91 Results for "

acetaminophen

" in MedChemExpress (MCE) Product Catalog:
Products (91)

91 Results for "acetaminophen" in MCE Product Catalog:

70
Acetaminophen
Acetaminophen
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70 Publications Verification
Cat. No.: HY-66005
CAS No.: 103-90-2
Synonyms: Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide
Category:  

Alkaloids Monophenols Other Alkaloids Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Environmental Pollutants Endogenous Metabolite COX Histone Acetyltransferase Parasite Bacterial Ferroptosis

Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent. . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor . Acetaminophen induces ferroptosis and leads to acute liver injury in mice model .
70
Acetaminophen (Standard)
Acetaminophen (Standard)
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70 Publications Verification
Cat. No.: HY-66005R
CAS No.: 103-90-2
Synonyms: Paracetamol (Standard); 4-Acetamidophenol (Standard); 4'-Hydroxyacetanilide (Standard)
Target:  

Reference Standards COX Histone Acetyltransferase Endogenous Metabolite Bacterial Parasite

Research Areas:  

Inflammation/Immunology Cancer

Acetaminophen (Standard) is the analytical standard of Acetaminophen. This product is intended for research and analytical applications. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
4
CCZ01048 TFA
CCZ01048 TFA
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4 Cited Publications
Cat. No.: HY-P2336A
Target:  

Melanocortin Receptor

Research Areas:  

Cancer

CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .
2
Sesame Oil
Sesame Oil
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2 Cited Publications
Cat. No.: HY-154629
CAS No.: 8008-74-0
Purity:  ≥98.0%
Target:  

Environmental Pollutants Biochemical Assay Reagents Interleukin Related NO Synthase Aminotransferases (Transaminases) NF-κB

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4 and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities .
2
Lathosterol
Lathosterol
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2 Cited Publications
Cat. No.: HY-113486
CAS No.: 80-99-9
Purity:  98.09%
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite SOD Lactate Dehydrogenase

Lathosterol is a plant sterol and cholesterol-like molecule. Lathosterol increases antioxidant enzymes (such as SOD, CAT, and GSH) and decreases LDH. Lathosterol has a hepatoprotective effect on mice with acetaminophen (HY-66005)-induced liver injury [1] .
1
2-Hydroxybutyric acid
2-Hydroxybutyric acid
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1 Cited Publications
Cat. No.: HY-113381
CAS No.: 600-15-7
Purity:  ≥98.0%
Synonyms: α-Hydroxybutyric acid
Category:  

Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Endogenous metabolite Disease Research Fields Cardiovascular System Disorder

Target:  

Endogenous Metabolite

2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia . 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury .
1
Didemnin B
Didemnin B
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1 Cited Publications
Cat. No.: HY-105055
CAS No.: 77327-05-0
Purity:  99.95%
Category:  

Natural Products Animals Marine natural products Other marine organisms Disease Research Fields Cancer

Target:  

Others

Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .
1
Sodium 2-hydroxybutanoate
Sodium 2-hydroxybutanoate
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1 Cited Publications
Cat. No.: HY-W012790
CAS No.: 5094-24-6
Synonyms: 2-Hydroxybutyric acid sodium
Category:  

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .
1
Paracetamol-cysteine TFA
Paracetamol-cysteine TFA
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1 Cited Publications
Cat. No.: HY-139093A
CAS No.: 1331891-93-0
Purity:  ≥99.0%
Synonyms: APAP-Cys TFA
Target:  

Drug Derivative

Research Areas:  

Others

Paracetamol-cysteine (TFA) is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (HY-66005) .
1
DI-1859
DI-1859
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1 Cited Publications
Cat. No.: HY-145733
CAS No.: 2247061-09-0
Purity:  99.62%
Target:  

E1/E2/E3 Enzyme

Research Areas:  

Cardiovascular Disease

DI-1859 is a potent, selective and covalent inhibitor of DCN1. DI-1859 inhibits neddylation of cullin 3 in cells at low nanomolar concentrations. DI-1859 induces a robust increase of NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver damage .
Cholesteryl hemisuccinate
Cholesteryl hemisuccinate
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Cat. No.: HY-W010800
CAS No.: 1510-21-0
Target:  

Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis

Research Areas:  

Cancer

Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .
D-Glucan
D-Glucan
0 Images
Cat. No.: HY-134816
CAS No.: 9012-72-0
Purity:  ≥96.0%
D-Glucan is an orally effective Dectin-1 receptor immune activator with antioxidant properties (reducing TNF-α). D-Glucan activates macrophages and neutrophils to scavenge free radicals, inhibit oxidative stress and inflammatory responses, and improve insulin sensitivity. D-Glucan promotes glycolysis by enhancing the activity of the antioxidant enzyme glutathione, inhibiting gluconeogenesis and activating GK. D-Glucan can be used in the research of liver damage protection (antagonizing Acetaminophen (HY-66005) toxicity), radiation protection (synergistic with vitamin E) and diabetes (improving glucose metabolism) .
Cholesterol hemisuccinate Tris salt
Cholesterol hemisuccinate Tris salt
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Cat. No.: HY-W010800A
CAS No.: 102601-49-0
Synonyms: Cholesterol hydrogen succinate Tris salt; CHS-Tris
Target:  

Biochemical Assay Reagents Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis

Research Areas:  

Inflammation/Immunology Cancer

Cholesterol hemisuccinate (Cholesterol hydrogen succinate) Tris salt is a compound with hepatoprotective and anticancer activity. Cholesterol hemisuccinate Tris salt inhibits Acetaminophen (AAP) (HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesterol hemisuccinate Tris salt inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Cholesterol hemisuccinate Tris salt inhibits tumor growth. Cholesterol hemisuccinate Tris salt can be used for buffer preparation .
Acetaminophen-d4
Acetaminophen-d4
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Cat. No.: HY-66005S
CAS No.: 64315-36-2
Synonyms: Paracetamol-d4; 4-Acetamidophenol-d4; 4'-Hydroxyacetanilide-d4
Acetaminophen-d4 is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
Insulin icodec
Insulin icodec
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Cat. No.: HY-P4070
CAS No.: 1188379-43-2
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .
NAPQI
NAPQI
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Cat. No.: HY-W017464
CAS No.: 50700-49-7
Synonyms: N-Acetyl-4-benzoquinone Imine
Category:  

Alkaloids Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Drug Metabolite Endogenous Metabolite

NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .
Acetaminophen glucuronide
Acetaminophen glucuronide
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Cat. No.: HY-113083
CAS No.: 16110-10-4
Purity:  ≥99.0%
Synonyms: APAP-glu
Category:  

Alkaloids Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Drug Metabolite Endogenous Metabolite

Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
NecroX-7
NecroX-7
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Cat. No.: HY-124750
CAS No.: 1120332-55-9
Purity:  99.69%
Target:  

TNF Receptor Interleukin Related Toll-like Receptor (TLR) Reactive Oxygen Species (ROS)

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

NecroX-7 is a potent free radical scavenger and a HMGB1 (high-mobility group box 1) inhibitor. NecroX-7 can be used as an antidote to acetaminophen toxicity. NecroX-7 exerts a protective effect by preventing the release of HMGB1 in ischemia/reperfusion injury. NecroX-7 inhibits the HMGB1-induced release of TNF and IL-6, as well as the expression of TLR-4 and receptor for advanced glycation end products. NecroX-7 can be used graft-versus-host disease (GVHD) research .
Metacetamol
Metacetamol
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Cat. No.: HY-B1309
CAS No.: 621-42-1
Synonyms: AMAP
Category:  

Monophenols Boswellia serrata Roxb. Phenols Plants Burseraceae

Target:  

Drug Derivative Mitochondrial Metabolism

Metacetamol (AMAP) is an analog of Acetaminophen (HY-66005). Metacetamol induces dose-dependent necrosis in primary hepatocytes via glutathione depletion, mitochondrial damage, and formation of mitochondrial protein adducts. Metacetamol derivatives act as anticancer and antibacterial agents. Metacetamol can be used in studies related to breast cancer, bacterial infections, and fungal infections (candidiasis) .
FH1
FH1
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Cat. No.: HY-12346
CAS No.: 2719-05-3
Purity:  99.17%
Synonyms: NSC 12407; BRD-K4477
Target:  

Quinone Reductase

Research Areas:  

Others

FH1 (NSC 12407) is a NQO2 inhibitor with hepatoprotective effects. FH1 enhances hepatocyte function and promotes differentiation of induced pluripotent stem (iPS)-derived hepatocytes to a more mature phenotype and maturation of well-differentiated hepatocyte-like cell (iHeps) cultures. FH1 protects against Acetaminophen (HY-66005)-induced hepatotoxicity in both embryos and adult zebrafish .
Assay Types