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CLPS

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By Targets:	Adrenergic Receptor (1) Androgen Receptor (1) Bacterial (2) CD28 (2) HCN Channel (1) Potassium Channel (2) Sirtuin (1) Small Interfering RNA (siRNA) (2) β-catenin (1)
By Research Areas:	Cancer (1) Infection (2) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (3)

12

Inhibitors & Agonists

2

Peptides

1

Natural
Products

2

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BRL-44408 maleate	Adrenergic Receptor	Neurological Disease
BRL-44408 maleate is an α2A-adrenoceptor antagonist (K_i: 8.5 nM). BRL-44408 maleate has antidepressant and analgesic activity. BRL-44408 also improves cecal ligation puncture (CLP)-induced acute lung injury .

CLP-3094 2 Publications Verification	Androgen Receptor	Metabolic Disease Inflammation/Immunology
CLP-3094 is a potent BF3 (binding function 3)-directed inhibitor of the androgen receptor (AR). CLP-3094 inhibits AR transcriptional activity (IC₅₀=4 μM) . CLP-3094 is a selective, potent GPR142 antagonist .

CLP257	Potassium Channel	Neurological Disease
CLP257 is a selective K ⁺-Cl ⁻ cotransporter KCC2 activator with an EC₅₀ of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl ⁻ transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally .

CLPS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CLPS Human Pre-designed siRNA Set A contains three designed siRNAs for CLPS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CLPS Human Pre-designed siRNA Set A CLPS Human Pre-designed siRNA Set A

CLP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CLP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CLP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CLP1 Human Pre-designed siRNA Set A CLP1 Human Pre-designed siRNA Set A

BPU-11	HCN Channel	Inflammation/Immunology
BPU-11 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) C-linker pocket (CLP) HCN4 CLP ligand. BPU-11 can be used for the research of congenital immune disease .

CLP290 1 Publications Verification	Potassium Channel	Neurological Disease
CLP290 is an orally available activator of the neuron-specific K ⁺-Cl ⁻ cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ rats .

CGK012	β-catenin	Inflammation/Immunology Cancer
CKG012 is an inhibitor for Wnt/βcatenin signaling pathway. CGK012 inhibits release of HMGB1 and transcription of β-catenin, exhibits attenuating activities against cecal ligation and puncture (CLP)-induced sepsis and multiple myeloma cancer .

Tussilagone 1 Publications Verification	Others	Inflammation/Immunology
Tussilagone, a major active component in Tussilago farfara, has anti-inflammatory effect. Tussilagone ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis. Tussilagone inhibits the inflammatory response and improves survival in cecal ligation and puncture (CLP)-induced septic mice .

SIRT5 inhibitor 7	Sirtuin	Inflammation/Immunology
SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury .

Reltecimod TFA AB-103 TFA	Bacterial CD28	Infection Inflammation/Immunology
Reltecimod (AB-103) TFA is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod TFA has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod TFA modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod TFA can be used to research necrotizing soft-tissue infections (NSTIs) .

Reltecimod AB-103	Bacterial CD28	Infection Inflammation/Immunology
Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs) .

Species:	Human (1) Rat (1)
Tag:	His (2)
Source:	HEK293 (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

	CLPS Protein, Rat (HEK293, His) Colipase; CLPS	Rat	HEK293
	CLPS protein activates enzymes, regulates catalytic activity, and responds to food. It is located extracellularly and may play a role in type 2 diabetes. CLPS expression is tissue-specific, with a high expression level of RPKM 1512.3. CLPS Protein, Rat (HEK293, His) is the recombinant rat-derived CLPS protein, expressed by HEK293 , with C-His labeled tag. The total length of CLPS Protein, Rat (HEK293, His) is 112 a.a., with molecular weight of ~12 kDa.

	CLPS Protein, Human (sf9, His) Colipase; CLPS	Human	Sf9 insect cells
	CLPS or colipase is an important cofactor for pancreatic lipase that helps anchor it at the lipid-water interface. In the absence of colipase, pancreatic lipase is easily washed away by bile salts, which inhibit the enzyme. CLPS Protein, Human (sf9, His) is the recombinant human-derived CLPS protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of CLPS Protein, Human (sf9, His) is 95 a.a., with molecular weight of ~12 kDa.

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