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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
Colistin
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "Colistin" in MCE Product Catalog:
31
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Research Areas:
Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli .
31
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Infection Microorganisms Antibiotics Animal Husbandry Disease Research Antibacterial Disease Research Fields Other Antibiotics
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11
11 Cited Publications
PFK-158 is a potent and selective PFKFB3 inhibitor with an IC50 value 137 nM. PFK-158 reduces glucose uptake, ATP production, lactate release, and induces apoptosis and autophagy in cancer cells. PFK-158 has broad anti-tumor activity. PFK-158 can also enhance Colistin's resistance to bacteria .
3
Category:
Quinones Other Diseases Plants Other Families Extract Disease Research Fields Naphthalene Quinones Pteris livida Mett.
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2
2 Cited Publications
Cat. No.: HY-N10549
CAS No.: 83088-28-2
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Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC50: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers .
1
Cat. No.: HY-N11722
CAS No.: 89837-52-5
Cat. No.: HY-P2123A
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Cat. No.: HY-107027
CAS No.: 1338055-88-1
Synonyms: Polymyxin E2 sulfate
Colistin B (Polymyxin E2) sulfate is a major component of Colistin (HY-113678) and also an antibacterial agent active against multidrug-resistant Gram-negative bacteria. Colistin B sulfate exerts apoptotic effects on human renal proximal tubular cells. Colistin B sulfate induces mild to moderate renal histological damage in mouse models. Colistin B sulfate can be used in the research of multidrug-resistant Gram-negative bacterial infections .
Cat. No.: HY-145440
CAS No.: 2862800-23-3
Colistin adjuvant-2 is a colistin adjuvant, shows increased colistin potentiation activity against Gram-negative bacteria .
Cat. No.: HY-P10159
CAS No.: 1809102-71-3
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DJK-5 is an antimicrobial peptide that targets and degrades guanosine pentaphosphate and tetraphosphate (pppGpp and ppGpp). DJK-5 kills bacteria within dentinal tubules, dental plaque and preformed oral biofilms, delays biofilm recovery, reduces the abundance of extracellular polysaccharides and the structural integrity of biofilm matrices, and inhibits the formation and biomass accumulation of dental plaque biofilms. DJK-5 permeabilizes bacterial membranes, induces bacterial morphological changes, inhibits bacterial growth, and exerts a synergistic effect on bacterial biofilms when used in combination with traditional antibiotics and Colistin (HY-113678). DJK-5 exhibits protease resistance and broad-spectrum antibiofilm activity, though its activity decreases in fetal bovine serum. DJK-5 can be used in studies of pulpitis, mixed biofilm infections, skin abscesses, dental caries, infections associated with failed root canal therapy, and Pseudomonas aeruginosa biofilm-related respiratory tract infections .
Cat. No.: HY-159929
Antibiotic adjuvant 2 (compound 5q) is an antibiotic adjuvant with potent colistin-potentiating activity and low mammalian toxicity. Antibiotic adjuvant 2 has minimum re-sensitizing concentration of 0.125 μg/mL agnist of Escherichia coli AR-0493 .
Cat. No.: HY-159930
CAS No.: 2972593-21-6
Antibiotic adjuvant 3 (compound 8g) is an antibiotic adjuvant with potent colistin-potentiating activity and low mammalian toxicity. Antibiotic adjuvant 3 has minimum re-sensitizing concentration of 0.25 μg/mL agnist of Escherichia coli AR-0493 .
Cat. No.: HY-146078
CAS No.: 2579696-45-8
Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128 μg/mL in Caco-2 and Vero cell lines .
Colistin B (Polymyxin E2) is a major component of Colistin (HY-113678) and also an antibacterial agent active against multidrug-resistant Gram-negative bacteria. Colistin B exerts apoptotic effects on human renal proximal tubular cells. Colistin B induces mild to moderate renal histological damage in mouse models. Colistin B can be used in the research of multidrug-resistant Gram-negative bacterial infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
