![3,9-Dimethyl-3,9-diazaspiro[5.5]undecane](https://file.medchemexpress.com/product_pic/hy-46871.gif "Click to View 3,9-Dimethyl-3,9-diazaspiro[5.5]undecane Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
FIP
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "FIP" in MCE Product Catalog:
Cat. No.: HY-175764
CAS No.: 3091132-73-6
Research Areas:
FIP22 is a potent and selective IRAK4 PROTAC degrader (HEK293T cells: DC50 = 3.2 nM; THP-1 cells: DC50 = 10.6 nM). FIP22 induces the ubiquitin-proteasome system by forming an IRAK4-FIP22-CRBN ternary complex (EC50 = 12.63 nM), thereby potently blocking IRAK4-mediated NF-κB and MAPK signaling pathways. FIP22 can be used for the study of atopic dermatitis .
Cat. No.: HY-46871
CAS No.: 93004-48-9
Target:
Research Areas:
3,9-Dimethyl-3,9-diazaspiro[5.5]undecane is a rigid PROTAC linker can be used in the synthesis of PROTACs, such as FIP22 (HY-175764). FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity .
Synonyms: KHK-IN-3
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation .
Cat. No.: HY-158405
CAS No.: 2923674-83-1
Synonyms: MAV-104
Target:
Research Areas:
PAV-104 (MAV-104) is a host-targeted, pan-respiratory viral assembly inhibitor. PAV-104 targets a small subset of the host protein 14-3-3 within a transient multi-protein complex. PAV-104 inhibits SARS-CoV-2 replication by blocking post-entry viral assembly/budding through interaction with viral nucleocapsid (N) protein and interference with its oligomerization. PAV-104 is orally active in cats and shows favorable pharmacokinetic properties in rats. PAV-104 can be used for the study of COVID-19 and other respiratory viral infections, including Feline Infectious Peritonitis (FIP) .
Cat. No.: HY-175766
CAS No.: 2476319-08-9
Research Areas:
CRBN Ligand-Linker Conjugate 2 is a synthesized E3 ligand-linker conjugate that can be used for synthesis of PROTACs, such as FIP22 (HY-175764). FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity .
Synonyms: Z-D-Phe-Phe-Gly-OH; FIP; Virus Replication Inhibitory Peptide
Target:
Research Areas:
Cat. No.: HY-RS04950
Target:
Research Areas:
FIP1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for FIP1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11517
Target:
Research Areas:
RAB11FIP1 Human Pre-designed siRNA Set A contains three designed siRNAs for RAB11FIP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11518
Target:
Research Areas:
RAB11FIP3 Human Pre-designed siRNA Set A contains three designed siRNAs for RAB11FIP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11519
Target:
Research Areas:
RAB11FIP4 Human Pre-designed siRNA Set A contains three designed siRNAs for RAB11FIP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS15514
Target:
Research Areas:
USF2 Human Pre-designed siRNA Set A contains three designed siRNAs for USF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS11520
Target:
Research Areas:
RAB11FIP5 Human Pre-designed siRNA Set A contains three designed siRNAs for RAB11FIP5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P701686
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FIP1L1; Pre-mRNA 3'-end-processing factor FIP1; hFIP1; FIP1-like 1 protein; Factor interacting with PAP; Rearranged in hypereosinophilia
Species:
Source:
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
