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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
HCMs
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "HCMs" in MCE Product Catalog:
3
3 Cited Publications
Synonyms: CK-274; CK-3773274
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Research Areas:
Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM) .
1
1 Cited Publications
Synonyms: 1-Methyl-DL-tryptophan; (Rac)-NLG-8189
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(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes .
Cat. No.: HY-128326
CAS No.: 2362525-64-0
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ZAK-IN-1 is an orally active and selective selective leucine-zipper and sterile‑α motif kinase (ZAK) inhibitor with IC50 of 4 nM and KD of 8 nM. ZAK-IN-1 exhibits excellent selectivity against a panel of 403 wild-type kinases. ZAK-IN-1 blocks p38/GATA-4 and JNK/c-Jun signaling and shows promising anti antihypertrophic cardiomyopathy (HCM) efficacy. ZAK-IN-1 can be used for the study of HCM .
Cat. No.: HY-148852
CAS No.: 282536-25-8
PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC50 values of 0.69 μM, 0.37 μM and 0.58 μM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human α, γ and δ polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV) .
Cat. No.: HY-172424
CAS No.: 2417411-02-8
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Delocamten is an orally active, selective Cardiac Myosin inhibitor with an IC50 of approximately 1.11 μM. Delocamten directly modulates myosin complexes, inhibits excessive myocardial contraction, and improves diastolic function. Delocamten can be used in studies of hypertrophic cardiomyopathy (HCM), left ventricular hypertrophy, and diastolic dysfunction .
Cat. No.: HY-176850
CAS No.: 2770280-70-9
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Myosin-IN-2 (Example 16) is a Myosin ATPase inhibitor with a IC50 of 1.06 μM. Myosin-IN-2 can be used for heart diseases like hypertrophic cardiomyopathy (HCM) research .
Cat. No.: HY-114793
CAS No.: 748816-43-5
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AL-12180 is a potent and selective FP-receptor agonist with a Ki of 143 nM. AL-12180 stimulates the mobilization of intracellular Ca 2+ in h-TM and h-CM cells with EC50s of 111 and 11 nM, respectively .
Cat. No.: HY-W759845
Synonyms: CK-274-d3; CK-3773274-d3
Cat. No.: HY-125641A
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AL-34662 (formate) is a 5-HT2 receptor agonist (IC50: 0.8-1.5 nM). AL-34662 (formate) stimulates inositol phosphate turnover and Ca 2+ release in human ciliary muscle cells (h-CM) (E50: 289 nM) and human trabecular meshwork cells (h-TM) (E50: 254 nM). AL-34662 (formate) can be used in studies to lower intraocular pressure (IOP) .
Cat. No.: HY-183588
CAS No.: 2117631-52-2
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HCM-01 is an Excitatory amino acid transporter 2 (EAAT2) activator with oral effectiveness and blood-brain barrier penetration.HCM-01 binds to the allosteric site of EAAT2, increases EAAT2 expression in astrocytes, enhances glutamate-handling capacity, and modulates glutamate homeostasis.HCM-01 acts as an antioxidant, improves oxidative/antioxidative balance and increases total antioxidant capacity. HCM-01 can be used for the research of Alzheimer's disease .
Cat. No.: HY-17681
CAS No.: 2839464-02-5
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Myosin-IN-5 (example 3) is a selective cardiac myosin inhibitor with an IC50 of 1.5 μM. Myosin-IN-5 shows much less effective in inhibiting skeletal myofibril activity (IC50 of 43.4 μM). Myosin-IN-5 can be used for the study of hypertrophic cardiomyopathy (HCM) and cardiac diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
