24 Results for "

Colistin

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "Colistin" in MCE Product Catalog:

29
29 Publications Verification
Cat. No.: HY-A0089
CAS No.: 1264-72-8
Synonyms: Polymyxin E sulfate
Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.
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29
29 Publications Verification
Cat. No.: HY-113678
CAS No.: 1066-17-7
Synonyms: Polymyxin E
Category:  

Natural Products

Target:  

Antibiotic Bacterial

Colistin is an orally active polypeptide antibiotic. Colistin has excellent activity against various Gram-negative rod-shaped bacteria, including multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. Colistin is associated with nephrotoxicity. Colistin can be used for the research of infections caused by Gram-negative bacilli .
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11
11 Cited Publications
Cat. No.: HY-12203
CAS No.: 1462249-75-7
Purity:  98.88%
Target:  

Autophagy Apoptosis

Research Areas:  

Cancer

PFK-158 is a potent and selective PFKFB3 inhibitor with an IC50 value 137 nM. PFK-158 reduces glucose uptake, ATP production, lactate release, and induces apoptosis and autophagy in cancer cells. PFK-158 has broad anti-tumor activity. PFK-158 can also enhance Colistin's resistance to bacteria .
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3
3 Cited Publications
Cat. No.: HY-N5112A
CAS No.: 34539-65-6
Synonyms: Arnebin 1
β,β-Dimethylacrylalkannin (Arnebin 1) is an orally active FGFR1 inhibitor (IC50=2.5 μM) and the main active component of Lithospermum erythrorhizon. β,β-Dimethylacrylalkannin blocks downstream signaling by binding to the ATP pocket of FGFR1, and regulates the CDK1/Cdc25C pathway and ROS-JNK axis, thereby inducing G2/M phase arrest, necrosis and apoptosis in cancer cells, and inhibiting tumor proliferation. β,β-Dimethylacrylalkannin also acts as a colistin adjuvant to disrupt the cell membrane of Gram-negative bacteria. β,β-Dimethylacrylalkannin exhibits significant tumor-inhibitory effects with no obvious toxicity in PDX models, but chronic exposure to high doses may alter the relative lung/liver weights of rats, while acute exposure to high doses causes responses such as reduced motor activity. β,β-Dimethylacrylalkannin finds wide application in studies related to hepatocellular carcinoma, colorectal cancer, colistin-resistant bacterial infections, hepatitis and psoriasis .
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1
1 Cited Publications
Cat. No.: HY-B1467
CAS No.: 538-71-6
Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC50: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers .
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1
1 Cited Publications
Cat. No.: HY-A0214
CAS No.: 8068-28-8
Synonyms: Colistimethate sodium
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Colistin methanesulfonate sodium salt exhibits MIC values ranged from 4 to 16 mg/liter against susceptible strains (P. aeruginosa) .
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1
1 Cited Publications
Cat. No.: HY-N10549
CAS No.: 83088-28-2
Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .
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Cat. No.: HY-A0089R
CAS No.: 1264-72-8
Synonyms: Polymyxin E sulfate (Standard)
Colistin (sulfate) (Standard) is the analytical standard of Colistin (sulfate). This product is intended for research and analytical applications. Colistin sulfate is a polypeptide antibiotic which inhibits gram-negative bacteria by binding to lipopolysaccharides and phospholipids in the outer cell membrane of gram-negative bacteria.
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Cat. No.: HY-N11722
CAS No.: 89837-52-5
Panduratin A is an orally active natural compound with multiple pharmacological activities. By specifically inhibiting the NF-κB signaling pathway, Panduratin A exerts potent anti-inflammatory and antioxidant effects in intestinal and vascular inflammation models. Panduratin A exerts a definite protective effect against Colistin (HY-113678)-induced nephrotoxicity by alleviating oxidative stress, improving mitochondrial dysfunction and inhibiting cell apoptosis. Panduratin A activates autophagy via an AMPK-dependent pathway and exhibits anti-tuberculosis activity. Panduratin A exerts antiviral effects by inhibiting the methyltransferase (DNA Methyltransferase) of SARS-CoV-2 .
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Cat. No.: HY-P2123A
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Colistin A sulfate hydrate is a major component of Colistin. Colistin is a polymyxin antibiotic and can be used to combat infections caused by problematic gram-negative bacteria .
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Cat. No.: HY-107027
CAS No.: 1338055-88-1
Synonyms: Polymyxin E2 sulfate
Target:  

Bacterial Apoptosis

Research Areas:  

Infection

Colistin B (Polymyxin E2) sulfate is a major component of Colistin (HY-113678) and also an antibacterial agent active against multidrug-resistant Gram-negative bacteria. Colistin B sulfate exerts apoptotic effects on human renal proximal tubular cells. Colistin B sulfate induces mild to moderate renal histological damage in mouse models. Colistin B sulfate can be used in the research of multidrug-resistant Gram-negative bacterial infections .
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Cat. No.: HY-145440
CAS No.: 2862800-23-3
Target:  

Bacterial

Research Areas:  

Infection

Colistin adjuvant-2 is a colistin adjuvant, shows increased colistin potentiation activity against Gram-negative bacteria .
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Cat. No.: HY-145439
CAS No.: 2862800-15-3
Target:  

Bacterial NF-κB

Research Areas:  

Infection

Colistin adjuvant-1 is a colistin adjuvant, shows increased colistin potentiation activity against Gram-negative bacteria. Colistin adjuvant-1 inhibits NF-κB with an IC50 of 0.209 μM .
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Cat. No.: HY-146078
CAS No.: 2579696-45-8
Target:  

Bacterial

Research Areas:  

Infection

Antimicrobial agent-1 (compound 6C) possesses potent activity against TolC mutant E. coli with an MIC value of 2 μg/mL. Antimicrobial agent-1 and Colistin exhibit synergistic activity against Gram-negative bacteria. Antimicrobial agent-1 has no cytotoxicity on mammalian cell lines, with MICs > 128 μg/mL in Caco-2 and Vero cell lines .
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Cat. No.: HY-168281
Target:  

Bacterial

Research Areas:  

Infection

P6P-10,10 is an antimicrobial agent. P6P-10,10 has an IC50 value of 3 μM against colistin-resistant Acinetobacter baumannii .
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Cat. No.: HY-159929
Target:  

Bacterial

Research Areas:  

Infection

Antibiotic adjuvant 2 (compound 5q) is an antibiotic adjuvant with potent colistin-potentiating activity and low mammalian toxicity. Antibiotic adjuvant 2 has minimum re-sensitizing concentration of 0.125 μg/mL agnist of Escherichia coli AR-0493 .
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Cat. No.: HY-159930
CAS No.: 2972593-21-6
Target:  

Bacterial

Research Areas:  

Infection

Antibiotic adjuvant 3 (compound 8g) is an antibiotic adjuvant with potent colistin-potentiating activity and low mammalian toxicity. Antibiotic adjuvant 3 has minimum re-sensitizing concentration of 0.25 μg/mL agnist of Escherichia coli AR-0493 .
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Cat. No.: HY-P2123S
Research Areas:  

Others

Colistin A-d7 TFA is the deuterium labeled Colistin A.
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Cat. No.: HY-B1467R
CAS No.: 538-71-6
Domiphen bromide (Standard) is the analytical standard of Domiphen bromide (HY-B1467). This product is intended for research and analytical applications. Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC50: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers.
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Cat. No.: HY-184858
CAS No.: 7239-48-7
Synonyms: Polymyxin E2
Target:  

Bacterial Apoptosis

Research Areas:  

Infection

Colistin B (Polymyxin E2) is a major component of Colistin (HY-113678) and also an antibacterial agent active against multidrug-resistant Gram-negative bacteria. Colistin B exerts apoptotic effects on human renal proximal tubular cells. Colistin B induces mild to moderate renal histological damage in mouse models. Colistin B can be used in the research of multidrug-resistant Gram-negative bacterial infections .
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