Search Result

Results for "

H2O

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Akt (5) Aldose Reductase (1) Amino Acid Derivatives (1) AMPK (2) Amyloid-β (7) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (24) Aquaporin (1) Autophagy (5) Bacterial (14) Bcl-2 Family (1) Beta-lactamase (1) Beta-secretase (1) Biochemical Assay Reagents (25) Calcium Channel (3) CaMK (1) Cannabinoid Receptor (1) Caspase (6) CDK (1) Cholinesterase (ChE) (10) COX (2) DNA/RNA Synthesis (7) Drug Derivative (2) Drug Intermediate (1) Drug Metabolite (1) EGFR (2) Endogenous Metabolite (23) Environmental Pollutants (1) ERK (5) Ferroptosis (2) Fluorescent Dye (19) Fungal (5) Glutathione Peroxidase (2) Glycosidase (1) HDAC (2) Heme Oxygenase (HO) (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (1) Histone Demethylase (1) HIV Protease (1) HSV (1) Influenza Virus (2) Insecticide (1) Interleukin Related (3) Isotope-Labeled Compounds (10) JNK (1) Keap1-Nrf2 (9) KMO (1) Lactate Dehydrogenase (1) Lipase (6) LOX-1 (1) Melanocortin Receptor (2) mGluR (1) Mitochondrial Metabolism (1) Monoamine Oxidase (5) mTOR (5) NADPH Oxidase (2) Necroptosis (2) NF-κB (3) NO Synthase (3) NOD-like Receptor (NLR) (1) Nuclear Factor of activated T Cells (NFAT) (2) Nucleoside Antimetabolite/Analog (3) P2Y Receptor (1) p38 MAPK (4) Paraptosis (1) Parasite (3) PARP (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Phosphoglycerate Dehydrogenase (PHGDH) (1) Phospholipase (1) Phytohormone (2) PI3K (1) PKC (1) Potassium Channel (1) PPAR (2) Pyroptosis (1) Quinone Reductase (1) Reactive Oxygen Species (ROS) (46) Reference Standards (16) ROS Kinase (2) SARS-CoV (2) Ser/Thr Protease (1) Sirtuin (2) SOD (2) STAT (1) Tau Protein (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) TRP Channel (3) Tyrosinase (1) Virus Protease (1) Xanthine Oxidase (1)
By Research Areas:	Cancer (44) Cardiovascular Disease (25) Infection (19) Inflammation/Immunology (59) Metabolic Disease (57) Neurological Disease (44)
Oligonucleotides:	Guanosine (1) Nucleoside Analogs (1) Phospholipids (1)

209

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0115

Gastrodin 15+ Cited Publications Gastrodine	Apoptosis Ferroptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin inhibits ethanol-induced hepatocellular apoptosis. Gastrodin inhibits H₂O₂-induced ferroptosis through its antioxidative effect. Gastrodin can be used for study of dizziness, epilepsy, stroke and dementia ^[2] .

HY-P9930

Evolocumab 3 Publications Verification AMG 145	NF-κB Ser/Thr Protease Toll-like Receptor (TLR)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H₂O₂-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation ^[2] .

HY-N0540

Cynaroside 10+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal	Infection Cardiovascular Disease Cancer
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-135849

Catalase, Aspergillus niger 4 Publications Verification	Reactive Oxygen Species (ROS)	Cancer
Catalase, Aspergillus niger is a key enzyme in the metabolism of *H₂O₂* and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors . Free oxygen radical scavenger.

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H₂O₂-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research ^[2].

HY-N1318

Salvigenin 5+ Cited Publications Psathyrotin	Autophagy Apoptosis ROS Kinase	Neurological Disease Inflammation/Immunology Cancer
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis ^[2].

HY-W014423

L-Histidine hydrochloride hydrate 3 Publications Verification H-His-OH.HCl.H2O	Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable ^[2] .

HY-N0615

Notoginsenoside R1 2 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Amyloid-β Apoptosis	Others
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells ^[2] .

HY-P2833

Glutathione Peroxidase GSH-Px; EC 1.11.1.9	Glutathione Peroxidase	Metabolic Disease
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9) belongs to the peroxidase family and is commonly used in biochemical research. Glutathione Peroxidase can catalyze reduced glutathione (GSH) to form a disulfide bridge with another glutathione molecule, convert it into oxidized glutathione (GSSG), and react with hydrogen peroxide or lipid peroxide reaction, reducing it to H₂O. Glutathione Peroxidase is an effective antioxidant against oxidative stress .

HY-109804

CORM-401 10+ Cited Publications	Reactive Oxygen Species (ROS)	Inflammation/Immunology
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis ^[2] .

HY-D1458

Peroxyfluor 1	Fluorescent Dye	Cardiovascular Disease Neurological Disease Cancer
Peroxyfluor 1 is a cell-permeable probe for H₂O₂. Peroxyfluor 1 represents a first-generation, green-fluorescent probe .

HY-133114

Ezetimibe ketone EZM-K	Keap1-Nrf2 Autophagy	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Ezetimibe ketone is an orall active *Nrf2* activator and ROS inhibitor. Ezetimibe ketone attenuates H₂O₂-induced reactive oxygen species production and reduces H₂O₂-induced apoptosis in renal tubular epithelial cells. Ezetimibe ketone suppresses renal tubular injury and inflammation .

HY-148009

Cardiolipin (16:0/18:1/16:0/18:1) sodium 16:0-18:1 Cardiolipin sodium	Biochemical Assay Reagents	Others
Cardiolipin (16:0/18:1/16:0/18:1) (16:0-18:1 Cardiolipin) sodium is a di-saturated mitochondrial-specific anionic phospholipid sodium salt containing the long-chain fatty acid palmitic acid (HY-N0830) and the monounsaturated fatty acid oleic acid (HY-N1446). Cardiolipin (16:0/18:1/16:0/18:1) sodium undergoes in-source fragmentation via diglyceride (DG)-H₂O fragment formation and (DG-H₂O) fragment loss pathways. Cardiolipin (16:0/18:1/16:0/18:1) sodium can be used in the synthesis of lipid nanodiscs for application in in situ mass spectrometry .

HY-76440

3-Oxetanone Oxetan-3-one	Biochemical Assay Reagents	Others
3-Oxetanone (Oxetan-3-one) is a four-membered cyclic ketone and strained cyclic ether derivative with measurable molecular g-value, magnetic susceptibility anisotropy and molecular quadrupole moment. 3-Oxetanone acts not only as a hydrogen bond acceptor, a tetrel donor and a weak hydrogen bond acceptor, but also forms a classic O-H···O hydrogen bond with H₂O via the ether oxygen atom. Alternatively, it forms a C···O tetrel bond with formaldehyde using its carbonyl group as a tetrel donor, while acting as a proton acceptor to form a C-H···O weak hydrogen bond with formaldehyde. 3-Oxetanone can be used to prepare various oxetanes ^[2].

HY-101859

NucPE1 5 Publications Verification Nuc-H2O2 Probe	Reactive Oxygen Species (ROS)	Others
NucPE1 (Nuc-H2O2 Probe) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

HY-120972

Pentafluorobenzenesulfonyl fluorescein	Fluorescent Dye	Others
Pentafluorobenzenesulfonyl fluorescein is a H₂O₂-selective sensor that can be used to detect H₂O₂ levels in cells. Pentafluorobenzenesulfonyl fluorescein is generally non-fluorescent, but emits fluorescence when its sulfonyl bond undergoes perhydrolysis by H₂O₂ . Pentafluorobenzenesulfonyl fluorescein undergoes slight cleavage of its sulfonate ester bond by [Cu (phen)₂] ²⁺, and can detect hydrogen peroxide around the ablation sites of fin tissues and keratinocytes in zebrafish larvae ^[2] .

HY-N2565

Rosamultin 1 Publications Verification	HIV Protease Apoptosis	Infection
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L. Rosamultin has inhibitory effects against HIV-1 protease . Rosamultin has the potential for treating H₂O₂-induced oxidative stress injury through its antioxidant and antiapoptosis effects ^[2].

HY-108351

IM-54	Necroptosis	Cardiovascular Disease
IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H₂O₂-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death ^[2].

HY-D1157

HKPerox-2 5 Publications Verification	Fluorescent Dye Reactive Oxygen Species (ROS)	Others
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively ^[2].

HY-W250172

*Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O)*	Biochemical Assay Reagents	Others
Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) is a nonionic surfactant commonly used in a variety of industrial and research applications. Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail and is suitable for use in emulsions, detergents and solubilizers. Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) is particularly useful in the study of membrane proteins, where it is used to solubilize and stabilize proteins for structural analysis techniques. It is also used in a variety of other applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Additionally, Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) is used in the production of microemulsions, salves and lotions due to its emulsifying and solubilizing properties. However, it can be toxic if ingested or inhaled, so proper handling and safety precautions are required.

HY-N7880

Salvianolic acid Y	Reactive Oxygen Species (ROS)	Cancer
Salvianolic acid Y is a phenolic acid with the same planar structure as Salvianolic acid B. Salvianolic acid Y rescues cell injury by H₂O₂ .

HY-N2024B

Maltose solution, 20% in H2O	Endogenous Metabolite Glycosidase	Metabolic Disease
Maltose solution, 20% in H₂O is a 20% aqueous maltose solution. Maltose is a disaccharide composed of two glucose molecules linked together. Maltose is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders ^[2] .

HY-115386

MitoTEMPOL 3 Publications Verification	Reactive Oxygen Species (ROS)	Cancer
MitoTEMPOL is a a mitochondria-targeted nitroxide that reduces mitochondrial O2 ^-to H2O2 .

HY-N5021

Anhydrosafflor yellow B AHSYB	Others	Neurological Disease
Anhydrosafflor yellow B (AHSYB) is a quinochalcone C-glycoside isolated from Carthamus tinctorius. Anhydrosafflor yellow B inhibits ADP-induced platelet aggregation, exhibits significant anti-oxidative effects in vitro, and possesses certain activity against H₂O₂-induced cytotoxicity in cultured PC12 cells and primary neuronal cells .

HY-W013322

Ac-Tyr-OEt.H2O	Amino Acid Derivatives	Others
Ac-Tyr-OEt.H2O is a tyrosine derivative .

HY-W000923

(4-Boc-aminophenyl)boronic acid	Biochemical Assay Reagents	Others
(4-Boc-aminophenyl) boronic acid is an arylboronic acid. As a substrate in H₂O, (4-Boc-aminophenyl) boronic acid participates in the CuO-catalyzed three-component reaction with α-ketoaldehydes and 1,3-dicarbonyl compounds to produce 1,4-diketone products .

HY-125919

Vulpinic acid	Reactive Oxygen Species (ROS) Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
Vulpinic acid, a lichen metabolite, decreases H₂O₂-induced ROS production, oxidative stress and oxidative stress-related damages in human umbilical vein endothelial cells (HUVEC). Vulpinic acid is active against staphylococci, enterococci, and anaerobic bacteria.Vulpinic acid has the potential for atherosclerosis research ^[2].

HY-130022

HKPerox-1 2 Publications Verification	Fluorescent Dye	Others
HKPerox-1 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively ^[2].

HY-155743A

ddUTP lithium, 100 mM in H2O 2',3'-Dideoxyuridine-5'-triphosphate lithium	Nucleoside Antimetabolite/Analog	Others
ddUTP (lithium), 100 mM in H₂O is a nucleotide analog that can be incorporated into DNA, RNA, or other nucleic acids. ddUTP (lithium), 100 mM in H₂O can be used to prepare DNA/RNA hybridization experiments, such as Southern blots and Northern blots.

HY-D1693

FBBBE	Fluorescent Dye	Inflammation/Immunology Cancer
FBBBE is used to detect the production of H₂O₂ by cells. FBBBE can be triggered by intracellular H₂O₂ and converted to fluorescein, resulting in an increase in intracellular fluorescence (Ex=4480 nm, Em=512 nm) .

HY-N7697E

Chitotriose trihydrochloride	Others	Others
Chitotriose trihydrochloride is an orally active chitooligosaccharide with antioxidant activities. Chitotriose trihydrochloride inhibits hydroxylation of benzoate to salicylate by H₂O₂ in the presence of Cu ²⁺ (IC₅₀ value of 80 μM) .

HY-157881

*2-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O)* β-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O)	Biochemical Assay Reagents	Others
2-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O) is a biochemical reagent that can be used for protein sequence analysis .

HY-W075791

Copper(II) perchlorate hexahydrate	Biochemical Assay Reagents	Others
Copper(II) perchlorate hexahydrate is an inorganic compound with the chemical formula Cu(ClO₄) ₂ (H₂O) ₆ and can be used as a catalyst in certain reaction .

HY-W101495S3

*Boc-Leu-OH·H2O-d7*	Isotope-Labeled Compounds	Others
Boc-Leu-OH·H2O-d₇ is the deuterium labeled Boc-Leu-OH·H2O.

HY-W101495S2

*Boc-Leu-OH·H2O-d10*	Isotope-Labeled Compounds	Others
Boc-Leu-OH·H2O-d₁₀ is the deuterium labeled Boc-Leu-OH·H2O .

HY-N15756

N-Demethylsinomenine	Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
N-Demethylsinomenine is a morphinane alkaloid that can be isolated from Sinomenium acutum. N-Demethylsinomenine has a protective effect against H₂O₂-induced cell injury. N-Demethylsinomenine can be used in the research of diseases such as Alzheimer's disease .

HY-W101495S1

*Boc-Leu-OH·H2O-d3* N-Boc-L-leucine-d3 monohydrate	Isotope-Labeled Compounds	Others
Boc-Leu-OH·H2O-d₃ is the deuterium labeled Boc-Leu-OH·H2O .

HY-125859E

Myeloperoxidase, Human Neutrophil	Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Myeloperoxidase, Human Neutrophil is a peroxidase. Myeloperoxidase, Human Neutrophil is a potent antibacterial agent by catalyzing the H₂O₂-dependent oxidation of chloride anion to generate hypochlorous acid. Myeloperoxidase, Human Neutrophil catalyzes the degradation of N-retinyl-idene-N-retinylethanolamine, a toxic form of retinal lipofuscin. Myeloperoxidase, Human Neutrophil also triggers lysosomal stress and cell death. Myeloperoxidase, Human Neutrophil can be used for the researches of inflammation and infection .

HY-N2442

Methylophiopogonone B	Reactive Oxygen Species (ROS)	Metabolic Disease
Methylophiopogonone B, a homoisoflavonoidal compound that could be isolated from Ophiopogonis Tiber, could scavenge •OH and H₂O₂ in vitro to a certain extent ^[2].

HY-W927359

Fluorescein hydrazide (3,6-Dihydroxyxanthane)	Fluorescent Dye	Others
Fluorescein hydrazide (3,6-Dihydroxyxanthane) is a fluorescein dye that can be used for the fluorophotometric determination of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS) .

HY-155718

*fac-[Re(CO)3(L6)(H2O)][NO3]*	Apoptosis	Cancer
fac-[Re(CO)3(L6)(H2O)][NO3] (compound 6), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L6)(H2O)][NO3] is cytotoxic to prostate cancer cells, IC₅₀=50 nM (PC-3 cells). fac-[Re(CO)3(L6)(H2O)][NO3] mainly accumulates in the nucleus, down-regulates ATP production in PC3 cells, and promotes apoptosis. However, fac-[Re(CO)3(L6)(H2O)][NO3] did not induce necrosis, pyrodeath and autophagy .

HY-155719

*fac-[Re(CO)3(L3)(H2O)][NO3]*	Paraptosis	Cancer
fac-[Re(CO)3(L3)(H2O)][NO3] (compound 3), the rhenium(I) tricarbonyl aqua complex, is an anticancer agent associated with mitochondrial dysfunction. fac-[Re(CO)3(L3)(H2O)][NO3] is cytotoxic to prostate cancer cells with IC₅₀=0.32 μM (PC-3 cells). fac-[Re(CO)3(L3)(H2O)][NO3] mainly accumulates in mitochondria, down-regulates ATP production in PC3 cells, and promotes paraptosis. However, fac-[Re(CO)3(L3)(H2O)][NO3] did not induce necrosis, apoptosis and autophagy .

HY-D1065

*NIR-H2O2*	Fluorescent Dye	Inflammation/Immunology
NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor. NIR-H2O2 has both absorption and emission in the NIR region. NIR-H2O2 responds to H₂O₂ with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-H2O2 is capable of imaging endogenously produced H₂O₂ in living cells and mice .

HY-D3000

*NIR-RED ROS-H2O2 Probe*	Fluorescent Dye	Metabolic Disease
NIR-RED ROS-H2O2 Probe is a near-infrared fluorescent probe used for detecting hydrogen peroxide (H₂O₂) and featuring dual-modal fluorescence/photoacoustic imaging capabilities. NIR-RED ROS-H2O2 Probe successfully detects the upregulated fluorescence signal of H₂O₂ in HepG2 cells and a mouse liver injury model. NIR-RED ROS-H2O2 Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI) .

HY-151909S

*Endothall-3,4,4,5,5,6 H2O-d6*	Isotope-Labeled Compounds	Others
Endothall-3,4,4,5,5,6 H2O-d₆ is the deuterium labeled 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid hydrate (HY-W714211).

HY-W101495S

*Boc-Leu-OH·H2O-13C*	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Boc-Leu-OH·H₂O- ¹³C is a ¹³C-labeled Boc-Leu-OH (HY-W101495). Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .

HY-W040074

Glycylglycine hydrochloride hydrate Diglycine hydrochloride hydrate; Gly-Gly (HCl H2O)	Biochemical Assay Reagents	Metabolic Disease
Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) ^[2].

HY-N1318R

Salvigenin (Standard) Psathyrotin (Standard)	Reference Standards Autophagy Apoptosis ROS Kinase	Neurological Disease Inflammation/Immunology Cancer
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis ^[2].

HY-N2190

Hederagenin 28-O-beta-D-glucopyranosyl ester	Others	Cardiovascular Disease Inflammation/Immunology
Hederagenin 28-O-beta-D-glucopyranosyl ester, a triterpenoid saponin isolated from Ilex cornuta, exhibits protective effects against H₂O₂-induced myocardial cell injury .

HY-W073183

Dibenzo-24-crown-8-ether	Biochemical Assay Reagents	Others
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H ²PtCl ⁶·6H ²O and FeCl ²·4H ²O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .

Cat. No.	Product Name	Type

HY-D1458

Peroxyfluor 1	Fluorescent Dye
Peroxyfluor 1 is a cell-permeable probe for H₂O₂. Peroxyfluor 1 represents a first-generation, green-fluorescent probe .

HY-103469

Peroxy Orange 1 3 Publications Verification PO1	Fluorescent Dye
Peroxy Orange 1 (PO1) is a new H₂O₂ specific probe that can bind to green fluorescent highly reactive oxygen species (hROS) probe APF. Peroxy Orange 1 is also a living cell dye ^[2].

HY-15914

DHBS DCHBS	Fluorescent Dye
DHBS (3, 5-dichloro-2-hydroxybenzenesulfonate) is used in conjunction with 4-aminoantipyrine (4-AAP) (HY-W100990) and hydrogen peroxide (H₂O₂) for chromogenic quantitation of peroxidase in coupled enzymatic reactions. Component of Trinder reagent for use with peroxidase to measure generation of hydrogen peroxide in automated systems ^[2] .

HY-129109

NBD-Pen

Fluorescent Dye

NBD-Pen is the first fluorescence probe for lipid radicals with high selectivity and sensitivity (λ_ex: 470 nm, λ_em: 530 nm). NBD-Pen specifically detects lipid derived radicals over other reactive species present in biological systems, including H₂O₂, ClO ^-, O₂ ^-?, and ?OH. NBD-Pen directly detects lipid radicals in living cells by turn-on fluorescence. NBD-Pen decreases inflammation, apoptosis, and oxidative stress markers. NBD-Pen can be studied in various disease models such as hepatic carcinoma .

HY-101859

NucPE1 5 Publications Verification Nuc-H2O2 Probe	Fluorescent Dye
NucPE1 (Nuc-H2O2 Probe) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

HY-D1157

HKPerox-2 5 Publications Verification	Fluorescent Dye
HKPerox-2 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively ^[2].

HY-130022

HKPerox-1 2 Publications Verification	Fluorescent Dye
HKPerox-1 is a highly sensitive green fluorescent probe for the specific detection of H₂O₂ in living cells with a maximum excitation wavelength and emission wavelength of 520 nm and 543 nm, respectively ^[2].

HY-D1693

FBBBE	Fluorescent Dye
FBBBE is used to detect the production of H₂O₂ by cells. FBBBE can be triggered by intracellular H₂O₂ and converted to fluorescein, resulting in an increase in intracellular fluorescence (Ex=4480 nm, Em=512 nm) .

HY-W927359

Fluorescein hydrazide (3,6-Dihydroxyxanthane)	Fluorescent Dye
Fluorescein hydrazide (3,6-Dihydroxyxanthane) is a fluorescein dye that can be used for the fluorophotometric determination of hydrogen peroxide (H2O2) and other reactive oxygen species (ROS) .

HY-D2965

SNAP-Peroxy-Green-1 SPG1	Fluorescent Dye
SNAP-Peroxy-Green-1 (SPG1) a SNAP tag fluorescent probe. SNAP-Peroxy-Green-1 can be used for detecting H₂O₂ in the extracellular space or on the surface of the cell membrane .

HY-D1065

*NIR-H2O2*	Fluorescent Dye
NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor. NIR-H2O2 has both absorption and emission in the NIR region. NIR-H2O2 responds to H₂O₂ with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-H2O2 is capable of imaging endogenously produced H₂O₂ in living cells and mice .

HY-D3000

NIR-RED ROS-H2O2 Probe

Fluorescent Dye

NIR-RED ROS-H2O2 Probe is a near-infrared fluorescent probe used for detecting hydrogen peroxide (H₂O₂) and featuring dual-modal fluorescence/photoacoustic imaging capabilities. NIR-RED ROS-H2O2 Probe successfully detects the upregulated fluorescence signal of H₂O₂ in HepG2 cells and a mouse liver injury model. NIR-RED ROS-H2O2 Probe can be used as a biomarker detection tool for drug-induced liver injury (DILI) .

HY-15923

MAOS	Fluorescent Dye
MAOS is a modified Trinder’s reagent that can be used as a chromogenic probe for the determination of *H₂O₂*. MAOS is strongly dependent on the pH of the reaction medium .

HY-D2964

NBzF-BG

Fluorescent Dye

NBzF-BG is a novel H₂O₂-specific fluorescent probe. NBzF-BG shows visible absorption centered at 505 nm and weak fluorescence with an emission maximum at 525 nm. NBzF-BG is covalently and selectively conjugated with the SNAP-tag protein, leading to formation of the fluorophore-protein conjugate (SNAP-NBzF). SNAP-NBzF rapidly reacts with H₂O₂ and thereby shows an enhancement in fluorescence .

HY-101859R

NucPE1 (Standard) Nuc-H2O2 Probe (Standard)	Fluorescent Dye
NucPE1 (Standard) (Nuc-H2O2 Probe (Standard)) is the analytical standard of NucPE1 (HY-101859). This product is intended for research and analytical applications. NucPE1 (Nuc-H2O2 Probe) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties.

HY-D2963

R-MA-SLM

Fluorescent Dye

R-MA-SLM is an Aβ-targeted and blood-brain barrier-permeable ratiometric H₂O₂-responsive fluorescent probe. When excited at 490 nm, the fluorescence intensity of the R-MA-SLM gradually decreases at 574 nm, while the emission intensity gradually increases at 661 nm. R-MA-SLM can detect and exhibits a ratiometric response to Aβ-induced endogenous H₂O₂. R-MA-SLM can be used in the research of Alzheimer's disease .

HY-D3169

IETDC	Fluorescent Dye
IETDC is a caspase 8 probe substrate. IETDC is cleaved by activated caspase 8 to release D-cysteine. The D-cysteine released by IETDC binds to HCBT to generate firefly luciferin in situ, accompanied by a bioluminescent signal produced by H₂O₂-mediated release of 6-hydroxy-2-cyanobenzothiazole. IETDC is applicable to studies related to acute inflammation .

HY-D3143

QM-B-CF	Fluorescent Dye
QM-B-CF is a sequential dual-lock chemiluminescent/fluorescent dual-mode probe designed for the specific detection of H₂O₂, and it can produce enhanced chemiluminescence upon photoirradiation. QM-B-CF generates chemiluminescent signals only under the conditions of H₂O₂ and light exposure in vitro, in cancer cells, and in tumor-bearing nude mice (Ex/Em = 514 nm/600 nm) .

HY-D3139

Pinkment-OAc	Fluorescent Dye
Pinkment-OAc is an AND logic gate-based dual-analyte-dependent fluorescence inducer (Ex/Em = 545 nm/590 nm) that can be used for the simultaneous detection of hydrogen peroxide (H₂O₂) and esterases (e.g., porcine liver esterase PLE). Pinkment-OAc triggers a fluorescent response only when both esterase and hydrogen peroxide are present .

Cat. No.	Product Name	Type

HY-76440

3-Oxetanone

Oxetan-3-one

Biochemical Assay Reagents

3-Oxetanone (Oxetan-3-one) is a four-membered cyclic ketone and strained cyclic ether derivative with measurable molecular g-value, magnetic susceptibility anisotropy and molecular quadrupole moment. 3-Oxetanone acts not only as a hydrogen bond acceptor, a tetrel donor and a weak hydrogen bond acceptor, but also forms a classic O-H···O hydrogen bond with H₂O via the ether oxygen atom. Alternatively, it forms a C···O tetrel bond with formaldehyde using its carbonyl group as a tetrel donor, while acting as a proton acceptor to form a C-H···O weak hydrogen bond with formaldehyde. 3-Oxetanone can be used to prepare various oxetanes ^[2].

HY-15933

TOPS 1 Publications Verification	Biochemical Assay Reagents
TOPS is a chromogenic substrate. TOPS undergoes an oxidative coupling reaction with 4-aminoantipyrine in the presence of H₂O₂ and nanocrystalline cobalt selenide. TOPS is used in studies related to uric acid detection .

HY-Y1885

Tetrasodium pyrophosphate

Biochemical Assay Reagents

Tetrasodium pyrophosphate is a chelating that can bind calcium and help improve olfaction. Tetrasodium pyrophosphate is an antimicrobial agent that can reduce microbial colonization. Tetrasodium pyrophosphate blocks IPP translocation, enhances astaxanthin, phenol, flavonoid, and H₂O₂ levels, activates PAL and DPPH scavenging activity. Tetrasodium pyrophosphate can be used for the research of alleviating symptoms post COVID-19 ^[2] .

HY-15929

TBHBA

1 Publications Verification

2,4,6-Tribromo-3-hydroxybenzoic acid

Biochemical Assay Reagents

TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a chemical colorimetric agent and nanomaterial surface modifier. TBHBA can react with some oxidants (such as H₂O₂) to generate high-absorbance quinoneimine dyes, which enhance the sensitivity of HDL cholesterol enzymatic determination. TBHBA can be used as a bromine-containing coupling agent to modify the surface of silica nanoparticles through esterification reaction. Thereby, organic flame retardant groups are introduced to improve the thermal stability and flame retardant properties of nanocomposites. TBHBA can be used in clinical biochemical testing (such as serum lipoprotein analysis) and the preparation of flame-retardant polymer nanocomposites ^[2].

HY-W250172

Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O)

Biochemical Assay Reagents

Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) is a nonionic surfactant commonly used in a variety of industrial and research applications. Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) belongs to the family of polyethylene glycol (PEG) ethers with a hydrophilic head and lipophilic tail and is suitable for use in emulsions, detergents and solubilizers. Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) is particularly useful in the study of membrane proteins, where it is used to solubilize and stabilize proteins for structural analysis techniques. It is also used in a variety of other applications, including drug delivery systems, nanotechnology, and diagnostic analysis. Additionally, Polyethylene glycol tert-octylphenyl ether X-405 (70% in H2O) is used in the production of microemulsions, salves and lotions due to its emulsifying and solubilizing properties. However, it can be toxic if ingested or inhaled, so proper handling and safety precautions are required.

HY-W423191

Maltobionic acid

4-O-α-D-Glucopyranosyl-D-gluconic acid

Biochemical Assay Reagents

Maltobionic acid (4-O-α-D-Glucopyranosyl-D-gluconic acid) is an orally active oligosaccharide and iron chelator with antibacterial activity. Maltobionic acid inhibits the expression of NFATc1, suppresses osteoclast differentiation, inhibits bone resorption, and increases serum calcitonin levels. Maltobionic acid protects mammalian cells from hydrogen peroxide (H₂O₂)-induced oxidative damage; resists fermentation by the gut microbiota; and exhibits anti-digestive and anti-fermentative properties. Maltobionic acid can be used in research related to osteoporosis, bacterial infections, and constipation ^[2] .

HY-N2024B

Maltose solution, 20% in H2O

Biochemical Assay Reagents

Maltose solution, 20% in H₂O is a 20% aqueous maltose solution. Maltose is a disaccharide composed of two glucose molecules linked together. Maltose is an endogenous metabolic product in plants, yeast, or bacteria, and it participates in carbon source storage and metabolism. Maltose is a key core metabolite and main transport form in the temporary starch degradation, carbon output, and subsequent sucrose synthesis metabolism of the night chloroplast. In X. dendrorhous, maltose can act as a sugar donor and is converted into isomaltulose by α-glucosidase. Maltose can act as a osmotic agent, supporting continuous capillary ultrafiltration and preventing severe metabolic disorders ^[2] .

HY-W000923

(4-Boc-aminophenyl)boronic acid	Biochemical Assay Reagents
(4-Boc-aminophenyl) boronic acid is an arylboronic acid. As a substrate in H₂O, (4-Boc-aminophenyl) boronic acid participates in the CuO-catalyzed three-component reaction with α-ketoaldehydes and 1,3-dicarbonyl compounds to produce 1,4-diketone products .

HY-155743A

ddUTP lithium, 100 mM in H2O 2',3'-Dideoxyuridine-5'-triphosphate lithium	Biochemical Assay Reagents
ddUTP (lithium), 100 mM in H₂O is a nucleotide analog that can be incorporated into DNA, RNA, or other nucleic acids. ddUTP (lithium), 100 mM in H₂O can be used to prepare DNA/RNA hybridization experiments, such as Southern blots and Northern blots.

HY-157881

*2-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O)* β-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O)	Biochemical Assay Reagents
2-Mercaptoethanesulfonic acid (ampule,3.0M±0.1M in H2O) is a biochemical reagent that can be used for protein sequence analysis .

HY-W075791

Copper(II) perchlorate hexahydrate	Biochemical Assay Reagents
Copper(II) perchlorate hexahydrate is an inorganic compound with the chemical formula Cu(ClO₄) ₂ (H₂O) ₆ and can be used as a catalyst in certain reaction .

HY-W040074

Glycylglycine hydrochloride hydrate

Diglycine hydrochloride hydrate; Gly-Gly (HCl H2O)

Biochemical Assay Reagents

Glycylglycine hydrochloride hydrate is a non-selective Glycylglycine hydrochloride hydrate dipeptidase substrate and iNOS inhibitor. Glycylglycine hydrochloride hydrate can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine hydrochloride hydrate promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine hydrochloride hydrate can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) ^[2].

HY-W073183

Dibenzo-24-crown-8-ether	Biochemical Assay Reagents
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H ²PtCl ⁶·6H ²O and FeCl ²·4H ²O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .

Cat. No.	Product Name	Target	Research Area

HY-P5883

TAT-M2NX tatM2NX	TRP Channel	Cardiovascular Disease Neurological Disease
TAT-M2NX (tatM2NX) is a selective inhibitor targeting human *TRPM2* channels and exerts inhibitory effects on ischemic stroke. TAT-M2NX reduces H₂O₂-induced calcium influx via TRPM2 channels. After traumatic brain injury in mice, TAT-M2NX preserves hippocampal long-term potentiation, improves memory function, and reduces infarct volume after middle cerebral artery occlusion, but it shows no effect on female mice. TAT-M2NX can be used in studies related to traumatic brain injury and ischemic stroke ^[2].

HY-P5247

Palmitoyl tetrapeptide-20 PTP20	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce *H₂O₂* accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 can be used in research on preventing hair loss and improving hair graying .

HY-W013322

Ac-Tyr-OEt.H2O	Amino Acid Derivatives	Others
Ac-Tyr-OEt.H2O is a tyrosine derivative .

HY-P10400

AtPep1	Phytohormone	Inflammation/Immunology
AtPep1 is a plant elicitor peptide. AtPep1 activates transcription of the defensive gene defensin (PDF1.2) and activates the synthesis of H₂O₂, which are components of the innate immune response against pathogens. AtPep1 can be isolated from extracts of Arabidopsis leaves ^[2].

HY-P5247A

Palmitoyl tetrapeptide-20 TFA PTP20 TFA	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce *H₂O₂* accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying .

HY-P10400A

AtPep1 TFA	Phytohormone	Infection
AtPep1 TFA is an endogenous inducer of innate immune responses. AtPep1 TFA can be isolated from Arabidopsis thaliana leaves. AtPep1 TFA activates the transcription of defensin (PDF1.2), the expression of PROPEP1, the synthesis of hydrogen peroxide (H₂O₂) near leaf veins, and the alkalization of Arabidopsis suspension cell culture medium. AtPep1 TFA induces the expression of genes encoding defensins and PR-1. AtPep1 TFA is applicable to studies related to Pythium irregulare infection and pathogen infection ^[2].

HY-P5318

MDYYFEER	Reactive Oxygen Species (ROS)	Inflammation/Immunology
MDYYFEER is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MDYYFEER has high DPPH and ABTS radical scavenging ability. MDYYFEER protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5317

MAQAAEYYR	Reactive Oxygen Species (ROS)	Inflammation/Immunology
MAQAAEYYR is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MAQAAEYYR has high DPPH, ABTS radical and ROS-scavenging ability. MAQAAEYYR protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5316A

MHLWAAK TFA	Peptides	Inflammation/Immunology
MHLWAAK TFA is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MHLWAAK TFA has high DPPH and ABTS radical scavenging ability. MHLWAAK TFA protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5318A

MDYYFEER TFA	Peptides	Inflammation/Immunology
MDYYFEER TFA is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MDYYFEER TFA has high DPPH and ABTS radical scavenging ability. MDYYFEER TFA protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5317A

MAQAAEYYR TFA	Reactive Oxygen Species (ROS)	Inflammation/Immunology
MAQAAEYYR TFA is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MAQAAEYYR TFA has high DPPH, ABTS radical and ROS-scavenging ability. MAQAAEYYR TFA protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-P5316

MHLWAAK	Peptides	Inflammation/Immunology
MHLWAAK is an antioxidant active peptide that can be isolated from pancreatin hydrolysate of C-phycocyanin. MHLWAAK has high DPPH and ABTS radical scavenging ability. MHLWAAK protects zebrafish larvae from H₂O₂-induced oxidative damage .

HY-D3169

IETDC	Fluorescent Dye Caspase	Inflammation/Immunology
IETDC is a caspase 8 probe substrate. IETDC is cleaved by activated caspase 8 to release D-cysteine. The D-cysteine released by IETDC binds to HCBT to generate firefly luciferin in situ, accompanied by a bioluminescent signal produced by H₂O₂-mediated release of 6-hydroxy-2-cyanobenzothiazole. IETDC is applicable to studies related to acute inflammation .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9930

Evolocumab 3 Publications Verification AMG 145	NF-κB Ser/Thr Protease Toll-like Receptor (TLR)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H₂O₂-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation ^[2] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1776

Spermidine Maximum Cited Publications 19 Publications Verification	Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-N0115

Gastrodin 15+ Cited Publications Gastrodine	Natural Products Gastrodia elata Bl. Neurological Disease Classification of Application Fields Anti-aging Orchidaceae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Ferroptosis
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin inhibits ethanol-induced hepatocellular apoptosis. Gastrodin inhibits H₂O₂-induced ferroptosis through its antioxidative effect. Gastrodin can be used for study of dizziness, epilepsy, stroke and dementia ^[2] .

HY-N0540

Cynaroside 10+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants Disease Research Fields	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-B1776A

Spermidine hydrochloride Maximum Cited Publications 19 Publications Verification	Natural Products other families Animals Classification of Application Fields Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-N2410

N-trans-Feruloyltyramine N-feruloyltyramine; Moupinamide	Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Piperaceae Plants Inflammation/Immunology Disease Research Fields Piper nigrum Linn. Source Classification	Reactive Oxygen Species (ROS) Apoptosis
N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H₂O₂-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research ^[2].

HY-N0515

Ophiopogonin D 1 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Cardiovascular Disease Liliaceae Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK
Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases ^[2] .

HY-N1318

Salvigenin 5+ Cited Publications Psathyrotin	Monophenols Flavonoids other families Neurological Disease Classification of Application Fields Flavones Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H₂O₂-induced cell apoptosis ^[2].

HY-W014423

L-Histidine hydrochloride hydrate 3 Publications Verification H-His-OH.HCl.H2O	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable ^[2] .

HY-N0615

Notoginsenoside R1 2 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Triterpenes Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Araliaceae Source Classification	Amyloid-β Apoptosis
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells ^[2] .

HY-N2736

3′,4′,7-Trihydroxyflavone 1 Publications Verification	Flavonoids Classification of Application Fields Flavones Leguminosae Other Diseases Phenols Polyphenols Plants Vicia faba L. Disease Research Fields Source Classification	Beta-lactamase COX Interleukin Related Bacterial JNK ERK p38 MAPK STAT Apoptosis NO Synthase Nuclear Factor of activated T Cells (NFAT) Lactate Dehydrogenase Reactive Oxygen Species (ROS) SOD Akt Caspase Bcl-2 Family
3′,4′,7-Trihydroxyflavone is an orally active inhibitor of OXA-48 (IC₅₀ = 1.89 μM) and COX-1 (IC₅₀ = 36.37 μM). 3′,4′,7-Trihydroxyflavone exhibits antioxidant and anti-inflammatory properties, inhibiting the release of inflammatory cytokines such as IL-6, IL-8, and TNF-α. 3′,4′,7-Trihydroxyflavone inhibits H₂O₂-induced neuronal apoptosis and ROS accumulation, and exerts anti-neuroinflammatory effects by suppressing the JNK-STAT1 pathway. 3′,4′,7-Trihydroxyflavone exhibits antimicrobial and antibiotic-modifying activities against multidrug-resistant Gram-negative enteric bacteria. 3′,4′,7-Trihydroxyflavone inhibits RANKL-induced osteoclast formation via NFATc1. 3′,4′,7-Trihydroxyflavone activates the CREB-BDNF axis and restores scopolamine (HY-N0296)-induced memory deficits in mice ^[2] .

HY-B1776R

Spermidine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Spermidine (Standard) is the analytical standard of Spermidine. This product is intended for research and analytical applications. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-N2565

Rosamultin 1 Publications Verification	Infection Triterpenes Classification of Application Fields Terpenoids Rosaceae Potentilla anserina Linn. Plants Disease Research Fields Source Classification	HIV Protease Apoptosis
Rosamultin is a 19 α-hydroxyursane-type triterpenoid isolated from Potentilla anserina?L. Rosamultin has inhibitory effects against HIV-1 protease . Rosamultin has the potential for treating H₂O₂-induced oxidative stress injury through its antioxidant and antiapoptosis effects ^[2].

HY-N0501

11-oxo-mogroside V 1 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Source Classification Food Research	Reactive Oxygen Species (ROS)
11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O₂ ^-, *H₂O₂* and OH) with EC₅₀* of 4.79, 16.52, and 146.17 μg/mL, respectively.

HY-107858

Veratryl alcohol 1 Publications Verification 3,4-Dimethoxybenzyl alcohol	Natural Products Microorganisms Classification of Application Fields Other Diseases Disease Research Fields	Endogenous Metabolite Bacterial
Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H₂O₂ and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy ^[2] .

HY-N3558

Ceanothic acid Emmolic acid	Other Terpenoids Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Bacterial
Ceanothic acid (Emmolic acid) is an orally active pentacyclic triterpenoid. Ceanothic acid inhibits the growth of various oral bacteria, including Streptococcus mutans, Actinomyces viscosus, Porphyromonas gingivalis, and Prevotella intermedia. Ceanothic acid scavenges DPPH and H₂O₂ free radicals. Ceanothic acid inhibits acetic acid (HY-Y0319)-induced writhing response, xylene-induced ear swelling, and carrageenan-induced paw swelling in mice. Ceanothic acid can be used in research related to oral bacterial infections, ovarian cancer, liver cancer, and liver injury ^[2].

HY-N1677

2,6-Dimethoxy-1,4-benzoquinone	Infection Quinones other families Classification of Application Fields Metabolic Disease Benzene Quinones Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Akt mTOR Bacterial Fungal AMPK
2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1 activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H₂O₂ generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness ^[2] .

HY-N7880

Salvianolic acid Y	Classification of Application Fields Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS)
Salvianolic acid Y is a phenolic acid with the same planar structure as Salvianolic acid B. Salvianolic acid Y rescues cell injury by H₂O₂ .

HY-126061

1,7-Dimethyluric acid	Structural Classification Natural Products Human Gut Microbiota Metabolites Immune System Disorder Neurological Disease Classification of Application Fields Disease markers Endogenous metabolite Disease Research Fields Source Classification	Biochemical Assay Reagents Drug Metabolite
1,7-Dimethyluric acid is an N-methylated uric acid and purine derivative, as well as a caffeine metabolite. When 1,7-Dimethyluric acid is acted upon by peroxidase in the presence of H₂O₂, it follows the same oxidation pathway to generate a UV-absorbing intermediate, which decays via first-order kinetics. 1,7-Dimethyluric acid can adsorb onto pyrolytic graphite electrodes, but not onto glassy carbon electrodes or platinum electrodes. The N-methylation modification of its pyrimidine ring prevents ring contraction of the diol intermediate, and no NMR evidence of O-alkylation is observed during propylation under the test conditions ^[2] .

HY-N5021

Anhydrosafflor yellow B AHSYB	Quinones Simple Phenylpropanols Carthamus tinctorius L. Phenols Polyphenols Benzene Quinones Phenylpropanoids Plants Compositae Source Classification	Others
Anhydrosafflor yellow B (AHSYB) is a quinochalcone C-glycoside isolated from Carthamus tinctorius. Anhydrosafflor yellow B inhibits ADP-induced platelet aggregation, exhibits significant anti-oxidative effects in vitro, and possesses certain activity against H₂O₂-induced cytotoxicity in cultured PC12 cells and primary neuronal cells .

HY-125919

Vulpinic acid	Plants Endogenous metabolite Source Classification	Reactive Oxygen Species (ROS) Bacterial Endogenous Metabolite
Vulpinic acid, a lichen metabolite, decreases H₂O₂-induced ROS production, oxidative stress and oxidative stress-related damages in human umbilical vein endothelial cells (HUVEC). Vulpinic acid is active against staphylococci, enterococci, and anaerobic bacteria.Vulpinic acid has the potential for atherosclerosis research ^[2].

HY-N2627

Isorhamnetin 3-O-robinobioside	Structural Classification Flavonols Flavonoids Cactaceae Opuntia ficus-indica (L.) Mill. Plants Source Classification	Others
Isorhamnetin 3-O-robinobioside is a flavonoid compound. Isorhamnetin shows a protective effect against lipid peroxidation induced by H₂O₂. Isorhamnetin 3-O-robinobioside also inhibits the genotoxicity induced by hydroxyl radicals .

HY-N7697E

Chitotriose trihydrochloride	Polysaccharides Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Others
Chitotriose trihydrochloride is an orally active chitooligosaccharide with antioxidant activities. Chitotriose trihydrochloride inhibits hydroxylation of benzoate to salicylate by H₂O₂ in the presence of Cu ²⁺ (IC₅₀ value of 80 μM) .

HY-N0540R

Cynaroside (Standard) 10+ Cited Publications Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Structural Classification Flavonoids Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal Reference Standards
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-N3287

Methyl 3-hydroxy-4,5-dimethoxybenzoate	Infection Monophenols Classification of Application Fields Phenols Euphorbiaceae Plants Macaranga sinensis (Baill.) Muell. Arg. Disease Research Fields Source Classification	Bacterial Fungal Reactive Oxygen Species (ROS)
Methyl 3-hydroxy-4,5-dimethoxybenzoate is a gallic acid derivant that can be isolated from myricaria Laxiflora. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows obvious antimicrobial activities. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows fairly active for oxidation resistance in the presence of H₂O₂ .

HY-N0515R

Ophiopogonin D (Standard)	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Steroids Source Classification	Reference Standards PPAR NF-κB Calcium Channel ERK Reactive Oxygen Species (ROS)
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases ^[2] .

HY-101193R

Zinc Protoporphyrin (Standard) Zn(II)-protoporphyrin IX (Standard); ZnPP (Standard); Zinc Protoporphyrin-9 (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) Endogenous Metabolite Apoptosis
Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 . Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration ^[2]. Zinc Protoporphyrin has anti-cancer activity .

HY-N15756

N-Demethylsinomenine	Alkaloids Other Alkaloids Plants Menispermaceae Source Classification	Reactive Oxygen Species (ROS)
N-Demethylsinomenine is a morphinane alkaloid that can be isolated from Sinomenium acutum. N-Demethylsinomenine has a protective effect against H₂O₂-induced cell injury. N-Demethylsinomenine can be used in the research of diseases such as Alzheimer's disease .

HY-N2442

Methylophiopogonone B	Natural Products other families Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
Methylophiopogonone B, a homoisoflavonoidal compound that could be isolated from Ophiopogonis Tiber, could scavenge •OH and H₂O₂ in vitro to a certain extent ^[2].

HY-N8788

Baicalein 7-O-β-D-ethylglucuronide	Flavonoids Flavones Labiatae Plants Medicago truncatula Gaertn. Source Classification	Others
Baicalein 7-O-β-D-ethylglucuronide is a natural flavone glycoside that can be extracted from Scutellaria baicalensis Georgi. Baicalein 7-O-β-D-ethylglucuronide has antioxidant activity. Baicalein 7-O-β-D-ethylglucuronide inhibits FeSO₄-Cys-induced lipid peroxidation of liver homogenate. Baicalein 7-O-β-D-ethylglucuronide also shows strong cytoprotective effect on H₂O₂-induced oxidative damage of human umbilical vein endothelial cells ^[2].

HY-N2203A

Vitexin2''-O-p-trans-coumarate	Flavonoids Flavones Leguminosae Plants Trigonella foenum-graecum Linn. Source Classification	Others
Vitexin2''-O-p-trans-coumarate is a flavonoid, can be isolated from the Et acetate-soluble fraction of the ethanolic extract of the seeds of Trigonella foenum-graecum. Vitexin2''-O-p-trans-coumarate strongly promotes 2BS cell proliferation induced by H₂O₂ .

HY-N1318R

Salvigenin (Standard) Psathyrotin (Standard)	Structural Classification Monophenols Flavonoids other families Flavones Phenols Plants Source Classification	Reference Standards Autophagy Apoptosis ROS Kinase
Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties. Salvigenin inhibits H2O2-induced cell apoptosis ^[2].

HY-N2190

Hederagenin 28-O-beta-D-glucopyranosyl ester	Cardiovascular Disease Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification	Others
Hederagenin 28-O-beta-D-glucopyranosyl ester, a triterpenoid saponin isolated from Ilex cornuta, exhibits protective effects against H₂O₂-induced myocardial cell injury .

HY-N15711

Ganoleucoin R	Triterpenes Microorganisms Terpenoids Source Classification	Reactive Oxygen Species (ROS)
Ganoleucoin R is a triterpenoid compound that can be isolated from Ganoderma leucocontextum. Ganoleucoin R exerts a protective effect against H₂O₂-induced oxidative damage and can promote neurite outgrowth in PC12 cells. Ganoleucoin R possesses neuroprotective and neurogenic activities, and can be used in the research of neurodegenerative diseases .

HY-N2410R

N-trans-Feruloyltyramine (Standard) N-feruloyltyramine (Standard); Moupinamide (Standard)	Alkaloids Structural Classification Other Alkaloids Phenols Polyphenols Piperaceae Plants Piper nigrum Linn. Source Classification	Reference Standards Reactive Oxygen Species (ROS) Apoptosis
N-trans-Feruloyltyramine (Standard) is the analytical standard of N-trans-Feruloyltyramine. This product is intended for research and analytical applications. N-trans-Feruloyltyramine (N-feruloyltyramine), an alkaloid, is a potent antioxidant. N-trans-Feruloyltyramine improves H2O2-induced intracellular ROS generation and decreases apoptosis. N-trans-Feruloyltyramine has the potential for oxidative stress-related neurodegenerative conditions and cancer research ^[2].

HY-N3117

Paeonilactone B (+)-Paeonilactone B	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Plants Paeoniaceae Source Classification	Others
Paeonilactone B is a monoterpene with neuroprotective effect against oxidative stress. Paeonilactone B protects rat cortical cells against H₂O₂-induced neurotoxicity .

HY-N5045

Jionoside A1	Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Scrophulariaceae Phenylpropanoids Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Disease Research Fields Inflammation/Immunology Source Classification	Others
Jionoside A1 isolated from Radix Rehmanniae Praeparata displays dose dependent immune-enhancement activity and possesses moderate protective activities on H₂O₂-treated SH-SY5Y cells .

HY-W014423R

L-Histidine hydrochloride hydrate (Standard) H-His-OH.HCl.H2O (Standard)	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Apoptosis Reactive Oxygen Species (ROS) Endogenous Metabolite
L-Histidine hydrochloride hydrate (Standard) is the analytical standard of L-Histidine hydrochloride hydrate (HY-W014423). This product is intended for research and analytical applications. L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable ^[2] .

HY-121174

Alaternin Catharticin	Flavonoids Plants Rhamnaceae Rhamnus saxatilis X. H. Song Source Classification	NO Synthase CDK Tyrosinase Reactive Oxygen Species (ROS)
Alaternin (Catharticin) is an anthraquinone compound with antioxidant and hepatoprotective activities. Alaternin has an inhibitory activity against hydroxyl radicals generated in a cell-free chemical system (FeSO₄/H₂O₂) with an IC₅₀ value of 3.05 μM. Alaternin exhibits hepatoprotective activity against Tacrine (HY-111338)-induced toxicity in human hepatic HepG2 cells with an EC₅₀ value of 4.02 μM .

HY-N13174

Peanut procyanidin A	Arachis hypogaea L. Leguminosae Phenols Polyphenols Plants Source Classification	Reactive Oxygen Species (ROS) Apoptosis
Peanut procyanidin A is a type of A-type procyanidin that can be extracted from peanut skins. Peanut procyanidin A can protect prostate DU145 cells from *H₂O₂*-induced oxidative stress damage through the MAPKs signaling pathway, alleviate cell cycle arrest, and reduce cell apoptosis. Peanut procyanidin A can also regulate gut microbiota and metabolism in mice with DSS (HY-116282)-induced ulcerative colitis ^[2].

HY-N10277

Inubritannolide A	Natural Products other families Plants Source Classification	Others
Inubritannolide A displays slight strong neuroprotective potency against different types of neuronal cells mediated by various inducers including H₂O₂, 6-hydroxydopamine (6-OHDA), and lipopolysaccharide (LPS).

HY-N0615R

Notoginsenoside R1 (Standard) Sanchinoside R1 (Standard); Sanqi glucoside R1 (Standard)	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Terpenoids Plants Araliaceae Source Classification	Reference Standards Amyloid-β Apoptosis
Notoginsenoside R1 (Standard) is the analytical standard of Notoginsenoside R1. This product is intended for research and analytical applications. Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells ^[2] .

HY-N2203

Vitexin2''-O-p-coumarate	Flavonoids other families Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Others
Vitexin2''-O-p-coumarate is isolated from fenugreek seeds. Vitexin2''-O-p-coumarate strongly promotes 2BS cell proliferation induced by H₂O₂ ^[2].

HY-N6595

Lucidone A	Structural Classification Human Gut Microbiota Metabolites Microorganisms Terpenoids Diterpenoids Endogenous metabolite Source Classification	Others
Lucidone A is a lanostanoid isolated from the fruiting bodies of G. resinaceum. lucidone A showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC) .

HY-B1776AR

Spermidine hydrochloride (Standard)	Structural Classification Natural Products other families Animals Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Spermidine (hydrochloride) (Standard) is the analytical standard of Spermidine (hydrochloride). This product is intended for research and analytical applications. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-N0025

Jionoside D	Phenols Polyphenols Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Source Classification	Reactive Oxygen Species (ROS) Apoptosis
Jionoside D is a hydroxycinnamic acid ester with antioxidant property. Jionoside D has scavenging activity of intracellular reactive oxygen species (ROS) and of DPPH radical, and lipid peroxidation inhibitory activity. Jionoside D reduces the apoptotic cells induced by H₂O₂ in V79-4 cells. Jionoside D increases the activities of cellular antioxidant enzymes, SOD and catalase ^[2].

HY-N0501R

11-oxo-mogroside V (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Source Classification	Reference Standards Reactive Oxygen Species (ROS)
11-oxo-mogroside V (Standard) is the analytical standard of 11-oxo-mogroside V. This product is intended for research and analytical applications. 11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O2-, H2O2 and OH) with EC₅₀* of 4.79, 16.52, and 146.17 μg/mL, respectively.

HY-N15536

N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside	Piperaceae Piper crocatum Ruiz & Pav. Plants Saccharides Monosaccharides Source Classification	Reactive Oxygen Species (ROS)
N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside is a phenolic amide glycoside compound found in Suaeda japonica. N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside exhibits antioxidant activity, capable of effectively scavenging DPPH free radicals and reducing the production of ROS induced by H₂O₂ in cells, thus protecting cells from oxidative stress damage. N-trans-Feruloyltyramine 4′-O-β-D-glucopyranoside is promising for research of cardiovascular diseases and neurodegenerative diseases .

HY-N1677R

2,6-Dimethoxy-1,4-benzoquinone (Standard)	Quinones other families Benzene Quinones Plants Endogenous metabolite Source Classification	Reference Standards Akt mTOR Bacterial Fungal AMPK
2,6-Dimethoxy-1,4-benzoquinone (Standard) is the analytical standard of 2,6-Dimethoxy-1,4-benzoquinone (HY-N1677). This product is intended for research and analytical applications. 2,6-Dimethoxy-1,4-benzoquinone is a 1,4-benzoquinone derivative. 2,6-Dimethoxy-1,4-benzoquinone promotes phosphorylation of AKT, S6K, mTOR, 4E-BP1, and AMPK, and attenuates mTORC1 activity as part of the AKT/mTOR pathway. 2,6-Dimethoxy-1,4-benzoquinone stimulates myoblast differentiation, increases myotube size, elevates MHC protein expression, enhances mitochondrial biogenesis, respiration, and DNA content, and increases skeletal muscle weights, fiber size, grip strength, and treadmill performance. 2,6-Dimethoxy-1,4-benzoquinone exerts anti-cancer, anti-inflammatory, anti-adipogenic, antibacterial, and antimutagenic effects, inhibits adipogenic transcription factors, nitric oxide production, skin tumor development, Magnaporthe oryzae growth, spore germination, appressorium formation, and growth of select bacterial species, induces H2O2 generation and rice defense gene expression, and reduces rice blast lesion formation. 2,6-Dimethoxy-1,4-benzoquinone can be used for the research of obesity, skin tumorigenesis, rice blast disease, and food-borne illness.

HY-N17964

Congmuyenoside I	Structural Classification Terpenoids Aralia elata (Miq.) Seem. Plants Pentacyclic Triterpenoids Araliaceae Source Classification	Others
Congmuyenoside I is a triterpenoid saponin. Congmuyenoside I mediates neuroprotective effects against H₂O₂-induced cellular damage. Congmuyenoside I can be used in the research of neurodegenerative diseases .

HY-N17611

5,6,7-Trihydroxy-4'-methoxyflavone 4'-O-Methylscutellarein	Structural Classification Flavonoids Flavones Labiatae Plants Medicago truncatula Gaertn. Source Classification	Xanthine Oxidase
5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC₅₀ value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H₂O₂-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders ^[2].

Cat. No.	Product Name	Chemical Structure

HY-B1776AS1

Spermidine-13C4 hydrochloride 1 Publications Verification
Spermidine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-B1776S

Spermidine-d6 1 Publications Verification
Spermidine-d₆ is the deuterium labeled Spermidine . Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents ^[2].

HY-B1776AS

Spermidine-d8 hydrochloride
Spermidine-d₈ (hydrochloride)e is the deuterium labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-W101495S3

*Boc-Leu-OH·H2O-d7*
Boc-Leu-OH·H2O-d₇ is the deuterium labeled Boc-Leu-OH·H2O.

HY-W101495S2

*Boc-Leu-OH·H2O-d10*
Boc-Leu-OH·H2O-d₁₀ is the deuterium labeled Boc-Leu-OH·H2O .

HY-W101495S1

*Boc-Leu-OH·H2O-d3*
Boc-Leu-OH·H2O-d₃ is the deuterium labeled Boc-Leu-OH·H2O .

HY-151909S

*Endothall-3,4,4,5,5,6 H2O-d6*
Endothall-3,4,4,5,5,6 H2O-d₆ is the deuterium labeled 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid hydrate (HY-W714211).

HY-W101495S

*Boc-Leu-OH·H2O-13C*
Boc-Leu-OH·H₂O- ¹³C is a ¹³C-labeled Boc-Leu-OH (HY-W101495). Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is an amino acid derivative with a Boc protecting group, which can be used to synthesize L-prolyl-L-leucyl-glycinamide peptide, a peptide mimetic with dopamine receptor modulatory activity .

HY-W777959

Azasetron Hydrochloride-13C,d3

Azasetron Hydrochloride- ¹³C,d₃ is the deuterium and ¹³C-labeled Azasetron (HY-B0019). Azasetron ((Rac)-SENS-401 free base) is an antiemetic drug with 5-HT3 receptor antagonist activity. Azasetron is often used as a preventive measure for postoperative nausea and vomiting or chemotherapy-induced nausea and vomiting. Azasetron does not impair neutrophil chemotaxis or phagocytosis and does not scavenge O(-)(2) or H(2)O(2) generated by cell-free systems .

HY-W738271

Veratryl alcohol-13C

Veratryl alcohol- ¹³C (3,4-Dimethoxybenzyl alcohol- ¹³C) is the ¹³C-labeled Veratryl alcohol (HY-107858). Veratryl alcohol (3,4-Dimethoxybenzyl alcohol) is a secondary metabolite of lignin-degrading fungi, commonly used as a substrate for lignin peroxidase (LiP) to measure lignin degradation activity. Veratryl alcohol protects LiP from inactivation by H2O2 and prevents the accumulation of LiP III compounds. Veratryl alcohol also acts as a stabilizer for manganese-dependent peroxidases (MnP). Veratryl alcohol is a quorum-sensing inhibitor (QSI) and exhibits antibacterial efficacy ^[2] .

HY-W767399

8-Bromo-2'-deoxyguanosine-13C,15N2

8-Bromo-2'-deoxyguanosine- ¹³C, ¹⁵N2 is the ¹³C- and ¹⁵N-labeled 8-Bromo-2'-deoxyguanosine (HY-W011168). 8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H₂O₂-Cl ^--Br ^- system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation ^[2] .

Cat. No.	Product Name		Classification

HY-148009

Cardiolipin (16:0/18:1/16:0/18:1) sodium 16:0-18:1 Cardiolipin sodium		Phospholipids
Cardiolipin (16:0/18:1/16:0/18:1) (16:0-18:1 Cardiolipin) sodium is a di-saturated mitochondrial-specific anionic phospholipid sodium salt containing the long-chain fatty acid palmitic acid (HY-N0830) and the monounsaturated fatty acid oleic acid (HY-N1446). Cardiolipin (16:0/18:1/16:0/18:1) sodium undergoes in-source fragmentation via diglyceride (DG)-H₂O fragment formation and (DG-H₂O) fragment loss pathways. Cardiolipin (16:0/18:1/16:0/18:1) sodium can be used in the synthesis of lipid nanodiscs for application in in situ mass spectrometry .

HY-W011168

8-Bromo-2'-deoxyguanosine		Nucleoside Analogs Guanosine
8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H₂O₂-Cl ^--Br ^- system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation ^[2] .

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