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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
270 Results for "
IL-6 expression
" in MedChemExpress (MCE) Product Catalog:
Products (270)
270 Results for "IL-6 expression" in MCE Product Catalog:
524
524 Publications Verification
Synonyms: TAK-242; CLI-095
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-α and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases .
10
10 Cited Publications
Target:
Research Areas:
SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells .
10
10 Cited Publications
Target:
Research Areas:
SC144 hydrochloride is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 hydrochloride shows potent inhibition of gp130 ligand-triggered signaling. SC144 hydrochloride induces apoptosis in human ovarian cancer cells .
8
8 Cited Publications
Cat. No.: HY-N1949
CAS No.: 17680-84-1
Category:
Flavonoids Flavones Labiatae Cassia Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology
Target:
6
6 Cited Publications
Cat. No.: HY-N0604
CAS No.: 63223-86-9
Synonyms: Prosapogenin A2; Sanchinoside B2; Sanchinoside Rh1
5
Category:
Infection Polysaccharides Animals Disease Research Fields Inflammation/Immunology Saccharides
Target:
5
5 Cited Publications
Cat. No.: HY-N0619
CAS No.: 102841-42-9
5
5 Cited Publications
Cat. No.: HY-N5124
CAS No.: 60767-80-8
Synonyms: Isovitexin 2''-O-glucoside; Isovitexin 2''-O-β-D-glucoside
5
5 Cited Publications
Cat. No.: HY-N0853
CAS No.: 19885-10-0
4
4 Cited Publications
Target:
Research Areas:
DPQ is a selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD +/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases .
4
4 Cited Publications
Cat. No.: HY-N7674
CAS No.: 21080-31-9
Category:
Alkaloids Macleaya cordata (Willd.) R. Br. Plants Disease Research Fields Isoquinoline Alkaloids Papaveraceae Cancer
Target:
4
4 Cited Publications
Cat. No.: HY-W424851
CAS No.: 84050-22-6
Synonyms: 6,7-Dimethoxy-2-(1-piperazinyl)-4-quinazolinamine hydrochloride
Target:
Research Areas:
DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD +/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases .
3
3 Cited Publications
Cat. No.: HY-B0141S1
CAS No.: 66789-03-5
Synonyms: β-Estradiol-d4; 17β-Estradiol-d4; 17β-Oestradiol-d4
3
3 Cited Publications
Cat. No.: HY-B0419
CAS No.: 89226-50-6
Target:
Research Areas:
Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy .
3
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology
BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, AP-1 and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis .
3
Category:
Flavonols Flavonoids Plants Burseraceae Disease Research Fields Inflammation/Immunology Boswellia carterii
Target:
3
Category:
Cardiovascular Disease Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields
Target:
3
Target:
Research Areas:
2
2 Cited Publications
2
Category:
Alkaloids Chelidonium majus Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Papaveraceae
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
