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Limonoid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (6) Bacterial (3) Caspase (1) Cytochrome P450 (1) Dengue Virus (1) Drug Derivative (12) EBV (3) Flavivirus (1) Fungal (2) Histamine Receptor (1) HSP (2) IKK (1) Influenza Virus (1) Insecticide (3) NO Synthase (2) Parasite (5) Phosphatase (1) PPAR (1) Reference Standards (2) TMV (1) TNF Receptor (1)
By Research Areas:	Cancer (20) Infection (17) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (5)

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0428

Obacunone 4 Publications Verification	Apoptosis	Cancer
Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-N0547

Nomilin 2 Publications Verification	Others	Metabolic Disease
Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .

HY-123026

Salannin	Bacterial	Infection
Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .

HY-107577

Gedunin	HSP	Infection Inflammation/Immunology Cancer
Gedunin is a limonoid with anti-cancer, anti-viral, anti-inflammatory and insecticidal activities. Gedunin acts as a potent Hsp90 inhibitor and induces the degradation of Hsp90-dependent client proteins. Geduni may obstructs the entry of SARS-CoV-2 virus into human host cells and can be used for COVID-19 research .

HY-133108

Azadirachtin B	EBV Parasite Phosphatase Influenza Virus	Infection Metabolic Disease Inflammation/Immunology Cancer
Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties .

HY-N3187

Nimbin	Flavivirus Dengue Virus Fungal Bacterial Histamine Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin is promising for research of neurodegenerative diseases and viral infections .

HY-N8761

Kihadanin A	NO Synthase	Metabolic Disease
Kihadanin A (compound 3) is a limonoid NOS3 inhibitor that can be isolated from the methanol extract of Dictamnus dasycarpus root bark. Kihadanin A is useful in the study of hyperuricemia (HUA) [3].

HY-N3944

Glaucin B 6β-Acetoxy-5-epilimonin	Others	Others
Glaucin B is a bitter limonoid isolated from the root bark of Evodia glauca .

HY-N10096

Epoxyazadiradione	Parasite	Infection
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-N1710

28-Deoxonimbolide	Apoptosis Caspase	Cancer
28-Deoxonimbolide is a Nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways .

HY-N3444

Jangomolide	Others	Others
Jangomolide is a natural product, a limonoid isolated from flacourtia jangomas .

HY-122959

Kihadanin B	Akt PPAR	Metabolic Disease
Kihadanin B is a citrus limonoid that can be purified from the peels of immature Citrus unshiu. Kihadanin B suppresses adipogenesis through repression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes .

HY-N9615

Azadiradione	HSP	Infection Neurological Disease Inflammation/Immunology
Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a HSF1 activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities .

HY-N0428R

Obacunone (Standard)	Reference Standards Apoptosis	Cancer
Obacunone (Standard) is the analytical standard of Obacunone. This product is intended for research and analytical applications. Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-N16544

Perforatin A O-Methylalloptaeroxylin	Others	Others
Perforatin A (O-Methylalloptaeroxylin) (Compound 1) is a natural product that can be found in C. gracilis.

HY-N3698

Deacetylsalannin	Others	Others
Deacetylsalannin is a limonoid on peach leaves .

HY-N3150

Ohchinin acetate	Others	Others
Ohchinin acetate is a limonoid, that can be isolated from the fruit of M. azedarach Linn. var. japonica Makino .

HY-N3285

Methyl 6-acetoxyangolensate	Others	Others
Methyl 6-acetoxyangolensate (compound 37) is a limonoid, which can be isolated from isolated the leaves and twigs of Khaya senegalensis .

HY-N3151

Ohchinin	Others	Others
Ohchinin is a limonoid, that can be isolated from the fruit of Melia azedarach L. .

HY-N1621

1-Deacetylnimbolinin B	Fungal Parasite	Infection
1-Deacetylnimbolinin B is a nimbolinin-type limonoid isolated from the fruits of Melia toosendan. Limonoids are a class of highly oxygenated nortriterpenoids that exhibit insecticidal, antifungal, nematicidal and cytotoxic properties .

HY-N15545

Thaigranatumin I	Drug Derivative	Neurological Disease
Thaigranatumin I is a limonoid compound found in the seeds of the Thai mangrove (Xylocarpus granatum). Thaigranatumin I is promising for research of neurodegenerative diseases such as Parkinson's diseases .

HY-N9232

Rutaevin 7-acetate	Others	Others
Rutaevin 7-acetate (compound 1) is a limonoid .

HY-N0547R

Nomilin (Standard)	Apoptosis IKK TNF Receptor Reference Standards	Metabolic Disease
Nomilin (Standard) is the analytical standard of Nomilin. This product is intended for research and analytical applications. Nomilin is a limonoid compound obtained from the extracts of citrus fruits. Nomilin is an anti-obesity and anti-hyperglycemic agent .

HY-N8405

Isolimonexic acid	Cytochrome P450	Cancer
Isolimonexic acid is a limonoid isolated from lemon (Citrus lemon L. Burm) seed, has anti-cancer and anti-aromatase (IC₅₀=25.60 μM) properties .

HY-N3561

Cedrelone	Apoptosis	Cancer
Cedrelone, a limonoid, is a Phenazine biosynthesis-like domain-containing protein (PBLD) activator. Cedrelone induces cancer cell apoptosis, and possess antitumor effects .

HY-N3694

Deacetylnimbin Desacetyl nimbin	Others	Others
Deacetylnimbin is a limonoid isolated from Azadirachta indica. Deacetylnimbin can be used as a plant metabolite, a food repellent and as a growth regulator for insects such as S. litura, P. ricini and O. fscovittata .

HY-N10091

2,3-Dihydro-3α-methoxynimbolide	Apoptosis	Others
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521 .

HY-N1075

Walsuronoid B	Parasite	Infection
Walsuronoid B is a limonoid can be isolated from Walsura robusta and has weak antimalarial activity .

HY-N3283

6-Methylhydroxyangolensate	Parasite	Infection
6-Methylhydroxyyangolensate is a limonoid can be extracted from Khaya grandifoliola. 6-Methylhydroxyyangolensate has low antimalarial activity in vitro, with an IC₅₀ of 21.59 μg/ml against P. falciparum (W2/Indochina clone) .

HY-N1654

2',3'-Dehydrosalannol	Bacterial	Infection
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 μg/mL, respectively .

HY-117901

Sandoricin	Insecticide	Others
Sandoricin is a limonoid compound that can be extracted from the seeds of Sandoricum koetjape. Sandoricin exhibits strong antifeedant properties in larvae of Fall Armyworm (Spodoptera frugiperda) and European Corn Borer (Ostrinia nubilalis) fed on artificial diets. Sandoricin induces reduced growth rate and delayed pupation at lower doses, while higher doses cause massive mortality of larvae. Sandoricin is a potential field insecticide .

HY-N18326

Toosendone	Others	Others
Toosendone (Compound 1) is a limonoid. Toosendone can be isolated from Melia toosendan .

HY-N18123

Meliatoosenin P	Others	Others
Meliatoosenin P (Compound 12) is a limonoid found in the fruits of Melia toosendan .

HY-N18141

Meliatoosenin N	TMV	Infection
Meliatoosenin N is a limonoid compound. Meliatoosenin N inhibits the replication of tobacco mosaic virus in vitro .

HY-N18172

Meliatoosenin K	Drug Derivative	Others
Meliatoosenin K is a trichilinin-type limonoid found in the fruits of Melia toosendan .

HY-N18183

Meliatoosenin I	Others	Others
Meliatoosenin I (Compound 287) is a Trichilin class limonoid. Meliatoosenin I can be isolated from Melia toosendan .

HY-N18166

Nimbolinin B	Others	Others
Nimbolinin B is a limonoid found in the root bark of Turraea robusta .

HY-N18322

12-O-Ethyl-nimbolinin B	Drug Derivative	Others
12-O-Ethyl-nimbolinin B is a limonoid that can be found in the fruits of Melia toosendan .

HY-N18213

1-O-Detigloyl-1-O-benzoylohchinolal	Drug Derivative	Others
1-O-Detigloyl-1-O-benzoylohchinolal is a limonoid compound present in the leaves and twigs of Melia toosendan .

HY-N18044

Toosendanal	Drug Derivative	Others
Toosendanal is a limonoid compound present in the fruits of Melia toosendan Sieb. et al. .

HY-N18195

Trichilin B	Others	Cancer
Trichilin B is a limonoid compound found in the twigs and leaves of Trichilia connaroides. Trichilin B exhibits no in vitro cytotoxic activity against tumor cell lines .

HY-N18115A

Toosendansin A	Drug Derivative	Cancer
Toosendansin A is a salannin-type limonoid and cytotoxic agent found in the fruits of Melia azedarach. Toosendansin A can be used for the research of leukemia, stomach cancer, breast cancer .

HY-N18208

12-O-Methyl-1-O-deacetylnimbolinin B	Others	Others
12-O-Methyl-1-O-deacetylnimbolinin B is a limonoid. 12-O-Methyl-1-O-deacetylnimbolinin B can be isolated from the fruits of Melia toosendan .

HY-N18247

12-Ethoxynimbolinin F	Others	Cancer
12-Ethoxynimbolinin F is a nimbolinin-type limonoid found in the fruits of Melia toosendan. 12-Ethoxynimbolinin F shows low cytotoxic activity against cancer cells .

HY-N18212

12-O-Methyl-1-O-tigloyl-1-O-deacetylnimbolinin B	Drug Derivative	Others
12-O-Methyl-1-O-tigloyl-1-O-deacetylnimbolinin B (Compound 2) is a limonoid compound present in the fruits of Melia toosendan .

HY-N18151

Ohchinolide C	Others	Others
Ohchinolide C is a ring C-seco limonoid and insect antifeedant. Ohchinolide C can be found in the root bark of Melia toosendan. Ohchinolide C exerts antifeedant activity against Spodoptera eridania larvae .

HY-N18291

12β-1-O-Tigloyl-1-O-deacetyl-nimbolinin B	Others	Others
12β-1-O-Tigloyl-1-O-deacetyl-nimbolinin B (Compound 1b) is a nimbolinin-type limonoid found in the fruits of Melia toosendan.12β-1-O-Tigloyl-1-O-deacetyl-nimbolinin B exists as a tautomer of 12α-1-O-tigloyl-1-O-deacetyl-nimbolinin B .

HY-N15546

Thaigranatumin H	Others	Infection
Thaigranatumin H is a limonoid compound that can be obtained from the fruit of the Thai mangrove plant .

HY-107296

1-Acetyltrichilinin	Others	Others
1-Acetyltrichilinin is a limonoid that can be isolated from the fruit of Melia toosendan and is a biosynthetic precursor of voltagenin .

HY-N18210

12-O-Ethyl-1-deacetylnimbolinin B	Others	Others
12-O-Ethyl-1-deacetylnimbolinin B (Compound 1) is a limonoid-type triterpenoid that can be found in the fruit of Melia toosendan Sieb. et Zucc .

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Limonoid

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