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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
65 Results for "
COX-2 inhibitory
" in MedChemExpress (MCE) Product Catalog:
Products (65)
65 Results for "COX-2 inhibitory" in MCE Product Catalog:
7
7 Cited Publications
Cat. No.: HY-N1435
CAS No.: 114482-86-9
5
Research Areas:
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
4
4 Cited Publications
Cat. No.: HY-N0396
CAS No.: 19210-12-9
Category:
Iridoids Terpenoids Pedaliaceae Plants Disease Research Fields Inflammation/Immunology Harpagophytum procumbens
Target:
2
2 Cited Publications
Cat. No.: HY-N0632
CAS No.: 65497-07-6
2
Research Areas:
Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair .
2
2 Cited Publications
Target:
Research Areas:
Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active COX-1 inhibitor with an IC50 of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC50 of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities .
2
Category:
Monophenols Ophryosporus axilliflorus Hieron. Ketones, Aldehydes, Acids Phenols Plants Umbelliferae Disease Research Fields Inflammation/Immunology
Target:
1
Category:
Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae Cancer
Target:
1
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .
1
1 Cited Publications
Category:
Natural Products Plants Brassicaceae Disease Research Fields Inflammation/Immunology Rorippa indica (L.) Hiern
Target:
Cat. No.: HY-N2176
CAS No.: 13849-08-6
Synonyms: (+)-Marmesin; (S)-Marmesin
Category:
Other Diseases Coumarins Phenylpropanoids Plants Umbelliferae Disease Research Fields Bidens parviflora Willd.
Target:
Cat. No.: HY-B0367
CAS No.: 70374-39-9
Synonyms: Chlortenoxicam; Ro 13-9297
Research Areas:
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both COX-1 and COX-2 (COX-1: IC50=0.005 μM; COX-2:IC50=0.008 μM) and inhibits the production of NO by iNOS (IC50=65 μM) and the proinflammatory cytokine IL-6 (IC50=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer .
Cat. No.: HY-17357
CAS No.: 78281-72-8
Synonyms: AHR 9434; AL 6515
Target:
Research Areas:
Neurological Disease Inflammation/Immunology Endocrinology Cancer
Nepafenac (AHR 9434; AL 6515), a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC50 of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC50 = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE₂. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries .
Category:
Coumarins Phenylpropanoids Plants Umbelliferae Seriphidium transiliense Disease Research Fields Inflammation/Immunology
Target:
Synonyms: D-1-O-G
Cat. No.: HY-N8167
CAS No.: 55780-30-8
Synonyms: Kaempferol 3-O-rhamnosylgentiobioside
Category:
Flavonols Flavonoids Camellia oleifera Abel. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Theaceae
Target:
Target:
Research Areas:
NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research .
Cat. No.: HY-N11011
CAS No.: 57423-72-0
Category:
Cat. No.: HY-W007328
CAS No.: 1006-94-6
Cat. No.: HY-N3364
CAS No.: 19956-53-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
