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Results for "

P2X7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adiponectin Receptor (1) Angiotensin Receptor (1) Apoptosis (3) Autophagy (1) c-Myc (1) CaMK (1) Caspase (1) COX (2) Drug Derivative (1) Drug Intermediate (1) Drug Isomer (1) ERK (1) FAK (1) Gap Junction Protein (1) Histamine Receptor (2) IFNAR (1) Interleukin Related (5) MMP (1) NF-κB (1) NOD-like Receptor (NLR) (3) P2X Receptor (53) p38 MAPK (3) PERK (3) Prokineticin Receptor (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (3) Reference Standards (6) Small Interfering RNA (siRNA) (2) Tyrosinase (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (27) Metabolic Disease (3) Neurological Disease (34)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136254

BzATP triethylammonium salt 10+ Cited Publications	P2X Receptor	Inflammation/Immunology Cancer
BzATP triethylammonium salt acts as a P2X receptor agonist with pEC₅₀s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively . BzATP triethylammonium salt is potent at P2X7 receptors with EC₅₀s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively .

HY-50697

A-740003 15+ Cited Publications	P2X Receptor	Neurological Disease
A-740003 is a potent, selective and competitive P2X7 receptor antagonist with IC₅₀ values are 18 and 40 nM for rat and human P2X7 receptors, respectively.

HY-13290

KN-62 10+ Cited Publications	CaMK P2X Receptor	Metabolic Disease Cancer
KN-62 is a selective and reversible inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with a K_i of 0.9 μM for rat brain CaMK-II. KN-62 directly binds to the calmodulin binding site of CaMK-II. KN-62 displays noncompetitive antagonism at *P2X₇* receptors in HEK293 cells, with an IC₅₀ value of approximately 15 nM.

HY-15488

A 438079 Maximum Cited Publications 26 Publications Verification	P2X Receptor	Neurological Disease
A 438079 is a potent, and selective P2X₇ receptor antagonist with pIC₅₀ of 6.9.

HY-15488A

A 438079 hydrochloride Maximum Cited Publications 26 Publications Verification	P2X Receptor	Neurological Disease
A 438079 (hydrochloride) is a potent, and selective P2X₇ receptor antagonist with pIC₅₀ of 6.9.

HY-19427A

AZD9056 hydrochloride 5+ Cited Publications	P2X Receptor	Inflammation/Immunology
AZD9056 hydrochloride is a selective orally active inhibitor of *P2X7* which plays a significant role in inflammation and pain-causing diseases.

HY-123857

JNJ-55308942 2 Publications Verification	P2X Receptor	Neurological Disease Inflammation/Immunology
JNJ-55308942 is a high-affinity, selective, brain-penetrant *P2X7* functional antagonist (hP2X7: IC₅₀=10 nM, K_i=7.1 nM; rP2X7: IC₅₀=15 nM, K_i=2.9 nM). JNJ-55308942 is orally bioavailable, binds to brain P2X7 and blocks IL-1β release from adult rodent brain .

HY-101418

JNJ-47965567 5 Publications Verification	P2X Receptor	Neurological Disease
JNJ-47965567 is a centrally permeable, high-affinity, selective *P2X7* antagonist, with pK_is of 7.9 and 8.7 for human and rat P2X7, respectively. JNJ-47965567 can be used to probe the role of central P2X7 in rodent models of CNS pathophysiology .

HY-108669

AZ10606120 dihydrochloride 2 Publications Verification	P2X Receptor	Neurological Disease Cancer
AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC₅₀ of about 10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth .

HY-B1901

Eperisone hydrochloride (±)-Eperisone hydrochloride	P2X Receptor	Neurological Disease
Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an orally active antispastic agent with a vasodilator effect, used for the research of muscle stiffness and pain. Eperisone Hydrochloride is a potent and selectively P2X7 receptor antagonist, also shows antagonism for human P2X3. Eperisone Hydrochloride works by relaxing both skeletal muscles and vascularsmooth muscles, demonstrating a variety of effects such as reduction ofmyotonia, improvement of circulationand and suppression of the pain reflex .

HY-P1137

10Panx 1 Publications Verification	Gap Junction Protein	Others
10Panx is a competitive inhibitor of selective Pannexin 1 (PANX1) channels. 10Panx blocks the opening of PANX1 channels, inhibits ATP release and downstream P2X7 receptor-mediated signaling pathways, thereby reducing cell death and inflammatory responses. 10Panx can be used in the study of diseases such as neuropathic pain, inflammatory bowel disease, and Clostridioides difficile infection. 10Panx can effectively reduce mechanical hyperalgesia and enhanced C-reflexes, and inhibit the expression of pro-inflammatory factors such as IL-6[1][2][3].

HY-100483

A-804598 3 Publications Verification	P2X Receptor	Neurological Disease Cancer
A-804598 is a BBB penetrant, competitive and selective *P2X7* receptor antagonist with IC₅₀s of 9 nM, 10 nM and 11 nM for mouse, rat and human *P2X7* receptors, respectively .

HY-150059

P2X7 receptor antagonist-2	P2X Receptor	Neurological Disease Inflammation/Immunology
P2X7 receptor antagonist-2 is a potent P2X7 receptor antagonist with a pIC₅₀ value of 6.5-7.5. P2X7 receptor antagonist-2 has efficacy of combating neuroinflammation .

HY-123205

Oxatomide KW-4354	Histamine Receptor P2X Receptor 5-HT Receptor Apoptosis PERK p38 MAPK COX	Inflammation/Immunology
Oxatomide (KW-4354) is an orally active dual antagonist of the H1-histamine receptor and the P2X7 receptor, as well as an inhibitor of serotonin. Oxatomide possesses antihistaminic, antiallergic and anti-inflammatory activities. Oxatomide can be used in the research of allergic diseases .

HY-117508

JNJ-54175446	P2X Receptor	Neurological Disease
JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC₅₀s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.

HY-N1478

Gardenoside 2 Publications Verification	P2X Receptor Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and *P2X7* receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study .

HY-N9182

Zeaxanthin dipalmitate Physalien	Adiponectin Receptor P2X Receptor Autophagy	Inflammation/Immunology
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (K_d=81.2 nM) and adiponectin receptor 1 (AdipoR1; K_d=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) .

HY-13954

A 839977 1 Publications Verification	P2X Receptor	Neurological Disease Inflammation/Immunology
A 839977 is a *P2X7* selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC₅₀ values are 20 nM, 42 nM and 150 nM respectively) and reduces inflammatory and neuropathic pain in animal models; the antihyperalgesic effects of P2X7 receptor blockade are mediated by blocking the release of IL-1beta .

HY-137888A

Oxidized ATP trisodium salt oATP trisodium salt	P2X Receptor NOD-like Receptor (NLR)	Inflammation/Immunology
Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes *P2X7R* activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis .

HY-N5025

Bullatine A	P2X Receptor Apoptosis ERK p38 MAPK c-Myc NF-κB Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Bullatine A, a diterpenoid alkaloid, is a potent *P2X7* antagonist. Bullatine A possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A inhibits ATP-induced BV-2 cell death/apoptosis and P2X receptor-mediated inflammatory responses. Bullatine A suppresses glioma cell growth by targeting SIRT6. Bullatine A specifically attenuates pain hypersensitivity in rats. Bullatine A attenuates LPS (HY-D1056)-induced systemic inflammatory response by inhibiting the ROS/JNK/NF-κB pathway in mice. Bullatine A improves despair behavior in Chronic chronic social defeat stress (CSDS) mice. Bullatine A can be used for the study of inflammation, glioblastoma (GBM) and depression .

HY-15487

CE-224535 PF-04905428	P2X Receptor	Neurological Disease
CE-224535 is a selective P2X₇ receptor antagonist.

HY-132981

Lu AF27139	P2X Receptor	Neurological Disease
Lu AF27139 is a potent, selective, and orally active antagonist of P2X7 receptor (IC₅₀s of 12 and 2.4 nM for human and rat, K_is of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 has rodent-active and CNS-penetrant character. Lu AF27139 has the potential for the research of CNS diseases .

HY-124857

7DG 7-Desacetoxy-6,7-dehydrogedunin	PERK Prokineticin Receptor P2X Receptor Caspase NOD-like Receptor (NLR) Pyroptosis Tyrosinase	Neurological Disease Metabolic Disease Inflammation/Immunology
7DG (7-Desacetoxy-6,7-dehydrogedunin) is a PKR inhibitor, *P2X7* purinergic receptor inhibitor, and skin-lightening agent. 7DG binds outside the ATP-catalytic domain of PKR, blocks the kinase activity-independent protein-protein interactions of PKR, inhibits the phosphorylation and activity of PKR, disrupts ASC assembly and caspase-1 activation, and suppresses the activation of the NLRP1 inflammasome. 7DG inhibits pyroptosis, suppresses the *ATP-P2X7* signaling pathway, and abolishes ATP-induced increases in the expression levels of MITF, tyrosinase, PMEL/gp100, and melanin content. 7DG exerts skin-lightening effects in cultured skin in vitro. 7DG can be used in research related to chronic obstructive pulmonary disease, gout, type 2 diabetes, Alzheimer's disease, and hyperpigmentary skin disorders .

HY-164426

HEI3090 1 Publications Verification	P2X Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
HEI3090 is a P2X7R activator. HEI3090 stimulates dendritic cells expressing P2X7R to produce IL-18, which subsequently promotes Natural Killer cells and CD4 T cells within tumors to produce IFN-γ, leading to a sustained antitumor response. HEI3090 can be used to enhance the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC) .

HY-B1901R

Eperisone hydrochloride (Standard) (±)-Eperisone hydrochloride (Standard)	P2X Receptor Reference Standards	Neurological Disease
Eperisone (hydrochloride) (Standard) is the analytical standard of Eperisone (hydrochloride). This product is intended for research and analytical applications. Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an orally active antispastic agent with a vasodilator effect, used for the research of muscle stiffness and pain. Eperisone Hydrochloride is a potent and selectively P2X7 receptor antagonist, also shows antagonism for human P2X3. Eperisone Hydrochloride works by relaxing both skeletal muscles and vascularsmooth muscles, demonstrating a variety of effects such as reduction ofmyotonia, improvement of circulationand and suppression of the pain reflex .

HY-18745

BzATP triethylammonium Benzoylbenzoyl-ATP triethylammonium	P2X Receptor	Inflammation/Immunology Cancer
BzATP triethylammonium acts as a P2X receptor agonist with pEC₅₀s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively . BzATP triethylammonium is potent at P2X7 receptors with EC₅₀s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively .

HY-19888

GSK-1482160	P2X Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor (P2X7R) negative allosteric modulator with pIC₅₀s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β. GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI) .

HY-148558

P2X7 receptor antagonist-3	P2X Receptor	Neurological Disease
P2X7 receptor antagonist-3 is a potent *P2X7* receptor antagonist with P2X7R IC₅₀ values of 4.2 nM in humans and 6.8 nM in rats .

HY-175196

P2X7 receptor antagonist-6	P2X Receptor	Infection Neurological Disease Inflammation/Immunology Cancer
P2X7 receptor antagonist-6 (Compound 2g) is a negative allosteric P2X7 receptor antagonist with an IC₅₀ of 1.31  μM for hP2X7. P2X7 receptor antagonist-6 can be used for cancer, neurodegenerative, inflammatory, and infectious diseases research .

HY-145466

EVT-401	P2X Receptor	Neurological Disease
EVT-401 (P2X7 receptor antagonist-1) is a purinergic P2X7 receptor antagonist. EVT-401 has efficacy of combating neuroinflammation .

HY-162951

P2X7 receptor antagonist-5	P2X Receptor	Cancer
P2X7 receptor antagonist-5 (compund 13a) is a potent, orally active and long-lasting *P2X7* receptor antagonist .

HY-18725

P2X7-IN-2	P2X Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
P2X7-IN-2 (compound 58) is a *P2X7* receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC₅₀ value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease .

HY-108670

AZ 11645373	P2X Receptor	Inflammation/Immunology
AZ11645373 is a highly selective and potent antagonist at human but not rat *P2X7* receptors，AZ11645373 inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells , with an IC₅₀ value of 90 nM .

HY-15469

GW791343 dihydrochloride 1 Publications Verification	P2X Receptor	Neurological Disease
GW791343 dihydrochloride is a potent human *P2X7* receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human *P2X7* receptor, with a pIC₅₀ of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease .

HY-123481

JNJ-42253432	P2X Receptor	Metabolic Disease
JNJ-42253432 is a CNS-penetrant, high-affinity and orally active *P2X7* antagonist, with pK_i values of 9.1 and 7.9 for rat and human P2X7 channels, respectively .

HY-128891

Eperisone	P2X Receptor	Neurological Disease
Eperisone ((±)-Eperisone) is an antispasmodic agent and centrally acting muscle relaxant useful in the study of diseases characterized by muscle stiffness and pain. Eperisone acts by relaxing skeletal and vascular smooth muscle, resulting in vasodilation, decreased muscle tone, improved circulation, and inhibition of pain reflexes. Eperisone is also a potent *P2X7* receptor antagonist .

HY-179373

UB-MBX-46	P2X Receptor	Cardiovascular Disease Neurological Disease Cancer
UB-MBX-46 is a potent and selective P2X7 receptor antagonist with IC₅₀s of 0.514 nM (hP2X7R), 40.6 nM (rP2X7R), and 4.52 nM (mP2X7R), respectively. UB-MBX-46 interacts with the classical allosteric pocket of the human P2X7 receptor. UB-MBX-46 can be used for cancer, atherosclerosis, and neurode generation research .

HY-18725A

P2X7-IN-2 TFA 1 Publications Verification	P2X Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
P2X7-IN-2 TFA (compound 58) is a *P2X7* receptor inhibitor. P2X7-IN-2 TFA inhibits IL-Iβ release with an IC₅₀ value of 0.01 nM. P2X7-IN-2 TFA can be used for the research of autoimmunity, inflammation and cardiovascular disease .

HY-156986

ITH15004	P2X Receptor	Neurological Disease
ITH15004 is a CNS-penetrated *P2X7* antagonist, used for the study of neurodegenerative diseases .

HY-15470

GW791343 trihydrochloride	P2X Receptor	Neurological Disease
GW791343 trihydrochloride is a potent human *P2X7* receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human *P2X7* receptor, with a pIC₅₀ of 6.9-7.2. GW791343 trihydrochloride can enhance ATP rhythm. GW791343 trihydrochloride can be used in study of neurological disease .

HY-W015627

3,5-Dichloropyridine	Drug Intermediate	Inflammation/Immunology Cancer
3,5-dichloropyridine is a drug intermediate that can be used to synthesize metal-organic framework (MOF) materials and P2X7 receptor antagonists .

HY-RS09912

P2rx7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
P2rx7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2rx7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

P2rx7 Mouse Pre-designed siRNA Set A P2rx7 Mouse Pre-designed siRNA Set A

HY-124300

JNJ-54166060	P2X Receptor	Others
JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC₅₀s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively .

HY-124300A

(S)-JNJ-54166060	P2X Receptor	Neurological Disease
(S)-JNJ-54166060 is an enantiomer of JNJ 54166060. JNJ 54166060 is a potent *P2X7* antagonist .

HY-N1478R

Gardenoside (Standard)	Reference Standards P2X Receptor Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study .

HY-123382

GSK-1482160 (isomer)	Drug Isomer	Neurological Disease Inflammation/Immunology
GSK-1482160 isomer is the isomer of GSK-1482160 (HY-19888). GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor (P2X7R) negative allosteric modulator with pIC₅₀s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β. GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI).

HY-19427

AZD9056	P2X Receptor	Cancer
AZD9056 is a P2X7 purinergic receptor antagonist with anticancer activity. AZD9056 can inhibit the invasion and metastasis of cancer stem cells .

HY-15488AR

A 438079 hydrochloride (Standard)	P2X Receptor	Neurological Disease
A 438079 (hydrochloride) (Standard) is the analytical standard of A 438079 (hydrochloride). This product is intended for research and analytical applications. A 438079 (hydrochloride) is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

HY-15488R

A 438079 (Standard)	P2X Receptor	Neurological Disease
A 438079 (Standard) is the analytical standard of A 438079. This product is intended for research and analytical applications. A 438079 is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

HY-123205R

Oxatomide (Standard) KW-4354 (Standard)	Reference Standards Histamine Receptor P2X Receptor 5-HT Receptor Apoptosis PERK p38 MAPK COX	Inflammation/Immunology
Oxatomide (Standard) (KW-4354 (Standard)) is the analytical standard of Oxatomide (HY-123205). This product is intended for research and analytical applications. Oxatomide (KW-4354) is an orally active dual antagonist of the H1-histamine receptor and the P2X7 receptor, as well as an inhibitor of serotonin. Oxatomide possesses antihistaminic, antiallergic and anti-inflammatory activities. Oxatomide can be used in the research of allergic diseases .

Cat. No.	Product Name	Target	Research Area

HY-P1137

10Panx 1 Publications Verification	Gap Junction Protein	Others
10Panx is a competitive inhibitor of selective Pannexin 1 (PANX1) channels. 10Panx blocks the opening of PANX1 channels, inhibits ATP release and downstream P2X7 receptor-mediated signaling pathways, thereby reducing cell death and inflammatory responses. 10Panx can be used in the study of diseases such as neuropathic pain, inflammatory bowel disease, and Clostridioides difficile infection. 10Panx can effectively reduce mechanical hyperalgesia and enhanced C-reflexes, and inhibit the expression of pro-inflammatory factors such as IL-6[1][2][3].

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705903

	P2RX7 Protein, Human (His) P2X7; ATP receptor; P2Z receptor; Purinergic receptor	Human	E. coli

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Host:	Mouse (2)
Reactivity:	Human (2) Mouse (2) Rabbit (2)
Application:	IHC-P (2) WB (2) FC (2) ELISA (2)
Isotype:	IgG2b (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

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HY-P84752

	P2RX7 Antibody (YA4449) 1 Publications Verification P2X7	WB, IHC-P, FC, ELISA	Human, Mouse, Rabbit
	P2RX7 Antibody (YA4449) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to P2RX7.

HY-P84752A

	P2RX7 Antibody (YA4449)(PBS only) P2X7	WB, IHC-P, FC, ELISA	Human, Mouse, Rabbit
	P2RX7 Antibody (YA4449) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to P2RX7.

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P2X7

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