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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
89 Results for "
DesE
" in MedChemExpress (MCE) Product Catalog:
Products (89)
89 Results for "DesE" in MCE Product Catalog:
7
7 Publications Verification
Cat. No.: HY-17620
CAS No.: 149709-44-4
Synonyms: DesEthyl Sacubitril; LBQ-657
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Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
7
7 Publications Verification
Synonyms: SU-12662
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N-Desethyl Sunitinib (SU-12662) is a metabolite of Sunitinib (HY-10255A). N-Desethyl Sunitinib serves as a good transport substrate for human ABCB1, ABCG2 and murine ABCG2 .
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N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .
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2 Cited Publications
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Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine diphosphate possesses antiplasmodic activity .
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Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity .
1
1 Cited Publications
N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria .
1
1 Cited Publications
N-Desethyl amodiaquine dihydrochloride is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine dihydrochloride is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine dihydrochloride can be used for the research of malaria .
Cat. No.: HY-W004360
CAS No.: 212321-78-3
Synonyms: DesEthyl Dabigatran Etexilate
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BIBR 1087 SE is an intermediate metabolite of dabigatran etexilate.
Synonyms: N-DesEthylamiodarone hydrochloride; LB 33020 hydrochloride
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Desethylamiodarone hydrochloride (N-Desethylamiodarone hydrochloride; LB 33020 hydrochloride) is the major active metabolite of Amiodarone (HY-14187) generated via CYP3A4 metabolism. Desethylamiodarone hydrochloride downregulates p‑Akt, p‑Bad and Bcl‑2, upregulates Bax, promotes mitochondrial release of cytochrome c, activates caspase‑3 and cleaves PARP‑1, thereby inducing cell cycle arrest and apoptosis. Desethylamiodarone hydrochloride can be used in cervical cancer-related research .
Cat. No.: HY-146269
CAS No.: 103816-16-6
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11-Desethyl Irinotecan is a camptothecin (CPT) analog and one of the metabolites of irinotecan. It is promising for cancer research .
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Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment .
Cat. No.: HY-10873S
CAS No.: 1217247-62-5
Cat. No.: HY-136445S
CAS No.: 1219798-52-3
Synonyms: DesEthylterbuthylazine-d9
Cat. No.: HY-122139
CAS No.: 528851-31-2
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Desethylene Ciprofloxacin hydrochloride is a major metabolite and degradation product of Ciprofloxacin (HY-B0356). Desethylene Ciprofloxacin hydrochloride inhibits topoisomerase (Topoisomerase) IIα and IIβ-mediated DNA relaxation .
Cat. No.: HY-130353S
CAS No.: 1189960-80-2
Synonyms: N-DesEthylamiodarone-d4 hydrochloride; LB 33020-d4 hydrochloride
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Isotope-Labeled Compounds Drug Metabolite Cytochrome P450 Akt Bcl-2 Family Caspase PARP Apoptosis
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Desethylamiodarone-d4 hydrochloride (N-Desethylamiodarone-d4 hydrochloride; LB 33020-d4 hydrochloride) is the deuterated-labeled Desethylamiodarone hydrochloride (HY-130353). Desethylamiodarone hydrochloride (N-Desethylamiodarone hydrochloride; LB 33020 hydrochloride) is the major active metabolite of Amiodarone (HY-14187) generated via CYP3A4 metabolism. Desethylamiodarone hydrochloride downregulates p‑Akt, p‑Bad and Bcl‑2, upregulates Bax, promotes mitochondrial release of cytochrome c, activates caspase‑3 and cleaves PARP‑1, thereby inducing cell cycle arrest and apoptosis. Desethylamiodarone hydrochloride can be used in cervical cancer-related research .
Cat. No.: HY-136445
CAS No.: 30125-63-4
Synonyms: DesEthylterbuthylazine
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Terbuthylazine-desethyl (Desethylterbuthylazine) is a chloro dealkylated metabolite of Terbuthylazine (a triazine herbicide) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
