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Results for "

TPOR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) CDK (2) ERK (2) PI3K (2) Small Interfering RNA (siRNA) (2) STAT (3) Thrombopoietin Receptor (4)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Inflammation/Immunology (3)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122620

Rafutrombopag (tautomerism) Hetrombopag (tautomerism); SHR-8735 (tautomerism)	Thrombopoietin Receptor STAT PI3K ERK Apoptosis CDK	Cardiovascular Disease Inflammation/Immunology
Rafutrombopag (tautomerism) (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .

HY-145589

Rafutrombopag Hetrombopag; SHR-8735	Thrombopoietin Receptor STAT PI3K ERK Apoptosis CDK	Cardiovascular Disease Inflammation/Immunology Cancer
Rafutrombopag (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .

HY-RS08616

MPL Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MPL Human Pre-designed siRNA Set A contains three designed siRNAs for MPL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MPL Human Pre-designed siRNA Set A MPL Human Pre-designed siRNA Set A

HY-14756

Totrombopag	Thrombopoietin Receptor	Others
Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating *TpoR*, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology .

HY-135041

Totrombopag choline SB-559448 choline	Thrombopoietin Receptor	Others
Totrombopag (SB-559448) choline is an orally effective thrombopoietin receptor (TpoR) agonist. By activating *TpoR*, Totrombopag choline initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag choline can be used to study platelet production and megakaryocyte biology .

HY-RS08617

Mpl Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mpl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mpl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mpl Mouse Pre-designed siRNA Set A Mpl Mouse Pre-designed siRNA Set A

HY-P991888

INCA033989	STAT	Cardiovascular Disease Cancer
INCA033989 is a fully human IgG1 monoclonal antibody targeting mutCALR (K_D = 1.75 nM for mutCALR ^del52; K_D = 6.78 nM for mutCALR ^ins5). INCA033989 antagonizes mutCALR-driven signaling and proliferation. INCA033989 selectively inhibits pSTAT3/pSTAT5. INCA033989 prevents thrombocytosis and reduces the expansion of mutCALR-positive cells. INCA033989 is useful for research on myeloproliferative neoplasms .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990469

*Anti-MPL/TPOR/CD110 Antibody (TA136)* TA136	Inhibitory Antibodies	Inflammation/Immunology
The Anti-MPL/TPOR/CD110 Antibody (TA136) is a CHO-expressed humanized antibody that targets *MPL/TPOR/CD110. The Anti-MPL/TPOR/CD110 Antibody (TA136) features a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-MPL/TPOR*/CD110 Antibody (TA136) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991888

INCA033989	STAT	Cardiovascular Disease Cancer
INCA033989 is a fully human IgG1 monoclonal antibody targeting mutCALR (K_D = 1.75 nM for mutCALR ^del52; K_D = 6.78 nM for mutCALR ^ins5). INCA033989 antagonizes mutCALR-driven signaling and proliferation. INCA033989 selectively inhibits pSTAT3/pSTAT5. INCA033989 prevents thrombocytosis and reduces the expansion of mutCALR-positive cells. INCA033989 is useful for research on myeloproliferative neoplasms .

Species:	Human (1) Mouse (1) Rat (2) Cynomolgus (1)
Tag:	His (4) Fc (1)
Source:	HEK293 (4) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74244

	C-MPL Protein, Rat (HEK293, Fc) CD110; c-Mpl; MPL; MPLV; Thrombopoietin R; TPO-R	Rat	HEK293
	The C-MPL Protein, a receptor for thrombopoietin, is a protein encoded in humans by the oncogene of myeloproliferative leukemia virus. The C-MPL Protein is involved in the activation of the JAK/STAT/MAPK signaling pathway. C-MPL Protein is a biomarker for thrombocytopenia. C-MPL Protein, Rat (HEK293, Fc) is the recombinant rat-derived C-MPL protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74243

	C-MPL Protein, Rat (sf9, His) CD110; c-Mpl; MPL; MPLV; Thrombopoietin R; TPO-R	Rat	Sf9 insect cells
	The C-MPL Protein, a receptor for thrombopoietin, is a protein encoded in humans by the oncogene of myeloproliferative leukemia virus. The C-MPL Protein is involved in the activation of the JAK/STAT/MAPK signaling pathway. C-MPL Protein is a biomarker for thrombocytopenia. C-MPL Protein, Rat (sf9, His) is the recombinant rat-derived C-MPL protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P700977

	C-MPL Protein, Cynomolgus (HEK293, His) TPO-R; CD110; MPL; c-Mpl; MPLV; K12	Cynomolgus	HEK293
	C-MPL protein is a key member of the type I cytokine receptor family and is essential for mediating cellular responses to various cytokines. Its research enhances our understanding of cell signaling, providing potential applications for therapeutic intervention in hematopoietic disorders and immune disorders. C-MPL Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag.

HY-P78003

	C-MPL Protein, Mouse (HEK293, His) TPO-R; CD110; MPL; c-Mpl; MPLV; K12	Mouse	HEK293
	C-MPL Protein, the receptor for thrombopoietin (TPO), is a key regulator of megakaryopoiesis and platelet production.It plays a crucial role in TPO-R-dependent immune responses and inhibits thrombopoietin signaling by facilitating the down-regulation of the full-length isoform Mpl-fl.C-MPL Protein, Mouse (HEK293, His) is the recombinant mouse-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag.

HY-P78002

	C-MPL Protein, Human (HEK293, His) TPO-R; CD110; MPL; c-Mpl; MPLV; K12	Human	HEK293
	C-MPL Protein, the thrombopoietin receptor, is a pivotal regulator of megakaryopoiesis and platelet production, suggesting a specific role in TPO-R-dependent immune responses. Forming homodimers and interacting with ATXN2L, it contributes to its multifaceted role in hematopoiesis and immune modulation. C-MPL Protein, Human (HEK293, His) is the recombinant human-derived C-MPL protein, expressed by HEK293 , with C-His labeled tag.

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Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	WB (2) FC (2) ELISA (2)
Isotype:	IgG (2) IgG2a (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84297

	Thrombopoietin Receptor Antibody (YA3994) MPL; MPLV; TPOR; C-MPL; THCYT2	FC, ELISA	Human
	Thrombopoietin Receptor Antibody (YA3994) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Thrombopoietin Receptor.

HY-P84297A

	Thrombopoietin Receptor Antibody (YA3994)(PBS only) MPL; MPLV; TPOR; C-MPL; THCYT2	FC, ELISA	Human
	Thrombopoietin Receptor Antibody (YA3994) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Thrombopoietin Receptor.

HY-P82496

	Thrombopoietin Receptor Antibody (YA2241) MPL; TPOR; Thrombopoietin receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD110	WB	Human, Mouse, Rat
	Thrombopoietin Receptor Antibody (YA2241) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thrombopoietin Receptor.

HY-P82496A

	Thrombopoietin Receptor Antibody (YA2241)(PBS only) MPL; TPOR; Thrombopoietin receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD110	WB	Human, Mouse, Rat
	Thrombopoietin Receptor Antibody (YA2241) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thrombopoietin Receptor.

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Cat. No.	Product Name		Classification

HY-RS08616

MPL Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MPL Human Pre-designed siRNA Set A contains three designed siRNAs for MPL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS08617

Mpl Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mpl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mpl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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