Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
79 Results for "
CD44
" in MedChemExpress (MCE) Product Catalog:
Products (79)
79 Results for "CD44" in MCE Product Catalog:
4
4 Cited Publications
Referencia número: HY-P99126
Target:
Áreas de investigación:
3
3 Cited Publications
Synonyms: EC 3.4.21.1; Chymotrypsin A
3
3 Cited Publications
Target:
Áreas de investigación:
HA-CD44 interaction inhibitor 2 is a CD44 inhibitor that can inhibit the interaction between Hyaluronic acid (HA) (HY-B0633A) and CD44. HA-CD44 interaction inhibitor 2 acts as an antiproliferative agent against CD44 + cancer cells. HA-CD44 interaction inhibitor 2 can disrupt the integrity of cancer spheres and reduce cancer cell viability in a dose-dependent manner. HA-CD44 interaction inhibitor 2 is applicable for tumor research .
3
3 Cited Publications
Referencia número: HY-108910A
No. CAS: 9004-07-3
Synonyms: EC 3.4.21.1 (MS grade); Chymotrypsin A (MS grade)
Target:
Áreas de investigación:
Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) (MS grade) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin (MS grade) downregulates the TLR4/NF-κB signaling pathway, inhibits the release of inflammatory factors, reduces cell infiltration and tissue damage, and also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54). It can also be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin (MS grade) has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions, and can be used in the research of diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin (MS grade) can be used in studies of inflammation, edema, and expectoration .
3
3 Cited Publications
Referencia número: HY-P86463
Synonyms: CD44; LHR; MDU2; MDU3; MIC4; CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; ECMR-III; PGP-1; PGP-I
2
2 Cited Publications
Synonyms: KTX-1001
Target:
Áreas de investigación:
Gintemetostat (KTX-1001) is an orally active, highly specific NSD2/MMSET histone methyltransferase inhibitor with human NSD2 IC50 values ranging 0.460-2.17 nM and NSD2 SET domain IC50 of 2.32 nM and Kd values ranging 6.3-70.4 nM .Gintemetostat reduces H3K36me2 levels, impairs multiple myeloma cell adhesion and colony formation, enhances cytotoxicity, boosts T-cell activation, and sensitizes resistant multiple myeloma cells to other agents .Gintemetostat can be used for the research of multiple myeloma and relapsed and refractory multiple myeloma .
2
2
2 Cited Publications
Referencia número: HY-P2284
No. CAS: 959961-23-0
Target:
Áreas de investigación:
2
2 Cited Publications
Referencia número: HY-P990859
Target:
Áreas de investigación:
1
1 Cited Publications
Referencia número: HY-P70507
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD44; Chondroitin Sulfate Proteoglycan 8; Prev. MDU2; Heparan Sulfate Proteoglycan; Prev. MDU3; Phagocytic Glycoprotein I; Prev. MIC4; Phagocyte Glycoprotein 1; HUTCH-I; In(Lu) Related-P80; CDw44; Soluble CD44; GP90 Lymphocyte Homing/Adhesion Receptor; EC
Species:
Human
Source:
HEK293
1
1 Cited Publications
Referencia número: HY-P80062
Synonyms: LHR antibody;
BA-1 antibody;
CD 44 antibody;
CD44 antibody;
CD44 antigen antibody;
CD44 molecule (Indian blood group) antibody;
CD44 molecule antibody;
CD44_HUMAN antibody;
CDw44 antibody;
Cell surface glycoprotein CD44 antibody;
chondroitin sulfate proteoglycan 8 antibody;
CSPG8 antibody;
ECMR-III antibody;
Epican antibody;
Extracellular matrix receptor III antibody;
GP90 lymphocyte homing/adhesion receptor antibody;
HCELL antibody;
hematopoietic cell E- and L-selectin ligand antibody;
Heparan sulfate proteoglycan antibody;
Hermes antigen antibody;
homing function and Indian blood group system antibody;
HSA antibody;
HUTCH-I antibody;
HUTCH1 antibody;
Hyaluronate receptor antibody;
IN antibody;
MC56 antibody;
MDU2 antibody;
MDU3 antibody
1
1 Cited Publications
Referencia número: HY-P84122
Synonyms: CD44; LHR; MDU2; MDU3; MIC4; CD44 antigen; CDw44; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Heparan sulfate proteoglycan; Hermes antigen; Hyaluronate receptor; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; ECMR-III; PGP-1; PGP-I
Target:
Áreas de investigación:
HA-CD44 interaction inhibitor 1 is a CD44 inhibitor that can inhibit the interaction between Hyaluronic acid (HA) (HY-B0633A) and CD44. HA-CD44 interaction inhibitor 1 exerts an antiproliferative effect on CD44+ cancer cell lines. HA-CD44 interaction inhibitor 1 can be used for the research of cancer .
Referencia número: HY-P99281
No. CAS: 214559-60-1
Synonyms: BIWA 4; Anti-CD44 Recombinant Antibody
Target:
Áreas de investigación:
Bivatuzumab (BIWA 4) is a humanized monoclonal antibody targeting CD44v6 . Bivatuzumab binds the v6 variant exon of CD44 with a Kd of 3.4 nM, undergoes internalization after binding, and achieves tumor localization. Bivatuzumab is inactive in antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity. Bivatuzumab can serve as the antibody component for synthesizing antibody-drug conjugates (ADCs), such as Bivatuzumab mertansine (BIWI 1). Bivatuzumab can be used for research on head and neck squamous cell carcinoma or esophageal squamous cell carcinoma .
Referencia número: HY-P991558
Synonyms: RG-7356
RO-5429083 (RG-7356) is a humanized monoclonal antibody targeting CD44. RO-5429083 binds to the extracellular domain of CD44 and inhibits constitutive EGFR phosphorylation. RO-5429083 suppresses tumor growth in xenograft models and can be used in research related to head and neck squamous cell carcinoma and acute myeloid leukemia .
Target:
Áreas de investigación:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Hyaluronic acid sodium (MW 200-1560) is a biopolymer composed of repeating disaccharide units, with a molecular weight of 200-1560. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid sodium exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid sodium activates PI3K-Akt signaling. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid sodium is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid sodium can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid sodium can lubricate the corneal endothelium. Hyaluronic acid sodium can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid sodium has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid sodium can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases .
Synonyms: Hyaluronan, low endotoxin; Hyaluronate, low endotoxin
Referencia número: HY-D2836
Synonyms: FITC-Hyaluronate (MW 1000000)
Referencia número: HY-P990045
No. CAS: 2749515-10-2
Synonyms: ALE.F02
Target:
Áreas de investigación:
Referencia número: HY-RS02248
Target:
Áreas de investigación:
CD44 Human Pre-designed siRNA Set A contains three designed siRNAs for CD44 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
