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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
225 Results for "
PLA
" in MedChemExpress (MCE) Product Catalog:
Products (225)
225 Results for "PLA" in MCE Product Catalog:
32
32 Publications Verification
Cat. No.: HY-B2247
CAS No.: 34346-01-5
Synonyms: poly(lactic-co-glycolic acid) (50:50)
17
17 Cited Publications
Cat. No.: HY-P0233
CAS No.: 20449-79-0
Target:
Research Areas:
17
17 Cited Publications
Cat. No.: HY-P0233A
Target:
8
Target:
Research Areas:
Darapladib (SB-480848) is an orally active, selective and reversible Lp-PLA2 inhibitor (IC50=0.25 nM). Darapladib can trigger irreversible actions on glioma cell apoptosis and induce cycle arrest. Darapladib can be used in the study of atherosclerosis and cancer .
8
8 Cited Publications
Synonyms: N-(p-Amylcinnamoyl) anthranilic acid; ACA
Target:
Research Areas:
(E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker . (E/Z)-BML264 is a SLC13A3 inhibitor. (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia .
7
7 Cited Publications
Cat. No.: HY-B2247A
CAS No.: 34346-01-5
Synonyms: poly(lactic-co-glycolic acid) (75:25)
Target:
Research Areas:
PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides .
7
7 Cited Publications
Cat. No.: HY-18705
CAS No.: 932986-18-0
Research Areas:
Azoramide is a potent, orally active small-molecule modulator of the unfolded protein response (UPR). Azoramide improves ER protein folding and elevates ER chaperone capacity, which together protects cells against ER stress. Azoramide alleviates PLA2G6 mutant-induced ER stress through modulating unfolded protein response, and enhances the CERB signaling to rescue mitochondrial function, thereby preventing apoptosis of DA neurons. Azoramide has antidiabetic activity .
3
3 Cited Publications
Cat. No.: HY-P74628
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Phospholipase A2, membrane associated; EF; GIIC sPLA2
Species:
Source:
3
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Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM . Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist .
2
2 Cited Publications
1
Target:
Research Areas:
Phospholipase A2 (PLA2) is a calcium-dependent, heat-stable enzyme that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position of cellular membranes, thereby releasing Arachidonic Acid (AA) (HY-109590). Phospholipase A2 is a key mediator in the biosynthesis of pro-inflammatory lipid mediators, critically involved in inflammatory processes. Phospholipase A2 can be used for cardiovascular and inflammatory diseases research .
1
1
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Varespladib methyl (A-002; LY333013) is a selective inhibitor of group II secretory phospholipase A2 (PLA2).
1
1
1 Cited Publications
Cat. No.: HY-18570A
CAS No.: 15165-79-4
Synonyms: Potassium 1-Naphthaleneacetate
Research Areas:
1-Naphthaleneacetic acid potassium salt (Potassium 1-Naphthaleneacetate), a synthetic auxin, can promote plant growth. 1-Naphthaleneacetic acid potassium salt is also an inhibitor of PLA2, with an IC50 of 13.16 μM .
1
1 Cited Publications
Cat. No.: HY-P99263
CAS No.: 1256258-86-2
Synonyms: Anti-Human selectin P Recombinant Antibody
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-18540
CAS No.: 1402612-55-8
Research Areas:
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC50 of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC50=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .
1
1 Cited Publications
Target:
Research Areas:
LEI110 is a potent, selective and cell-permeable pan-inhibitor of the HRASLS family of thiol hydrolases. LEI110 inhibits PLA2G16, HRASLS2, RARRES3 and iNAT, with pIC50 values of 7.0, 6.8, 6.8, and 7.6, respectively. LEI110 reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in HepG2 cells .
1
1 Cited Publications
Cat. No.: HY-W329357
CAS No.: 108273-89-8
Cat. No.: HY-W250313
CAS No.: 26100-51-6
Synonyms: PLA
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
