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Results for "

SphK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SphK (44) Akt (1) Apoptosis (9) Aryl Hydrocarbon Receptor (3) Autophagy (5) CaMK (1) Environmental Pollutants (1) Filovirus (1) HCV (2) Interleukin Related (2) LPL Receptor (3) mTOR (1) NF-κB (1) PI3K (1) PKC (1) RAR/RXR (2) Reference Standards (4) Small Interfering RNA (siRNA) (6) TNF Receptor (2)
By Research Areas:	Cancer (34) Cardiovascular Disease (8) Infection (3) Inflammation/Immunology (17) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (6)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: SphK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate 725+ Cited Publications PMA; TPA; Phorbol myristate acetate	PKC SphK NF-κB	Neurological Disease Inflammation/Immunology Cancer
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual *SphK* and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress (MCE)) .

HY-15425

PF-543 20+ Cited Publications Sphingosine Kinase 1 Inhibitor II	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive *SPHK1* inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 is >100-fold selectivity for *SPHK1* over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 induces apoptosis, necrosis, and autophagy .

HY-W011338

Benzyl butyl phthalate 1 Publications Verification	Environmental Pollutants Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-15425A

PF-543 Citrate 20+ Cited Publications Sphingosine Kinase 1 Inhibitor II Citrate	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive *SPHK1* inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for *SPHK1* over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 Citrate induces apoptosis, necrosis, and autophagy .

HY-100008

Peretinoin 5+ Cited Publications NIK333	RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC₅₀ of 9 μM .

HY-15779A

K145 hydrochloride 5+ Cited Publications	SphK Apoptosis	Cancer
K145 hydrochloride is a selective, substrate-competitive and orally active *SphK2* inhibitor with an IC₅₀ of 4.3 μM and a K_i of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity .

HY-12892

SKI-178 1 Publications Verification	SphK Apoptosis	Cancer
SKI-178 is a potent sphingosine kinase-1 (SphK1) and *SphK2* inhibitor. SKI-178 is cytotoxic at IC₅₀ concentrations ranging from 1.8 to 0.1 μM in both agent sensitive and multi-agent resistant cancer cell lines (i.e., MTR3, NCI-ADR and HL60/VCR cells). SKI-178 induces apoptosis in a CDK1-dependent manner in human acute myeloid leukemia cell lines .

HY-101572

MHP Methyl caprooyl tyrosinate	SphK	Inflammation/Immunology Cancer
MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production. MHP (Methyl caprooyl tyrosinate) enhances antimicrobial defense and innate immunity .

HY-19794

MP-A08	SphK	Cancer
MP-A08 is a highly selective ATP competitive sphingosine kinase (SPHK1) inhibitor that targets both SphK1 and SphK2 with Ki values of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.

HY-W011338S

Benzyl butyl phthalate-d4	Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate . Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-12895

SKI V 1 Publications Verification	SphK PI3K Apoptosis	Cancer
SKI V is a noncompetitive and potent non-lipid *sphingosine kinase (SPHK; SK)* inhibitor with an IC₅₀ of 2 μM for GST-hSK. SKI V potently inhibits PI3K with an IC₅₀ of 6 μM for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity .

HY-148707

SphK1&2-IN-1	SphK	Cardiovascular Disease Inflammation/Immunology Cancer
SphK1&2-IN-1 is a *SphK* inhibitor targeting to *SphK1* and *SphK2. SphK*1&2-IN-1 has thermal stability .

HY-124042

K6PC-5 4 Publications Verification	SphK Filovirus	Infection Neurological Disease Inflammation/Immunology
K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research .

HY-119016

SK1-I 1 Publications Verification BML-258	SphK CaMK	Cancer
SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive *SPHK1* inhibitor with a K_i value of 10 μM . SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity .

HY-117563

CAY10621 SKI 5C	SphK	Cancer
CAY10621 (SKI 5C; compound 5c) is a specific sphingosine kinase 1 (SPHK1) inhibitor with an IC₅₀ of 3.3 μM. CAY10621 is low toxic toward cells. CAY10621 has the potential for resistant cancer tumors research .

HY-147282

Amgen-23	SphK	Cancer
Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor with IC₅₀ values of 20 nM and 1.6 μM for SPHK1 and SPHK2, respectively. Amgen-23 can be used for researching anticancer .

HY-162143

SKI-349	SphK Akt mTOR	Cancer
SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells .

HY-101805

SK1-IN-1 2 Publications Verification	SphK	Inflammation/Immunology Cancer
SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC₅₀ of 58 nM.

HY-120268A

SLM6031434 hydrochloride	SphK	Inflammation/Immunology
SLM6031434 hydrochloride is the hydrochloride salt form of SLM6031434 (HY-120268). SLM6031434 is a highly selective sphingosine kinase 2 (SphK2) inhibitor with an IC₅₀ value of 0.4 μM for *SphK2. SLM6031434 exerts anti-fibrotic effects by increasing sphingosine accumulation and Smad7* expression. SLM6031434 demonstrates effective anti-fibrotic efficacy in a unilateral ureteral obstruction (UUO)-induced tubulointerstitial fibrosis mouse model. SLM6031434 can be used for the study of proteinuric kidney diseases or chronic kidney disease (CKD) .

HY-151350

SphK2-IN-1	SphK	Cardiovascular Disease Inflammation/Immunology Cancer
SphK2-IN-1 is a *SphK2* inhibitor (IC₅₀: 0.359 μM). SphK2-IN-1 can be used in the research of cancer, inflammation, neurological and cardiovascular disorders .

HY-151351

SphK2-IN-2	SphK	Cancer
SphK2-IN-2 (21g) is a potent and selective *SphK2* inhibitor with an IC₅₀ value of 0.23 μM .

HY-15425B

PF-543 hydrochloride Sphingosine Kinase 1 Inhibitor II hydrochloride	SphK LPL Receptor Apoptosis Autophagy	Cardiovascular Disease Inflammation/Immunology Cancer
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive *SPHK1* inhibitor with an IC₅₀ of 2 nM and a K_i of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for *SPHK1* over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC₅₀ of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy .

HY-124863A

(R)-AAL	SphK	Inflammation/Immunology
(R)-AAL is an immunomodulator. (R)-AAL decreases circulating T lymphocytes in rats, with an ID₅₀ value of 0.009 mg/kg. (R)-AAL is a substrate of sphingosine kinase (SphK), which catalyzes the phosphorylation of (R)-AAL .

HY-15779

K145	SphK Apoptosis	Cancer
K145 is a selective, substrate-competitive and orally active *SphK2* inhibitor with an IC₅₀ of 4.3 µM and a K_i of 6.4 µM. K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity .

HY-RS13667

SPHK2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) SphK	Others
SPHK2 Human Pre-designed siRNA Set A contains three designed siRNAs for SPHK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SPHK2 Human Pre-designed siRNA Set A SPHK2 Human Pre-designed siRNA Set A

HY-RS13664

SPHK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) SphK	Others
SPHK1 Human Pre-designed siRNA Set A contains three designed siRNAs for SPHK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SPHK1 Human Pre-designed siRNA Set A SPHK1 Human Pre-designed siRNA Set A

HY-120268

SLM6031434	SphK	Inflammation/Immunology
SLM6031434 is a highly selective sphingosine kinase 2 (SphK2) inhibitor with an IC₅₀ value of 0.4 μM for *SphK2. SLM6031434 exerts anti-fibrotic effects by increasing sphingosine accumulation and Smad7* expression. SLM6031434 demonstrates effective anti-fibrotic efficacy in a unilateral ureteral obstruction (UUO)-induced tubulointerstitial fibrosis mouse model. SLM6031434 can be used for the study of proteinuric kidney diseases or chronic kidney disease (CKD) .

HY-W011338R

Benzyl butyl phthalate (Standard)	Reference Standards Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate (Standard) is the analytical standard of Benzyl butyl phthalate. This product is intended for research and analytical applications. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-143296

SphK1-IN-1	SphK	Cancer
SphK1-IN-1 (compound 48) is a *SphK1* inhibitor with effective antitumor activity. SphK1-IN-1 inhibits SphK1 ATPase with an IC₅₀ value of 4.02 μM. SphK1-IN-1 can be used for the research of cancer .

HY-150615

SphK1-IN-2	SphK Apoptosis	Cancer
SphK1-IN-2 is a potent, selective *SphK1* inhibitor with IC₅₀ values of 19.81 nM and ＞10 μM for SphK1 and SphK2, respectively. SphK1-IN-2 exhibits anti-proliferative activities and induces cell cycle arrest and apoptosis. SphK1-IN-2 can be used for cancer research .

HY-148262

SphK1-IN-3	SphK	Cancer
SphK1-IN-3 is an effective *sphingosine kinase-1 (SphK1)* inhibitor. SphK1-IN-3 inhibits SphK1 kinase activity with an IC₅₀ value of 2.48 μM. SphK1-IN-3 can be used for the research of many diseases such as cancer, rheumatoid arthritis, diabetes, asthma, and pulmonary fibrosis .

HY-178992

SphK1-IN-4	SphK	Cancer
SphK1-IN-4 (Compound 6b) is a sphingosine kinase 1 (SphK1) inhibitor. SphK1-IN-4 can be used for the research of cancer, such as lung cancer .

HY-162580

SphK2-IN-3	SphK	Cancer
SphK2-IN-3 (compound 12q) is a selective active sphingosine kinase-2 inhibitor. SphK2-IN-3 has anti-proliferative activity against various cancer cells, inducing G2 phase arrest and apoptosis in liver cancer cells HepG2 .

HY-RS13666

Sphk1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) SphK	Others
Sphk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sphk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sphk1 Rat Pre-designed siRNA Set A Sphk1 Rat Pre-designed siRNA Set A

HY-RS13669

Sphk2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sphk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sphk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sphk2 Rat Pre-designed siRNA Set A Sphk2 Rat Pre-designed siRNA Set A

HY-RS13668

Sphk2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) SphK	Others
Sphk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sphk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sphk2 Mouse Pre-designed siRNA Set A Sphk2 Mouse Pre-designed siRNA Set A

HY-RS13665

Sphk1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) SphK	Others
Sphk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sphk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sphk1 Mouse Pre-designed siRNA Set A Sphk1 Mouse Pre-designed siRNA Set A

HY-W019781

Biotinylated sphingosine Biotinyl-Sph	SphK	Metabolic Disease
Biotinylated sphingosine (Biotinyl-Sph) is a substrate of sphingosine kinase that can b used to detect the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 .

HY-150513

SLP9101555	SphK	Cancer
SLP9101555 (compound 14c) is a potent and selective *SphK2* (sphingosine kinase 2) inhibitor (K_i=90 nM) with 200-fold selectivity over SphK1. SLP9101555 markedly decreases extracellular S1P (sphingosine 1-phosphate) levels .

HY-120152

SLP7111228	SphK Interleukin Related TNF Receptor	Cardiovascular Disease Inflammation/Immunology
SLP7111228 is a selective sphingosine kinase 1 (SphK1) inhibitor and anti-inflammatory agent. SLP7111228 selectively inhibits SphK1 and reduces the production of sphingosine-1-phosphate. SLP7111228 decreases lipopolysaccharide-induced TNFα and IL-1β levels. SLP7111228 alleviates obliterative pulmonary arteriopathy, increases cardiac index and decreases total pulmonary vascular resistance index. SLP7111228 can be used in research related to neuroinflammatory diseases and pulmonary hypertension .

HY-183338

SphK2-IN-4	Apoptosis SphK	Cancer
SphK2-IN-4 is a selective *SphK2* inhibitor (IC₅₀=6.2 μM) with extremely low activity against *SphK1* (IC₅₀ > 50 μM). SphK2-IN-4 exhibits broad-spectrum antiproliferative activity against colorectal cancer cells and induces apoptosis .

HY-100008R

Peretinoin (Standard) NIK333 (Standard)	Reference Standards RAR/RXR SphK Autophagy HCV	Infection Cancer
Peretinoin (Standard) is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].

HY-12896

SLR080811	SphK	Cancer
SLR080811 is a guanidine-based selective sphingosine kinase 2 (SphK2) inhibitor with a K_i of 1.3 μM, exhibiting ~10-fold selectivity over *SphK1* (K_i = 12 μM). SLR080811 reduces sphingosine 1-phosphate (S1P) levels in vitro, but drives a SphK1-dependent increase in S1P in mice. SLR080811 can be used for cancers and fibrosis research .

HY-120440

VT-ME6	SphK	Inflammation/Immunology
VT-ME6 is a selective *SphK2* inhibitor with a K_i of 8 µM. VT-ME6 can be used in the research of inflammatory diseases .

HY-120152A

SLP7111228 hydrochloride	SphK Interleukin Related TNF Receptor	Cardiovascular Disease Inflammation/Immunology
SLP7111228 hydrochloride is a selective sphingosine kinase 1 (SphK1) inhibitor and anti-inflammatory agent. SLP7111228 hydrochloride selectively inhibits SphK1 and reduces the production of sphingosine-1-phosphate. SLP7111228 hydrochloride decreases lipopolysaccharide-induced TNFα and IL-1β levels. SLP7111228 hydrochloride alleviates obliterative pulmonary arteriopathy, increases cardiac index and decreases total pulmonary vascular resistance index. SLP7111228 hydrochloride can be used in research related to neuroinflammatory diseases and pulmonary hypertension .

HY-12897

(R)-FTY720-OMe	SphK	Cardiovascular Disease Neurological Disease Cancer
(R)-FTY720-OMe is a selective *SphK2* inhibitor with an IC₅₀ of 16.5  μM. (R)-FTY720-OMe can be used for cancer, fibrosis, and Alzheimer’s and sickle cell diseases research .

HY-101805R

SK1-IN-1 (Standard)	Reference Standards SphK	Inflammation/Immunology Cancer
SK1-IN-1 (Standard) is the analytical standard of SK1-IN-1 (HY-101805). This product is intended for research and analytical applications. SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC₅₀ of 58 nM.

HY-101572R

MHP (Standard) Methyl caprooyl tyrosinate (Standard)	SphK Reference Standards	Inflammation/Immunology Cancer
MHP (Standard) is the analytical standard of MHP (HY-101572). This product is intended for research and analytical applications. MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production. MHP (Methyl caprooyl tyrosinate) enhances antimicrobial defense and innate immunity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-18739

Phorbol 12-myristate 13-acetate 725+ Cited Publications PMA; TPA; Phorbol myristate acetate	Ketones, Aldehydes, Acids Croton tiglium Linn. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	PKC SphK NF-κB
Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual *SphK* and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress (MCE)) .

Recombinant Proteins Recommended:

SPHK

Species:	Human (3)
Tag:	His (2) Tag Free (1) GST (1)
Source:	Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73631

	SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, His-GST) Sphingosine kinase 1; SPK 1; SphK1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, His-GST) is the recombinant human-derived SPHK1/Sphingosine Kinase 1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702765

	SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, 363a.a) SK1; sphingosine kinase 1; SphK1; SPK 1; SPK	Human	Sf9 insect cells
	The SPHK1/sphingosine kinase 1 protein is a multifunctional lipid mediator that phosphorylates sphingosine to generate sphingosine-1-phosphate (SPP). SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, 363a.a) is the recombinant human-derived SPHK1/Sphingosine Kinase 1, expressed by Sf9 insect cells, with tag-free.

HY-P702913

	SPHK2 Protein, Human (Active, sf9, His) SK2; Sphingosine kinase 2	Human	Sf9 insect cells
	SPHK2 Protein, Human (sf9, His) is the recombinant human-derived SPHK2, expressed by Sf9 insect cells , with N-6*His labeled tag. ,

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HY-W011338S

Benzyl butyl phthalate-d4

Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate . Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (2) Mouse (2)
Application:	IHC-P (2) WB (3) FC (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80337

	SPHK1 Antibody (YA063)	WB, IHC-P, FC	Human
	SPHK1 Antibody (YA063) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SPHK1.

HY-P89415

	SPHK1 Antibody(YA8859)	WB, FC	Human, Mouse, Rat
	SPHK1 Antibody (YA8859) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SPHK1.

HY-P85786

	SphK2 Antibody (YA5478) Sphingosine kinase 2; SK 2; SPK 2;	WB, IHC-P	Human, Mouse, Rat
	SphK2 Antibody (YA5478) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SphK2.