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Results for "

Fe

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ACSL Family (1) Akt (4) Amyloid-β (3) Antibiotic (6) Apoptosis (21) Autophagy (6) Bacterial (19) Biochemical Assay Reagents (38) Calcium Channel (1) Cholecystokinin Receptor (2) Cholinesterase (ChE) (7) COX (2) Cuproptosis (2) Dipeptidyl Peptidase (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (5) Drug Intermediate (1) Drug Metabolite (1) Dynamin (2) Endogenous Metabolite (7) Environmental Pollutants (5) ERK (1) Factor XI (1) FAK (1) Ferroportin (1) Ferroptosis (22) Fluorescent Dye (14) Fungal (4) GLP Receptor (3) Glutaminase (1) Glutathione Peroxidase (7) Glycosidase (1) GnRH Receptor (4) GSK-3 (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (6) Histamine Receptor (1) Histone Demethylase (1) HSP (1) IKZF Family (1) Integrin (1) Interleukin Related (2) Isotope-Labeled Compounds (6) Kallikrein (1) LDLR (3) Lipase (2) Lipoxygenase (1) MDM-2/p53 (1) MEK (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitophagy (2) MMP (4) MOFs (17) Monoamine Oxidase (1) mTOR (1) Opioid Receptor (6) Oxytocin Receptor (1) Parasite (1) Phosphatase (1) PINK1/Parkin (2) PKC (1) PROTACs (3) Reactive Oxygen Species (ROS) (23) Reference Standards (11) SARS-CoV (1) SHP1 (1) Sirtuin (1) Small Interfering RNA (siRNA) (4) Src (1) Tau Protein (2) TET Protein (1) TNF Receptor (2) Transferrin Receptor (3) Tryptophan Hydroxylase (1) Vasopressin Receptor (3) VDAC (1) Virus Protease (1) Zinc Finger Protein (1)
By Research Areas:	Cancer (50) Cardiovascular Disease (12) Endocrinology (4) Infection (25) Inflammation/Immunology (26) Metabolic Disease (20) Neurological Disease (24)
Click Chemistry:	Alkynes (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

178

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12040

Elesclomol 110+ Cited Publications STA-4783	Reactive Oxygen Species (ROS) Apoptosis Cuproptosis	Cancer
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

HY-16168A

Degarelix Maximum Cited Publications 11 Publications Verification Fe 200486 free base	GnRH Receptor Apoptosis	Endocrinology Cancer
Degarelix acetate (FE 200486) is a decapeptide that shows high affinity/selectivity to human gonadotropin-releasing hormone (GnRH) receptor (IC₅₀ = 3 nM). Degarelix acetate Degarelix acetate (FE 200486) is used for the research of prostate cancer .

HY-137805

Ferrozine 3 Publications Verification	Fluorescent Dye	Others
Ferrozine is a spectrophotometric reagent for iron ions, can react with divalent Fe to form a stable magenta complex species. The complex has an absorption peak at 562 nm . Ferrozine-based colorimetric assays can quantify iron in cells

HY-D1533

RhoNox-1 Maximum Cited Publications 39 Publications Verification	Fluorescent Dye	Others
RhoNox-1 is a fluorescent probe for the specific detection of divalent iron ions, and when RhoNox-1 reacts with Fe ²⁺. RhoNox-1 can generate an irreversible orange (red) fluorescent product (Ex/Em：540/575 nm) . FeRhoNox-1 can enter the cell well, suitable for the detection of Fe ²⁺ in living cells, and tends to be localized in the Golgi apparatus .

HY-D1913

Fe2Orange 20+ Cited Publications	Fluorescent Dye	Others
Fe2Orange is a Fe ²⁺ selective probe with an excitation wavelength of 543 nm and an emission wavelength of 580 nm. Fe2Orange emits fluorescence after binding to intracellular Fe ²⁺, thereby achieving specific labeling of Fe ²⁺. Fe2Orange is used to detect the content and distribution of Fe ²⁺ in cells .

HY-107928

Iron dextran 1 Publications Verification Fe dextran	Transferrin Receptor	Metabolic Disease Cancer
Iron dextran (Fe dextran) can be used in the study of iron-deficiency anemia in animals .

HY-W075707

FeTCPP chloride 1 Publications Verification Iron(III) meso-Tetra(4-carboxyphenyl)porphine chloride	MOFs	Others
FeTCPP chloride (Iron(III) meso-Tetra(4-carboxyphenyl)porphine chloride) is a metallic porphyrin compound formed by the coordination of a central iron ion (Fe ³⁺) with four 4-carboxyphenylporphyrins (TCPP). FeTCPP chloride can be used as a catalyst for catalytic, electrochemical, photochemical and biomedical research. FeTCPP chloride has high photocatalytic performance for p-nitrophenol under visible light. FeTCPP chloride also has peroxisase-like activity, which is used in bionic catalysis research .

HY-17609

Difelikefalin 1 Publications Verification CR-845; Fe-202845	Opioid Receptor	Neurological Disease Inflammation/Immunology
Difelikefalin (CR-845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-132989

Mal-Deferoxamine	Biochemical Assay Reagents Bacterial	Cardiovascular Disease Infection Inflammation/Immunology
Mal-Deferoxamine is a maleimide-functionalized trihydroxamate siderophore derivative that can be isolated from Streptomyces pilosus. Mal-Deferoxamine possesses highly specific Fe (III) chelating ability, and the stability of complexes formed between it and non-Fe (III) metal ions is significantly lower. Mal-Deferoxamine exhibits growth inhibitory effects against Gram-positive bacteria, but shows no obvious inhibitory activity against Gram-negative bacteria (MIC>50 μM). Mal-Deferoxamine is mainly suitable for scientific research in hematology and related fields .

HY-145157

Ferric nitrilotriacetate	Biochemical Assay Reagents	Metabolic Disease Cancer
Ferric nitrilotriacetate (Fe-NTA), a complexation of nitriloacetic acid with iron, is a highly reactive compound used to induce degenerative disorders through oxidative stress (OS). Ferric nitrilotriacetate is also used in several studies to induce hyperglycemia, glycosuria, and both renal and liver carcinogenesis .

HY-W698249

Ferrous gluconate	Ferroptosis Bacterial	Cardiovascular Disease Infection
Ferrous gluconate is a highly water-soluble iron-containing agent with high bioavailability and bactericidal activity. As a non-heme iron, Ferrous gluconate is used for meat product fortification and improvement of iron deficiency anemia. Ferrous gluconate induces ferroptosis in E. coli through Fe ²⁺ infiltration, reactive oxygen species burst, lipid peroxidation and direct interaction with DNA. Ferrous gluconate also downregulates the SOS responsive transcriptional repressor LexA. In addition, Ferrous gluconate regulates multiple key pathways in E. coli such as fatty acid metabolism, iron-sulfur cluster assembly and pyruvate metabolism, and is applied in studies related to E. coli infection and iron deficiency anemia .

HY-105239

Selepressin Fe 202158	Vasopressin Receptor	Cardiovascular Disease
Selepressin (FE 202158) is a selective vasopressin V_1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock .

HY-P1714

Apraglutide Fe 203799	GLP Receptor	Metabolic Disease
Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .

HY-P3267A

Apo-Bovine Transferrin	Ferroportin Transferrin Receptor	Neurological Disease
Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe ²⁺ to Fe ³⁺. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research .

HY-108017

Ferric maltol	Biochemical Assay Reagents	Metabolic Disease Cancer
Ferric maltol is an orally active monovalent iron (Fe ³⁺) complex. Ferric maltol is used in the study of iron deficiency anemia in inflammatory bowel disease .

HY-D0945

Xylene Cyanol FF	Fluorescent Dye	Others
Xylene Cyanol FF is an acid triphenylmethane dye. Xylene Cyanol FF can be used for histochemical staining of hemoglobin peroxidase or as a tracking dye for DNA sequencing in electrophoresis. Xylene Cyanol FF will be catalyzed by Fe and Al to accelerate oxidation under the addition of double oxidant hydrogen peroxide and potassium periodate. Xylene Cyanol FF thus enables the spectrophotometric determination of Fe and Al in the solution to be tested .

HY-DY1030

RhoNox-1 (solution)	Fluorescent Dye	Others
RhoNox-1 (solution) is a fluorescent probe for the specific detection of divalent iron ions, and when RhoNox-1 reacts with Fe ²⁺. RhoNox-1 can generate an irreversible orange (red) fluorescent product (Ex/Em：540/575 nm). FeRhoNox-1 can enter the cell well, suitable for the detection of Fe ²⁺ in living cells, and tends to be localized in the Golgi apparatus . Solvent and concentration: DMSO: 5 mM

HY-Y1422I

Lipase,Pseudomonas fluorescens (Immobilized)	Environmental Pollutants Biochemical Assay Reagents Lipase	Others
Lipase, Pseudomonas fluorescens (Immobilized) is an immobilized biocatalyst derived from Pseudomonas fluorescens. Lipase, Pseudomonas fluorescens (Immobilized) efficiently catalyzes the hydrolysis, esterification and transesterification of triacylglycerols in solvent-free systems, and is particularly suitable for biodiesel production from soybean oil and selective modification of oils rich in EPA and DHA. Lipase, Pseudomonas fluorescens (Immobilized) exhibits optimal activity at pH 8.5 and 45°C, and retains residual activity after repeated cycles of use. Lipase, Pseudomonas fluorescens (Immobilized) is activated by Ca ²⁺, but inhibited by Co ²⁺, Ni ²⁺, Fe ³⁺, Fe ²⁺ and EDTA .

HY-N0046

Notoginsenoside Fe Notoginseng triterpenes; Ginsenoside Mb	Apoptosis Src	Neurological Disease Metabolic Disease Cancer
Notoginsenoside Fe (Notoginseng triterpenes; Ginsenoside Mb) is a saponin with anti-obesity and anti-neuroblastoma activities. Notoginsenoside Fe can be isolated from leaves of Panax notoginseng. Notoginsenoside Fe specifically activates paraventricular nucleus neurons in the hypothalamus, effectively reducing body weight, improving fasting blood glucose and protecting liver function by decreasing food intake, increasing resting metabolic rate and enhancing energy expenditure. Notoginsenoside Fe also inhibits the c-Src signaling pathway, blocks the proliferation and viability of human neuroblastoma cells, while improving mitochondrial dysfunction and alleviating apoptosis. Notoginsenoside Fe can be used in studies related to diet-induced obesity and neuroblastoma .

HY-16564

Deferasirox (Fe3+ chelate)	Ferroptosis Bacterial	Others
Deferasirox Fe3+ Chelate is an iron chelating agent extracted from patent WO2003053986 .

HY-107928B

Iron–Dextran(Fe 35-40% w/w)	Biochemical Assay Reagents	Others Inflammation/Immunology Cancer
Iron-dextran (Fe 35-40% w/w) is an iron supplement (Fe 35-40% w/w). Iron-dextran can cause severe immune reactions, including anaphylactic shock. Iron-dextran can be used in studies of iron deficiency anemia .

HY-P3609

CR 665 2 Publications Verification JNJ 38488502; Fe 200665	Opioid Receptor	Neurological Disease
CR 665 (JNJ 38488502) is a peripherally selective κ-opioid agonist. CR 665 can activate the kappa opioid receptor with EC₅₀ value of 10.9 nM. CR 665 can be used for the research of peripheral pain .

HY-105239A

Selepressin acetate Fe 202158 acetate	Vasopressin Receptor	Cardiovascular Disease
Selepressin (FE 202158) acetate is a selective vasopressin V_1A receptor agonist. Selepressin acetate is a potent vasopressin. Selepressin acetate can be used in the study of septic shock.

HY-D2339

H-FluNox	Fluorescent Dye	Others
H-FluNox is a selective fluorescent probe that senses labile heme using biomimetic N-oxide deoxygenation to trigger fluorescence. H-FluNox is more than 100-fold selective for labile heme over Fe(II), enabling the discrimination of labile heme from labile Fe(II) pools in living cells. H-FluNox is sensitive enough to detect the subcellular labile heme. (λ_ex=490 nm, λ_em=535 nm)

HY-P2777

Ceruloplasmin	Biochemical Assay Reagents	Neurological Disease Metabolic Disease Inflammation/Immunology
Ceruloplasmin is a copper-containing multifunctional ferrous oxidase glycoprotein. Ceruloplasmin specifically oxidizes Fe ²⁺ to Fe ³⁺, promoting the binding of Fe ³⁺ to transferrin. Ceruloplasmin can bind to copper ions to prevent the toxicity of free copper to cells. Ceruloplasmin can be used for the research of inflammation, metabolic and neurological disease such as Parkinson’s disease .

HY-158779

Sulfane sulfur probe 4 SSP4	Fluorescent Dye	Others
Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

HY-158739

Rhodamine dithenoyl hydrazide	Fluorescent Dye	Cancer
Rhodamine dithenoyl hydrazide (probe 1) possesses excellent recognition and selectivity for Fe ³⁺ ion. Rhodamine dithenoyl hydrazide exhibits Excitation/Emission maxima of 543/550-700 nm, respectively .

HY-177506

FE100726	Cholecystokinin Receptor	Metabolic Disease
FE100726 (Compound 39) is a Cholecystokinin 2 (CCK2) receptor agonist. FE100726 has a superior binding capacity on CCK2 receptor. FE100726 can induce gastric acid secretion in anaesthetized rat models. FE100726 can be used for diabetes research .

HY-16168

Degarelix acetate 10+ Cited Publications Fe 200486	GnRH Receptor	Cancer
Degarelix acetate (FE 200486) is a decapeptide that shows high affinity/selectivity to human gonadotropin-releasing hormone (GnRH) receptor (IC₅₀ = 3 nM). Degarelix acetate (FE 200486) is used for the research of prostate cancer .

HY-P3516

Barusiban Fe-200440	Oxytocin Receptor	Endocrinology
Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (K_i=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research .

HY-107928A

Iron–Dextran(Fe 25-35% w/w)	Biochemical Assay Reagents	Others
Iron-Dextran is an injectable complex of iron and dextran, a complex carbohydrate. It is often used to improve iron deficiency anemia, a condition characterized by low levels of iron in the blood due to insufficient dietary intake or malabsorption. Iron-glucan works by providing a source of supplemental iron that the body can use to produce hemoglobin, the protein responsible for carrying oxygen in the blood. However, caution should be exercised when taking iron dextran because it may cause hypersensitivity reactions, including anaphylaxis, and may also increase the risk of infection or other adverse reactions. Therefore, it should only be administered under the supervision of a qualified healthcare provider in a clinical setting.

HY-W249602

MIL-88A(Fe) MIL-88-Fe	MOFs	Others
MIL-88A(Fe)(MIL-88-Fe) is a metal-organic framework (MOF).

HY-117478

FE-999024 CH-2856	Kallikrein	Inflammation/Immunology Cancer
FE-999024 (CH-2856) is a specific tissue kallikrein inhibitor. FE-999024 can inhibit cancer cells invasion with a maximum of 39%. FE-999024 can reduce eosinophilia in a model of allergic inflammation. FE-999024 can be used for the researches of cancer, inflammation and immunology .

HY-W124354

MIL-101-Fe	MOFs	Others
MIL-101-Fe is a metal-organic framework (MOF).

HY-W075508

MIL-100(Fe)	MOFs	Others
MIL-100(Fe) is a metal-organic framework (MOF).

HY-W112939

Fe(III)(TDCPP) chloride	MOFs	Others
Fe(III)(TDCPP) chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P1714A

Apraglutide TFA Fe 203799 TFA	GLP Receptor	Metabolic Disease
Apraglutide TFA (FE 203799 TFA), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum .

HY-W151629A

Ferrozine sodium hydrate	Fluorescent Dye	Others
Ferrozine sodium hydrate is a spectrophotometric reagent for iron, can react with divalent Fe to form a stable magenta complex species. The complex has an absorption peak at 562 nm .Ferrozine sodium hydrate-based colorimetric assays can quantify iron in cells

HY-W107177

5,10,15,20-tetrakis(p-chlorophenyl)porphyrin iron(III) chloride meso-Tetrakis(4-chlorophenyl)porphyrin-Fe(III)chloride	MOFs	Others
5,10,15,20-tetrakis(p-chlorophenyl)porphyrin iron(III) chloride (meso-Tetrakis(4-chlorophenyl)porphyrin-Fe(III)chloride) is a metal-organic framework (MOF).

HY-W113011

5,10,15,20-Tetra(4-methylphenyl)-21H,23H-porphine iron(III) chloride meso-Tetratolylporphyrin-Fe(III)chloride	MOFs	Others
5,?10,?15,?20-?Tetra(4-?methylphenyl)?-?21H,?23H-?porphine iron(III) chloride (meso-Tetratolylporphyrin-Fe(III)chloride) is a metal-organic framework (MOF).

HY-W011816

1,2-Hexadecanediol	Biochemical Assay Reagents	Others
1,2-Hexadecanediol is a reducing agent. 1,2-Hexadecanediol facilitates the decomposition of the metal-organic precursor, forms an intermediate Co ²⁺Fe ³⁺-oleate complex .

HY-N13871

Anguibactin	Antibiotic Bacterial	Infection
Anguibactin is an antibiotic that acts as a siderophore. Anguibactin has a strong affinity with Fe ³⁺ .

HY-17609S1

Difelikefalin-d5 hydrochloride CR-845-d5 hydrochloride; Fe-202845-d5 hydrochloride	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease Inflammation/Immunology
Difelikefalin-d₅ (CR-845-d₅) hydrochloride is the deuterium labeled Difelikefalin (HY-17609). Difelikefalin (CR-845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-176212

Ferroptosis-IN-20	Ferroptosis VDAC Reactive Oxygen Species (ROS)	Inflammation/Immunology
Ferroptosis-IN-20 (Compound 34a) is a Ferroptosis inhibitor (EC₅₀: 24.2 nM) targeting voltage-dependent anion channel (VDAC). Ferroptosis-IN-20 inhibits VDAC oligomerization and lipid peroxidation. Ferroptosis-IN-20 reduces content of ROS, attenuates TFR1-mediated iron uptake, inhibits Fe ²⁺ level and restores glutathione (GSH) level. Ferroptosis-IN-20 alleviates Folic acid (HY-16637)-induced acute kidney injury (AKI) .

HY-16168B

Degarelix acetate hydrate Fe 200486 acetate hydrate	GnRH Receptor Apoptosis	Endocrinology Cancer
Degarelix acetate hydrate (FE 200486 acetate hydrate) is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR/LHRHR) antagonist. Degarelix acetate hydrate can be used for prostate cancer research .

HY-17609S

Difelikefalin-d5 CR-845-d₅; Fe-202845-d₅	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease
Difelikefalin-d₅ (CR-845-d₅) is deuterium labeled Difelikefalin. Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-P11424

Cyclo(GRGDSPA)	Integrin	Cancer
Cyclo(GRGDSPA) is a cyclic RGD peptide targeting αvβ3 integrin. Cyclo(GRGDSPA) reduces the formation of colonies in mice injected with B16-FE7 melanoma cells. Cyclo(GRGDSPA) can be used for melanoma research .

HY-B1159S

Nitroxoline-d4 8-Hydroxy-5-nitroquinoline-d₄; 5-Nitro-8-quinolinol-d₄	Bacterial Autophagy Antibiotic	Infection Cancer
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe ²⁺ and Zn ²⁺ ions from the biofilm matrix .

HY-178370

Ferroptosis inducer-12	Ferroptosis Reactive Oxygen Species (ROS)	Cancer
Ferroptosis inducer-12 is a potent and selective ferroptosis inducer. Ferroptosis inducer-12 exhibits potent antiproliferative activity against HT1080 and OS-RC-2, with IC₅₀ values of 3 nM and 5 nM, respectively. Ferroptosis inducer-12 strongly inhibits GPX4 enzymatic activity, induces intracellular ROS and elevates intracellular Fe ²⁺ levels in OS-RC-2 cells. Ferroptosis inducer-12 significantly inhibits tumor growth in BALB/c nude mice bearing OS-RC-2 xenografts. Ferroptosis inducer-12 can be used for the study of cancer .

HY-175698

Ferroptosis inducer-9	ACSL Family Ferroptosis Microtubule/Tubulin COX Glutathione Peroxidase	Cancer
Ferroptosis inducer-9 is a ferroptosis inducer and colchicine site tubulin polymerization inhibitor. Ferroptosis inducer-9 inhibits MCF-7 cell growth with an IC₅₀ of 14 nM and inhibits [ ³H]colchicine binding. Ferroptosis inducer-9 reduces expression of GPX4 and FTH, increases COX2 and ACSL4, lowers GSH, NADP+, and NADPH levels, increases LPO, MDA, and *Fe(II)* levels, and decreases SOD concentrations. Ferroptosis inducer-9 demonstrates significant anti-tumor efficacy in HCT116 CRC xenograft model. Ferroptosis inducer-9 can be used for the study of triple negative breast cancer (TNBC) and colorectal cancer (CRC) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0928

Mimosine 4 Publications Verification	Natural Products other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.

HY-160238

Bacillibactin Corynebactin	Microorganisms Phenols Polyphenols Source Classification	Bacterial Fungal
Bacillibactin (Corynebactin) is a cyclic tricatecholate siderophore. Bacillibactin’s primary function is to facilitate bacterial iron acquisition by chelating iron ions (Fe ³⁺) from the environment, thereby aiding bacterial survival under iron-limited conditions. Bacillibactin exhibits direct antimicrobial activity, such as inhibition of the growth of the producing bacteria Pseudomonas aeruginosa and Aeromonas veronae, as well as plant pathogens such as Pseudomonas syringae.Bacillibactin can be used in antibacterial and antifungal research .

HY-N10470

Bleomycin A5 1 Publications Verification Pingyangmycin	Structural Classification Natural Products Microorganisms Animals Source Classification	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy
Bleomycin A5 (Pingyangmycin) is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 can be used in cancer research .

HY-B1306

4-Aminohippuric acid 4 Publications Verification p-Aminohippuric acid	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Others
4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu ²⁺, Fe ³⁺, Hg ²⁺) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .

HY-128525

Enterobactin	Microorganisms Phenols Polyphenols Source Classification	Bacterial Reactive Oxygen Species (ROS)
Enterobactin is a siderophore produced by Gram-negative bacteria and has an extremely high affinity for iron. During the process of Salmonella typhimurium infecting macrophages, Enterobactin can not only help bacteria uptake iron but also reduce the antibacterial activity of macrophages. In addition, Enterobactin is also involved in the oxidative stress response of Escherichia coli. Enterobactin can be hydrolyzed by Fes in the cell and exert antioxidant effects by scavenging free radicals .

HY-N10473

Pulcherriminic acid 3 Publications Verification	Microorganisms Cyclopeptides	Bacterial Fungal
Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe ³⁺, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries .

HY-N0046

Notoginsenoside Fe Notoginseng triterpenes; Ginsenoside Mb	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Apoptosis Src
Notoginsenoside Fe (Notoginseng triterpenes; Ginsenoside Mb) is a saponin with anti-obesity and anti-neuroblastoma activities. Notoginsenoside Fe can be isolated from leaves of Panax notoginseng. Notoginsenoside Fe specifically activates paraventricular nucleus neurons in the hypothalamus, effectively reducing body weight, improving fasting blood glucose and protecting liver function by decreasing food intake, increasing resting metabolic rate and enhancing energy expenditure. Notoginsenoside Fe also inhibits the c-Src signaling pathway, blocks the proliferation and viability of human neuroblastoma cells, while improving mitochondrial dysfunction and alleviating apoptosis. Notoginsenoside Fe can be used in studies related to diet-induced obesity and neuroblastoma .

HY-125918

Bleomycin A5 hydrochloride Pingyangmycin hydrochloride	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic DNA/RNA Synthesis Apoptosis Dynamin PINK1/Parkin Mitophagy
Bleomycin A5 (Pingyangmycin) hydrochloride is a glycopeptide antibiotic with multiple biological activities, which can be isolated from Streptomyces. Bleomycin A5 hydrochloride exerts cytotoxic effects by binding to Fe ²⁺ to form a complex, inducing single-strand and double-strand DNA breaks, and inhibiting DNA replication. Bleomycin A5 hydrochloride inhibits Drp1-mediated mitochondrial fission and suppresses PINK1/Parkin pathway-mediated mitophagy, ultimately triggering mitochondria-mediated cellular apoptosis. Bleomycin A5 hydrochloride can be used in cancer research .

HY-W747297

β-Selinene	Other Terpenoids Structural Classification Terpenoids Psidium guajava Linn. Myrtaceae Plants Source Classification	COX Endogenous Metabolite
β-Selinene is a sesquiterpene and is the main active component of the essential oil of red purple hibiscus (Callicarpa macrophylla). β-Selinene exhibits significant related antioxidant activity, anti-inflammatory activity, and antipyretic analgesic activity. β-Selinene may exert antioxidant effects by directly scavenging free radicals (DPPH, NO, •OH) and chelating pro-oxidative metal ions (Fe²⁺); inhibit cyclooxygenase (COX) activity, reduce prostaglandin (such as PGE₂) synthesis to exert anti-inflammatory effects; regulate the thermoregulatory set point of the hypothalamus and inhibit inflammatory mediators to exert antipyretic and analgesic effects .

HY-B1306R

4-Aminohippuric acid (Standard) p-Aminohippuric acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Biochemical Assay Reagents
4-Aminohippuric acid (p-Aminohippuric acid) (Standard) is the analytical standard of 4-Aminohippuric acid (HY-B1306). This product is intended for research and analytical applications. 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu ²⁺, Fe ³⁺, Hg ²⁺) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .

HY-N13871

Anguibactin	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Anguibactin is an antibiotic that acts as a siderophore. Anguibactin has a strong affinity with Fe ³⁺ .

HY-N0928R

Mimosine (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards Apoptosis
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.

HY-N14059

Halymecin B	Microorganisms Ketones, Aldehydes, Acids Source Classification	Others
Halymecin B is found in the strain of Fusarium sp. FE-71-1 .

HY-N15282

Broussoflavonol G	Flavonols Flavonoids Plants Moraceae Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat Source Classification	Interleukin Related
Broussoflavonol G is an active ingredient of Moraceae plants, which can be isolated from Broussonetia papyrifera. Broussoflavonol G can effectively inhibit Fe ²⁺-induced lipid oxidation in rat brain homogenate and significantly inhibit the proliferation of rat vascular smooth muscle cells .

HY-128525R

Enterobactin (Standard)	Microorganisms Phenols Polyphenols Source Classification	Bacterial Reference Standards Reactive Oxygen Species (ROS)
Enterobactin (Standard) is the analytical standard of Enterobactin. This product is intended for research and analytical applications. Enterobactin is a siderophore produced by Gram-negative bacteria and has an extremely high affinity for iron. During the process of Salmonella typhimurium infecting macrophages, Enterobactin can not only help bacteria uptake iron but also reduce the antibacterial activity of macrophages. In addition, Enterobactin is also involved in the oxidative stress response of Escherichia coli. Enterobactin can be hydrolyzed by Fes in the cell and exert antioxidant effects by scavenging free radicals .

HY-N14060

Halymecin C	Microorganisms Ketones, Aldehydes, Acids Source Classification	Others
Halymecin C is found in the strain of Fusarium sp. FE-71-1 .

HY-N17362

Anhydroevoxine	Structural Classification Alkaloids Rutaceae Vepris glomerata (F.Hoffm.) Engl. Quinoline Alkaloids Plants Source Classification	Others
Anhydroevoxine is a furoquinoline alkaloid that can be found in Vepris glomerata. Anhydroevoxine demonstrates in vitro antioxidant activity, reducing Fe ³⁺ to Fe ²⁺ and scavenging DPPH radicals .

HY-182578

Mimosinamine	Structural Classification Alkaloids Piperidine Alkaloids Mimosa pudica Linn. Leguminosae Plants Source Classification	Tryptophan Hydroxylase
Mimosinamine is a hydroxylase inhibitor with Fe ²⁺ chelating activity. Mimosinamine inhibits bovine adrenal tyrosine hydroxylase, rat liver phenylalanine hydroxylase, and rat brainstem tryptophan hydroxylase. Mimosinamine can be used in the research of hypertension .

HY-N18050

Petrobactin	Structural Classification Marine natural products Phenols Polyphenols Marine microorganism Source Classification	Endogenous Metabolite Bacterial
Petrobactin is a photoreactive siderophore. Petrobactin can be produced by the oil-degrading marine bacterium Marinobacter hydrocarbonoclasticus. Petrobactin can be synthesized by Bacillus anthracis str. Sterne under conditions of iron starvation. Petrobactin readily undergoes a light-mediated decarboxylation reaction when bound to Fe(III) .

HY-149151

Variegatic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite PKC Glycosidase TNF Receptor Reactive Oxygen Species (ROS)
Variegatic acid is a secondary metabolite derived from basidiomycete fungi. Variegatic acid is a PKCβ1 inhibitor with an IC₅₀ of 36.2 μM. Variegatic acid inhibits antigen- or calcium ionophore-induced β-hexosaminidase release (IC₅₀ values of 10.4 μM and 22.2 μM, respectively) and TNF-α secretion (IC₅₀ values of 16.8 μM and 20.1 μM, respectively). Variegatic acid suppresses the enzymatic activity of calcium-activated PKCβ1 and reduces Fe(III) to Fe(II) in a pH-dependent manner, enabling the generation of hydroxyl radicals (·OH) through reaction with H₂O₂, which facilitates the degradation of lignocellulose. Variegatic acid is useful for studying biological degradation and allergic responses.

HY-W722245

Pyochelin	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Endogenous Metabolite Bacterial
Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe ³⁺ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn ²⁺, Co ²⁺, and Ni ²⁺, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection .

Cat. No.	Product Name	Chemical Structure

HY-W015600S

2-Acetamidophenol-d3

2-Acetamidophenol-d₃ (Orthocetamol-d₃) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 μM and 40 μM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation .

HY-17609S1

Difelikefalin-d5 hydrochloride
Difelikefalin-d₅ (CR-845-d₅) hydrochloride is the deuterium labeled Difelikefalin (HY-17609). Difelikefalin (CR-845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-B1306S

4-Aminohippuric acid-d4

4-Aminohippuric acid-d₄ (p-Aminohippuric acid-d₄) is the deuterium labeled 4-Aminohippuric acid (HY-B1306). 4-Aminohippuric acid (p-Aminohippuric acid) is a coordination ligand for metal ions (such as Cu ²⁺, Fe ³⁺, Hg ²⁺) and a functionalization reagent for nanomaterials. 4-Aminohippuric acid can coordinate with metal ions or modify the surface of materials such as carbon nanotubes and gold nanoparticles through amino and carboxyl groups. 4-Aminohippuric acid can form stable complexes with metal ions or participate in the synthesis of nanomaterials as a reducing agent/stabilizer, enriching metal ions or giving nanoparticles peroxidase-mimicking activity. 4-Aminohippuric acid can be used to construct highly sensitive electrochemical sensors or colorimetric sensors to detect and quantitatively analyze heavy metal ions such as copper, iron, and mercury in environmental water samples and biological samples. 4-Aminohippuric acid may also be a biomarker for attention-deficit/hyperactivity disorder (ADHD) .

HY-17609S

Difelikefalin-d5
Difelikefalin-d₅ (CR-845-d₅) is deuterium labeled Difelikefalin. Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease .

HY-B1159S

Nitroxoline-d4
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe ²⁺ and Zn ²⁺ ions from the biofilm matrix .

HY-12040S

Elesclomol-d2

Elesclomol-d₂ (STA-4783-d₂) is a deuterium labeled Elesclomol (HY-12040). Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .

HY-16168AS

Degarelix-d7
Degarelix-d₇ (FE 200486-d₇ free base) is deuterium labeled Degarelix. Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.

HY-W004544S

o-Phenanthroline-d8
o-Phenanthroline-d₈ is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .

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