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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
TPOR
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "TPOR" in MCE Product Catalog:
Synonyms: Hetrombopag (tautomerism); SHR-8735 (tautomerism)
Research Areas:
Rafutrombopag (tautomerism) (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Cat. No.: HY-145589
CAS No.: 2600513-51-5
Synonyms: Hetrombopag; SHR-8735
Research Areas:
Rafutrombopag (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Cat. No.: HY-RS08616
Target:
Research Areas:
MPL Human Pre-designed siRNA Set A contains three designed siRNAs for MPL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P990469
Synonyms: TA136
Target:
Research Areas:
Cat. No.: HY-14756
CAS No.: 376592-42-6
Target:
Research Areas:
Totrombopag is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag can be used to study platelet production and megakaryocyte biology .
Cat. No.: HY-135041
CAS No.: 851606-62-7
Synonyms: SB-559448 choline
Target:
Research Areas:
Totrombopag (SB-559448) choline is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag choline initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag choline can be used to study platelet production and megakaryocyte biology .
Cat. No.: HY-RS08617
Target:
Research Areas:
Mpl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mpl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-125101A
CAS No.: 1257792-42-9
Rafutrombopag (Hetrombopag) diolamine is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag diolamine can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag diolamine specifically stimulates proliferation and differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag diolamine effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag diolamine protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag diolamine can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Cat. No.: HY-P74244
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MPL; Myeloproliferative Leukemia Virus Oncogene; MPL Proto-Oncogene, Thrombopoietin Receptor; TPO-R; TPOR; Thrombopoietin Receptor Variant; Myeloproliferative Leukemia Protein; CD110 Antigen; Thrombopoietin Receptor; THCYT2; Proto-Oncogene C-Mpl; C-MPL; C
Species:
Rat
Source:
HEK293
Cat. No.: HY-P74243
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MPL; Myeloproliferative Leukemia Virus Oncogene; MPL Proto-Oncogene, Thrombopoietin Receptor; TPO-R; TPOR; Thrombopoietin Receptor Variant; Myeloproliferative Leukemia Protein; CD110 Antigen; Thrombopoietin Receptor; THCYT2; Proto-Oncogene C-Mpl; C-MPL; C
Species:
Rat
Source:
Sf9 insect cells
Cat. No.: HY-P700977
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MPL; Myeloproliferative Leukemia Virus Oncogene; MPL Proto-Oncogene, Thrombopoietin Receptor; TPO-R; TPOR; Thrombopoietin Receptor Variant; Myeloproliferative Leukemia Protein; CD110 Antigen; Thrombopoietin Receptor; THCYT2; Proto-Oncogene C-Mpl; C-MPL; C
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P78003
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MPL; Myeloproliferative Leukemia Virus Oncogene; MPL Proto-Oncogene, Thrombopoietin Receptor; TPO-R; TPOR; Thrombopoietin Receptor Variant; Myeloproliferative Leukemia Protein; CD110 Antigen; Thrombopoietin Receptor; THCYT2; Proto-Oncogene C-Mpl; C-MPL; C
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P78002
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MPL; Myeloproliferative Leukemia Virus Oncogene; MPL Proto-Oncogene, Thrombopoietin Receptor; TPO-R; TPOR; Thrombopoietin Receptor Variant; Myeloproliferative Leukemia Protein; CD110 Antigen; Thrombopoietin Receptor; THCYT2; Proto-Oncogene C-Mpl; C-MPL; C
Species:
Human
Source:
HEK293
Cat. No.: HY-P84297A
Synonyms: MPL; MPLV; TPOR; C-MPL; THCYT2
Cat. No.: HY-P703708
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MPL; Myeloproliferative Leukemia Virus Oncogene; MPL Proto-Oncogene, Thrombopoietin Receptor; TPO-R; TPOR; Thrombopoietin Receptor Variant; Myeloproliferative Leukemia Protein; CD110 Antigen; Thrombopoietin Receptor; THCYT2; Proto-Oncogene C-Mpl; C-MPL; C
Species:
Canine
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
