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IL-6 expression

" in MedChemExpress (MCE) Product Catalog:

246

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1

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7

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9

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4

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69

Natural
Products

16

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1

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2

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1

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-11109
    Resatorvid
    Maximum Cited Publications
    494 Publications Verification

    TAK-242; CLI-095

    		 Toll-like Receptor (TLR) TNF Receptor Interleukin Related Autophagy Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .
    Resatorvid
  • HY-N9965
    2'-Fucosyllactose
    4 Publications Verification

    2'-FL

    		 TNF Receptor Interleukin Related Infection Inflammation/Immunology
    2'-Fucosyllactose (2'-FL) is an oligosaccharide that could be derived from human milk. 2'-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2'-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines .
    2'-Fucosyllactose
  • HY-N0619
    Mulberroside A
    4 Publications Verification

    		 TNF Receptor Interleukin Related Tyrosinase Inflammation/Immunology
    Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC50 of 53.6 μM .
    Mulberroside A
  • HY-15614
    SC144
    5+ Cited Publications

    		 Interleukin Related Apoptosis Cancer
    SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells .
    SC144
  • HY-P99165
    Teprotumumab
    1 Publications Verification

    		 IGF-1R TSH Receptor Endocrinology
    Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research .
    Teprotumumab
  • HY-N0604
    Ginsenoside Rh1
    5 Publications Verification

    Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1

    		 Interleukin Related PPAR TNF Receptor Endogenous Metabolite Inflammation/Immunology
    Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.
    Ginsenoside Rh1
  • HY-114360A
    Taurohyodeoxycholic acid sodium
    2 Publications Verification

    		 Interleukin Related TNF Receptor Inflammation/Immunology
    Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.
    Taurohyodeoxycholic acid sodium
  • HY-B0141S2
    Estradiol-d5

    β-Estradiol-d5; 17β-Estradiol-d5; 17β-Oestradiol-d5

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol-d5 is deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
    Estradiol-d5
  • HY-N6636
    Valencene
    1 Publications Verification

    		 NF-κB Interleukin Related Inflammation/Immunology
    Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model .
    Valencene
  • HY-N1949
    Homoplantaginin
    Maximum Cited Publications
    7 Publications Verification

    		 TNF Receptor NF-κB Inflammation/Immunology
    Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation.
    Homoplantaginin
  • HY-B0141S1
    Estradiol-d4
    2 Publications Verification

    β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol-d4 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
    Estradiol-d4
  • HY-N1356
    Reticuline
    1 Publications Verification

    		 JAK STAT NF-κB Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology
    Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3 . Reticuline exhibits cardiovascular effects .
    Reticuline
  • HY-N0936
    Coixol
    1 Publications Verification

    6-Methoxy-2-benzoxazolinone; 6-MBOA

    		 Others Inflammation/Immunology
    Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-α, IL-6, and IL-1β. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level .
    Coixol
  • HY-N6069
    Raspberry ketone glucoside
    1 Publications Verification

    		 Interleukin Related JAK STAT Inflammation/Immunology
    Raspberry ketone glucoside is a melanogenesis inhibitor. Raspberry ketone glucoside inhibits melanogenesis by activating the IL6/JAK1/STAT3 pathway, inhibiting the transcriptional activity of MITFa, and its downstream expression levels of the TYR and TYRP1a genes. Raspberry ketone glucoside shows remarkable whitening activity on both B16F10 cells in vitro and zebrafish model in vivo .
    Raspberry ketone glucoside
  • HY-129113
    α-​Chaconine

    		COX Inflammation/Immunology
    α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .
    α-​Chaconine
  • HY-B0419
    Manidipine
    3 Publications Verification

    		 Calcium Channel Interleukin Related Cardiovascular Disease Neurological Disease Endocrinology
    Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy .
    Manidipine
  • HY-N2007
    Veratric acid

    3,4-Dimethoxybenzoic acid

    		 COX Reactive Oxygen Species (ROS) Cardiovascular Disease Inflammation/Immunology
    Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities . Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling . Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation .
    Veratric acid
  • HY-N2368
    Arecaidine
    1 Publications Verification

    		 GABA Receptor Interleukin Related TGF-β Receptor TNF Receptor PPAR Neurological Disease
    Arecaidine is a GABA transport system inhibitor. Arecaidine inhibits the proliferation of oral mucosal fibroblasts, increases the secretion of IL-6, TGF-β and TNF-α in cells, downregulates the expression of PPAR-γ and PCK1 in cells, and upregulates the expression of TGF-β1 . Arecaidine inhibits the uptake of γ-aminobutyric acid and β-alanine by the central nervous system of cats . Arecaidine inhibits hPAT1-mediated L-[ 3H]proline uptake in cells. Arecaidine can be used in research related to neurological diseases .
    Arecaidine
  • HY-15614A
    SC144 hydrochloride
    5+ Cited Publications

    		 Interleukin Related Apoptosis Cancer
    SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells .
    SC144 hydrochloride
  • HY-B0141S
    Estradiol-d3

    β-Estradiol-d3; 17β-Estradiol-d3; 17β-Oestradiol-d3

    		 Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol-d3 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.
    Estradiol-d3
  • HY-14837
    Amizon

    Enisamium iodide

    		 Influenza Virus SARS-CoV Infection
    Amizon is an orally effective antiviral and anti-inflammatory agent. Amizon inhibits influenza virus replication and restricts viral RNA synthesis. Amizon reduces the mRNA expression of COX-1, COX-2, NF-κB, TGF1β, IL-1 and IL-6, and stimulates the secretion and mRNA expression of IL-10. Amizon inhibits the oxidative activity of macrophages and possesses antioxidant and free radical-scavenging activities. Amizon is applicable to research related to influenza and acute respiratory viral infections .
    Amizon
  • HY-N0412
    Sesamoside

    		PERK JNK TNF Receptor Interleukin Related Neurological Disease Inflammation/Immunology
    Sesamoside is an orally active anti-inflammatory, anti-hypoxic and analgesic agent. Sesamoside inhibits the phosphorylation of ERK and JNK, downregulates NLRP3 expression, restricts the nuclear localization of P65, regulates AKR1B1 expression, and reduces the expression of TRPV1 gene in the spinal cord. Sesamoside reduces the production of TNF-α, IL-6, IL-1β, iNOS and NO, restores cellular metabolism and organ function, and alleviates cold and mechanical hyperalgesia. Sesamoside can be used in research related to septic shock, high-altitude pulmonary edema and neuropathic pain .
    Sesamoside
  • HY-114869
    DPQ
    3 Publications Verification

    		 PARP Neurological Disease Cancer
    DPQ is a selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD +/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases .
    DPQ
  • HY-N0167
    Gynostemma Extract
    1 Publications Verification

    Ginsenoside C-Mx1; Gypenoside IX

    		 p38 MAPK Akt NF-κB COX Interleukin Related NO Synthase Metabolic Disease Inflammation/Immunology
    Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation .
    Gynostemma Extract
  • HY-N0924
    (±)-Stylopine
    1 Publications Verification

    Tetrahydrocoptisine

    		 Interleukin Related NO Synthase p38 MAPK PERK NF-κB Neurological Disease Inflammation/Immunology
    (±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound. (±)-Stylopine can be isolated from the tubers of the plant Corydalis. (±)-Stylopine inhibits TNF-α, IL-6, and NO production, and attenuates phosphorylation of p38 MAPK, ERK1/2. (±)-Stylopine inhibits NF-κB expression. (±)-Stylopine exhibits anti-inflammatory activity. (±)-Stylopine has protective effects against foot edema, gastric ulcers, anxiety, depression, and acute lung injury .
    (±)-Stylopine
  • HY-P3412
    MMI-0100

    		MAPKAPK2 (MK2) Inflammation/Immunology
    MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .
    MMI-0100
  • HY-N1921
    Edpetiline
    2 Publications Verification

    		 NF-κB p38 MAPK TNF Receptor Reactive Oxygen Species (ROS) COX Interleukin Related Inflammation/Immunology
    Edpetiline is an anti-inflammatory agent. Edpetiline inhibits the phosphorylation of IκB, nuclear transcription/translocation of NF-κB p65, as well as the phosphorylation of p38 MAPK and ERK MAPK. Edpetiline reduces intracellular ROS levels, inhibits the expression of TNF-α, IL-6, iNOS, COX-2, and promotes the expression of IL-4. Edpetiline is applicable to the research of diseases associated with inflammation and oxidative stress .
    Edpetiline
  • HY-N5124
    Meloside A
    4 Publications Verification

    Isovitexin 2''-O-glucoside; Isovitexin 2''-O-β-D-glucoside

    		 Androgen Receptor Apoptosis Reactive Oxygen Species (ROS) Interleukin Related TGF-β Receptor Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Meloside A (Isovitexin 2''-O-glucoside) is a flavonoid with antioxidant activity. Meloside A can inhibit cell apoptosis and ROS production. Meloside A can inhibit androgen receptor (AR) nuclear translocation and AR protein expression. Meloside A can reduce IL-6, TGF-β1 and DKK-1 levels. Meloside A can be used for the researches of inflammation and endocrinology, such as hair loss .
    Meloside A
  • HY-132850
    Dazcapistat

    BLD-2660

    		 Proteasome Interleukin Related Infection Inflammation/Immunology
    Dazcapistat (BLD-2660) is an orally active small-molecule inhibitor of calpain 1, 2, and 9 (calpain 1, 2, 9). Dazcapistat reduces the expression/production level of IL-6 in injured lung tissue and alleviates fibrosis . Dazcapistat exerts anti-fibrotic effects in various animal models of fibrosis in the skin, liver and lung . Dazcapistat can be used in research related to coronavirus disease 2019 (COVID-19) and idiopathic pulmonary fibrosis .
    Dazcapistat
  • HY-103471
    Y11

    		FAK Interleukin Related Cancer
    Y11 inhibits the autophosphorylation of FAK1 by blocking the phosphorylation of Y397. Y11 increases the expression level of IL-6. Y11 is applicable for cancer research .
    Y11
  • HY-N7674
    Angoline
    3 Publications Verification

    		 Interleukin Related STAT Cancer
    Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation .
    Angoline
  • HY-B0141S3
    Estradiol-d2

    β-Estradiol-d2; 17β-Estradiol-d2; 17β-Oestradiol-d2

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol-d2 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
    Estradiol-d2
  • HY-145846
    iNOs-IN-1
    1 Publications Verification

    		 NO Synthase Interleukin Related Inflammation/Immunology
    iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .
    iNOs-IN-1
  • HY-B0141S5
    Estradiol-13C2

    β-Estradiol-13C2; E2-13C2; 17β-Estradiol-13C2; 17β-Oestradiol-13C2

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol- 13C2 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
    Estradiol-13C2
  • HY-N4126
    6-Demethoxytangeretin
    1 Publications Verification

    		 Anaplastic lymphoma kinase (ALK) p38 MAPK Interleukin Related ERK JNK JAK STAT Akt Neurological Disease Inflammation/Immunology
    6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons .
    6-Demethoxytangeretin
  • HY-101259
    BMS-195614
    3 Publications Verification

    BMS 614

    		 RAR/RXR Bcl-2 Family NF-κB PPAR VEGFR Interleukin Related Cardiovascular Disease Inflammation/Immunology Endocrinology
    BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, AP-1 and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis .
    BMS-195614
  • HY-151876
    Glucocorticoid receptor modulator 1

    		Glucocorticoid Receptor NF-κB AP-1 Inflammation/Immunology
    Glucocorticoid receptor modulator 1 is a highly potent and orally active non-steroidal selective glucocorticoid receptor modulator with an IC50 value of 9 nM and 130 nM for NF-κB and AP-1, respectively. Glucocorticoid receptor modulator 1 can effectively reduce the expression of inflammatory factors IL-6, IL-1β, TNF-α, also can relieve dermatitis in mice .
    Glucocorticoid receptor modulator 1
  • HY-174066
    SI-W052

    		mTOR Autophagy Interleukin Related Neurological Disease Inflammation/Immunology
    SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targeting mTOR and TEX264. SI-W052 activates autophagy by inhibiting mTOR phosphorylation and enhances TEX264 expression to promote ER turnover, suppressing LPS-induced release of inflammatory factors (TNF-α, IL-6). SI-W052 is promising for research of Alzheimer’s disease (AD)-associated neuroinflammation .
    SI-W052
  • HY-149391
    PROTAC BTK Degrader-6

    		PROTACs Btk Inflammation/Immunology
    PROTAC BTK Degrader-6 (Compound 15) is a PROTAC BTK degrader (DC50: 3.18 nM. PROTAC BTK Degrader-6 has anti-inflammatory activity, inhibits NF-κB activation, and inhibits the expression of pro-inflammatory cytokines (e.g. IL-1β, IL-6) .
    PROTAC BTK Degrader-6
  • HY-W1127089
    Antifungal agent 136

    		Fungal Cytochrome P450 Interleukin Related Infection Inflammation/Immunology
    Antifungal agent 136 (Compound M-15) is an irreversible fungal lanosterol 14α-demethylase (CYP51) inhibitor. Antifungal agent 136 exhibits potent antifungal activity against drug-resistant Candida albicans and downregulates IL-6 expression. Antifungal agent 136 is promising for research of fungal infection and inflammatory disease .
    Antifungal agent 136
  • HY-134000
    Emodic acid

    NSC624610

    		 p38 MAPK NF-κB ERK JNK VEGFR MMP Cancer
    Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells .
    Emodic acid
  • HY-176553
    KBD4466

    		Toll-like Receptor (TLR) Interleukin Related IFNAR Inflammation/Immunology
    KBD4466 is an orally active potent TLR7 and TLR8 inhibitor with IC50s of 0.9 nM and 2.8 nM, respectively. KBD4466 inhibits the expression of inflammatory cytokines IL-6 and IFN-α. KBD4466 improves disease progression and survival in the BXSB/MpJ mouse model of Systemic Lupus Erythematosus (SLE). KBD4466 can be used in the study of autoimmune diseases .
    KBD4466
  • HY-131668
    9-POHSA

    		Endogenous Metabolite Inflammation/Immunology
    9-POHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-POHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression .
    9-POHSA
  • HY-N0604R
    Ginsenoside Rh1 (Standard)

    Prosapogenin A2 (Standard); Sanchinoside B2 (Standard); Sanchinoside Rh1 (Standard)

    		 Interleukin Related Reference Standards PPAR TNF Receptor Endogenous Metabolite Inflammation/Immunology
    Ginsenoside Rh1 (Standard) is the analytical standard of Ginsenoside Rh1. This product is intended for research and analytical applications. Ginsenoside Rh1 (Prosapogenin A2) inhibits the expression of PPAR-γ, TNF-α, IL-6, and IL-1β.
    Ginsenoside Rh1 (Standard)
  • HY-N3421
    Koaburaside

    		Interleukin Related TNF Receptor Influenza Virus Infection Inflammation/Immunology Cancer
    Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC50 of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits histamine release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .
    Koaburaside
  • HY-131934
    9-OAHSA

    		Endogenous Metabolite Inflammation/Immunology
    9-OAHSA is a fatty acid ester of hydroxy fatty acids (FAHFAs). 9-OAHSA shows anti-inflammatory effects via inhibiting cytokine production and reduces IL-1β and IL-6 expression. 9-OAHSA is also a protective molecule to prevent colon carcinoma cells from apoptotic cell death .
    9-OAHSA
  • HY-152213
    BET-IN-13

    		Epigenetic Reader Domain Inflammation/Immunology
    BET-IN-13 is a potent BET inhibitor with an IC50 value of 1.6 nM. BET-IN-13 reduces LPS-induced TNF-α, IL-1β, IL-6, and NOS2 mRNA expression levels. BET-IN-13 shows anti-inflammatory activity. BET-IN-13 has the potential for the research of acute liver injury .
    BET-IN-13
  • HY-N2007S
    Veratric acid-d6

    3,4-Dimethoxybenzoic acid-d6

    		 Isotope-Labeled Compounds COX Reactive Oxygen Species (ROS) Cardiovascular Disease Inflammation/Immunology
    Veratric acid-d6 is deuterium labeled Veratric acid. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant and anti-inflammatory activities . Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling . Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation .
    Veratric acid-d6
  • HY-B0141S4
    Estradiol-13C6

    β-Estradiol-13C6; E2-13C6; 17β-Estradiol-13C6; 17β-Oestradiol-13C6

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite Endocrinology Cancer
    Estradiol- 13C6 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
    Estradiol-13C6
  • HY-172451
    MC4762

    		NADPH Oxidase Monoamine Oxidase Reactive Oxygen Species (ROS) NO Synthase Interleukin Related Inflammation/Immunology
    MC4762 is an inhibitor of NOX2 and MAOB, with IC50 values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, IL-1β, and IL-6 .
    MC4762

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