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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
107 Results for "
TPA
" in MedChemExpress (MCE) Product Catalog:
Products (107)
107 Results for "TPA" in MCE Product Catalog:
861
861 Publications Verification
Cat. No.: HY-18739
CAS No.: 16561-29-8
Synonyms: PMA; TPA; Phorbol myristate acetate
8
8 Cited Publications
Cat. No.: HY-P2333
CAS No.: 533902-29-3
Target:
Research Areas:
8
8 Cited Publications
Cat. No.: HY-P2333A
Target:
Research Areas:
5
5 Cited Publications
Cat. No.: HY-P71051
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PLAT; T-PA; Plasminogen Activator, Tissue Type; TPA; Tissue-Type Plasminogen Activator; Plasminogen Activator, Tissue; T-Plasminogen Activator; Plasminogen/Activator Kringle; Alteplase; Plasminogen Activator; Reteplase
Species:
Human
Source:
HEK293
3
3 Cited Publications
Target:
Research Areas:
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .
3
Category:
Quinones Anthraquinones Other Diseases Aloe vera (L.) Burm. f. Phenols Polyphenols Plants Liliaceae Extract Disease Research Fields
Target:
3
3 Cited Publications
Cat. No.: HY-111056A
Target:
Research Areas:
UK122 hydrochloride is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 hydrochloride shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50s > 100 μM). UK122 hydrochloride, a 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .
2
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Research Areas:
Valrubicin is a chemotherapy agent, inhibits TPA- and PDBu-induced PKC activation with IC50s of 0.85 and 1.25 μM, respectively, and has antitumor and antiinflammatory activity.
2
2
2 Cited Publications
Cat. No.: HY-N0508
CAS No.: 85026-55-7
Category:
Rhodiola rosea Linn. Simple Phenylpropanols Crassulaceae Extract Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology
Target:
1
Research Areas:
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .
1
1 Cited Publications
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Research Areas:
ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .
1
1 Cited Publications
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Research Areas:
D-Ile-Pro-Arg p-nitroanilide dihydrochloride is a chromogenic peptide substrate of tissue plasminogen activator (tPA) .
1
1 Cited Publications
Cat. No.: HY-126361
CAS No.: 2254001-81-3
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Research Areas:
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .
1
1 Cited Publications
Target:
Research Areas:
ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .
1
Cat. No.: HY-100897
CAS No.: 57821-29-1
Synonyms: Vessel due F
Target:
Research Areas:
Sulodexide is a mixture of glycosaminoglycans available in soft capsule form for oral administration. It is composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease .
Sulodexide is a glycosaminoglycan mixture available in soft gelatin capsule form for oral administration.
Cat. No.: HY-18739R
CAS No.: 16561-29-8
Synonyms: PMA (Standard); TPA (Standard); Phorbol myristate acetate (Standard)
Target:
Synonyms: Lucidenic acid D2
Category:
Cardiovascular Disease Triterpenes Terpenoids Polyporaceae Extract Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-173591
CAS No.: 2785323-68-2
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
T0080 is a central nervous system-penetrant FPR1 inhibitor. By functionally blocking the FPR1 signaling pathway, T0080 effectively reduces neutrophil infiltration into ischemic brain tissue and maintains the integrity of the blood-brain barrier. T0080 alleviates tPA-associated hemorrhagic transformation, inhibits demyelination responses and the expression of NOX2. T0080 also possesses anti-apoptotic (apoptosis) and anti-inflammatory properties, thereby protecting myelin and reducing neurological deficits. T0080 is widely used in studies related to ischemic stroke complicated by hemorrhagic transformation after tPA thrombolysis, as well as multiple sclerosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
