification Classification of Application Fields Terpenoids Gramineae Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification	HIV ULK Bcl-2 Family
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of *BCL-2* to effect apoptosis ^[2].

HY-N0674B

Dehydrocorydaline (hydroxyl) 40+ Cited Publications 13-Methylpalmatine (hydroxyl)	Alkaloids Corydalis yanhusuo W. T. Wang Plants Papaveraceae Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N4238

Dehydrocorydaline nitrate 40+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. ^[2]. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0292R

Oleuropein (Standard)	Structural Classification Iridoids Canarium album (Lour.) Rauesch. Terpenoids Phenols Polyphenols Plants Burseraceae Source Classification	Cytochrome P450 Reference Standards PPAR Apoptosis
Oleuropein (Standard) is the analytical standard of Oleuropein. This product is intended for research and analytical applications. Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

Cat. No.	Product Name	Chemical Structure

HY-15531S

Venetoclax-d8
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy ^[2] .

HY-N1423S

Glycocholic acid-d4

Glycocholic acid-d₄ is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-10087S

Navitoclax-d8 1 Publications Verification
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-15531S1

Venetoclax-d6
Venetoclax-d₆ (ABT-199-d₆) is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable *Bcl-2* inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy ^[2] .

HY-N1423S1

Glycocholic acid-d5

Glycocholic acid-d₅ is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research ^[2] .

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃ is the deuterium labeled Dihydrocapsaicin (HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-W754548

Glycocholic acid-13C2,d4

Glycocholic acid- ¹³C₂,d₄ is the deuterium labeled and ¹³C-labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-W713297

Moroxydine hydrochloride-d8

Moroxydine hydrochloride-d₈ (ABOB hydrochloride-d₈) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels ^[1][2][3].

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