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MLA

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By Targets:	Biochemical Assay Reagents (1) nAChR (2) NO Synthase (1)
By Research Areas:	Cardiovascular Disease (1) Infection (1) Neurological Disease (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2332A

Methyllycaconitine citrate 40+ Cited Publications MLA citrate	nAChR	Neurological Disease
Methyllycaconitine (MLA) citrate is a potent, selective, CNS-penetrant, competitive α7nAChR antagonist. Methyllycaconitine citrate alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. Methyllycaconitine citrate prevents methamphetamine-induced effects in mouse striatum. Methyllycaconitine citrate can be used for neurological disease research, such as Alzheimer’s disease .

HY-123515

Clorobiocin		Infection
Clorobiocin is an antibacterial agent with an IC₅₀ of 0.21 μM against the B subunit of E. coli DNA gyrase. Clorobiocin targets the mLaC protein of Gram-negative bacteria. Clorobiocin potently inhibits bacterial DNA replication. Clorobiocin can be used in studies on Gram-negative bacterial infections, such as Acinetobacter baumannii and E. coli infections .

HY-W423502

WS5 Menthane carboxamidoethyl acetate	Biochemical Assay Reagents	Others
WS5 (Menthane carboxamidoethyl acetate) is a cooling agent fragrance ingredient .

HY-106193

RC-552	NO Synthase	Cardiovascular Disease
RC-552 is a novel synthetic glycolipid related in chemical structure to MLA. RC-552 induces delayed cardioprotective effects via an iNOS-dependent pathway. RC-552 attenuates myocardial stunning .

HY-N2332

Methyllycaconitine MLA	nAChR	Neurological Disease
Methyllycaconitine (MLA) is a potent, selective, CNS-penetrant, competitive α7nAChR antagonist. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum. Methyllycaconitine can be used for neurological disease research, such as Alzheimer’s disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2332

Methyllycaconitine MLA	Structural Classification Alkaloids Piperidine Alkaloids Ranunculaceae Delphinium ajacis Plants Source Classification	nAChR
Methyllycaconitine (MLA) is a potent, selective, CNS-penetrant, competitive α7nAChR antagonist. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum. Methyllycaconitine can be used for neurological disease research, such as Alzheimer’s disease .

Species:	Human (3) Rat (2) Cynomolgus (2) Pig (1)
Tag:	His (3) Tag Free (1) Fc (2)
Source:	HEK293 (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74280

	CD63 Protein, Rat (HEK293, His) CD63 antigen; LAMP-3; Tspan-30; CD63; MLA1; TSPAN30	Rat	HEK293
	The CD63 protein serves as a cell surface receptor for TIMP1 and is critical for activating signaling cascades. It contributes to ITGB1 and integrin signaling, activating AKT, FAK/PTK2 and MAP kinases to promote cell survival, cytoskeletal reorganization, adhesion, spreading and migration. CD63 Protein, Rat (HEK293, His) is the recombinant rat-derived CD63 protein, expressed by HEK293 , with N-His labeled tag.

HY-P76810

	CD63 Protein, Pig (HEK293, Fc) CD63 antigen; LAMP-3; Tspan-30; CD63; MLA1; TSPAN30	Pig	HEK293
	The CD63 protein serves as a cell surface receptor for TIMP1 and is critical for activating signaling cascades. It contributes to ITGB1 and integrin signaling, activating AKT, FAK/PTK2 and MAP kinases to promote cell survival, cytoskeletal reorganization, adhesion, spreading and migration. CD63 Protein, Pig (HEK293, Fc) is the recombinant pig-derived CD63 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P74281

	CD63 Protein, Rat (HEK293, Fc) CD63 antigen; LAMP-3; Tspan-30; CD63; MLA1; TSPAN30	Rat	HEK293
	The CD63 protein serves as a cell surface receptor for TIMP1 and is critical for activating signaling cascades. It contributes to ITGB1 and integrin signaling, activating AKT, FAK/PTK2 and MAP kinases to promote cell survival, cytoskeletal reorganization, adhesion, spreading and migration. CD63 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD63 protein, expressed by HEK293 , with N-mFc labeled tag.

HY-P704482

	CD63 Protein-VLP, Human (HEK293) CD63 antigen; LAMP-3; Tspan-30; CD63; MLA1; TSPAN30	Human	HEK293
	CD63 Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P705433.

HY-P76243

	CD63 Protein, Human/Cynomolgus (HEK293, His) CD63 antigen; LAMP-3; Tspan-30; CD63; MLA1; TSPAN30	Cynomolgus;Human	HEK293
	The CD63 protein serves as a cell surface receptor for TIMP1 and is critical for activating signaling cascades. It contributes to ITGB1 and integrin signaling, activating AKT, FAK/PTK2 and MAP kinases to promote cell survival, cytoskeletal reorganization, adhesion, spreading and migration. CD63 Protein, Human/Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD63 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72715

	CD63 Protein, Human/Cynomolgus (HEK293, N-His) 3 Publications Verification CD63 antigen; LAMP-3; Tspan-30; CD63; MLA1; TSPAN30	Human;Cynomolgus	HEK293
	CD63 protein acts as a receptor for TIMP1, activating cell signaling pathways and promoting cell survival. It plays a key role in integrin signaling, leading to activation of AKT, FAK/PTK2, and MAP kinases. CD63 Protein, Human/Cynomolgus (HEK293, N-His) is the recombinant human-derived CD63 protein, expressed by HEK293 , with N-6*His labeled tag.

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Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (2)
Application:	IHC-P (1) ICC/IF (1) IP (1) WB (1) FC (1) ELISA (1)
Isotype:	IgG (1)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85885

	CD63 Antibody (YA5577) Lysosomal associated membrane protein 3 antibody; CD 63 antibody; CD63 antibody; CD63 antigen; melanoma 1 antigen; antibody; CD63 antigen antibody; CD63 antigen melanoma 1 antigen antibody; CD63 molecule antibody; CD63_HUMAN antibody; gp55 antibody; Granulophysin antibody; LAMP 3 antibody; LAMP-3 antibody; LAMP3 antibody; LIMP antibody; Lysosomal-associated membrane protein 3 antibody; Lysosome associated membrane glycoprotein 3 antibody; Lysosome-associated membrane glycoprotein 3 antibody; Mast cell antigen AD1 antibody; ME491 antibody; Melanoma 1 antigen antibody; Melanoma associated antigen ME491 antibody; Melanoma associated antigen MLA1 antibody; Melanoma-associated antigen ME491 antibody; MGC72893 antibody; MLA 1 antibody; MLA1 antibody; NGA antibody; Ocular melanoma associated antigen antibody; Ocular melanoma-associated antigen antibody; OMA81H antibody; PTLGP40 antibody; Tetraspanin 30 antibody; Tetraspanin-30 antibody; Tspan 30 antibody; Tspan-30 antibody; TSPAN30 antibody;	WB, IHC-P, ICC/IF, IP, FC	Human
	CD63 Antibody (YA5577) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD63.

HY-P85885A

	CD63 Antibody (YA5577)(PBS only) Lysosomal associated membrane protein 3 antibody; CD 63 antibody; CD63 antibody; CD63 antigen; melanoma 1 antigen; antibody; CD63 antigen antibody; CD63 antigen melanoma 1 antigen antibody; CD63 molecule antibody; CD63_HUMAN antibody; gp55 antibody; Granulophysin antibody; LAMP 3 antibody; LAMP-3 antibody; LAMP3 antibody; LIMP antibody; Lysosomal-associated membrane protein 3 antibody; Lysosome associated membrane glycoprotein 3 antibody; Lysosome-associated membrane glycoprotein 3 antibody; Mast cell antigen AD1 antibody; ME491 antibody; Melanoma 1 antigen antibody; Melanoma associated antigen ME491 antibody; Melanoma associated antigen MLA1 antibody; Melanoma-associated antigen ME491 antibody; MGC72893 antibody; MLA 1 antibody; MLA1 antibody; NGA antibody; Ocular melanoma associated antigen antibody; Ocular melanoma-associated antigen antibody; OMA81H antibody; PTLGP40 antibody; Tetraspanin 30 antibody; Tetraspanin-30 antibody; Tspan 30 antibody; Tspan-30 antibody; TSPAN30 antibody;
	CD63 Antibody (YA5577)(PBS only) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD63.

HY-P85002

	CD63 Antibody (YA4694) CD63; MLA1; TSPAN30; CD63 antigen; Granulophysin; Lysosomal-associated membrane protein 3; LAMP-3; Melanoma-associated antigen ME491; OMA81H; Ocular melanoma-associated antigen; Tetraspanin-30; Tspan-30; CD63; CD63 nanobody;	ELISA	Human
	CD63 Antibody (YA4694) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD63.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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MLA

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Antibodies

Natural
Products