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Results for "

IRAK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IRAK (142) AAK1 (1) Akt (6) Apoptosis (30) Autophagy (7) Bacterial (1) Bcr-Abl (1) c-Met/HGFR (3) Calcium Channel (6) Casein Kinase (3) CCR (1) CDK (3) CXCR (1) Cyclic GMP-AMP Synthase (1) Cyclin G-associated Kinase (GAK) (1) Drug Intermediate (1) E3 Ligase Ligand-Linker Conjugates (4) Endogenous Metabolite (2) Enolase (1) Environmental Pollutants (1) Ephrin Receptor (1) ERK (7) FGFR (1) FLT3 (10) Glucocorticoid Receptor (2) HSV (2) IFNAR (5) Interleukin Related (16) Isotope-Labeled Compounds (2) Itk (1) JAK (2) JNK (6) Ligands for E3 Ligase (3) Ligands for Target Protein for PROTAC (10) MAP3K (2) MAP4K (3) MELK (1) Mitophagy (2) MyD88 (9) Na+/K+ ATPase (2) NADH Dehydrogenase (1) NF-κB (26) NO Synthase (1) Opioid Receptor (6) p38 MAPK (6) Pim (1) Potassium Channel (6) PROTAC Linkers (3) PROTACs (33) Reactive Oxygen Species (ROS) (2) Reference Standards (10) Small Interfering RNA (siRNA) (12) Src (1) STAT (2) TGF-β Receptor (2) TNF Receptor (11) Toll-like Receptor (TLR) (15) Trk Receptor (1) ULK (1) Wee1 (1)
By Research Areas:	Cancer (87) Infection (9) Inflammation/Immunology (101) Metabolic Disease (7) Neurological Disease (10)
Click Chemistry:	PROTAC Synthesis (2)
Oligonucleotides:	CpG ODNs (4) Rat Pre-designed siRNA Sets (4) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (4) siRNAs (12)

182

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: IRAK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145483

KT-474 1 Publications Verification KYM-001; PROTAC IRAK4 degrader-7	PROTACs IRAK Apoptosis	Cancer
KT-474 (KYM-001; PROTAC IRAK4 degrader-7) is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis. KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL. KT-474 is a click chemistry reagent, containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups .

HY-18992

AS2444697	IRAK	Inflammation/Immunology
AS2444697 is an orally active *IRAK-4* inhibitor with an IC₅₀ of 21 nM . AS2444697 potently inhibits human and rat IRAK-4 activity. AS2444697 exhibits renoprotective effects through anti-inflammatory action .

HY-103017A

JH-X-119-01 5+ Cited Publications	IRAK	Infection Inflammation/Immunology Cancer
JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice . JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC₅₀ of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM .

HY-13329

IRAK-1-4 Inhibitor I 5+ Cited Publications IRAK-1/4 Inhibitor I	IRAK	Inflammation/Immunology
IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC₅₀s of 0.2 μM and 0.3 μM, respectively.

HY-111101

AZ1495	IRAK	Cancer
AZ1495, a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 *(IRAK4)* inhibitor. AZ1495 has a favorable physicochemical and kinase selectivity for IRAK4 and IRAK1 with IC₅₀ values of 0.005 μM and 0.023 μM, respectively. AZ1495 has IRAK4 inhibition with a K_d value of 0.0007 μM. AZ1495 can be used for the research of diffuse large B-cell lymphoma (DLBCL) .

HY-W087383

Thalidomide 5-fluoride	Ligands for E3 Ligase Autophagy Apoptosis	Cancer
Thalidomide 5-fluoride is a thalidomide-based Cereblon ligand used to recruit Cereblon protein. Thalidomide 5-fluoride can be linked to target protein ligands (e.g. *IRAK4) through a linker to form PROTAC molecules (e.g. PROTAC IRAK4 degrader-1). PROTAC IRAK4 degrader-1 caused <20%, >20-50%, and >50% IRAK*4 protein degradation in OCI-LY-10 cells at concentrations of 0.01, 0.1, and 1 μM, respectively .

HY-153188

JNJ-1013	PROTACs Apoptosis IRAK	Cancer
JNJ-1013 is a potent and selective IRAK1 PROTAC degrader with an IC₅₀s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) (Pink: ligand for target protein (HY-138834); black: linker (HY-Y1760); Blue: E3 ligase ligand (HY-112078)) .

HY-114181

IRAK4-IN-4 1 Publications Verification	IRAK Cyclic GMP-AMP Synthase	Inflammation/Immunology
IRAK4-IN-4 (Compound 15) is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, with an IC₅₀ of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC₅₀ of 2.1 nM. IRAK4-IN-4 can be used for research of autoimmune diseases .

HY-101922

IRAK4-IN-1	IRAK	Inflammation/Immunology
IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC₅₀ of 7 nM.

HY-109585

IRAK4-IN-7	IRAK	Inflammation/Immunology Cancer
IRAK4-IN-7 is a selective, potent and orally active interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, extracted from patent WO2015104688 (example 1). IRAK4-IN-7 has the potential for cancer and inflammatory diseases treatment .

HY-13275

IRAK inhibitor 1	IRAK	Inflammation/Immunology
IRAK inhibitor 1 is a potent *IRAK-4* inhibitor with IC₅₀ of 216 nM, is poorly active against JNK-1 and JNK-2 with IC₅₀ of 3.801 μM, and >10 μM, respectively.

HY-129966

*PROTAC IRAK4 degrader-1* 1 Publications Verification	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon-based IRAK4 PROTAC. PROTAC IRAK4 degrader-1 is composed of IRAK4 ligand (red part) PROTAC IRAK4 ligand-1 (HY-129967), E3 ligase ligand (blue part) Pomalidomide (HY-10984), and PROTAC linker (black part) AM-Imidazole-PA-Boc (HY-129968) .

HY-135382A

*PROTAC IRAK4 degrader-3*	PROTACs IRAK	Inflammation/Immunology
PROTAC IRAK4 degrader-3 is a PROTAC-induced *IRAK4* degrader based on von Hippel-Lindau .

HY-142662A

*PROTAC IRAK3 degrade-1 formic*	PROTACs IRAK	Others
PROTAC IRAK3 degrade-1 (compound 23) formic is a potent and selective degrader of *IRAK3* (IC₅₀=5 nM) .

HY-13276

IRAK inhibitor 2	IRAK	Inflammation/Immunology
IRAK inhibitor 2 is an interleukin-1 receptor-associated kinase (IRAK) inhibitor. IRAK inhibitor 2 can be used for the research of inflammatory and immune diseases .

HY-175764

FIP22	PROTACs IRAK NF-κB p38 MAPK TNF Receptor Interleukin Related	Inflammation/Immunology
FIP22 is a potent and selective IRAK4 PROTAC degrader (HEK293T cells: DC₅₀ = 3.2 nM; THP-1 cells: DC₅₀ = 10.6 nM). FIP22 induces the ubiquitin-proteasome system by forming an IRAK4-FIP22-CRBN ternary complex (EC₅₀ = 12.63 nM), thereby potently blocking IRAK4-mediated NF-κB and MAPK signaling pathways. FIP22 can be used for the study of atopic dermatitis (Pink: IRAK4 ligand (HY-175765); Blue: CRBN ligand (HY-W087383); Black: Linker (HY-46871)) .

HY-153224

GLPG2534	IRAK	Inflammation/Immunology
GLPG2534 is an orally active and selective *IRAK4* inhibitor, with IC₅₀ values of 6.4 nM and 3.5 nM for human and mouse IRAK4. GLPG2534 can be used for the research of inflammatory skin diseases .

HY-P5432

IRAK-4 Peptide substrate IRAK-1 (360-380)	IRAK	Others
IRAK-4 Peptide substrate (IRAK-1 (360-380)) is a biological active peptide. (This is a substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4)

HY-150735

IRAK4-IN-20	IRAK	Inflammation/Immunology
IRAK4-IN-20 (Compound BAY-1834845) is an orally active *IRAK4* inhibitor with an IC₅₀ of 3.55 nM. IRAK4-IN-20 can be used for acute respiratory distress syndrome (ARDS) research .

HY-146112

IRAK4-IN-14	IRAK	Cancer
IRAK4-IN-14 (compound 28) is a potent, selective and orally active *IRAK4* inhibitor with an IC₅₀ of 0.003 µM. IRAK4-IN-14 shows good PK parameters in rats and mouse. IRAK4-IN-14 shows synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib .

HY-151363

IRAK4-IN-21	IRAK	Inflammation/Immunology
IRAK4-IN-21 (compound 17) is an orally active, potent and selective *IRAK4* inhibitor with IC₅₀ values of 5 and 56 nM for *IRAK4* and TAK1, respectively. IRAK4-IN-21 effectively inhibits IL-23 production (IC₅₀=0.17 μM) and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis .

HY-151365

IRAK4-IN-22	IRAK	Inflammation/Immunology
IRAK4-IN-22 (compound 18) is an orally active, potent and selective *IRAK4* inhibitor with IC₅₀ values of 3 and 17 nM for *IRAK4* and TAK1, respectively. IRAK4-IN-21 effectively inhibits IL-23 production (IC₅₀=0.10 µM) and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis .

HY-77048

IRAK-4 protein kinase inhibitor 2	IRAK	Inflammation/Immunology
IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC₅₀ of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders .

HY-159953

IRAK1/4/pan-FLT3 Kinase-IN-1	IRAK FLT3	Cancer
IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of *IRAK1, IRAK4, and FLT3* kinases, with an IC₅₀ of 5 nM for *IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. IRAK*1/4/pan-FLT3 Kinase-IN-1 has good pharmacokinetic properties and shows promising potential for research in acute myeloid leukemia, with a survival prolongation effect comparable to that of Gilteritinib (HY-12432) .

HY-134911

HS-243	IRAK CDK	Inflammation/Immunology Cancer
HS-243 is a potent and selective *IRAK-4* and *IRAK-1* inhibitor, with IC₅₀ values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC₅₀ of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity .

HY-130253

IRAK4-IN-6	IRAK	Cancer
IRAK4-IN-6 is an orally efficacious and selective *IRAK4* inhibitor with an IC₅₀ of 4 nM, and targetes MyD88 L265P mutant diffuse large B cell lymphoma .

HY-129967

*PROTAC IRAK4 ligand-1*	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4 (IRAK4). PROTAC IRAK4 ligand-1 can be used in the synthesis of PROTAC IRAK4 degrader-1 (HY-129966) .

HY-153673

*PROTAC IRAK4 degrader-8*	IRAK PROTACs	Cancer
PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC *IRAK4* degrader (IC₅₀: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC₅₀: 1.8 nM)。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC₅₀s of 246 nM and 2.2 nM respectively .

HY-142662

*PROTAC IRAK3 degrader-1*	PROTACs IRAK	Others
PROTAC IRAK3 degrade-1 (compound 23) is a potent and selective degrader of IRAK3 (IC₅₀ = 5 nM) .

HY-175022

*PROTAC IRAK4 degrader-13*	PROTACs IRAK Toll-like Receptor (TLR) Interleukin Related	Inflammation/Immunology
PROTAC IRAK4 degrader-13 (Degrader 1) is a selective *IRAK4* PROTAC degrader with DC₅₀s of 0.86 and 1.1 nM for monocytes and lymphocytes in PBMCs, respectively. PROTAC IRAK4 degrader-13 significantly induces TIR signal activation, and inhibits the expression of circulating proinflammatory cytokines in Imiquimod (HY-B0180) induced psoriasis mice model. PROTAC IRAK4 degrader-13 can be used for TLR- and IL-1R-driven driven neutrophilic inflammation diseases like hidradenitis suppurativa (HS) and atopic dermatitis (AD) research . Pink: IRAK4 ligand; Blue: E3 ligase ligand; Black: linker

HY-145484

*PROTAC IRAK4 ligand-3*	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-3 is a ligand of PROTAC KT-474 (HY-145483) that can be used in cancer research .

HY-13278

IRAK inhibitor 4 1 Publications Verification	IRAK	Inflammation/Immunology
IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.

HY-13280

IRAK inhibitor 6	IRAK	Inflammation/Immunology
IRAK inhibitor 6 is an inhibitor of interleukin-1 receptor associated kinase 4 (IRAK-4) with IC₅₀ of 160 nM.

HY-135382

*PROTAC IRAK4 degrader-2*	PROTACs IRAK	Inflammation/Immunology Cancer
PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC₅₀ in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC₅₀ of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs .

HY-177515

IRAK4 modulator-2	IRAK STAT JAK NF-κB	Inflammation/Immunology
IRAK4 modulator-2 (Compound 5) is a selective dual Interleukin-1 Receptor Associated Kinase 4 (IRAK4) and *IRAK1* inhibitor with IC₅₀ values of 0.005 μM and 0.97 μM, erespectively. IRAK4 modulator-2 blocks IRAK-mediated signaling pathways (e.g., JAK-STAT, NF-κB pathways), reduces the production of pro-inflammatory cytokines (e.g., IL-1, TNF), and exerts anti-inflammatory activity. IRAK4 modulator-2 is promising for research of autoimmune diseases and inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel disease .

HY-13277

IRAK inhibitor 3 1 Publications Verification	IRAK	Inflammation/Immunology
IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.

HY-139316

*PROTAC IRAK4 degrader-5*	IRAK PROTACs	Cancer
PROTAC IRAK4 degrader-5 is a Cereblon-based *IRAK4* degrader extracted from patent US20190192668A1, compound I-171 .

HY-139315

*PROTAC IRAK4 degrader-4*	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127 .

HY-179095

UR241-2	Ligands for Target Protein for PROTAC IRAK NF-κB p38 MAPK	Cancer
UR241-2 is an *IRAK4* inhibitor. UR241-2 suppresses IL-1–induced *IRAK1/4* signaling, NF-κβ activation, and phosphorylation of p65 and p38. UR241-2 selectively inhibits leukemia stem cell clonogenicity. UR241-2 can serve as a ligand for target proteins for PROTAC, facilitating the development and design of PROTAC degraders for IRAK4. UR241-2 can be used in the research of acute myeloid leukemia .

HY-155132

IRAK4-IN-28	IRAK	Inflammation/Immunology
IRAK4-IN-28 (compound 42) is an orally active *IRAK4* inhibitor (IC₅₀=8.9 nM). IRAK4-IN-28 has binding affinity for IRAK4 with a Kd of 0.58 nM. IRAK4-IN-28 can be used in the research of inflammation and autoimmune diseases .

HY-155519

IRAK4-IN-26	IRAK	Inflammation/Immunology
IRAK4-IN-26 (Compound 21) is a *IRAK4* inhibitor (IC₅₀: 6.2 nM). IRAK4-IN-26 displays an oral bioavailability of 21%. IRAK4-IN-26 can be used for research of inflammatory and autoimmune disorders .

HY-143485

IRAK4-IN-9	IRAK	Inflammation/Immunology Cancer
IRAK4-IN-9 (compound 73) is a potent *IRAK4* inhibitor with an IC₅₀ of 1.5 nM. IRAK4-IN-9 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer .

HY-150594

IRAK4-IN-17	IRAK NF-κB	Cancer
IRAK4-IN-17 (Compound 5) is a potent *IRAK4* inhibitor with the IC₅₀ of 1.3 nM . IRAK4-IN-17 can be used in large B-cell lymphoma (DLBCL) research .

HY-155574

IRAK4-IN-27	IRAK Apoptosis	Cancer
IRAK4-IN-27 (Compound 22) is a potent, selective inhibitor of *IRAK4, with IC₅₀* of 8.7 nM. IRAK4-IN-27 inhibits cell growth, and promotes apoptosis in MYD88 L265P diffuse large B-cell lymphoma (DLBCL) cell line. IRAK4-IN-27 can be used for DLBCL study .

HY-143231

IRAK4-IN-8	IRAK	Infection
IRAK4-IN-8 (VI-177) is a potent *IRAK4* inhibitor .

HY-150733

IRAK4-IN-19	IRAK	Inflammation/Immunology
IRAK4-IN-19 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 4.3 nM. IRAK4-IN-19 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-19 can be used for researching arthritis disease .

HY-160654

IRAK4 modulator-1	IRAK	Inflammation/Immunology
IRAK4 modulator-1 (example 161) is a modulator of *IRAK4* with IC₅₀=4.647 μM. IRAK4 modulator-1 can be used to study IRAK-mediated disorders .

HY-174843

IRAK4-IN-32	IRAK	Inflammation/Immunology
IRAK4-IN-32 (Compound 10) is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an enzymatic IC₅₀ value of 18.86 nM and a cellular IC₅₀ value of 6.19 nM. IRAK4-IN-32 is promising for research of inflammatory and autoimmune diseases .

HY-174470

IRAK4 ligand-14	Ligands for Target Protein for PROTAC IRAK	Inflammation/Immunology
IRAK4 ligand-14 is a ligand for IRAK4. IRAK4 ligand-14 can be used for synthesizing PROTACs such as APH02174 (HY-174455) .

HY-150593

IRAK4-IN-16	IRAK	Cancer
IRAK4-IN-16 (compound 4) is a potent *IRAK4* (interleukin-1 receptor associated kinase 4) inhibitor, with an IC₅₀ of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC₅₀ values of 0.2, 0.2, 0.6, and 2.7 μM, respectively .

Cat. No.	Product Name

HY-L007

Immunology/Inflammation Compound Library

7,846 compounds

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. Inflammation is also the body's attempt at self-protection to remove harmful stimuli and begin the healing process. It’s part of the body's immune response. The immune system recognizes damaged cells, irritants, and pathogens, and inflammation begins the healing process. Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal inflammation.

MCE designs a unique collection of 7,846 compounds that are useful tool for Immunology/Inflammation research or autoimmune inflammatory diseases drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P5432

IRAK-4 Peptide substrate IRAK-1 (360-380)	IRAK	Others
IRAK-4 Peptide substrate (IRAK-1 (360-380)) is a biological active peptide. (This is a substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0039

Ginsenoside Rb1 10+ Cited Publications Gypenoside III	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification Cancer	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits *IRAK-1* activation and phosphorylation of NF-κB p65 .

HY-N0039R

Ginsenoside Rb1 (Standard) 10+ Cited Publications Gypenoside III (Standard)	Panax ginseng C. A. Meyer Classification of Application Fields Terpenoids Plants Disease Research Fields Araliaceae Source Classification Cancer	Reference Standards Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits *IRAK-1* activation and phosphorylation of NF-κB p65 .

Recombinant Proteins Recommended:

IRAK

Species:	Human (5) Mouse (2)
Tag:	His (5) Tag Free (1) Strep (1) GST (1)
Source:	sf9 insect cells (3) Sf9 insect cells (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701789

	IRAK1 Protein, Human (Active, sf9, GST) IRAK1; Interleukin-1 receptor-associated kinase 1; IRAK-1	Human	Sf9 insect cells
	IRAK1 is a serine/threonine protein kinase that initiates innate immune responses against pathogens through Toll-like receptor (TLR) and IL-1R signaling. After TLR activation, IRAK1 is recruited by MYD88 and undergoes IRAK4 phosphorylation, autophosphorylation, and kinase activation. IRAK1 Protein, Human (sf9, GST) is the recombinant human-derived IRAK1 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P703078

	IRAK4 Protein, Mouse (His) Interleukin-1 receptor-associated kinase 4; IRAK-4; EC:2.7.11.1	Mouse	E. coli
	IRAK4 Protein, Mouse (His) is the recombinant mouse-derived IRAK4, expressed by E. coli , with N-6*His labeled tag. ,

HY-P704729

	IRAK4 Protein, Mouse (Active, Sf9, His) Interleukin-1 receptor-associated kinase 4; IRAK-4; EC:2.7.11.1	Mouse	sf9 insect cells
	IRAK4 Protein, Mouse (Active, Sf9, His) is the recombinant mouse-derived IRAK4 protein, expressed by sf9 insect cells, with N-His tag.

HY-P73255

	IRAK4 Protein, Human (Active, sf9, His) Interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; NY-REN-64; REN64	Human	Sf9 insect cells
	The IRAK4 protein is a serine/threonine protein kinase that is critical for initiating the innate immune response through the Toll-like receptor (TLR) and IL-1R signaling pathways. After TLR is activated, it rapidly forms the Myddosome with IRAK2. IRAK4 Protein, Human (Active, sf9, His) is the recombinant human-derived IRAK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.

HY-P705844

	IRAK4 Protein, Human (Active, sf9, His-Strep) Interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; NY-REN-64; REN64	Human	sf9 insect cells

HY-P705845

	IRAK4 Protein, Human (Active, 307a.a, sf9) Interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; NY-REN-64; REN64	Human	sf9 insect cells

HY-P702732

	IRAK4 Protein, Human (Active, 307a.a, sf9, His) Interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; NY-REN-64; REN64	Human	Sf9 insect cells
	The IRAK4 protein is a serine/threonine protein kinase that is critical for initiating the innate immune response through the Toll-like receptor (TLR) and IL-1R signaling pathways. After TLR is activated, it rapidly forms the Myddosome with IRAK2. IRAK4 Protein, Human (307a.a, sf9, His) is the recombinant human-derived IRAK4, expressed by Sf9 insect cells, with His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0380S1

Trimebutine-d5 fumarate

Trimebutine-d₅ fumarate is deuterium labeled Trimebutine fumarate. Trimebutine fumarate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine fumarate inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine fumarate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine fumarate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine fumarate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .

HY-B0380S2

Trimebutine-d3 hydrochloride

Trimebutine-d₃ hydrochloride is deuterium labeled Trimebutine hydrochloride. Trimebutine hydrochloride is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine hydrochloride inhibits L-type Ca ²⁺ channels and large-conductance calcium-activated potassium channels (BK_Ca channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine hydrochloride also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine hydrochloride also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine hydrochloride also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .

Host:	Mouse (2) Rabbit (8)
Reactivity:	Human (10) Rat (2) Mouse (4) Monkey (3)
Application:	IHC-P (6) ICC/IF (4) IP (4) IHC-F (2) WB (10) FC (3) ELISA (3)
Isotype:	IgG, Kappa (1) IgG (7) IgG1 (2)
Conjugation:	Non-conjugated (10)
Clonality:	Monoclonal (8) Recombinant (7)
Modification:	Unmodified (8)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82709

	IRAK-1 Antibody (YA2454) Il1rak; IRAK; IRAK1; IRAK1-S; mPLK; Pelle; Pelle homolog; Pelle-like protein kinase; Plpk	WB, ICC/IF, IP	Human
	IRAK-1 Antibody (YA2454) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRAK-1.

HY-P82122

	IRAK2 Antibody (YA1867) Interleukin 1 receptor associated kinase 2; IRAK 2; IRAK2	WB, IP, FC	Human
	IRAK2 Antibody (YA1867) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRAK2.

HY-P80420

	IRAK-1 Antibody (YA335)	WB, IHC-P	Human, Mouse
	IRAK-1 Antibody (YA335) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRAK-1.

HY-P85231

	IRAK-4 Antibody (YA4923)	WB, IHC-P	Human, Mouse, Monkey
	IRAK-4 Antibody (YA4923) is a Rabbit-derived and non-conjugated recombinant monoclonal antibody, targeting to IRAK-4.

HY-P87751

	IRAK-1 Antibody (YA7436)	WB, ICC/IF, IP, ELISA	Human
	IRAK-1 Antibody (YA7436) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to IRAK-1.

HY-P83307

	IRAKM Antibody (YA3052) IRAK3; Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M	WB, IP	Human
	IRAKM Antibody (YA3052) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRAKM.

HY-P84834

	IRAK4 Antibody (YA4531) IPD1; REN64; NY-REN-64	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey
	IRAK4 Antibody (YA4531) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IRAK4.

HY-P84834A

	IRAK4 Antibody (YA4531)(PBS only) IPD1; REN64; NY-REN-64	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Monkey
	IRAK4 Antibody (YA4531) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IRAK4.

HY-P83370

	IRAK4 Antibody (YA3115) IL-1 receptor-associated kinase 4; Interleukin 1 receptor associated kinase 4 mutant form 1; IPD1; IRAK4; LOC 51135; NY REN 64; REN64	WB, IHC-F, IHC-P, ICC/IF	Human
	IRAK4 Antibody (YA3115) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRAK4.

HY-P83370A

	IRAK4 Antibody (YA3115)(PBS only) IL-1 receptor-associated kinase 4; Interleukin 1 receptor associated kinase 4 mutant form 1; IPD1; IRAK4; LOC 51135; NY REN 64; REN64	WB, IHC-F, IHC-P, ICC/IF	Human
	IRAK4 Antibody (YA3115) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRAK4.

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Cat. No.	Product Name		Classification

HY-145483

KT-474 1 Publications Verification KYM-001; PROTAC IRAK4 degrader-7		PROTAC Synthesis
KT-474 (KYM-001; PROTAC IRAK4 degrader-7) is an orally active PROTAC IRAK4 degrader with anti-tumor effects. KT-474 inhibits the cell cycle and induces apoptosis. KT-474 induces tumor regression in a xenograft model of MYD88-mutated ABC DLBCL. KT-474 is a click chemistry reagent, containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups .

HY-137342

SB1-G-187		PROTAC Synthesis
SB1-G-187 is a multi-target kinase PROTAC degrader with activity against various kinases including GCK, YES1, *IRAK1* and LYN. SB1-G-187 induces degradation of target kinases via a p97-dependent pathway, and forms ternary complexes with CRBN and specific functional kinases. SB1-G-187 can be used in tumor-related research. (Pink: multi-target kinase ligand (HY-125142); Blue: CRBN ligand (HY-A0003); Black: linker) .

Cat. No.	Product Name		Classification

HY-146244

Agatolimod 1 Publications Verification ODN 2006; PF-3512676; CpG 7909; ODN 7909		CpG ODNs
Agatolimod ((ODN 2006; PF-3512676; CpG 7909)) is a TLR9 agonist and immunomodulator with an EC₅₀ of 180 nM against human TLR9. Agatolimod activates and upregulates the expression of both TLR9 and TLR6, and mediates downstream signaling pathways via IRAK4, IRF5, IRF7. Agatolimod induces Th1-type innate and adaptive immune responses, activates various immune cells and promotes antigen presentation, regulates antibody levels and immune cell infiltration, upregulates the secretion of multiple cytokines, induces apoptosis and cell cycle arrest, enhances cytotoxicity, and clears intracellular Salmonella. Agatolimod is applicable to research on COVID-19, breast cancer, lung adenocarcinoma, HPV-related tumors, melanoma, and salmonellosis .

HY-150741

ODN 2216 1 Publications Verification		CpG ODNs
ODN 2216 is a type A CpG oligodeoxynucleotide vaccine adjuvant and a TLR9 agonist. ODN 2216 interacts with TLR9 in the lysosomes of CD4 ⁺ T cells and activates feedback-dependent signaling pathways. ODN 2216 induces the production of type I interferons, IL-6 and TGF-β via the IRAK4/IRF7 axis, while increasing intracellular ATP levels. ODN 2216 not only induces the differentiation of CD4 ⁺ T cells into anti-inflammatory Th3-like regulatory phenotypes to inhibit autologous proliferation, but also enhances the specific CD8 ⁺ T cell-mediated cytotoxicity against Mammaglobin-A in breast cancer cells. ODN 2216 is widely used in studies related to breast cancer and systemic lupus erythematosus .

HY-150741C

ODN 2216 sodium 1 Publications Verification		CpG ODNs
ODN 2216 sodium is a type A CpG oligodeoxynucleotide vaccine adjuvant and a TLR9 agonist. ODN 2216 sodium interacts with TLR9 in the lysosomes of CD4 ⁺ T cells and activates feedback-dependent signaling pathways. ODN 2216 sodium induces the production of type I interferons, IL-6 and TGF-β via the IRAK4/IRF7 axis, while increasing intracellular ATP levels. ODN 2216 sodium not only induces the differentiation of CD4 ⁺ T cells into anti-inflammatory Th3-like regulatory phenotypes to inhibit autologous proliferation, but also enhances the specific CD8 ⁺ T cell-mediated cytotoxicity against Mammaglobin-A in breast cancer cells. ODN 2216 sodium is widely used in studies related to breast cancer and systemic lupus erythematosus .

HY-150750A

ODN M362 sodium		CpG ODNs
ODN M362 sodium is a TLR9 agonist that acts as a vaccine adjuvant. ODN M362 sodium activates mouse splenocytes, induces apoptosis in human hepatocellular carcinoma cells, upregulates proinflammatory cytokines in human hepatocellular carcinoma cells, and inhibits the proliferation of human hepatocellular carcinoma cells. ODN M362 sodium upregulates the expression of TLR9/TLR6, activates downstream signaling pathways via IRAK4 and IRF7, and strongly amplifies antigen-specific cellular immune responses to participate in innate immune activation. ODN M362 sodium can be used in research related to hepatocellular carcinoma and breast cancer .

HY-RS06893

IRAK1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IRAK1 Human Pre-designed siRNA Set A contains three designed siRNAs for IRAK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06894

Irak1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Irak1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irak1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06899

Irak4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Irak4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irak4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06897

IRAK3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IRAK3 Human Pre-designed siRNA Set A contains three designed siRNAs for IRAK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23757

Irak3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Irak3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irak3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06896

IRAK2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IRAK2 Human Pre-designed siRNA Set A contains three designed siRNAs for IRAK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06900

Irak4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Irak4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irak4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17302

Irak3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Irak3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irak3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06895

Irak1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Irak1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irak1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06898

IRAK4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IRAK4 Human Pre-designed siRNA Set A contains three designed siRNAs for IRAK4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS25505

Irak2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Irak2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Irak2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19016

Irak2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Irak2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Irak2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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