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Results for "

amide coupling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (4) Biochemical Assay Reagents (10) Drug Intermediate (2) Fluorescent Dye (4) G2A (GPR132) (1) Radionuclide-Drug Conjugates (RDCs) (2) Reference Standards (2)
By Research Areas:	Cancer (5) Infection (1) Inflammation/Immunology (2) Neurological Disease (3)
Click Chemistry:	Azide (1) Tetrazine (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Click Chemistry

Targets Recommended: FAAH

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1703

HATU	Biochemical Assay Reagents	Others
HATU is a third-generation uronium salt peptide coupling reagent. HATU increases the rate of peptide coupling reactions, activates amino acids, promotes peptide bond formation in both solution-phase and solid-phase synthesis, and also facilitates peptide assembly, fragment coupling, and linear peptide cyclization. HATU can promote the N-acylation of chitosan to generate amide-linked cationic derivatives with a controllable degree of substitution. HATU is commonly used in amine acylation reactions .

HY-Y1168

DMTMM 2 Publications Verification 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride	Biochemical Assay Reagents	Neurological Disease Cancer
DMTMM (4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials .

HY-100138

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester)	Radionuclide-Drug Conjugates (RDCs) ADC Linker	Cancer
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as ⁶⁸Ga, ¹⁷⁷Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine .

HY-130086

Bis-PEG4-NHS ester	ADC Linker	Cancer
Bis-PEG4-NHS ester is a crosslinking reagent and amine-reactive modulator .Bis-PEG4-NHS ester reacts with primary amine groups on liposome surfaces via amide bond formation to covalently attach dibenzylcyclooctyne groups, with a hydrophilic PEG4 spacer reducing steric hindrance for subsequent click chemistry .Bis-PEG4-NHS ester enables site-specific antibody coupling to liposome surfaces via copper-free strain-promoted alkyne-azide cycloaddition click chemistry without disrupting liposome structure in minimal organic solvent volumes .Bis-PEG4-NHS ester undergoes hydrolysis during annealing to form -COOH groups that interact with PbI and FAI to enhance perovskite structural integrity, passivate defects, and modulate nucleation kinetics to regulate crystal growth .Bis-PEG4-NHS ester enhances device efficiency and long-term stability when used as an antisolvent additive for p-i-n perovskite solar cells .

HY-Y0973

BOP hexafluorophosphate	Biochemical Assay Reagents Drug Intermediate	Others
BOP hexafluorophosphate is a phosphonium-type condensing agent. BOP hexafluorophosphate activates the carboxylic acid component to form a highly reactive O-benzotriazole ester (active ester) intermediate, which then reacts with the amino component to form an amide bond (peptide bond). BOP hexafluorophosphate is applicable to solid-phase polypeptide synthesis and nucleoside modification .

HY-W099632

2-Hexyldecanoic acid	Biochemical Assay Reagents	Infection Inflammation/Immunology
2-Hexyldecanoic acid is a lipid containing one carboxylic acid group and two non-polar tails. In the presence of EDC, HATU and DCC, carboxylic acid groups can undergo continuous amide coupling reactions with amine-containing biomolecules to form stable amide bonds. 2-Hexyldecanoic acid can be used as an aerolysin inhibitor to prevent bacterial pathogens. 2-Hexyldecanoic acid can cause contact dermatitis .

HY-171854

SB-583355	G2A (GPR132)	Neurological Disease Inflammation/Immunology
SB-583355 (Compound 56) is a potent G2A antagonist. SB-583355 can be prepared by a Suzuki reaction between 4-methoxyphenyl boronic acid and 3-bromo-4-hydroxybenzoic acid following the conditions followed by an amide coupling reaction. SB-583355 blocks the activation of G2A mediated either by 9-HOPE or T-10148 in human G2A expressing CHO-K1 cells. SB-583355 can be studied in research for inflammation, myeloid leukemia, and neuropathic pain .

HY-D2956

BC-GLA-NHS CLIP-GLA-NHS	Biochemical Assay Reagents	Others
BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

HY-151686

Bz-(Me)Tz-NHS	Biochemical Assay Reagents	Others
Bz-(Me)Tz-NHS is a methyltetrazine carboxylic acid NHS ester that enables conjugation of the tetrazine moiety to the 5' end of oligonucleotides via amide coupling reaction, and it is used in oligonucleotide template-mediated fluorescent bioorthogonal cycloaddition reactions. Bz-(Me) Tz-NHS is applicable to click chemistry-related studies .

HY-133883

Cyanine7.5 amine	Fluorescent Dye	Others
Cyanine7.5 amine is a near-infrared Cy7.5-based dye and also a substrate for amide bond coupling (Ex/Em = 788 nm/808 nm). Cyanine7.5 amine contains a free amino group and can be used for coupling with activated carboxylic acid derivatives .

HY-157921

Amino-EG6-undecanethiol hydrochloride 20-(9-Mercaptononyl)-3,6,9,12,15,18-hexaoxaeicosane-1-amine, hydrochloride	Biochemical Assay Reagents	Others
Amino-EG6-undecanethiol hydrochloride is a biochemical assay reagent, and can be used as a linker through amide coupling .

HY-W800846

Fmoc-Amido-Tri-(carboxyethoxymethyl)-methane	Biochemical Assay Reagents	Others
Fmoc-Amido-Tri-(carboxyethoxymethyl)-methane is a multifunctional reagent containing three carboxylic acids and a primary amine that is Fmoc-protected. The carboxylic acids can react with primary amine groups to form stable amide bonds. The Fmoc protecting group can be removed using piperidine, freeing up the amine for a variety of uses such as coupling with carboxylic acids to form amide bonds.

HY-177942

Azide-C5-amide-tri-SA-bis(amide-PBA)	ADC Linker	Neurological Disease
Azide-C5-amide-tri-SA-bis(amide-PBA) (compound 15) is a linker targeting eye tissue specific protein, can be used for oligonucleotide coupling .

HY-155885

mPEG40000-amine mPEG40000-NH2	Biochemical Assay Reagents	Others
mPEG40000-amine (mPEG40000-NH2) is a monofunctional polyPEG with a terminal amine. The coupling between NHS ester and amine produces a stable amide bond. The amine moieties is also reactive with carboxyl in the presence of activating agent .

HY-W099632R

2-Hexyldecanoic acid (Standard)	Biochemical Assay Reagents Reference Standards	Others
Dipotassium glycyrrhizinate (Standard) is the analytical standard of Dipotassium glycyrrhizinate. This product is intended for research and analytical applications. 2-Hexyldecanoic acid is a lipid containing one carboxylic acid group and two non-polar tails. In the presence of EDC, HATU and DCC, carboxylic acid groups can undergo continuous amide coupling reactions with amine-containing biomolecules to form stable amide bonds. 2-Hexyldecanoic acid can be used as an aerolysin inhibitor to prevent bacterial pathogens. 2-Hexyldecanoic acid can cause contact dermatitis.

HY-D3049

5(6)-carbonylated rhodamine 110 NHS ester	Fluorescent Dye	Others
5(6)-carbonylated rhodamine 110 NHS ester is a reactive ester fluorescent reagent based on 5(6)-carbonylated rhodamine 110. NHS ester is a highly reactive ester capable of covalently coupling with primary amine groups in molecules such as proteins, peptides, amino sugars, and nucleic acids to form stable amide bonds (Ex/Em = 502/527 nm).

HY-176947

Demethyl-sapanisertib-C2-amide-PEG7-C2-N3	Drug Intermediate	Cancer
Demethyl-sapanisertib-C2-amide-PEG7-C2-N3 (Compound 10c) is an azide group linker used for coupling, which can be employed in the synthesis of "Rapa-Link" compounds, such as M-1111 (HY-176948), an mTOR inhibitor .

HY-D3050

5(6)-carbonylated rhodamine 110 X NHS ester	Fluorescent Dye	Others
5(6)-carbonylated rhodamine 110 X NHS ester is a reactive ester fluorescent reagent based on 5(6)-carbonylated rhodamine 110 X. NHS ester is a highly reactive ester capable of covalently coupling with primary amine groups in molecules such as proteins, peptides, amino sugars, and nucleic acids to form stable amide bonds (Ex/Em = 496/522 nm).

HY-D3053

5(6)-Rhodamine 6G NHS ester	Fluorescent Dye	Others
5(6)-Rhodamine 6G NHS ester is a reactive ester fluorescent reagent based on Rhodamine 6G (HY-D0309). NHS ester is a highly reactive ester capable of covalently coupling with primary amine groups in molecules such as proteins, peptides, amino sugars, and nucleic acids to form stable amide bonds (Ex/Em = 526/547 nm).

HY-100138R

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (Standard)	Radionuclide-Drug Conjugates (RDCs) ADC Linker Reference Standards	Cancer
2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (Standard) is the analytical standard of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (HY-100138). This product is intended for research and analytical applications. 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga, 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine .

Cat. No.	Product Name	Type

HY-D2956

BC-GLA-NHS CLIP-GLA-NHS	Fluorescent Dye
BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

BC-GLA-NHS

CLIP-GLA-NHS

Fluorescent Dye

BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

HY-133883

Cyanine7.5 amine	Fluorescent Dye
Cyanine7.5 amine is a near-infrared Cy7.5-based dye and also a substrate for amide bond coupling (Ex/Em = 788 nm/808 nm). Cyanine7.5 amine contains a free amino group and can be used for coupling with activated carboxylic acid derivatives .

HY-D3049

5(6)-carbonylated rhodamine 110 NHS ester	Fluorescent Dye
5(6)-carbonylated rhodamine 110 NHS ester is a reactive ester fluorescent reagent based on 5(6)-carbonylated rhodamine 110. NHS ester is a highly reactive ester capable of covalently coupling with primary amine groups in molecules such as proteins, peptides, amino sugars, and nucleic acids to form stable amide bonds (Ex/Em = 502/527 nm).

HY-D3050

5(6)-carbonylated rhodamine 110 X NHS ester	Fluorescent Dye
5(6)-carbonylated rhodamine 110 X NHS ester is a reactive ester fluorescent reagent based on 5(6)-carbonylated rhodamine 110 X. NHS ester is a highly reactive ester capable of covalently coupling with primary amine groups in molecules such as proteins, peptides, amino sugars, and nucleic acids to form stable amide bonds (Ex/Em = 496/522 nm).

HY-D3053

5(6)-Rhodamine 6G NHS ester	Fluorescent Dye
5(6)-Rhodamine 6G NHS ester is a reactive ester fluorescent reagent based on Rhodamine 6G (HY-D0309). NHS ester is a highly reactive ester capable of covalently coupling with primary amine groups in molecules such as proteins, peptides, amino sugars, and nucleic acids to form stable amide bonds (Ex/Em = 526/547 nm).

Cat. No.	Product Name	Type

HY-Y1168

DMTMM 2 Publications Verification 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride	Biochemical Assay Reagents
DMTMM (4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials .

DMTMM

2 Publications Verification

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride

Biochemical Assay Reagents

DMTMM (4-(4,6-dimethoxy-1,3,5-triazine-2-yl)-4-methylmorpholinium chloride) is a coupling agent. DMTMM can activate carboxyl groups and promote the formation of amide bonds. DMTMM plays an important role in promoting the chemical modification of biomacromolecules such as polysaccharides and proteins. DMTMM can be used for research of tissue engineering, breast cancer, corneal regeneration, and biomaterials .