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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA dimer

" in MedChemExpress (MCE) Product Catalog:

41

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3

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3

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4

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0844
    Glutathione oxidized
    5+ Cited Publications

    L-Glutathione oxidized; GSSG; Oxiglutatione

    		 Endogenous Metabolite Reactive Oxygen Species (ROS) Metabolic Disease
    Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .
    Glutathione oxidized
  • HY-101161
    SG3199
    3 Publications Verification

    		 DNA Alkylator/Crosslinker ADC Payload Cancer
    SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
    SG3199
  • HY-128952
    Tesirine
    5+ Cited Publications

    SG3249

    		 Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
    Tesirine
  • HY-101127
    SGD-1882

    PBD dimer

    		 ADC Payload Cancer
    SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
    SGD-1882
  • HY-W040129
    Chromomycin A3
    1 Publications Verification

    		 DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase Infection Neurological Disease Cancer
    Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .
    Chromomycin A3
  • HY-101160
    SG2057

    DRG16

    		 DNA Alkylator/Crosslinker ADC Payload Cancer
    SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .
    SG2057
  • HY-161252
    PBD-monoamide

    		ADC Payload Cancer
    PBD-monoamide, a modified PBD (pyrrolobenzodiazepine) dimer, is an ADC Cytotoxin. PBD-monoamide can be used for synthesis of DHES0815A (an HER2 ADC). PBD-monoamide has DNA-binding activity and reduces cell viability .
    PBD-monoamide
  • HY-148424
    PBD dimer-2

    		ADC Payload DNA Alkylator/Crosslinker Cancer
    PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5′-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody–agent conjugates (ADCs), and it can be used for the research of cancer .
    PBD dimer-2
  • HY-153804
    Naphthyridine carbamate dimer

    NCD

    		 Molecular Glues Others Cancer
    Naphthyridine caebamate dimer (NCD) is a DNA molecular glue that induces designed structural changes in target functional DNA to modulate function .
    Naphthyridine carbamate dimer
  • HY-W008849
    DMT-dC(bz) Phosphoramidite

    		Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others
    DMT-dC (bz) Phosphoramidite is a protected deoxycytidine phosphoramidite monomer, as well as a building block for mechanochemical DNA synthesis. DMT-dC (bz) Phosphoramidite serves as a reagent for oligonucleotide synthesis .
    DMT-dC(bz) Phosphoramidite
  • HY-D0916
    Thiazole orange dimer YOYO 1

    YOYO 1; YOYO1

    		 Fluorescent Dye Others
    Thiazole orange dimer YOYO 1 (YOYO 1) is a cell-impermeable cyanine dimer with no inherent fluorescence, and its fluorescence intensity increases significantly upon binding to double-stranded DNA (dsDNA) . Thiazole orange dimer YOYO 1 can serve as a nuclear counterstain or a dead cell indicator (Ex/Em = 505/512 nm).
    Thiazole orange dimer YOYO 1
  • HY-126979
    Mycro2

    		c-Myc Cancer
    Mycro2 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 23 μM for the inhibition of Myc/Max DNA binding activity. Mycro2 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .
    Mycro2
  • HY-D2353
    Biotin-PEG3-benzophenone

    		DNA/RNA Synthesis Cancer
    Biotin-PEG3-benzophenone is biotin-labeled Benzophenone (HY-Y0546). Benzophenone is an endogenous metabolite and a photosensitizer that has been implicated in photosensitive damage to DNA. Benzophenone causes nucleobase oxidation, formation of cyclobutane-pyrimidine dimers, single-strand breaks, DNA-protein cross-links or abasic sites, different pathologies that may occur in nucleosides, oligonucleotides or DNA .
    Biotin-PEG3-benzophenone
  • HY-E70578
    T4 Endonuclease V

    		DNA Glycosylase Others
    T4 Endonuclease V is a dual-activity DNA glycosylase that combines the activities of DNA N-glycosylase and AP lyase. T4 Endonuclease V can repair ultraviolet (UV)-induced cyclobutane pyrimidine dimers in DNA .
    T4 Endonuclease V
  • HY-175004
    PBD dimer-4

    		ADC Payload DNA Alkylator/Crosslinker Cancer
    PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types .
    PBD dimer-4
  • HY-176495
    SG3683

    		DNA Alkylator/Crosslinker DNA/RNA Synthesis Cancer
    SG3683 is a DNA-targeted cytotoxic agent belonging to pyrrolobenzodiazepine (PBD) dimers. SG3683 exerts antitumor activity with an IC50 value of 0.74 nM in MDA-MB-436 cells. SG3683 is promising for research of cancers, such as breast cancer .
    SG3683
  • HY-U00265
    3-CPs

    3-Carbethoxypsoralen; 3-Ethoxycarbonylpsoralen

    		 Bacterial Infection
    3-CPs is a monofunctional furanocoumarin and a photoprotective agent targeting Staphylococcus aureus DNA, possessesing anti-UVB lethal activity. 3-CPs competitively intercalates into DNA, forming exclusively 4',5'-furan-side mono-adducts upon UVB irradiation, and irreversibly inhibits the formation of cyclobutane pyrimidine dimers. 3-CPs prevents UVB-induced DNA damage by preferentially binding to strong (AT)n sites within the DNA, without inducing lethal interstrand DNA cross-links; the limited number of mono-adducts it induces can be efficiently repaired by bacteria. 3-CPs holds potential for use in the development of photoprotective formulations for skin diseases, as well as in studies investigating bacterial DNA photodamage repair mechanisms and the optimization of photochemotherapy safety .
    3-CPs
  • HY-D1660
    Acridine homodimer

    NSC 219743

    		 DNA Stain Others
    Acridine homodimer (NSC 219743), acridine dimer, is a fluorescence dye. Acridine homodimer emits a blue-green fluorescence when bound to DNA. Acridine homodimer has extremely high affinity for AT-rich regions of nucleic acids, can be used for chromosome banding .
    Acridine homodimer
  • HY-126678
    Dimethyl-SGD-1882

    Dimethyl-PBD dimer

    		 ADC Payload Cancer
    Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication .
    Dimethyl-SGD-1882
  • HY-125636
    Mycro1

    		c-Myc Cancer
    Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .
    Mycro1
  • HY-24144
    Tesirine intermediate-2

    		DNA Alkylator/Crosslinker Cancer
    Tesirine intermediate-2 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
    Tesirine intermediate-2
  • HY-47820
    Tesirine intermediate-1

    		DNA Alkylator/Crosslinker Cancer
    Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
    Tesirine intermediate-1
  • HY-128952G
    Tesirine

    SG3249

    		 Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
    Tesirine
  • HY-P3223A
    Biphalin acetate

    		Opioid Receptor Neurological Disease
    Biphalin acetate, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores.Biphalin acetate has high affinity for opioid receptors. Biphalin acetate shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin acetate is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .
    Biphalin acetate
  • HY-W013059R
    DMT-dA(bz) Phosphoramidite (Standard)

    DA-CE phosphoramidite (Standard)

    		 Reference Standards DNA/RNA Synthesis Others
    DMT-dA(bz) Phosphoramidite (Standard) is the analytical standard of DMT-dA(bz) Phosphoramidite. This product is intended for research and analytical applications. DMT-dA(bz) Phosphoramidite is a phosphoramide monomer for the synthesis of oligonucleotides (ONs) through formation of DNA dimers and trimers via mechanochemistry .
    DMT-dA(bz) Phosphoramidite (Standard)
  • HY-E70371
    Cre recombinase

    		Biochemical Assay Reagents Others
    Cre recombinase is a resolvase derived from the P1 bacteriophage. Cre recombinase catalyzes site-specific recombination between two loxP DNA sequences, converts dimers of P1 chromosome into monomers before cell division. Cre recombinase is utilized in genetic engineering and molecular biology applications .
    Cre recombinase
  • HY-W040129R
    Chromomycin A3 (Standard)

    		Reference Standards Bacterial Fungal Apoptosis Antibiotic Infection Neurological Disease Cancer
    Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .
    Chromomycin A3 (Standard)
  • HY-P3223
    Biphalin TFA

    		Opioid Receptor Neurological Disease
    Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent .
    Biphalin TFA
  • HY-101161R
    SG3199 (Standard)

    		Reference Standards DNA Alkylator/Crosslinker ADC Payload Cancer
    SG3199 (Standard) is the analytical standard of SG3199 (HY-101161). This product is intended for research and analytical applications. SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
    SG3199 (Standard)
  • HY-185488
    seco-CBI dimer

    		DNA Alkylator/Crosslinker ADC Payload Cancer
    seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma .
    seco-CBI dimer
  • HY-185494
    Mal-Val-Lys-PAB-CBI-PBD dimer

    		Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    Mal-Val-Lys-PAB-CBI-PBD dimer is a Drug-Linker Conjugates for ADC. Mal-Val-Lys-PAB-CBI-PBD dimer consists of the ADC Cytotoxin CBI-PBD dimer and a linker Mal-Val-Lys-PAB. Mal-Val-Lys-PAB-CBI-PBD dimer exhibits alkylating activity at A-T-rich DNA minor groove adenine residues, disrupting DNA integrity. Mal-Val-Lys-PAB-CBI-PBD dimer induces cancer cell growth inhibition and cellular death. Mal-Val-Lys-PAB-CBI-PBD dimer can be used for the research of cancer .
    Mal-Val-Lys-PAB-CBI-PBD dimer
  • HY-185493
    Mal-VC-PAB-seco-CBI-PBD dimer

    		Drug-Linker Conjugates for ADC Cancer
    Mal-VC-PAB-seco-CBI-PBD dimer is a highly active drug-linker conjugate. Mal-VC-PAB-seco-CBI-PBD dimer integrates the DNA-damaging effects of two distinct types of compounds: seco-cyclopropabenzindoline (seco-CBI) and pyrrolobenzodiazepine (PBD). Mal-VC-PAB-seco-CBI-PBD dimer is linked via a valine-alanine (VC) linker cleavable by cathepsin B and achieves targeted delivery relying on monoclonal antibodies. Mal-VC-PAB-seco-CBI-PBD dimer is applicable for cancer research .
    Mal-VC-PAB-seco-CBI-PBD dimer
  • HY-171718
    seco-CBI-PBD dimer

    		DNA Alkylator/Crosslinker ADC Payload Cancer
    seco-CBI-PBD dimer is a CBI-PBD heterodimer and a minor groove DNA crosslinker. seco-CBI-PBD dimer exhibits cytotoxicity against human tumor cells at sub-pM to low nM levels, shows low sensitivity to P-glycoprotein-mediated drug resistance, and can serve as an ADC payload. seco-CBI-PBD dimer can be used in studies of uterine cancer, breast cancer, non-small cell lung cancer, etc.
    seco-CBI-PBD dimer
  • HY-185492
    MC-cBu-Cit-seco-CBI dimer

    		Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    MC-cBu-Cit-seco-CBI dimer (Compound 10) is a conjugate of an ADC drug toxin molecule and a linker, which consists of a DNA alkylating agent connected to a reactive maleimide via a protease-cleavable peptidomimetic linker .
    MC-cBu-Cit-seco-CBI dimer
  • HY-101160R
    SG2057 (Standard)

    DRG16 (Standard)

    		 DNA Alkylator/Crosslinker Reference Standards ADC Payload Cancer
    SG2057 (Standard) is the analytical standard of SG2057 (HY-101160). This product is intended for research and analytical applications. SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .
    SG2057 (Standard)
  • HY-101161S
    SG3199-d6

    		Isotope-Labeled Compounds DNA Alkylator/Crosslinker ADC Payload Cancer
    SG3199-d6 is the deuterium labeled SG3199 (HY-101161). SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249).
    SG3199-d6
  • HY-122715
    (S,S)-D211

    		ADC Payload DNA/RNA Synthesis Cancer
    (S,S)-D211 is a stereoisomer of D211. (S,S)-D211 belongs to PBD dimer family with DNA damage activity. (S,S)-D211 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .
    (S,S)-D211
  • HY-176972
    Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid

    		ADC Payload DNA/RNA Synthesis Cancer
    Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid (Compound 5) is a cytotoxic pyrrolobenzodiazepine (PBD) dimer derivative. Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid exhibits moderate DNA alkylating activity. Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid can be used as the payload of ADC, thereby demonstrating strong antigen-dependent cytotoxicity .
    Di(MMY-SJG)-Ph-prop-2-yne-1-sulfonic acid
  • HY-P11882
    SYN1436

    		Fc Receptor (FcR) Inflammation/Immunology
    SYN1436 is a selective human neonatal Fc receptor (hFcRn) antagonist with an IC50 of 2.4 nM. SYN1436 binds to hFcRn and inhibits hFcRn-hIgG interaction. SYN1436 can be used for the research of autoimmune diseases .
    SYN1436
  • HY-N18470
    Gadusol

    		DNA/RNA Synthesis Apoptosis Reactive Oxygen Species (ROS) Inflammation/Immunology
    Gadusol is a potent, maternally supplied natural sunscreen. Gadusol is synthesized by the mother during oogenesis and stored in eggs, representing the primary sunscreen mechanism during the early developmental stages of fish. Gadusol directly prevents UVB-induced DNA damage and reduces the generation of ROS thereby avoiding cellular stress and apoptosis. Gadusol does not exert antioxidant functions in zebrafish embryos. Gadusol can be used in studies related to topical photoprotective cosmetics .
    Gadusol
  • HY-182392
    NFYi5

    		DNA/RNA Synthesis Inflammation/Immunology
    NFYi5 is a nuclear transcription factor-Y (NF-Y) inhibitor. NFYi5 disrupts the binding of NF-Y to DNA, accelerates the ubiquitin-independent degradation of the NF-YA subunit, and reduces the transcriptional activity of NF-Y. As an antimitotic agent, NFYi5 decreases the mRNA levels of NF-Y target genes without affecting the expression of housekeeping genes, and inhibits cell proliferation. NFYi5 can be used in the research of tissue fibrosis .
    NFYi5

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